313
8
38
3
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T3475 |
MD 39-AM
|
Others | Others |
MD 39-AM 的活性通过在含有激动素但不含抗细胞分裂素的培养基上 50% 的愈伤组织生长来评估。 | |||
T11980 |
MD-224
|
Mdm2; E1/E2/E3 Enzyme; PROTACs | Apoptosis; PROTAC; Ubiquitination |
MD-224是一种基于蛋白水解靶向嵌合体(PROTAC)概念的高效、高效的MDM2降解剂,是一类新型抗癌剂。 | |||
T5323 |
Toloxatone
托洛沙酮,MD 69276 |
MAO; Monoamine Oxidase | Metabolism; Neuroscience |
Toloxatone (MD 69276) 是可逆的单胺氧化酶 A (MAOA) 抑制剂,是一种抗抑郁剂。 | |||
T37041 |
MD-222
|
PROTACs | PROTAC |
MD-222, a pioneering, highly potent PROTAC degrader targeting MDM2, efficiently mediates the rapid degradation of MDM2 protein and activates wild-type p53 within cells, showcasing significant anticancer effects[1][2]. | |||
T68784 |
MD 780236
|
Others | Others |
MD 780236 is a monoamine oxidase-B inhibitor. | |||
T68785 |
MD 220661
|
Others | Others |
MD 220661 is an inhibitor of semicarbazide-sensitive amine oxidase (SSAO), and a substrate of the enzyme. | |||
T0155 |
Argatroban
MCI-9038,阿加曲班,MD-805,Argipidine |
Thrombin | Proteases/Proteasome |
Argatroban (MCI-9038) 是一种选择性的凝血酶抑制剂。 | |||
T0368 |
Cinepazide maleate
马来酸桂哌齐特,MD-67350,Vasodistal,Brendil |
Calcium Channel | Membrane transporter/Ion channel; Metabolism |
Cinepazide maleate (MD-67350) 是哌嗪衍生物,是一种钙通道阻滞剂,也是一种强效血管扩张剂,可用于脑血管疾病的研究,如缺血性中风和脑梗塞等。 | |||
T4231 |
MD2-IN-1
|
TLR | Immunology/Inflammation |
MD2-IN-1 是骨髓分化蛋白 2 (MD2) 的抑制剂,对重组人 MD2 (rhMD2) 的 KD 为 189 μM。 | |||
T7672 |
MD2-TLR4-IN-1
|
TLR | Immunology/Inflammation |
MD2-TLR4-IN-1 是一种骨髓分化蛋白 2/toll 样受体 4 (MD2-TLR4) 复合物抑制剂,能够抑制巨噬细胞 LPS 诱导的 TNF-α 和 IL-6 的表达,IC50值分别为 0.89 和 0.53 μM。 | |||
T26761 |
Befloxatone
MD 370503,MD-370,503,MD370503,MD-370503 |
Others | Others |
Befloxatone is a potent, selective and reversible inhibitor of monoamine oxidase A. | |||
T41225 |
MD13
|
Others | Others |
MD13 是一种巨噬细胞迁移抑制因子 (MIF) 导向的 PROTAC,Ki 值为 71 nM。MD13 可用于癌症研究。 | |||
T25252 |
Cimoxatone
MD-780515,MD780515,MD 780515 |
Others | Others |
Cimoxatone is used as a Monoamine Oxidase Inhibitor. | |||
T70569 |
MD-230254
|
Others | Others |
MD-230254 is an inhibitor of MAO-B. | |||
T35800 |
MD001
|
Others | Others |
MD001 is a dual agonist of peroxisome proliferator-activated receptor α (PPARα) and PPARγ.1 It binds to PPARα and PPARγ (Kds = 9.55 and 0.14 μM, respectively) but does not bind to PPARβ/δ at concentrations up to 500 μM. It increases transcriptional activity of PPARα and PPARγ in a cell-based luciferase reporter assay when used at a concentration of 10 μM. MD001 (10 μM) increases expression of PPARα, PPARγ, and retinoid X receptor (RXR), as well as PPARα and PPARγ target genes, in HepG2 cells. It... | |||
T41229 |
MD15
MD15 |
Others | Others |
MD15 is a negative control for MD13. | |||
T40403 |
Antioxidant 1024
MD 1024 |
Others | Others |
Antioxidant 1024 (MD 1024) is an antioxidant agent and metal deactivator. | |||
T84649 |
CAY10398
MD 85 |
Others | Others |
CAY10398 is a compound that serves as an isoform-selective inhibitor of histone deacetylase (HDAC1). | |||
T25503 |
Hisphen
Synonyms Hisfen,MD 2 |
Others | Others |
Hisphen shows antileukemic activity. | |||
T0368L |
Cinepazide
Brendil,MD67350,Vasodistal,Cinepazide free base,MD-67350,MD 67350,NSC 291562 |
Others | Others |
Cinepazide is a vasodilator used for the treatment of cardiovascular, cerebrovascular, and peripheral vascular diseases. Cinepazide acts as a potentiator of adenosine A2 receptors. | |||
T33643 |
Nepetalactone
MD(sub 1) 84,MDI 84 |
Others | Others |
Nepetalactone is found in the plant Nepeta parnassica and has high mosquito repellency properties. | |||
T11852L |
Linaclotide acetate
