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Search Results for " mll1 "

Targets Recommended: Dopamine Receptor Histone Methyltransferase Adrenergic Receptor

17

抑制剂 & 化合物

4

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T3278	Piribedil EU-4200,Trivastan,ET-495,Trivastal	Dopamine Receptor; Histone Methyltransferase; Adrenergic Receptor	Chromatin/Epigenetic; GPCR/G Protein; Neuroscience
	Piribedil (Trivastan) 是多巴胺 D2受体激动剂，对 hα1A-肾上腺素受体也显示出拮抗作用。
T39584	MI-3454	Histone Methyltransferase	Chromatin/Epigenetic
	MI-3454 是一种具有口服活性，选择性和高效性的 Menin-MLL1 相互作用抑制剂，可抑制具有 MLL1 易位或 NPM1 突变的急性白血病细胞增殖并诱导分化。MI-3454 通过下调参与白血病发生的关键基因，诱导MLL1重排或NPM1突变白血病小鼠模型中白血病的完全缓解或消退。
T6333	MM-102 MM102,HMTase Inhibitor IX	Histone Methyltransferase	Chromatin/Epigenetic
	MM-102 (HMTase Inhibitor IX) 是一种有效的 WDR5/MLL 相互作用抑制剂，在 WDR5 结合检测中，IC50为 2.4 nM，Ki 小于 1 nM。
T67697	WDR5-47	Histone Methyltransferase	Chromatin/Epigenetic
	WDR5-47是一种干扰MLL1-WDR5相互作用的有效小分子，IC50值为0.3μM。
T8768	MM-102 TFA HMTase Inhibitor IX TFA	Histone Methyltransferase	Chromatin/Epigenetic
	MM-102 TFA (HMTase Inhibitor IX TFA) 是一种有效的 WDR5/MLL 相互作用抑制剂，在 WDR5 结合检测中，IC50为 2.4 nM，Ki 小于 1 nM。
T67947	WDR5-0102	Histone Methyltransferase	Chromatin/Epigenetic
	WDR5-0102为针对WDR5-MLL1的抑制剂(Kdis=7 μM, Kd=4 μM)。该化合物有效抑制MLL1活性，而对人类H3K4甲基转移酶SETD7及其他六种HMT（G9a、EHMT1、SUV39H2、SETD8、PRMT3、PRMT5）不表现出抑制作用。
T68821	DC_M5_2	Others	Others
	DC_M5_2 is a novel inhibitor of wdr5-mll1 interaction
T75258	MM-401 TFA	Others	Others
	MM-401 (TFA) 是一种针对MLL1 H3K4甲基转移酶的抑制剂，通过阻断MLL1与WDR5的相互作用，有效抑制MLL1活性，其IC50值为0.32 µM。此化合物能够诱导细胞周期停滞、凋亡及分化，主要用于MLL白血病的研究。
T24489	MM-401 MM401
	MM-401 is a specific inhibitor of histone H3K4 methyltransferase MLL1 activity that acts by reprogramming mouse epiblast stem cells to naive pluripotency.
T13334	WDR5-IN-1	Others	Others
	WDR5-IN-1 is a potent and selective inhibitor of WD repeat domain 5 (WDR5) (Kd <0.02 nM), and also inhibits MLL1 histone methyltransferase (HMT) activity (IC50: 2.2 nM).
T72239	DDO-2093 dihydrochloride	Others	Others
	DDO-2093 dihydrochloride 是一种有效的MLL1和WDR5蛋白-蛋白相互作用抑制剂 (IC50=8.6 nM ; Kd=11.6 nM)，具有抗肿瘤活性。DDO-2093 dihydrochloride 选择性抑制 MLL 复合物的催化活性。
T39769	DDO-2093	Others	Others
	DDO-2093, a powerful inhibitor of the MLL1-WDR5 protein-protein interaction (IC50 = 8.6 nM; Kd = 11.6 nM), exhibits prominent antitumor effects. Notably, DDO-2093 selectively hampers the catalytic activity of the MLL complex.
T24463	MI-1481 MI 1481	Others	Others
	MI-1481 is an effective MML1 inhibitor (IC50: 3.6 nM). MI-1481 showed very potent inhibition of the menin-MLL1 interaction (IC50: 3.6 nM). MI-1481 also demonstrates pronounced activity in MLL leukemia cells and in vivo in MLL leukemia models.
T61027	Piribedil hydrochloride	Others	Others
	Piribedil hydrochloride 可用于帕金森病，循环系统疾病，癌症等的研究。Piribedil hydrochloride 以0.18 μM 的EC50值抑制 MLL1 甲基转移酶的活性。Piribedil hydrochloride 是口服有效的多巴胺 D2 和多巴胺 D3 激动剂，也是 α2-肾上腺素能受体的拮抗剂。
T69624	TC-5115	Others	Others
	TC-5115 is a potent inhibitor of MLL methyltransferase with IC50 value of 16 nM. TC-5115 may lead to the development of a new therapy for the treatment of human MLL leukemia. The mixed-lineage leukemia (MLL) protein, also known as MLL1, is a lysine methyltransferase specifically responsible for methylation of histone 3 lysine 4. MLL has been pursued as an attractive therapeutic target for the treatment of acute leukemia carrying the MLL fusion gene or MLL leukemia.
T82598	DDO-2213	Others	Others
	DDO-2213是一口服有效的WDR5-MLL1抑制剂，具有29 nM的IC50和72.9 nM的Kd值针对WDR5蛋白。该化合物对MLL组蛋白甲基转移酶活性及MLL易位细胞增殖具有选择性抑制作用，可用于研究MLL融合型白血病。
T69014	Sekikaic Acid	Others	Others
	Sekikaic acid is a phenolic lichen metabolite that has been found in H. obscurata and has diverse biological activities. It scavenges superoxide and DPPH radicals in cell-free assays when used at a concentration of 0.5 µM. Sekikaic acid is active against the rg recombinant strain of respiratory syncytial virus (RSV; IC50 = 5.69 µg/ml). It inhibits the protein-protein interaction between mixed lineage leukemia 1 (MLL1) and the GACKIX domain of CREB-binding protein (CBP; IC50 = 34 µM).

