213
112
11
2
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T9973 |
FAK-IN-7
|
FAK | Angiogenesis; Cytoskeletal Signaling; Tyrosine Kinase/Adaptors |
FAK-IN-7 有潜在的抗增殖活性,是一种 FAK 抑制剂。 | |||
T11929 |
M2N12
|
Phosphatase | Metabolism |
M2N12 是一种高度选择性的细胞分裂周期蛋白磷酸酶 25C 抑制剂,IC50值为 0.09 μM。它还抑制 Cdc25A 和 Cdc25B 的活性,IC50值分别为 0.53 μM 和 1.39 μM。它具有抗肿瘤活性,可研究癌症。 | |||
T1933 |
NVP 231
|
Apoptosis; ERK | Apoptosis; MAPK |
NVP 231 是一种强效、特异、可逆的神经酰胺激酶抑制剂,IC50值为12 nM,可竞争性地抑制神经酰胺与 CerK 的结合。它通过增加 DNA 片段和 caspase-3 和 caspase-9 的裂解来诱导细胞凋亡。 | |||
T41248 |
Thiocolchicine
|
Microtubule Associated | Cytoskeletal Signaling |
Thiocolchicine 是一种有效的微管蛋白聚合抑制剂,IC50 为 2.5 µM,Ki 为 0.7 µM。 Thiocolchicine 诱导细胞凋亡。 Thiocolchicine 可用作 ADC 技术中的 ADC 细胞毒素。 | |||
T9541 |
CTB
Cholera Toxin B subunit |
Epigenetic Reader Domain | Chromatin/Epigenetic |
CTB (Cholera Toxin B subunit) 是一种 p300 组蛋白乙酰转移酶的激活剂,可诱导 MCF-7 细胞凋亡。 | |||
T9119 |
SU0268
|
Others | Others |
SU0268 是有效的 8-8-氧鸟嘌呤 DNA 糖基化酶1的选择性抑制剂,具有调控铜绿假单胞杆菌感染免疫反应的能力。 | |||
T8973 |
HS-1793
|
Others | Others |
HS-1793 是 resveratrol 类似物,可以诱导细胞凋亡,在多种癌细胞中有抗肿瘤的能力。 | |||
T9244 |
σ1 Receptor antagonist-1
|
Sigma receptor | GPCR/G Protein |
σ1 Receptor antagonist-1 是高选择性的 sigma 1受体拮抗剂,pKi 为10.28。它抑制细胞生长,在 G0/G1 期阻滞细胞周期并诱导 MCF-7/ADR 细胞凋亡。 | |||
T8954 |
ML179
ML-179 |
Others | Others |
ML179 是一种有效的选择性肝受体同源物 1 (LRH1, NR5A2) 反向激动剂,IC50 为 320 nM。 | |||
T50005 |
Sertaconazole
|
Antifungal | Microbiology/Virology |
Sertaconazole 是一种广谱抗真菌药。 | |||
T15249 |
Estrogen receptor modulator 1
|
Estrogen Receptor/ERR | Endocrinology/Hormones |
Estrogen receptor modulator 1 是一种有效的、具有口服活性的、选择性雌激素受体(estrogen receptor)调节剂 (SERM),其 pIC50为 0.46。它能够诱导 Tamoxifen 耐药、激素非依赖性异种移植瘤的消退。 | |||
T0308 |
Etidronic acid
HEDPA,Etidronate,HEDP,羟乙磷酸 |
Apoptosis; Phosphatase; Others; HBV | Apoptosis; Metabolism; Microbiology/Virology; Others |
Etidronic acid (HEDP) 是一种影响钙代谢的二膦酸盐,抑制异位钙化并减缓骨吸收和骨转换,可应用于洗涤,水处理,化妆品和制药业。 | |||
T9595 |
LP-261
|
Microtubule Associated | Cytoskeletal Signaling |
LP-261 是一种新型的微管蛋白靶向抗癌剂,可与微管蛋白上的秋水仙碱位点结合,诱导 G2/M 期阻滞,其EC50为 3.2 μM。它可抑制人非小细胞肺癌的生长,可用于癌症研究。 | |||
T9812 |
Tubulin inhibitor 24
|
Microtubule Associated | Cytoskeletal Signaling |
Tubulin inhibitor 24 是一种 tubulin 抑制剂,可以抑制微管蛋白聚合,以浓度依赖性方式诱导细胞周期停滞在 G2/M 期, 具有抗肿瘤活性且无明显毒性。 | |||
T1579 |
Mestranol
Devocin,Norquen,美雌醇,Menophase |
Estrogen Receptor/ERR; Estrogen/progestogen Receptor | Endocrinology/Hormones |
Mestranol (Devocin) 是一种雌激素受体激动剂,是一种非活性的前药,在转化为炔雌醇时具有生物活性。动物实验中,它可以与黄体酮联合使用,它可用于更年期激素或月经紊乱的研究。 | |||
T1210 |
Sodium etidronate
依替膦酸钠,Didronel |
Phosphatase | Metabolism |
Sodium etidronate (Didronel) 是一种内源性 pyrophosphate 的合成治疗性 diphosphonate 类似物。作为称为 bisphosphonates 盐类药物家族的一员,etidronate disodium 与内源性 pyrophosphate 的不同之处在于其对酶水解的耐受性。该药剂吸附 hydroxyapatite 细胞并减少破骨细胞的数量,从而抑制异常骨吸收。 Etidronate 还可以直接刺激成骨细胞的骨形成。 | |||
T7856 |
Naphthol AS-E
色酚 AS-E,nAS-E |
Epigenetic Reader Domain; Histone Acetyltransferase | Chromatin/Epigenetic |
Naphthol AS-E (nAS-E) 是一种具有细胞渗透性的KIX-KID 相互作用的抑制剂,可用于癌症研究。它直接结合 CBP 的 KIX 域,Kd 为 8.6 µM,阻断 KIX 域和 KID 域的相互作用,IC50为 2.26 µM。 | |||
T21806 |
HNHA
|
HDAC | Chromatin/Epigenetic; DNA Damage/DNA Repair |
HNHA 是组蛋白去乙酰化酶抑制剂。它通过 p21诱导将细胞周期阻滞在 G1/S 期,抑制肿瘤生长及肿瘤新生血管形成。HNHA 可能是一种有效的抗乳腺癌药物。 | |||
T2085 |
PQ401
IGF-1R Inhibitor II |
Apoptosis; IGF-1R | Apoptosis; Tyrosine Kinase/Adaptors |
PQ401 (IGF-1R Inhibitor II) 是一种IGF-IR 抑制剂。在 MCF-7 细胞中,它抑制 IGF-I 刺激的 IGF-IR 自磷酸化,可有效抑制 IGF-I 刺激的 MCF-7 细胞生长。它诱导 caspase 介导的细胞凋亡,有用于乳腺癌和其他对 IGF-I 敏感的癌症的研究潜力。 | |||
