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Search Results for " mpp "

Targets Recommended: Estrogen Receptor/ERR

22

抑制剂 & 化合物

7

天然产物

3

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T21897L	MPP hydrochloride MPP hydrochloride (289726-02-9 Free base)	Estrogen Receptor/ERR	Endocrinology/Hormones
	MPP hydrochloride 是一种选择性雌激素受体（ERR）调节剂。
T9169	MPP+ iodide	Mitochondrial Metabolism; Autophagy	Autophagy; Metabolism
	MPP+ iodide 是一种神经毒素 MPTP 的有毒代谢物，也是一种 5-羟色胺转运体 (SERT) 的高亲和力底物。MPP+ iodide 对多巴胺能神经元有毒，可以在动物模型中导致帕金森症。
T12101	MPP dihydrochloride (289726-02-9 Free base)	Others	Others
	MPP dihydrochloride is a highly selective antagonist of estrogen receptor alpha (ERα).
T4058	R-IMPP	Others; Serine/threonin kinase	Cell Cycle/Checkpoint; Metabolism; Others
	R-IMPP 是抗 PCSK9分泌的药物 (IC50=4.8 μM)，靶向作用于 80S 核糖体，抑制 PCSK9 蛋白的翻译。
T14280	AMPPD Lumigen PPD,3-(2'-Spiroadamantane)-4-methoxy-4-(3''-phosphoryloxy)phenyl-1,2-dioxetane,PPD,Lumi-Phos Plus	Others	Others
	AMPPD (Lumi-Phos Plus) 是一种超敏碱性磷酸酶底物，是 1,2-dioxo-cyclohexane 衍生物。
T16421	p-MPPI hydrochloride	5-HT Receptor	GPCR/G Protein; Neuroscience
	p-MPPI hydrochloride 是一种选择性的，具有高亲和力的5-HT1A 受体拮抗剂，能穿过血脑屏障，具有抗抑郁和抗焦虑样作用。
T28077	MMPP	VEGFR; STAT	Angiogenesis; JAK/STAT signaling; Stem Cells; Tyrosine Kinase/Adaptors
	MMPP 是一种新型 VEGFR2 抑制剂，具有抗炎活性和潜在的抗癌活性，抑制STAT3 ，可通过 VEGFR2/AKT/ERK/NF-kappaB 通路抑制血管生成，可用于缓解心肌损伤。
T37893	3-MPPI	Others	Others
	3-MPPI 是一种高亲和力非选择性 α1 拮抗剂。
T38212	MPPG	Others	Others
	MPPG 是一种有选择性的 L-AP4 敏感受体拮抗剂（kD=9.2 μM）。
T23043	N-MPPP Hydrochloride	Others	Others
	High affinity κ agonist
T22497	2-MPPA	Others	Others
	glutamate carboxypeptidase II (GCP II) inhibitor
T33493	Mppf F-18 J1.050.795B,P-18FMPPF,(18F) Mppf,(18F)Mppf,(18F)-Mppf	Others	Others
	Mppf F-18, which has been used as a radioactive ligand for positron emission tomography, is a compound that binds to the serotonin-1A receptor.
T28986	TMPPAA	Others	Others
	TMPPAA is an allosteric agonist of 5-HT3 receptor.
T26766	BemPPOX	Others	Others
	BemPPOX is a potent inhibitor of DGL.
T69750	p-MPPF dihydrochloride	Others	Others
	p-MPPF dihydrochloride is a selective 5-ht1a serotonin receptor antagonist
T40063	CBR-470-1	Nrf2	Immunology/Inflammation
	CBR-470-1 是一种有效的糖酵解磷酸甘油酸激酶1 (PGK1) 抑制剂，通过增加甲基乙二醛的水平来激活 NRF2。 CBR-470-1 是一种非共价的 Nrf2 激活剂，具有神经保护活性，通过激活 Keap1-Nrf2 级联反应来保护 SH-SY5Y 神经元细胞免受 MPP+ 诱导的细胞毒性。
T4081	MPTP hydrochloride MPTP-hydrochloride	Apoptosis; Dopamine Receptor	Apoptosis; GPCR/G Protein; Neuroscience
	MPTP hydrochloride 是 MPP+ 的前体，是一种多巴胺神经毒素，具有血脑屏障渗透性。MPTP hydrochloride 对多巴胺能神经元有毒，可以导致帕金森症，被广泛应用于帕金森动物模型的构建。
T3570	SU4312 SU 4312,NSC 86429	VEGFR; PDGFR	Angiogenesis; Tyrosine Kinase/Adaptors
	NSC-86429 是一种 (Z)-SU4312 (SU 4312) 和 (E)-SU4312 的外消旋体。其中(Z)-SU4312 能够抑制 PDGFR 和 FLK-1。(E)-SU4312 能够抑制 PDGFR, FLK-1, EGFR, HER-2, 和 IGF-1R。
T61268	Vutiglabridin HSG4112	Phosphatase	Metabolism
	Vutiglabridin (HSG4112) 是一种新型且安全的PON2调节剂，是一个外消旋化合物。Vutiglabridin 是Glabridin 的优化结构类似物，比Glabridin 在减重效果和化学稳定性方面更加优越。Vutiglabridin 通过靶向线粒体对氧磷酶-2改善mptp 诱导的帕金森病小鼠的神经变性。Vutiglabridin 是一种治疗肥胖的临床2期药物，在PD 模型中对对线粒体PON2具有治疗作用。Vutiglabridin 渗透到大脑，结合PON2，恢复1-甲基-4-苯基吡啶(MPP*)诱导的SH-SY5Y 神经母细胞瘤细胞线粒体功能障碍。Vutiglabridin 在小鼠实验中显著减轻了1-甲基-4苯基-1,2,3,6-四氢吡啶(MPTP)诱导的PD 模型小鼠的运动障碍和多巴胺能神经元损伤。
T38516	IDT307
	IDT307, an analog of the organic cation MPP+, serves as a specific fluorescent substrate for DAT, identified as APP+.
T79333	LZWL02003	Reactive Oxygen Species	Immunology/Inflammation; Metabolism; NF-κB
	LZWL02003为抗神经炎症化合物，对MPP+引起的神经元损害展示保护效果，有效降低ROS水平。此外，LZWL02003能改善鱼藤酮诱导的帕金森病(PD)大鼠模型在认知、记忆、学习及运动能力方面的缺陷。该化合物在神经退行性疾病的研究中具有应用潜力。
T68547	SNJ-1945	Others	Others
	SNJ-1945 is a calpain inhibitor with more favorable retinal penetration, high oral bioavailability, and long half-life. SNJ1945 rescued defective function in lissencephaly. SNJ-1945 protects SH-SY5Y cells against MPP(+) and rotenone. SNJ-1945 reduces murine retinal cell death in vitro and in vivo. SNJ-1945 has good aqueous solubility, can prevents the heart from KCl arrest-reperfusion injury associated with the impairment of total Ca(2+) handling by inhibiting the proteolysis of alpha-fodrin a...