MM 416775,MM416775 MD-1100 acetate,Linzess,MM-416775 |
Others | Others |
Linaclotide acetate is used as an oral guanylate cyclase C agonist linaclotide; 14 amino acid peptide for the potential treatment of constipation-predominant irritable bowel syndrome and chronic idiopathic constipation. | |||
T22246 |
Argatroban Monohydrate
阿加曲班一水合物,阿加曲班 |
Thrombin | Proteases/Proteasome |
Argatroban Monohydrate 是一种 thrombin 选择性抑制剂。 | |||
T25781 |
MDL 101146
MDL-101146,MD 101,146,MDL101146,MDL 101,146,MDL-101,146 |
Others | Others |
MDL 101146 is an orally active neutrophil elastase inhibitor. | |||
T20032 |
CI Direct Brown 2
Airedale Brown MD,Brown M,NSC 74701,Direct Brown 2,NSC-74701,NSC74701 |
||
CI Direct Brown 2 is a direct dye. It is soluble in water and ionizable to form colored anions. It also can directly dye cellulose fibers or protein fibers. | |||
T68593 |
Almoxatone
|
Others | Others |
Almoxatone, also known as MD 780236, is a monoamine oxidase (MAO) inhibitor. | |||
T70567 |
CGS 25462
|
Others | Others |
CGS 25462 is a neutral endopeptidase (NEP) inhibitor. | |||
T70231 |
Osanetant HCl
|
Others | Others |
Osanetant HCl is the (R)-enantiomer; neurokinin-3 receptor antagonist | |||
T74736 |
2MD
|
Others | Others |
2MD是一种口服活性维生素D类似物,能刺激骨膜骨形成并减少小梁骨吸收,从而恢复小梁和皮质骨的质量与强度。在非人灵长类动物研究中,2MD还可以调节(IOP)相关基因,降低眼压。 | |||
T69525 |
MIF degrader MD13
|
Others | Others |
MIF degrader MD13 is involved in protein-protein interactions that play key roles in inflammation and cancer. Current strategies to develop small molecule modulators of MIF functions are mainly restricted to the MIF tautomerase active siteMIF degrader MD13. MD13 also exhibits antiproliferative effect in a 3D tumor spheroid model. In conclusion, we describe the first MIF-directed PROTAC (MD13) as a research tool, which also demonstrates the potential of PROTACs in cancer therapy. | |||
T67698 |
p53-Mdm2 inhibitor 4
|
Mdm2; p53 | Apoptosis |
p53-Mdm2 inhibitor 4 抑制 p53-MDM2 蛋白质-蛋白质相互作用。 | |||
T12302 |
OMDM-1
(Z)-N-[(2S)-1-hydroxy-3-(4-hydroxyphenyl)propan-2-yl]octadec-9-enamide |
Endogenous Metabolite | Metabolism |
OMDM-1 ((Z)-N-[(2S)-1-hydroxy-3-(4-hydroxyphenyl)propan-2-yl]octadec-9-enamide) 是有效选择性的代谢稳定 anandamide 细胞摄取抑制剂,Ki=为2.4 μM。 | |||
T72026 |
p53-MDM2-IN-1
|
Mdm2; p53 | Apoptosis |
p53-MDM2-IN-1 (Example 30) 是一种 p53-MDM2/X 蛋白相互作用的抑制剂,Ki 值为 23.35 µM。p53-MDM2-IN-1 能用于抗肿瘤研究。 | |||
T1772 |
MDK83190
Apoptosis Activator 2 |
Apoptosis; Caspase | Apoptosis; Proteases/Proteasome |
MDK83190 (Apoptosis Activator 2) 是一种细胞凋亡激活剂,可诱导 caspase-3 激活、Apaf-1 寡聚化、PARP 切割和 DNA 片段化。 | |||
T1897 |
MDL-29951
|
NMDAR; iGluR | Membrane transporter/Ion channel; Neuroscience |
MDL 29951 是一种新颖的 nMDA receptor 拮抗剂,能够抑制体内体外甘氨酸 ([3H]glycine) 的结合,Ki=0.14 μM。 | |||
T19765 |
MDK-4025
|
Calcium Channel | Membrane transporter/Ion channel; Metabolism |
MDK-4025 是锥体神经元中高压激活 (HVA) Ca2+ 电流的抑制剂。 | |||
T22565 |
AMD-070 hydrochloride
N-(1H-苯并咪唑-2-基甲基)-N-[(8S)-5,6,7,8-四氢-8-喹啉基]-1,4-丁二胺单盐酸盐 |
CXCR | Autophagy; GPCR/G Protein; Immunology/Inflammation |
AMD-070 hydrochloride 是一种 CXCR4 拮抗剂,可用于抗 HIV。 | |||
T3710 |
XMD16-5
|
Tyrosinase; PPAR | DNA Damage/DNA Repair; Metabolism; Proteases/Proteasome |
XMD16-5 是TNK2抑制剂,对D163E 和R806Q 突变体的IC50值分别为16和77nM。 | |||
T13102 |
TCMDC-135051
|
Others | Others |
TCMDC-135051 是一种高选择性和有效性的蛋白激酶 PfCLK3 抑制剂,具有低的靶外毒性。TCMDC-135051 可以防止滋养体到裂殖体的转变,破坏转录并减少向蚊子载体的传播。TCMDC-135051 具有抗寄生虫活性 (EC50=320 nM)。 | |||
T7766 |
Remdesivir
瑞德西韦,GS-5734 |
SARS-CoV; DNA/RNA Synthesis | Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Microbiology/Virology |