T6588 |
Mitoxantrone
米托蒽醌,mitozantrone |
Topoisomerase; PKC | Chromatin/Epigenetic; Cytoskeletal Signaling; DNA Damage/DNA Repair |
Mitoxantrone (mitozantrone) 是一种拓扑异构酶 II (Topo II) 的抑制剂,一种蛋白激酶 C (PKC) 的抑制剂 (IC50=8.5 μM)。Mitoxantrone 具有抗肿瘤活性,可以治疗急性髓系白血病、肝细胞癌、乳腺癌等。 | |||
T22288 |
(1E)-CFI-400437 dihydrochloride
CFI-400437 dihydrochloride |
PLK | Cell Cycle/Checkpoint |
(1E)-CFI-400437 dihydrochloride (CFI-400437 dihydrochloride) 是一种选择性和有效的 polo 样激酶 4 (PLK4) 抑制剂,IC50为 0.6 nM。它还抑制 Aurora A、 Aurora B、 KDR 和 FLT-3,IC50分别为 0.37、0.21、0.48 和 0.18 μM,具有抗增殖活性。 | |||
T16812 |
RWJ-67657
JNJ 3026582 |
p38 MAPK | MAPK |
RWJ-67657 (JNJ 3026582) 是一种可口服的选择性p38α和p38β抑制剂,IC50分别为 1 和 11 μM。它是心脏保护剂,具有抗炎和抗肿瘤活性。 | |||
T5858 |
Sertindole
Lu 23-174,舍吲哚 |
Dopamine Receptor; 5-HT Receptor; Adrenergic Receptor; Autophagy | Autophagy; GPCR/G Protein; Neuroscience |
Sertindole (Lu 23-174) 是一种非典型抗精神病药,可与多巴胺 D2 受体和血清素受体亚型 5-HT1D、5-HT2A 和 5-HT2C 结合,Kd 值分别为 2.7、20、0.14 和 6 nM。 | |||
T7698 |
BS194
(2S,3S)-3-[[3-(异丙基)-7-[(苯基甲基)氨基]吡唑并[1,5-A]嘧啶-5-基]氨基]-1,2,4-丁三醇 |
CDK | Cell Cycle/Checkpoint |
BS194 是一种有效的细胞周期蛋白依赖性蛋白激酶 (CDK) 抑制剂。 | |||
T11847L |
Liarozole
R75251 dihydrochloride,利阿唑 |
P450; Retinoid Receptor | Metabolism |
Liarozole (R75251 dihydrochloride) 是一种咪唑衍生物,是一种具有口服活性的维甲酸 (RA) 代谢阻断剂(RAMBA),具有抗肿瘤作用。它能够抑制维甲酸依赖的细胞色素P450(CYP26) 4- 羟基化 (IC50=7 μM),导致组织维甲酸水平增加。 | |||
T6426 |
Buclizine dihydrochloride
盐酸安其敏,Longifene,Buclina,Buclizine HCl,UCB-4445 |
5-HT Receptor; AChR; Histamine Receptor | GPCR/G Protein; Immunology/Inflammation; Neuroscience |
Buclizine dihydrochloride (Buclina) 是可口服的一种哌嗪组胺 H1 受体拮抗剂,主要具有止吐和抗眩晕活性。 | |||
T6928 |
Pantoprazole
SKF96022,泮托拉唑,BY1023 |
Apoptosis; Proton pump; Autophagy | Apoptosis; Autophagy; Membrane transporter/Ion channel |
Pantoprazole (BY1023) 是一种质子泵抑制剂,用于短期治疗由胃食管反流病引起的食管糜烂和溃疡。它联合阿霉素可显著增加肿瘤生长延迟。它是一种取代的苯并咪唑,是H+/K+-ATPase 抑制剂,可改善 pH 值稳定性,具有抗分泌和抗溃疡的作用。 | |||
T5882 |
3-Bromopyruvic acid
Hexokinase II Inhibitor II, 3-BP,3-溴丙酮酸,Bromopyruvic acid |
Apoptosis; Hexokinase; Autophagy | Apoptosis; Autophagy; Metabolism |
3-Bromopyruvic acid (Hexokinase II Inhibitor II, 3-BP) 是己糖激酶 II 抑制剂,是针对肝癌细胞的一种抗肿瘤剂。 | |||
T6665 |
Sertaconazole nitrate
FI-7045,Ginedermofix,FI7056,Ertaczo,硝酸舍他康唑 |
Antibiotic; Antifungal | Microbiology/Virology |
Sertaconazole nitrate (FI-7045) 是一种局部广谱抗真菌药,可用于治疗浅表皮肤和粘膜感染。 | |||
T33519 |
MTOB
α-keto-γ-Methylthiobutyric acid,4-甲硫基-2-氧丁酸钠,KMBA,MTOB salt,4-methylthio 2-oxobutyric acid |
Others | Others |
MTOB (α-keto-γ-Methylthiobutyric acid) 是 c 末端结合蛋白 (CtBP) 的底物,可干扰 CtBP 在细胞培养物和小鼠中的致癌活性。它还积极调节 TCF-4 信号传导,导致癌症干细胞 (CSC) 生长和自我更新。 | |||
T0158 |
Mitoxantrone dihydrochloride
米托蒽醌二盐酸盐,盐酸米托蒽醌,Mitoxantrone 2HCl,Mitoxantrone hydrochloride,NSC-301739,mitozantrone dihydrochloride |
Topoisomerase; PKC | Chromatin/Epigenetic; Cytoskeletal Signaling; DNA Damage/DNA Repair |
Mitoxantrone dihydrochloride (NSC-301739) 是一种拓扑异构酶 II 的抑制剂;也可抑制蛋白激酶C (PKC),IC50值为8.5 μM。 | |||
T2657 |
Elacridar
GW0918,依克立达,GW120918,GF120918,GG918 |
BCRP; P-gp | Membrane transporter/Ion channel; Neuroscience |
Elacridar (GG918) 是一种有效的 P-糖蛋白和BCRP 的抑制剂。 | |||
T0161 |
Pantoprazole Sodium Hydrate
SKF96022 sodium hydrate,泮托拉唑钠水合物,BY1023 (sodium hydrate),SKF96022 (sodium hydrate) |
Apoptosis; Potassium Channel; Proton pump; Autophagy | Apoptosis; Autophagy; Membrane transporter/Ion channel |
Pantoprazole Sodium Hydrate (BY1023 (sodium hydrate)) 是一种具有口服活性的质子泵抑制剂。它是取代的苯并咪唑,是H+/K+-ATPase 抑制剂。它可改善 pH 值稳定性,具有抗分泌和抗溃疡的作用。它联合阿霉素可显著增加肿瘤生长延迟。 | |||