化合物

MPP hydrochloride

Cat.No: T21897L

Synonym: MPP hydrochloride (289726-02-9 Free base)

Target: Estrogen Receptor/ERR

Cat.No: T9169

Target: Mitochondrial Metabolism, Autophagy

MPP dihydrochloride (289726-02-9 Free base)

Cat.No: T12101

Target: Others

Cat.No: T4058

Target: Others, Serine/threonin kinase

Cat.No: T14280

Synonym: Lumigen PPD,3-(2'-Spiroadamantane)-4-methoxy-4-(3''-phosphoryloxy)phenyl-1,2-dioxetane,PPD,Lumi-Phos Plus

Target: Others

p-MPPI hydrochloride

Cat.No: T16421

Target: 5-HT Receptor

Cat.No: T28077

Target: VEGFR, STAT

Cat.No: T37893

Target: Others

Cat.No: T38212

Target: Others

N-MPPP Hydrochloride

Cat.No: T23043

Target: Others

Cat.No: T22497

Target: Others

Cat.No: T33493

Synonym: J1.050.795B,P-18FMPPF,(18F) Mppf,(18F)Mppf,(18F)-Mppf

Target: Others

Cat.No: T28986

Target: Others

Cat.No: T26766

Target: Others

p-MPPF dihydrochloride

Cat.No: T69750

Target: Others

Cat.No: T40063

Target: Nrf2

MPTP hydrochloride

Cat.No: T4081

Synonym: MPTP-hydrochloride

Target: Apoptosis, Dopamine Receptor

Cat.No: T3570

Synonym: SU 4312,NSC 86429

Target: VEGFR, PDGFR

Cat.No: T61268

Synonym: HSG4112

Target: Phosphatase

Cat.No: T38516

Cat.No: T79333

Target: Reactive Oxygen Species

Cat.No: T68547

Target: Others

Cat. No.	Product Name	Target	Signaling Pathways
T2860	Vanillyl Alcohol 4-Hydroxy-3-methoxybenzenemethanol,3-Methoxy-4-hydroxybenzyl alcohol,4-Hydroxy-3-methoxybenzyl alcohol,香兰醇,Vanillin alcohol,Vanillic alcohol	Apoptosis; Others	Apoptosis; Others
	Vanillyl Alcohol (3-Methoxy-4-hydroxybenzyl alcohol) 是一种酚类醇，具有抗血管生成、抗惊厥、抗炎、抗氧化、神经保护和抗伤害活性。它由香兰素衍生而来，在食品和饮料中用作调味剂。
TN1038	Galgravin	Apoptosis	Apoptosis
	Galgravin 是望春花中的一种天然产物，具有抗炎和体外细胞毒活性，能诱导白血病细胞凋亡。
T2230	Paeoniflorin 芍药苷,Peoniflorin	HSP; COX	Cytoskeletal Signaling; Immunology/Inflammation; Metabolism; Neuroscience
	Paeoniflorin (Peoniflorin) 是从芍药根中提取的一种蒎烷单萜糖苷，具有抗癌作用、抗氧化应激、抗血小板聚集、血管扩张、降低血液粘度和抗炎活性等多种生物活性。它是一种热休克蛋白诱导剂，通过自噬途径保护 PC12 细胞免受 MPP+和酸性损伤。
TN4435	Licopyranocoumarin	P450; ROS; JNK	Immunology/Inflammation; MAPK; Metabolism
	Licopyranocoumarin could as a potent neuroprotective drug via markedly blocked MPP+-induced neuronal PC12D cell death and disappearance of mitochondrial membrane potential, which were mediated by JNK.
TN7332	Delta-9-Tetrahydrocannabinolic acid Δ9-Tetrahydrocannabinolic Acid A	Others	Others
	Delta-9-Tetrahydrocannabinolic acid has been shown to safeguard dopaminergic neurons from cell death induced by MPP(+).
T4954L	Smilagenin PYM50028,Cogane,AI3-44895,PYM 50028
	Smilagenin is an orally active inducer of nonpeptide neurotrophic factor. It also prevents and reverses neuronal damage induced by MPP+ in mesencephalic neurons, and by MPTP in a mouse model of Parkinson's disease.
TN3741	Cyclocurcumin	TNF; ROS	Apoptosis; Immunology/Inflammation