Remdesivir (GS-5734) 是一种核苷类似物,一种广谱的抗病毒化合物,通过抑制病毒的 RNA 依赖性 RNA 聚合酶发挥活性。Remdesivir 对埃博拉病毒、SARS 病毒、MERS病毒等均有活性,对 COVID-19 有潜在治疗价值。 | |||
T61270 |
MDH1-IN-1
|
Others | Others |
MDH1-IN-1 (5i) 是一种有效的 MDH1 抑制剂,对 MDH1 的 IC50 为 6.79 μM,对 MDH2 的 IC50 为 >40 μM。MDH1-IN-1 具有潜在的抗癌活性,可用于研究与免疫系统相关的疾病。 | |||
T73718 |
MDCG sodium
NOX 100 sodium,N-methyl-N-dithiocarboxyglucamine sodium |
Endogenous Metabolite | Metabolism |
MDCG sodium (N-methyl-N-dithiocarboxyglucamine sodium) 是一种金属螯合剂,可促进Cd的胆道排泄。 | |||
T25373 |
EMD57439
EMD-57439,EMD 57439 |
PDE | Metabolism |
EMD57439是一种选择性的PDE-III 抑制剂,对c-AMP 浓度没有显示出明显的增长 且在Ca(50)中产生的变化很小。 | |||
T1842 |
XMD17-109
XMD17 109,ERK5-IN-1 |
ERK | MAPK |
XMD17-109 (ERK5-IN-1) 是一种特异性的ERK-5抑制剂,在 HEK293 细胞系中的EC50为 4.2 μM。 | |||
T72662 |
NMDAR/TRPM4-IN-2
|
ERK; TRP/TRPV Channel; NMDAR; iGluR | MAPK; Membrane transporter/Ion channel; Neuroscience |
NMDAR/TRPM4-IN-2 是一种有效的 NMDAR/TRPM4 相互作用界面抑制剂。NMDAR/TRPM4-IN-2 保护小鼠免受 MCAO 诱导的脑损伤和 NMDA 诱导的视网膜神经节细胞丢失。NMDAR/TRPM4-IN-2 具有神经保护活性, 可预防 NMDA 诱导的海马神经元细胞死亡和线粒体功能障碍,其 IC50 值为 2.1 μM。 | |||
T22359 |
MDL 100009
|
5-HT Receptor | GPCR/G Protein; Neuroscience |
MDL 100009 是 MDL 100151 的 S-对映体和 MDL 100907 的相反对映体,是 5-HT2A 的选择性拮抗剂。 | |||
T22965 |
MDL 72527
N1,N4-Di(buta-2,3-dien-1-yl)butane-1,4-diamine dihydrochloride |
Others | Others |
MDL 72527 (N1,N4-Di(buta-2,3-dien-1-yl)butane-1,4-diamine dihydrochloride) 是一种多胺氧化酶 (POA) 抑制剂 | |||
T7208 |
AMD 3465 hexahydrobromide
GENZ-644494 (hexahydrobromide) |
HIV Protease; CXCR | Autophagy; GPCR/G Protein; Immunology/Inflammation; Microbiology/Virology; Proteases/Proteasome |
AMD 3465 hexahydrobromide (GENZ-644494 (hexahydrobromide)) 是一种 CXCR4受体拮抗剂,具有潜在的抗癌和抗 HIV 活性。 | |||
T62839 |
Dalzanemdor
SAGE-718 |
NMDAR; iGluR | Membrane transporter/Ion channel; Neuroscience |
Dalzanemdor (SAGE-718) 是 NMDA 受体阳性变构调节剂,可用于研究亨廷顿舞蹈病、阿尔茨海默病和认知功能障碍。 | |||
T12306 |
OMDM-5
|
Cannabinoid Receptor; Endogenous Metabolite; TRP/TRPV Channel | GPCR/G Protein; Membrane transporter/Ion channel; Metabolism |
OMDM-5 是有效的、选择性的anandamide 细胞摄取抑制剂,Ki 为 4.8 μM。它是VR1 (TRPV1)激动剂,EC50为 75 nM,显示出对大麻素 1 型受体 (CB1) 的弱配体活性 (Ki=4.9 μM)。 |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T5S0045 |
Isofraxidin
6,8-Dimethoxyumbelliferone,异秦皮啶,Phytodolor,异嗪皮啶 |
MMP; ERK; p38 MAPK; TLR; COX | Immunology/Inflammation; MAPK; Neuroscience; Proteases/Proteasome |
Isofraxidin (Phytodolor) 是来自刺五加的香豆素成分,抑制MMP-7表达和人肝癌细胞侵袭。它作用于肝癌细胞,抑制ERK1/2磷酸化。它减弱iNOS 和COX-2表达,还抑制TLR4/髓样分化蛋白 2 复合物的形成。 | |||
T6608 |
NMDA
N-甲基-D-天冬氨酸,N-Methyl-D-aspartic acid |
Endogenous Metabolite; NMDAR; iGluR | Membrane transporter/Ion channel; Metabolism; Neuroscience |
NMDA (N-Methyl-D-aspartic acid) 是一种氨基酸,作为 D-异构体,是谷氨酸受体的 NMDA 受体亚型的定义激动剂。 | |||
T34611 |
Semduramicin
UK 61,689,Aviax,UK-61,689,UK61,689 |
Others | Others |
Semduramicin is a carboxylic acid ionophore for management of chicken coccidiosis. | |||
T34611L |
Semduramicin sodium
UK-61,689-2,UK 61,689-2,UK 61689-2,UK-61689-2,UK61689-2 |
Others | Others |
Semduramicin sodium is a carboxylic acid ionophore for management of chicken coccidiosis. | |||
TN7520 |
Circumdatin A
|
Others | Others |
Circumdatin A, a benzodiazepine alkaloid derived from the fungus A. ochraceus, is a fungal metabolite. | |||
TQ0205 |
Procyanidin B1
原花青素B1,原花青素 B1 |
TLR | Immunology/Inflammation |
Procyanidin B1 是水果中常见的多酚类黄酮,能够与TLR4/MD-2复合体结合,具有抗炎活性。 | |||
T5S0167 |
Atractylenolide I
白术内酯 I,白术内酯I;苍术内酯I |
IL Receptor; TNF; TLR; JAK; STAT | Angiogenesis; Apoptosis; Chromatin/Epigenetic; Immunology/Inflammation; JAK/STAT signaling; Stem Cells |
Atractylenolide I 是从白术根中得到的一种倍半萜烯,具有神经保护、抗过敏、抗炎和抗癌等多种生物活性。它是一种TLR4拮抗剂,在 A375 细胞中,能够降低JAK2和STAT3的磷酸化水平。 | |||