T6010 |
Idarubicin hydrochloride
盐酸伊达比星,Idamycin,4-demethoxydaunorubicin (NSC256439, 4-DMDR) HCl,4-Demethoxydaunorubicin hydrochloride,Idarubicin HCl,伊达比星盐酸盐,Zavedos |
Topoisomerase; Antibacterial; Autophagy; Antifungal | Autophagy; DNA Damage/DNA Repair; Microbiology/Virology |
Idarubicin hydrochloride (Zavedos) 是一种蒽环类抗白血病药物,能抑制细菌和酵母菌生长,还抑制拓扑异构酶 II,干扰 DNA 复制和 RNA 转录。 | |||
T6929 |
Pantoprazole sodium
Pantecta,泮托拉唑钠盐,SKF96022 sodium,SKF96022 (sodium),BY1023 (sodium),泮托拉唑钠,BY-1023 sodium,Pantoloc |
Apoptosis; Others; Proton pump; HIF; Autophagy | Angiogenesis; Apoptosis; Autophagy; Chromatin/Epigenetic; Membrane transporter/Ion channel; Others |
Pantoprazole sodium (Pantecta) 是一种具有口服活性的质子泵抑制剂,是一种取代的苯并咪唑,是H+/K+-ATPase 抑制剂,IC50为 6.8 μM。它可以改善 pH 值稳定性,具有抗分泌和抗溃疡的作用。它联合阿霉素可显著增加肿瘤生长延迟。 | |||
T15578 |
Indotecan
NSC-724998,LMP-400 |
Topoisomerase | DNA Damage/DNA Repair |
Indotecan (LMP-400) 是一种有效的拓扑异构酶 1 抑制剂,对 P388、HCT116和MCF-7 细胞系的IC50值分别为 300、1200和560 nM。 | |||
T72470 |
Estrone O-sulfamate
Estrone 3-O-sulfamate |
Others | Others |
Estrone O-sulfamate (Estrone 3-O-sulfamate) 是一种高效的的类固醇硫酸酯酶 (STS) 抑制剂。Estrone O-sulfamate 是一种胎盘微粒体抑制剂 (P.M.) ,IC50 值分别为 18 nM。Estrone O-sulfamate 在 MCF-7 细胞中对 STS 显示出抑制作用,IC50 值分别为 0.83 nM。Estrone O-sulfamate 可用于研究癌症。 | |||
T5350 |
JG-98
JG98,JG 98 |
Apoptosis; HSP | Apoptosis; Cytoskeletal Signaling; Metabolism |
JG-98 是一种热休克蛋白 70 (Hsp70)变构抑制剂,可与 Hsp70 上的保守位点紧密结合,打断 Hsp70-Bag3 相互作用。它影响癌细胞和肿瘤相关巨噬细胞,具有抗癌活性。 | |||
T10325 |
ANI-7
|
Chk | Cell Cycle/Checkpoint |
ANI-7是芳香烃受体(AhR)途径的激活剂。ANI-7抑制多种癌症细胞的生长,并有效且选择性地抑制MCF-7乳腺癌症细胞的生长(GI50:0.56μM)。 | |||
T62515 |
SIRT2-IN-9
|
Sirtuin | Chromatin/Epigenetic; DNA Damage/DNA Repair |
SIRT2-IN-9 是一种具有选择性的SRIT2抑制剂,IC50值为 1.3 μM。SIRT2-IN-9对MCF-7 乳腺癌细胞的增殖有抑制作用。SIRT2-IN-9 可用于研究癌症。 | |||
T64348 |
Antiproliferative agent-16
Antiproliferative agent-16 |
Others | Others |
Antiproliferative agent-16 (Antiproliferative agent-16)是一种具有抗癌活性的吲哚酰肼-腙化合物。 Antiproliferative agent-16 对乳腺癌细胞表现出特异性 (对 MCF-7 细胞的 IC50 为 6.94 μM)。 | |||
T77718 |
FAK-IN-10
|
FAK | Angiogenesis; Cytoskeletal Signaling; Tyrosine Kinase/Adaptors |
FAK-IN-10 是一种 FAK 的抑制剂(IC50:76.3 μM)。FAK-IN-10 z MCF-7 和 A431 细胞系中显示出抗肿瘤活性,IC50 分别为 4.23 和 0.78 μM 。 | |||
T11098 |
Droloxifene
3-Hydroxytamoxifen |
Estrogen Receptor/ERR | Endocrinology/Hormones |
Droloxifene (3-Hydroxytamoxifen),Tamoxifen 衍生物,是一种具有口服活性和选择性的雌激素受体 (estrogen receptor) 调节剂。Droloxifene 具有抗雌激素和抗植入作用。Droloxifene 诱导 MCF-7 细胞 p53 表达及凋亡。Droloxifene 预防去卵巢大鼠骨丢失。 | |||
T36488 |
LYG-202
LYG202,LYG 202 |
Apoptosis; ROS | Apoptosis; Immunology/Inflammation |
LYG-202是一种具有哌嗪替代的新型类黄酮,在体内和体外都具有抗肿瘤作用。LYG-202 诱导 MCF-7、MDA-MB-231 和 MDA-MB-435 细胞凋亡, 增加了细胞内 ROS 的产生。 | |||
T36970 |
STD1T
|
DUB | Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Ubiquitination |
STD1T 是一种具有选择性和有效性的脱泛素酶 USP2a 抑制剂,具有潜在的抗癌活性,可降低 HCT116 结肠和 MCF-7 乳腺癌细胞中的细胞周期蛋白 D1 蛋白水平。 | |||
T28589 |
Ro 41-5253
Ro-41-5253,Ro 415253 |
Apoptosis; Retinoid Receptor | Apoptosis; Metabolism |
Ro 41-5253 是一种具有口服活性的 RARα 拮抗剂,是过氧化物酶体增殖物激活受体 (PPAR)-γ 的配体和部分激动剂,具有抗肿瘤活性,抑制 MCF-7 和 ZR-75.1 雌激素受体阳性乳腺癌细胞的增殖并诱导细胞凋亡。 | |||
T83627 |
Pim-1 kinase inhibitor 8
|
Pim; PKC | Chromatin/Epigenetic; Cytoskeletal Signaling; JAK/STAT signaling |
Pim-1 kinase inhibitor 8 是一种高效的 Pim-1 kinase 抑制剂,具有抗癌活性,可有效抑制细胞迁移。Pim-1 kinase inhibitor 8 对 MCF-7 和 HepG2 细胞有细胞毒性,是研究乳腺癌的候选化合物。 | |||
T40233 |
(Iso)-MS4322
(Iso)-YS43-22,MS4322 (isomer),YS43-22 (isomer) |