	Cyclocurcumin, a curcumin derivative, exhibits anticancer, anti-inflammatory, and immune-modulating abilities and is a potential compound for the treatment of rheumatoid arthritis as predicted by the MM-PBSA method. It may have a therapeutic potential as

天然产物

Vanillyl Alcohol

Cat.No: T2860

Synonym: 4-Hydroxy-3-methoxybenzenemethanol,3-Methoxy-4-hydroxybenzyl alcohol,4-Hydroxy-3-methoxybenzyl alcohol,香兰醇,Vanillin alcohol,Vanillic alcohol

Target: Apoptosis, Others

Cat.No: TN1038

Target: Apoptosis

Cat.No: T2230

Synonym: 芍药苷,Peoniflorin

Target: HSP, COX

Licopyranocoumarin

Cat.No: TN4435

Target: P450, ROS, JNK

Delta-9-Tetrahydrocannabinolic acid

Cat.No: TN7332

Synonym: Δ9-Tetrahydrocannabinolic Acid A

Target: Others

Cat.No: T4954L

Synonym: PYM50028,Cogane,AI3-44895,PYM 50028

Cat.No: TN3741

Target: TNF, ROS

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPJ-00913	MPZ Protein, Human, Recombinant (His) Myelin Peripheral Protein,Myelin Protein P0,MPZ,Myelin Prote...	Human	HEK293 Cells
	Myelin Protein P0 (MPZ) is a single-pass type I membrane glycoprotein which belongs to the myelin P0 protein family. MPZ contains one Ig-like V-type (immunoglobulin-like) domain, absent in the central nervous system. MPZ is a major component of the myelin sheath in peripheral nerves. It is postulated that MPZ is a structural element in the formation and stabilisation of peripheral nerve myelin, holding its characteristic coil structure together by the interaction of its positively-charged domain...
TMPH-00706	MppA Protein, E. coli, Recombinant (His & SUMO) Periplasmic murein peptide-binding protein,mppA	E. coli	E. coli
	Essential for the uptake of the murein peptide L-alanyl-gamma-D-glutamyl-meso-diaminopimelate. Also transports some alpha-linked peptides such as Pro-Phe-Lys with low affinity. The transport is effected by the oligopeptide permease system.
TMPH-01898	PARL Protein, Human, Recombinant (Myc) Mitochondrial intramembrane cleaving protease PARL,Presenili...	Human	E. coli
	Required for the control of apoptosis during postnatal growth. Essential for proteolytic processing of an antiapoptotic form of OPA1 which prevents the release of mitochondrial cytochrome c in response to intrinsic apoptotic signals. Required for the maturation of PINK1 into its 52kDa mature form after its cleavage by mitochondrial-processing peptidase (MPP). Promotes changes in mitochondria morphology regulated by phosphorylation of P-beta domain. PARL Protein, Human, Recombinant (Myc) is expre...

重组蛋白

MPZ Protein, Human, Recombinant (His)

Cat.No: TMPJ-00913

Species: Human

Expression System: HEK293 Cells

MppA Protein, E. coli, Recombinant (His & SUMO)

Cat.No: TMPH-00706

Species: E. coli

Expression System: E. coli

PARL Protein, Human, Recombinant (Myc)

Cat.No: TMPH-01898

Species: Human

Expression System: E. coli

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