TMA1944 |
Protopine hydrochloride
|
EGFR; cAMP | Angiogenesis; GPCR/G Protein; JAK/STAT signaling; Tyrosine Kinase/Adaptors |
Protopine has antiplatelet effects,which is due to inhibition on thromboxane formation and phosphoinositides breakdown and then lead to the decrease of intracellular calcium concentration.Protopine seems to inhibit the heterotypic cell adhesion between MD |
Cat. No. | Product Name | Species | Expression System |
---|---|---|---|
TMPY-00878 |
MD1 Protein, Mouse, Recombinant (His)
lymphocyte antigen 86,MD-1,MD1 |
Mouse | HEK293 Cells |
MD1 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 18 kDa and the accession number is O88188. | |||
TMPK-00632 |
MD2/LY96 Protein, Cynomolgus, Recombinant (His)
ESOP-1,LY96,Lymphocyte antigen 96,ESOP1,MD-2 |
Cynomolgus | E. coli |
MD2, a 160-residue accessory glycoprotein, is responsible for the recognition and binding of Gram-negative bacterial membrane component, lipopolysaccharide (LPS).Internalization of pathogen inside the mononuclear phagocytes has also been attributed to MD2 which leads to the clearance of pathogens from the host. MD2/LY96 Protein, Cynomolgus, Recombinant (His) is expressed in E. coli expression system with C-His tag. The predicted molecular weight is 17.97 kDa and the accession number is B3Y6B0. | |||
TMPY-03188 |
MD1 Protein, Human, Recombinant (hFc)
MMD-1,lymphocyte antigen 86,MD-1,dJ80N2.1,... |
Human | HEK293 Cells |
MD1 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 42.7 kDa and the accession number is O95711. | |||
TMPY-03999 |
MD2/LY96 Protein, Mouse, Recombinant (hFc)
lymphocyte antigen 96,ESOP-1,MD2,MD-2 |
Mouse | HEK293 Cells |
LY96 (Lymphocyte Antigen 96, also known as ESOP-1) is a Protein Coding gene. 2 alternatively spliced human isoforms have been reported. This gene encodes a protein that associates with toll-like receptor 4 on the cell surface and confers responsiveness to lipopolysaccharide (LPS), thus providing a link between the receptor and LPS signaling. LY-96 also cooperates with TLR2 in the response to cell wall components from Gram-positive and Gram-negative bacteria. It enhances the TLR4-dependent activa... | |||
TMPK-01242 |
MD2/LY96 Protein, Human, Recombinant (His)
MD-2,Ly-96,ESOP-1,Lymphocyte antigen 96,LY96,ESOP1 |
Human | E. coli |
MD2, a 160-residue accessory glycoprotein, is responsible for the recognition and binding of Gram-negative bacterial membrane component, lipopolysaccharide (LPS).Internalization of pathogen inside the mononuclear phagocytes has also been attributed to MD2 which leads to the clearance of pathogens from the host. MD2/LY96 Protein, Human, Recombinant (His) is expressed in E. coli expression system with C-His tag. The predicted molecular weight is 18.07 kDa and the accession number is Q9Y6Y9-1. | |||
TMPH-00002 |
PSMD3 Protein, Human, Recombinant (His)
PSMD3,26S proteasome regulatory subunit S3,26S prot... |
Human | P. pastoris (Yeast) |
PSMD3 Protein, Human, Recombinant (His) is expressed in yeast with N-6xHis tag. The predicted molecular weight is 63 kDa; 70 kDa, reducing conditions and the accession number is O43242. | |||
TMPY-05581 |
TIM-4/TIMD4 Protein, Human, Recombinant (His), Biotinylated
T-cell immunoglobulin and mucin domain containing 4,SMUCKLER... |
Human | HEK293 Cells |
TIM-4/TIMD4 Protein, Human, Recombinant (His), Biotinylated is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 32.7 kDa and the accession number is AAH08988.1. | |||
TMPY-01375 |
TIM-4/TIMD4 Protein, Mouse, Recombinant (His)
T-cell immunoglobulin and mucin domain containing 4,TIM-4,Ti... |