Histone Methyltransferase; PROTACs | Chromatin/Epigenetic; PROTAC |
(Iso)-MS4322 ((Iso)-YS43-22) 是一种具有选择性和强效性的蛋白质精氨酸甲基转移酶 5 (PRMT5) 降解剂,具有潜在的抗癌活性,有效地降低 MCF-7 细胞中的 PRMT5 蛋白水平,可抑制多种癌细胞的生长。 | |||
T21804 |
GW 610
|
Others | Others |
GW 610 是一种抗肿瘤剂,能够选择性作用于肺癌、结肠癌和乳腺癌细胞系,具有抗癌活性。 | |||
T77575 |
P-gb-IN-1
|
P-gp | Membrane transporter/Ion channel; Neuroscience |
P-gb-IN-1 是一种有效的 P-糖蛋白 (P-gp) 抑制剂,通过抑制 P-gp 外流展现出逆转活性。P-gb-IN-1 通过与残基 Asn 721 和 Met 986 形成氢键相互作用从而显示出对 P-gp 的抑制作用。P-gb-IN-1 在 MCF-7/ADR 细胞中显示出低毒性。 |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
TN1768 |
Iriflophenone
|
Estrogen Receptor/ERR; Estrogen/progestogen Receptor | Endocrinology/Hormones |
Iriflophenone 是从 Aquilaria sinensis 中分离得到,能诱导 MCF-7 和 T-47D 人乳腺癌细胞增殖。 | |||
TN2105 |
Proscillaridin A
|
Topoisomerase | DNA Damage/DNA Repair |
Proscillaridin A 是从Drimia robusta 中提取的一种天然产物。是强力的拓扑异构酶 I 和 II 的抑制剂,IC50值分别为 30 nM 和 100 nM。 | |||
TN7060 |
Methyl oleanonate
|
PPAR | DNA Damage/DNA Repair; Metabolism |
Methyl oleanonate 是从柃木中分离得到的一种三萜类天然产物,是齐墩果酸衍生物,是一种PPARγ激动剂,具有抗癌作用。 | |||
T2882 |
Genistin
染料木甙,Genistoside,Genistein glucoside,Genistein 7-glucoside,Genistine,Genistein 7-O-β-D-glucopyranoside,染料木苷 |
Apoptosis; Estrogen Receptor/ERR; Others | Apoptosis; Endocrinology/Hormones; Others |
Genistin (Genistoside) 是一种植物雌激素家族的异黄酮,是一种抗脂肪生成剂。它通过调节ERalpha 信号通路抑制乳腺癌细胞生长和促进凋亡细胞死亡。 | |||
T5724 |
Neogambogic acid
neo-gambogic acid,新藤黄酸 |
Apoptosis; Others; Antibacterial | Apoptosis; Microbiology/Virology; Others |
Neogambogic acid 是藤黄的有效成分,可诱导细胞凋亡并具有抗癌作用。它有效抑制耐甲氧西林的金黄色葡萄球菌。 | |||
TN7059 |
Deoxylimonin
NSC 314317,脱氧柠檬苦素,desoxylimonin |
Others | Others |
Deoxylimonin (NSC 314317) 是一种分离自葡萄柚籽中的三萜化合物。它是一种母体衍生物,其抗癌、缓解疼痛和抗炎活性比母体化合物强。 | |||
T7786 |
Tryptanthrin
|
DNA gyrase | DNA Damage/DNA Repair |
Tryptanthrin 是一种口服具有活性的细胞内Leukotriene (LT) biosynthesis 抑制剂。 它能够降低大鼠胸膜炎模型中的 LTB4 水平,并抑制人全血中Leukotriene 的形成 (IC50= 10 µM)。 | |||
T3322 |
trans-Chalcone
Chalcone,反-查耳酮,查尔酮,Cinnamophenone,Chalkone |
Apoptosis; Others; Antifungal; Fatty Acid Synthase | Apoptosis; Metabolism; Microbiology/Virology; Others |
trans-Chalcone (Chalkone) 是从 Aronia melanocarpa 果皮中分离出来的一种天然产物,是类黄酮前体的双酚核心结构。它是脂肪酸合酶和 α-淀粉酶的抑制剂,具有抗真菌和抗癌活性。 | |||
T3981 |
Acacetin
4'-Methoxyapigenin,金合欢素,5,7-Dihydroxy-4'-methoxyflavone,Linarigenin |
Apoptosis; IAP; COX; Autophagy | Apoptosis; Autophagy; Immunology/Inflammation; Neuroscience |
Acacetin (5,7-Dihydroxy-4'-methoxyflavone) 是一种来自狗舌草的口服有效类黄酮。它停在 PI3Kγ 的 ATP 结合口袋中,可导致癌细胞周期停滞,并诱导细胞凋亡和自噬。它有抗癌和抗炎活性,有潜力研究疼痛相关疾病。 | |||
T4454 |
Traumatic Acid
Dodec-2-Enedioic Acid,2E-Dodecenedioic Acid,愈伤酸,Trans-2-Dodecenedioic Acid |
Antioxidant | oxidation-reduction |
Traumatic Acid (Dodec-2-Enedioic Acid) 是一种单不饱和二元羧酸,从菜豆中分离得到。它可减少膜磷脂的过氧化,并表现出抗氧化和对胶原生物合成的刺激作用。它可用于许多与胶原蛋白生物合成障碍和氧化应激有关的皮肤疾病的研究。 | |||
T12581 |
Puerarin-4'-O-β-D-glucopyranoside
Puerarin4'-O-glucoside,葛根素-4'-Β-D-葡萄糖苷 |
Others | Others |
Puerarin-4'-O-β-D-glucopyranoside (Puerarin4'-O-glucoside) 是一种从葛根 (PLR) 中提取的异黄酮。它具有雌激素活性和抗 MCF-7 人乳腺癌细胞增殖作用。 | |||
T19768 |
γ-Tocotrienol
gamma Tocotrienol,gammaTocotrienol,gamma-Tocotrienol,D-gamma-Tocotrienol,Plastochromanol,γ-生育三烯酚 |
Others | Others |
γ-Tocotrienol (Plastochromanol) 是一种维生素 E 的活性形式。 | |||
T8724 |
6-Methoxydihydrosanguinarine
|
Others | Others |
6-Methoxydihydrosanguinarine 是一种从M. cordata 果实中分离出的生物碱,它对 MCF-7 细胞系(IC50:0.61 μM)和 SF-268 细胞系(IC50:0.54 μM)具有强的细胞毒性。 | |||
T1166 |
Ellipticine
玫瑰树碱,NSC 71795,Elliptisine |
Topoisomerase | DNA Damage/DNA Repair |