化合物

Cat.No: T3278

Synonym: EU-4200,Trivastan,ET-495,Trivastal

Target: Dopamine Receptor, Histone Methyltransferase, Adrenergic Receptor

Cat.No: T39584

Target: Histone Methyltransferase

Cat.No: T6333

Synonym: MM102,HMTase Inhibitor IX

Target: Histone Methyltransferase

Cat.No: T67697

Target: Histone Methyltransferase

Cat.No: T8768

Synonym: HMTase Inhibitor IX TFA

Target: Histone Methyltransferase

Cat.No: T67947

Target: Histone Methyltransferase

Cat.No: T68821

Target: Others

Cat.No: T75258

Target: Others

Cat.No: T24489

Synonym: MM401

Cat.No: T13334

Target: Others

DDO-2093 dihydrochloride

Cat.No: T72239

Target: Others

Cat.No: T39769

Target: Others

Cat.No: T24463

Synonym: MI 1481

Target: Others

Piribedil hydrochloride

Cat.No: T61027

Target: Others

Cat.No: T69624

Target: Others

Cat.No: T82598

Target: Others

Cat.No: T69014

Target: Others

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPJ-01443	HChFc2 Protein, Mouse, Recombinant (His) C2 factor,HCF-2,Host cell factor 2,Hcfc2	Mouse	E. coli
	Host cell factor 2(HCFC2) is a cytoplasmic protein. It contains 2 fibronectin type-III domains.HCFC2 binds KMT2A/MLL1, as component of the MLL1/MLL complex.Hcfc2 negative regulation of transcription from RNA polymerase II promoter.
TMPH-02105	ASH2L Protein, Human, Recombinant (His & SUMO) ASH2-like protein,ASH2L,ASH2L1,Set1/Ash2 h...	Human	E. coli
	Transcriptional regulator. Component or associated component of some histone methyltransferase complexes which regulates transcription through recruitment of those complexes to gene promoters. Component of the Set1/Ash2 histone methyltransferase (HMT) complex, a complex that specifically methylates 'Lys-4' of histone H3, but not if the neighboring 'Lys-9' residue is already methylated. As part of the MLL1/MLL complex it is involved in methylation and dimethylation at 'Lys-4' of histone H3. May p...
TMPY-02957	DYDC2 Protein, Human, Recombinant (GST) DPY30 domain containing 2	Human	E. coli
	DPY30 domain containing 2 belongs to the dpy-30 family. Dumpy-30 family members act as determinants of male fertility and interaction partners of metal-responsive transcription factor 1 (MTF-1) in Drosophila. MTF-1 plays a key role in transition metal detoxification and homeostasis. It binds to metal response elements (MREs). Two candidate dMTF-1 interactors are related to the small regulatory protein Dumpy-30 (Dpy-30) of the worm C. elegans. Dpy-30 is the founding member of a protein family inv...
TMPH-02131	SKP2 Protein, Human, Recombinant (His & SUMO) S-phase kinase-associated protein 2,SKP2,F-box protein Skp2,...	Human	E. coli
	Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins involved in cell cycle progression, signal transduction and transcription. Specifically recognizes phosphorylated CDKN1B/p27kip and is involved in regulation of G1/S transition. Degradation of CDKN1B/p27kip also requires CKS1. Recognizes target proteins ORC1, CDT1, RBL2, KMT2A/MLL1, CDK9, RAG2, FOXO1, UB...

重组蛋白

HChFc2 Protein, Mouse, Recombinant (His)

Cat.No: TMPJ-01443

Species: Mouse

Expression System: E. coli

ASH2L Protein, Human, Recombinant (His & SUMO)

Cat.No: TMPH-02105

Species: Human

Expression System: E. coli

DYDC2 Protein, Human, Recombinant (GST)

Cat.No: TMPY-02957

Species: Human

Expression System: E. coli

SKP2 Protein, Human, Recombinant (His & SUMO)

Cat.No: TMPH-02131

Species: Human

Expression System: E. coli

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