Mouse | HEK293 Cells |
TIM-4/TIMD4 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 29.3 kDa and the accession number is Q6U7R4. | |||
TMPY-00305 |
MDC Protein, Mouse, Recombinant (His)
DCBCK,MDC,ABCD-1,Scya22,chemokine (C-C motif) ligan... |
Mouse | E. coli |
MDC Protein, Mouse, Recombinant (His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 9.9 kDa and the accession number is O88430. | |||
TMPJ-00832 |
Granzyme D/GZMD Protein, Mouse, Recombinant (His)
Granzyme D,Gzmd |
Mouse | HEK293 Cells |
Granzyme D is a member of the granzyme family of the serine proteases which plays a role in the induction of apoptosis. T cells, lymphohematopoietic stromal cells, and granulated metrial gland cells express granzyme D, but the function of granzyme D is unknown. Previous studies reported that granzyme D is developmentally regulated during pregnancy together with granzymes E, F, and G in granulated metrial gland cells and is upregulated by IL-2 and IL-15. Granzyme D was also suggested to have a ro... | |||
TMPH-01125 |
COMMD4 Protein, Human, Recombinant (GST)
COMM domain-containing protein 4,COMMD4 |
Human | E. coli |
COMMD4 Protein, Human, Recombinant (GST) is expressed in E. coli. | |||
TMPH-00161 |
MDH Protein, Bacillus methanolicus, Recombinant (His)
Type 3 alcohol dehydrogenase,mdh,NAD-dependent meth... |
Bacillus methanolicus | P. pastoris (Yeast) |
Catalyzes the oxidation of methanol to yield formaldehyde. It possesses a NADH-dependent formaldehyde reductase activity and cannot use NADP. MDH Protein, Bacillus methanolicus, Recombinant (His) is expressed in yeast with N-10xHis tag. The predicted molecular weight is 42.4 kDa and the accession number is P31005. | |||
TMPY-01620 |
MDGA2 Protein, Mouse, Recombinant (His)
6720489L24Rik,Adp,MAM domain containing glycosylphosphatidyl... |
Mouse | HEK293 Cells |
MAM domain-containing glycosylphosphatidylinositol anchor protein 2, also known as MAM domain-containing protein 1, MDGA2, and MAMDC1, is a cell membrane protein that contains six Ig-like (immunoglobulin-like) domains and one MAM domain. Analyses of the full-length coding region of MDGA1 and MDGA2 indicate that they encode proteins that comprise a novel subgroup of the Ig superfamily and have a unique structural organization consisting of six immunoglobulin (Ig)-like domains followed by a single... | |||
TMPY-03613 |
COMMD8 Protein, Human, Recombinant (His)
COMM domain containing 8 |
Human | E. coli |
COMMD8 is a member of the COMMD family. Members of this family are a group of evolutionary conserved proteins that share a common COMM domain at the extreme C-terminus, which provides an interface for protein-protein interactions. Most COMMD proteins play a role in the regulation of NF˚B and, despite their similarities, seem to function in unique and non-redundant pathways. COMMD proteins may also play a role in the function of epithelial sodium channels, cell proliferation, copper homeostasis a... | |||
TMPY-02756 |
MDC Protein, Human, Recombinant (His)
A-152E5.1,MDC,ABCD-1,SCYA22,STCP-1,DC/B-CK,chemokin... |
Human | E. coli |
MDC Protein, Human, Recombinant (His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 9.7 kDa and the accession number is O00626. | |||
TMPY-01125 |
MDMX Protein, Human, Recombinant (His)
MRP1,MDM4, p53 regulator,HDMX,MDMX |
Human | E. coli |
MDM4 (MDM4 Regulator Of P53, also known as MDMX) is a Protein Coding gene. This gene encodes a nuclear protein that contains a p53 binding domain at the N-terminus and a RING finger domain at the C-terminus and shows structural similarity to p53-binding protein MDM2. MDM4 is a promising target for cancer therapy, as it is undetectable in most normal adult tissues but often upregulated in cancer cells to dampen p53 tumor-suppressor function. MDM4, an essential negative regulator of the P53 tumor ... | |||