Ellipticine (Elliptisine) 是一种有效的抗肿瘤剂,抑制 DNA 拓扑异构酶 II 活性,对白血病、神经母细胞瘤和胶质母细胞瘤有部分活性。 | |||
TN3049 |
4-Methoxycinnamyl alcohol
|
Others | Others |
4-Methoxycinnamyl alcohol 对MCF-7、HeLa 和DU145癌症细胞系显示出毒性,IC50值分别为14.24、7.82和22.10μg/mL。4-methoxycinnamyl alcohol 是从Foeniculum vulgare 中分离出来的。4-Methoxycinnamyl alcohol 没有显示出凋亡作用,却在10μg/mL DNA 碎片研究显示48小时后发生了坏死。 | |||
TMS0879 |
Asiaticoside B
积雪草苷 B,积雪草苷B |
Others | Others |
Asiaticoside B 是一种从类叶升麻中分离得到的三萜糖苷,具有抗肿瘤作用。 它对 HepG2 和 MCF-7 癌细胞系具有显著的细胞毒性。 | |||
T83321 |
4-Demethyldeoxypodophyllotoxin
|
Chk | Cell Cycle/Checkpoint |
4-Demethyldeoxypodophyllotoxin 是一种来自 Podophyllum peltatum 根部的芳基四氢萘木酚素类化合物,具有抗癌活性,可调节 MCF-7乳腺癌细胞中的Chk-2信号通路。 | |||
TN7041 |
(-)-Epipodophyllotoxin
|
Apoptosis | Apoptosis |
(-)-Epipodophyllotoxin 是一种从八角莲中分离的癌细胞抗增殖剂,在 HeLa 细胞和 MCF-7 细胞中的GI50值分别为 0.36 和 0.24 μM。它可在体外抑制有丝分裂纺锤体组装。 | |||
TMA2270 |
Alisol F 24-acetate
|
P-gp | Membrane transporter/Ion channel; Neuroscience |
Alisol F 24-acetate 是一种从 Alisma plantago-aquatica Linn [1] 中分离出来的天然产物。 Alisol F 24 Acetate 通过抑制 P-糖蛋白介导的药物流出来增强 MCF-7/DOX 细胞的化学敏感性和凋亡。 | |||
T4519 |
Alisol A
Alisol-A,泽泻醇 A |
Autophagy | Autophagy |
Alisol A (Alisol-A) 是泽泻中的一种三萜类天然产物,可能是一种自噬诱导剂,具有抗癌活性。 | |||
TN1464 |
Camellianin A
|
Apoptosis; RAAS | Apoptosis; Endocrinology/Hormones |
Camellianin A 是从 A. nitida 和 茶叶中提取得到的类黄酮列化合物,具有抗癌活性,抑制血管紧张素转换酶 (ACE) 活性,促进 Hep G2 和 MCF-7 细胞凋亡。Camellianin A 可预防CCl4-通过施加抗氧化应激、抗炎和抗细胞凋亡诱导肝损伤。 | |||
T4S0544 |
Furanodienone
呋喃二烯酮,莪术呋喃二烯酮 |
Apoptosis; HER | Angiogenesis; Apoptosis; JAK/STAT signaling; Tyrosine Kinase/Adaptors |
Furanodienone 是来源于姜黄根茎的一种主要生物活性成分,可诱导细胞凋亡。 | |||
T3411 |
Curdione
莪术二酮,(+)-Curdione |
P450 | Metabolism |
Curdione ((+)-Curdione) 是一种具有高生物活性的倍半萜类物质,从莪术中分离获得,具有抑制血小板聚集、抵抗血栓形成的作用。 | |||
TN1727 |
Helichrysetin
4,2',4'-三羟基-6'-甲氧基查耳酮,蜡菊亭 |
Apoptosis; HIV Protease | Apoptosis; Microbiology/Virology; Proteases/Proteasome |
Helichrysetin 是从豆蔻果实中分离出的一种天然产物,是一种 DNA 结合抑制剂,可抑制原位导管癌DCIS 的形成。它抑制细胞生长,可诱导 A549 细胞凋亡。 | |||
T8190 |
5-Hydroxyflavone
|
Others | Others |
5-Hydroxyflavone 是类黄酮配体,对 FaDU,MCF-7,U87,MDA-MB-435S,RPE-1 和 HEK293 细胞没有细胞毒性。 | |||
TJS0387 |
Desoxyrhaponticin
去氧土大黄苷,Deoxyrhapontin,脱氧土大黄苷,Deoxyrhaponticin |
Apoptosis; Fatty Acid Synthase | Apoptosis; Metabolism |
Desoxyrhaponticin (Deoxyrhaponticin) 是来自西藏营养食品唐古特大黄中的一种二苯乙烯苷。它是脂肪酸合成酶抑制剂,抑制细胞内 FAS 活性,下调人乳腺癌 MCF-7细胞中 FAS 的表达。它是控制糖尿病餐后高血糖的潜在药物。 | |||
T5S1607 |
Morusin
Mulberrochromene,桑辛素 |
NF-κB; Antibacterial; STAT | JAK/STAT signaling; Microbiology/Virology; NF-κB; Stem Cells |
Morusin (Mulberrochromene) 是从M. australis 分离的去乙烯基化黄酮,可抑制NF-κB 和STAT3的活性,具有抗菌、抗肿瘤、抗氧化等各种生物活性。 | |||
T2S0265 |
Robinin
NSC 9222,刺槐素 |
TLR | Immunology/Inflammation |
Flavone glycoside from Robinia with antibacterial and diuretic properties; derived from kaempferol.The ability of robinin to reverse the multidrug resistance of the human colon cancer cell line Colo 320 expreβing MDR1/LRP was explored by monitoring their uptake of Rhodamine 123, but was shown to have minimal effect. Robinin (NSC-9222) was detected in lysates of the human breast cancer cell line MCF-7 using liquid chromatography-tandem maβ spectrometry. | |||
TN3972 |
Epimedokoreanin B
|
Apoptosis; Others; Antibacterial | Apoptosis; Microbiology/Virology; Others |
Epimedokoreanin B (EKB) 是一种从韩国淫羊藿中分离出的异戊烯化类黄酮,在人非小细胞肺癌(NSCLC)A549和NCI-H292细胞中展现出抗癌活性。Epimedokoreanin B 还具有抗炎和抗菌活性,可有清除 DPPH 自由基的活性,能以剂量依赖的方式抑制 MCF-7 和 HepG2 的增殖。Epimedokoreanin B 能显著抑制 N (δ) -(羧甲基)赖氨酸(CML)和 N (Ï) -(羧甲基)精氨酸(CMA)的形成,可通过抑制高级糖化终产物(AGEs)预防糖尿病的临床并发症。 | |||