TMPK-01205 |
MDL-1/CLEC5A Protein, Human, Recombinant (hFc)
DAP12-associating lectin 1,MDL-1,MDL1,CLEC... |
Human | HEK293 Cells |
MDL-1/CLEC5A Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with N-hFc tag. The predicted molecular weight is 46 kDa and the accession number is Q9NY25-1. | |||
TMPH-01127 |
COMMD5 Protein, Human, Recombinant (His)
Hypertension-related calcium-regulated gene protein,COMM dom... |
Human | E. coli |
COMMD5 Protein, Human, Recombinant (His) is expressed in E. coli. | |||
TMPH-00849 |
PSMD14 Protein, Human, Recombinant (His & MBP)
26S proteasome non-ATPase regulatory subunit 14,PSMD |
Human | Baculovirus Insect Cells |
PSMD14 Protein, Human, Recombinant (His & MBP) is expressed in Baculovirus insect cells with N-MBP and C-6xHis tag. The predicted molecular weight is 79.2 kDa and the accession number is O00487. | |||
TMPY-03505 |
COMMD9 Protein, Human, Recombinant (His)
HSPC166,COMM domain containing 9 |
Human | E. coli |
COMMD9 is a COMM domain-containing or COMMD protein. COMMD family is comprised of ten members which are widely conserved throughout evolution and share certain functional properties. They represent a recently discovered set of evolutionarily conserved factors characterized by the presence of a defining carboxy-terminal motif. COMMD protein functions in the control of the transcription factor NFkappaB. NFkappaB plays a critical role in a number of homeostatic processes in multicellular orga... | |||
TMPY-02124 |
TIM-4/TIMD4 Protein, Human, Recombinant (His)
SMUCKLER,T-cell immunoglobulin and mucin domain containing 4... |
Human | HEK293 Cells |
TIM-4/TIMD4 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 32.7 kDa and the accession number is AAH08988.1. | |||
TMPY-02599 |
MDH1 Protein, Rat, Recombinant (His)
malate dehydrogenase 1, NAD (soluble) |
Rat | E. coli |
Malate dehydrogenases 1(MDH1 / MDHA) is a soluble form of malate dehydrogenases. Malate dehydrogenases (MDH) is a group of multimeric enzymes consisting of identical subunits usually organized as either dimer or tetramers with subunit molecular weights of 30-35 kDa. MDH has been isolated from different sources including archaea, eubacteria, fungi, plants, and mammals. MDH catalyzes the NAD/NADH-dependent interconversion of the substrates malate and oxaloacetate. This reaction plays a key part in... | |||
TMPK-01141 |
TIM-4/TIMD4 Protein, Human, Recombinant (aa 25-314, His)
TIMD-4,TIMD4,TIM-4,TIM4 |
Human | HEK293 Cells |
Tim4 is a transmembrane protein as the phosphatidylserine (PS) receptor, known as T cell immunoglobulin and mucin domain containing protein-4. It is expressed highly in macrophages, and macrophage Tim-4 inhibits inflammation under various conditions of immune activation. TIM-4/TIMD4 Protein, Human, Recombinant (aa 25-314, His) is expressed in HEK293 mammalian cells with C-His tag. The predicted molecular weight is 32.43 kDa and the accession number is Q96H15-1. | |||
TMPK-01272 |
TIM-4/TIMD4 Protein, Cynomolgus, Recombinant (His)
TIMD4,TIMD-4,TIM-4 |
Cynomolgus | HEK293 Cells |
Tim4 is a transmembrane protein as the phosphatidylserine (PS) receptor, known as T cell immunoglobulin and mucin domain containing protein-4. It is expressed highly in macrophages, and macrophage Tim-4 inhibits inflammation under various conditions of immune activation. TIM-4/TIMD4 Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells with C-His tag. The predicted molecular weight is 31.55 kDa and the accession number is XP_005558436.2. | |||
TMPK-01218 |
MDL-1/CLEC5A Protein, Mouse, Recombinant (hFc)
MDL1,DAP12-associating lectin 1,MDL-1,CLEC... |
Mouse | HEK293 Cells |
MDL-1/CLEC5A Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with N-hFc tag. The predicted molecular weight is 46.2 kDa and the accession number is Q9R007-1. | |||
TMPH-03139 |
MDR1 Protein, Plasmodium falciparum, Recombinant (His & SUMO)
Chloroquine resistance protein,MDR1,Multidrug resis... |
Plasmodium falciparum | E. coli |
Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells. MDR1 Protein, Plasmodium falciparum, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 54.2 kDa and the accession number is P13568. | |||
TMPH-00162 |
MDH Protein, Bacillus methanolicus, Recombinant (His & Myc & SUMO)
NAD-dependent methanol dehydrogenase,Type 3 alcohol dehydrog... |
Bacillus methanolicus | E. coli |
Catalyzes the oxidation of methanol to yield formaldehyde. It possesses a NADH-dependent formaldehyde reductase activity and cannot use NADP. MDH Protein, Bacillus methanolicus, Recombinant (His & Myc & SUMO) is expressed in E. coli expression system with N-10xHis-SUMO and C-Myc tag. The predicted molecular weight is 59.9 kDa and the accession number is P31005. | |||
TMPY-04668 |
Influenza A H3N2 (A/Philippines/472/2002) (MDCK) Hemagglutinin/HA1 Protein (His)
Harvey rat sarcoma viral oncogene homolog |
H3N2 | HEK293 Cells |
Influenza A H3N2 (A/Philippines/472/2002) (MDCK) Hemagglutinin/HA1 Protein (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 37.9 kDa and the accession number is A0A097PF18. | |||
TMPJ-00955 |
MDH1 Protein, Human, Recombinant (His)
Cytosolic Malate Dehydrogenase,MDH1,MDHA,D... |
Human | E. coli |
Malate Dehydrogenase, Cytoplasmic (MDH1) is an enzyme which belongs to the MDH Type 2 sub-family of LDH/MDH superfamily. MDH1 is involved in the Citric Acid Cycle that catalyzes the conversion of Malate into Oxaloacetate (using NAD+) and vice versa. MDH1 should not be confused with Malic Enzyme, which catalyzes the conversion of Malate to Pyruvate, producing NADPH. MDH1 also participates in Gluconeogenesis, the synthesis of Glucose from smaller molecules. Pyruvate in the mitochondria is acted up... | |||
TMPJ-00665 |
ADAMDEC1 Protein, Human, Recombinant (His)
a disintegrin and metalloproteinase domain-like protein decy... |
Human | HEK293 Cells |
ADAM DEC1 protein is expressed highly in the small intestine and appendix, moderately in lymph node, mucosal lining of the colon, thymus, spleen and very weakly in the bone marrow. ADAM DEC1 is induced during DC maturation and up-regulated in response to T-cell signals. It may play an important role in the control of the immune response and during pregnancy. | |||
TMPH-02493 |
ADAMDEC1 Protein, Mouse, Recombinant (His)
A disintegrin and metalloproteinase domain-like protein decy... |
Mouse | E. coli |
May play an important role in the control of the immune response and during pregnancy. ADAMDEC1 Protein, Mouse, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 34.9 kDa and the accession number is Q9R0X2. | |||
TMPH-03269 |
COMMD5 Protein, Rat, Recombinant (His & Myc)
COMM domain-containing protein 5,COMMD5,Hypertensio... |
Rat | E. coli |
May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes. Negatively regulates cell proliferation. Negatively regulates cell cycle G2/M phase transition probably by transactivating p21/CDKN1A through the p53/TP53-independent signaling pathway. Involved in kidney proximal tubule morphogenesis. Down-regulates activation of NF-kappa-B. | |||