T5S0506 |
Rotundic acid
Rutundic acid,铁冬青酸 |
Apoptosis; Others; p38 MAPK; Akt; mTOR | Apoptosis; Cytoskeletal Signaling; MAPK; Others; PI3K/Akt/mTOR signaling |
Rotundic acid (Rutundic acid) 是一种从圆形肠球菌中获得的三萜类天然产物,具有抗炎和保护心脏的能力。它可通过 AKT/mTOR 和 MAPK 途径在肝细胞癌中诱导 DNA 损伤和细胞凋亡。 | |||
TN2755 |
2-Desoxy-4-epi-pulchellin
|
Anti-infection | Microbiology/Virology |
2-Desoxy-4-epi-pulchellin 是分离自 Polygonum hydropiper 的二氯甲烷可溶部分的一种化合物。 | |||
TN1853 |
Lariciresinol
(+)-落叶松树脂醇 |
VEGFR; Antifection | Angiogenesis; Microbiology/Virology; Tyrosine Kinase/Adaptors |
Lariciresinol 是一种肠木脂素前体,它通过破坏真菌质膜具有杀真菌活性,并具有作为治疗人类真菌感染性疾病的新型抗真菌剂的治疗潜力。膳食 lariciresinol 可以减缓乳腺肿瘤的生长并降低人 MCF-7 乳腺癌异种移植物和致癌物诱导的大鼠乳腺肿瘤的血管密度。 | |||
T5S2358 |
Dehydrocorydaline
Dehydrocorydalin,脱氢紫堇碱,13-Methylpalmatine |
BCL; PARP; p38 MAPK; Caspase; Parasite; Autophagy | Apoptosis; Autophagy; Chromatin/Epigenetic; DNA Damage/DNA Repair; MAPK; Microbiology/Virology; Proteases/Proteasome |
Dehydrocorydaline (13-Methylpalmatine) 是一种生物碱。它调节Bax,Bcl-2蛋白表达,激活caspase-7,caspase-8,并使PARP 失活。它能增强p38 MAPK 活化,具有抗炎、抗癌等功效。它具有强大的抗疟疾作用,并具低细胞毒性。 | |||
T3S1416 |
Decursin
Decursinol angelate,前胡素,(+)-Decursin,紫花前胡素 |
Apoptosis; PKC | Apoptosis; Chromatin/Epigenetic; Cytoskeletal Signaling |
Decursin (Decursinol angelate) 是一种细胞毒性剂,是一种来自朝鲜当归根的有效蛋白激酶 C 激活剂。它通过 Hippo/YAP 信号通路抑制 HepG2 细胞的生长。它通过下调 CXCR7 表达来抑制胃癌中的肿瘤生长,迁移和侵袭。 | |||
T3S2344 |
β,β-Dimethylacrylshikonin
β,β-二甲基丙烯酰紫草素,Dimethylacrylshikonin,β, β-Dimethylacrylshikonin |
ERK; HIF/HIF Prolyl-Hydroxylase | Chromatin/Epigenetic; MAPK; Metabolism |
β,β-Dimethylacrylshikonin (Dimethylacrylshikonin) 是一种萘醌衍生物,从 Arnebia nobilis 中提取得到。它利用 PI3K 通路诱导 eNOS、VEGF 和 HIF-1α 的表达,促进血管生成,具有抗肿瘤活性。 | |||
T2S1865 |
Octyl gallate
Gallic acid octyl ester,n-Octylgallate,Octyl 3,4,5-trihydroxybenzoate,Progallin O,Stabilizer GA-8,没食子酸辛酯 |
Antioxidant; Influenza Virus; Reactive Oxygen Species; Antibacterial; Antifungal; HSV | Immunology/Inflammation; Metabolism; Microbiology/Virology; NF-κB; oxidation-reduction |
Octyl gallate (Octyl 3,4,5-trihydroxybenzoate) 具有抗菌、抗氧化作用,有选择性和敏感性的荧光特性,广泛用作食品添加剂。它对 HSV-1,水泡性口炎病毒和脊髓灰质炎病毒有显著的抗病毒作用。 | |||
T6S1315 |
Oroxylin A
千层纸素A,6-Methoxybaicalein,Baicalein 6-methyl ether |
Virus Protease; HIF/HIF Prolyl-Hydroxylase; Autophagy | Autophagy; Chromatin/Epigenetic; Metabolism; Microbiology/Virology |
Oroxylin A (Baicalein 6-methyl ether) 是一种有活性的黄酮,具有较强的抗癌作用。 | |||
T3729 |
Ethyl gallate
Nipagallin A,Phyllemblin,gallic acid ethyl ester,没食子酸乙酯 |
MMP; NF-κB; Akt; Antibacterial | Cytoskeletal Signaling; Microbiology/Virology; NF-κB; PI3K/Akt/mTOR signaling; Proteases/Proteasome |
Ethyl gallate (gallic acid ethyl ester) 是一种非类黄酮酚过氧化氢清除剂。 | |||
T17155 |
Trabectedin
Ecteinascidin 743,曲贝替定,ET-743 |
Apoptosis; Reactive Oxygen Species | Apoptosis; Immunology/Inflammation; Metabolism; NF-κB |
Trabectedin (Ecteinascidin 743) 是一种四氢异喹啉生物碱,有抗肿瘤的活性, 通过与 DNA 的小沟结合,阻断应激诱导的蛋白质的转录,诱导 DNA 骨架裂解和癌细胞凋亡,并增加 MCF-7 和 MDA-MB-453 细胞中 ROS 的生成。Trabectedin 在软组织肉瘤和卵巢癌中具有的研究价值。 | |||
T13551 |
Araliadiol
|
Others | Others |
Araliadiol is a polyacetylenic compound isolated from the leaves of Aralia cordata Thunb. Araliadiol inhibits MCF-7 cell growth (IC50: 6.41 µg/mL). | |||
TN2979 |
3-Oxotirucalla-7,24-dien-21-oic acid
|
Others | Others |
3-Oxotirucalla-7,24-dien-21-oic acid 是首次从蓼属植物中分离得到的已知化合物,可从黑参根中分离得到。3-Oxotirucalla-7,24-dien-21-oic acid 对 MCF-7细胞系显示出强大的细胞毒性。 | |||
TN4307 | Isolimonexic acid | BCL; Caspase; COX; p53 | Apoptosis; Immunology/Inflammation; Neuroscience; Proteases/Proteasome |
Isolimonexic acid exhibits cytotoxicity on MCF-7 cell lines, it also inhibits Panc-28 cancer cell growth. | |||
TN5287 |
3β,5α-Dihydroxyergosta-7,22-dien-6-one
|
||
3β,5α-Dihydroxy-(22E,24R)-ergosta-7,22-dien-6-one exhibits strong or moderate cytotoxic activities against MCF-7, A549, Hela and KB cell lines with IC50 values 4.98 (MCF-7), 1.95 (A549), 0.68(Hela), and 1.50 uM (KB), respectively. | |||
TQ0164 |
Dodecanoic acid ingenol ester
正十二烷酸巨大戟酯,13-Oxyingenol dodecanoat |
Others | Others |
Dodecanoic acid ingenol ester, a natural compound, shows moderate cytotoxicity with IC50 values being 35.59 μM (Caco-2), 24.04 μM (MCF-7), and 22.24 μM (MCF-7/ADM). | |||
TN2249 |
(+)-Syringaresinol
|
Sirtuin; Antifection | Chromatin/Epigenetic; DNA Damage/DNA Repair; Microbiology/Virology |
(+)-Syringaresinol shows antioxidant potential, it exhibits cytoprotective activity in cultured MCF-7 cells stressed by H2O2. | |||
T83301 |
5,7-Dimethoxy-2,3-phenanthrenediol
|
||
5,7-Dimethoxy-2,3-phenanthrenediol 表现出雌激素活性,能够促进MCF-7细胞的增殖,并增强ERβ在MCF-7细胞系中的表达。 | |||
T40940 |
7,3′,5′-Trihydroxyflavanone
|
Others | Others |
7,3′,5′-Trihydroxyflavanone, a flavanoid derivative, promotes apoptotic cell death in MCF-7 cells by augmenting Bax expression. Additionally, this compound demonstrates antioxidant properties. | |||
TN1578 |
Dihydroconiferyl alcohol
|
Others | Others |
Dihydroconiferyl alcohol exhibits cytoprotective activity in cultured MCF-7 cells stressed by H2O2. | |||
TN5538 |
6-Methoxykaempferol
|
Others | Others |
6-Methoxykaempferol 是一种存在于 brazilian propolis 中的黄酮。6-Methoxykaempferol 对癌细胞具有抗增殖活性,对离体大鼠脑突触体的神经保护作用,可降低的谷胱甘肽水平。6-Methoxykaempferol 表现出一定的脂肪酶活性,可用于恶病质的治疗。 | |||
TN5676 |
Musellarin B
|
||
Musellarin B is cytotoxic toward several of the human tumor cell lines (HL-60, SMMC-7721, A-549, MCF-7, and SW480). | |||
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Cat. No. | Product Name | Species | Expression System |
---|---|---|---|
TMPY-06036 |
FGFR1 Protein, Human, Recombinant (alpha (IIIb), His)
FGFR-1,FLG,CD331,HH2,FLT2,KAL2,FGFBR,HBGFR,CEK,HRTFDS,fibrob... |
Human | HEK293 Cells |
FGFR1 Protein, Human, Recombinant (alpha (IIIb), His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 40.5 kDa and the accession number is P11362-7. | |||
TMPJ-00655 |
TRAIL R1/DR4/TNFRSF10A Protein, Human, Recombinant (His)
TRAIL-R1,TNFRSF10A,cytotoxic TRAIL receptor,APO2,CD261 antig... |
Human | HEK293 Cells |
Tumor necrosis factor receptor superfamily member 10A (TNFRSF10A) is also known as TNF-related apoptosis-inducing ligand receptor 1 (TRAIL-R1), Death receptor 4 (DR4), CD261 and APO2, which belongs to TNF superfamily. TNFRSF10A / DR4 is widely expressed and high levels are found in spleen, peripheral blood leukocytes, small intestine and thymus, but also in K-562 erythroleukemia cells, MCF-7 breast carcinoma cells and activated T-cells. APO2 / TNFRSF10A is receptor for the cytotoxic ligand TNFSF... | |||
TMPY-01383 |
PRMT6 Protein, Human, Recombinant (His & Flag)
protein arginine methyltransferase 6,HRMT1L6 |
Human | HEK293 Cells |