TMPH-02630 |
MDM2 Protein, Mouse, Recombinant (His)
E3 ubiquitin-protein ligase Mdm2,RING-type E3 ubiqu... |
Mouse | E. coli |
MDM2 Protein, Mouse, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 58.6 kDa and the accession number is P23804. | |||
TMPJ-01205 |
MDP1 Protein, Human, Recombinant (His)
Magnesium-dependent phosphatase 1,MDP-1,EC=3.1.3.48 |
Human | HEK293 Cells |
MDP1, which is short for nesium-dependent phosphatase 1, is a 176 aa. protein. It has 3 forms by different alternative splicing. This protein belongs to the HAD-like hydrolase superfamily, and usually takes its function with Magnesium. It can be inhibited by vanadate and zinc, and slightly by calcium. MDP1 is a Magnesium-dependent phosphatase which may act as a tyrosine phosphatase. | |||
TMPJ-00956 |
MDH2 Protein, Human, Recombinant (His)
MDH2,Malate dehydrogenase,mitochondrial |
Human | HEK293 Cells |
Malate dehydrogenase, mitochondrial is a 338 amino acids protein that belongs to the LDH/MDH superfamily. MDH type 1 family. MDH2 catalyzes the reversible oxidation of malate to oxaloacetate, utilizing the NAD/NADH cofactor system in the citric acid cycle. MDH2 is localized to the mitochondria and takes part in the malate-aspartate shuttle that functions in the metabolic coordination between cytosol and mitochondria. MDH2 is highly expressed in the adrenal system, small intestine, heart and panc... | |||
TMPH-01126 |
COMMD5 Protein, Human, Recombinant (His & Myc)
Hypertension-related calcium-regulated gene protein,HCaRG,CO... |
Human | Baculovirus Insect Cells |
COMMD5 Protein, Human, Recombinant (His & Myc) is expressed in Baculovirus. | |||
TMPJ-00527 |
SP-D Protein, Human, Recombinant (His)
Lung Surfactant Protein D,SFTP4,COLEC7,SFTPD,PSP-D,SP-D,Pulm... |
Human | HEK293 Cells |
Surfactant Pulmonary-Associated Protein D (SP-D) is a 43 kDa member of the collectin family of innate immune modulators. Its principal components consist of a collagen-like region and a C-terminal carbohydrate recognition domain (CRD), a structure that places it in a subset of pattern recognition proteins termed defense collagens. SP-D is constitutively secreted by alveolar lining cells and epithelium associated with tubular structures and induced in cardiac smooth muscle and endothelial cells. ... | |||
TMPY-02122 |
IFNGR2 Protein, Mouse, Recombinant (His)
interferon γ receptor 2 (interferon γ transducer 1),interfer... |
Mouse | HEK293 Cells |
Interferon-gamma receptor beta chain (IFNgammaR2), also known as IFNGR2, belongs to the type II cytokine receptor family, whose deficiency is a cause of autosomal recessive mendelian susceptibility to mycobacterial disease (MSMD), also known as familial disseminated atypical mycobacterial infection. This accessory factor is an integral part of the IFN-gamma signal transduction pathway and is likely to interact with GAF, JAK1, and/or JAK2. IFNGR2 is a component of the IFNgamma receptor complex al... |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
TMIH-0491 |
Remdesivir Impurity 5-d5
|
||
Remdesivir Impurity 5-d5 是 Remdesivir Impurity 5 的氘代化合物。 | |||
T12702 |
Remdesivir-D5
GS-5734-D5 |
Others | Others |
Remdesivir-D5 is a deuterium labeled Remdesivir. Remdesivir is a nucleoside analogue, with effective antiviral activity. | |||
TMIJ-0254 |
Remdesivir-d4
|
||
Remdesivir-d4 是 Remdesivir 的氘代化合物。Remdesivir 的 CAS 号为 1809249-37-3。Remdesivir是一种核苷类似物,具有抗病毒活性,在 HAE 细胞中,对SARS-CoV和MERS-CoV的EC50值为 74 nM,有潜力用于 2019-nCoV (COVID-19) 研究。 |