Protein arginine N-methyltransferase 6, also known as Histone-arginine N-methyltransferase PRMT6, PRMT6, and HRMT1L6, is a member of the protein arginine N-methyltransferase family and PRMT6 subfamily. PRMT6 is highly expressed in kidney and testes. PRMT6 is known to catalyze the generation of asymmetric dimethylarginine in polypeptides. It has been implicated in human immunodeficiency virus pathogenesis, DNA repair, and transcriptional regulation. PRMT6 is known to methylate histone H3 Arg-2 (H... | |||
TMPY-02763 |
DEP-1 Protein, Human, Recombinant (aa 997-1337, His)
HPTPeta,SCC1,protein tyrosine phosphatase, receptor type, J,... |
Human | E. coli |
DEP1 / PTPRJ (Receptor-type tyrosine-protein phosphatase eta) is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes, including cell growth, differentiation, mitotic cycle, and oncogenic transformation. DEP1 / PTPRJ possesses an extracellular region containing five fibronectin type III repeats, a single transmembrane region, and a single intracytoplasmic catalytic domain, and thus represents a receptor-... | |||
TMPK-00828 |
Mucin-1/MUC1 Isoform Y Protein, Human, Recombinant (hFc)
PEMT,Episialin,Mucin1,PUM,KL-6,MUC-1,Mucin-1,H23AG,PEM,CA 15... |
Human | HEK293 Cells |
MUC1, the transmembrane glycoprotein Mucin 1, is usually found to be overexpressed in a variety of epithelial cancers playing an important role in disease progression. MUC1 isoforms such as MUC1/Y, which lacks the entire variable number of tandem repeat region, are involved in oncogenic processes by enhancing tumour initiation. MUC1/Y is therefore considered a promising target for the identification and treatment of epithelial cancers. | |||
TMPK-00392 |
FGFR1 beta (IIIc) Protein, Human, Recombinant (His & Avi)
CD331,FGFR-1,FLT-2,BFGFR,N-sam,FGFR1 β (IIIc),bFGF-R-1 |
Human | HEK293 Cells |
Fibroblast growth factor receptor 1 (FGFR1) transmits signals through the plasma membrane regulating essential cellular processes like division, motility, metabolism, and death. Overexpression of FGFR1 is observed in numerous tumors and thus constitutes an attractive molecular target for selective cancer treatment. FGFR1 beta (IIIc) Protein, Human, Recombinant (His & Avi) is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 25.23 kDa and the accession numb... | |||
TMPK-01371 |
IGFBP-7 Protein, Human, Recombinant (hFc)
RAMSVPS,TAF,IGFBPRP1,AGM,IBP7,MAC25,IGFBP-7 |
Human | HEK293 Cells |
IGFBP-7, also known as Mac25/Angiomodulin (AGM), GFBP-rp1, tumor-derived adhesion factor (TAF) and prostacyclin-stimulating factor (PSF), is a secreted protein that contains three protein domain modules. Human IGFBP-rp1 cDNA encodes 282 amino acid (aa) residue precursor protein with a putative 26 aa signal peptide. IGFBP-7 binds IGF-I and IGF-II with a relatively low affinity. Stimulates prostacyclin (PGI2) production. Stimulates cell adhesion. IGFBP-7 Protein, Human, Recombinant (hFc) is expres... | |||
TMPK-00394 |
FGFR1 beta (IIIc) Protein, Human, Recombinant (His & Avi), Biotinylated
FGFR1 β (IIIc),N-sam,FLT-2,BFGFR,bFGF-R-1,CD331,FGFR-1 |
Human | HEK293 Cells |
Fibroblast growth factor receptor 1 (FGFR1) transmits signals through the plasma membrane regulating essential cellular processes like division, motility, metabolism, and death. Overexpression of FGFR1 is observed in numerous tumors and thus constitutes an attractive molecular target for selective cancer treatment. FGFR1 beta (IIIc) Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 25.23 kDa and the ... | |||
TMPY-06035 |
FGFR1 Protein, Human, Recombinant (alpha (IIIb), hFc)
KAL2,OGD,N-SAM,CEK,FLT2,HH2,FLG,CD331,BFGFR,HBGFR,FLT-2,FGFB... |
Human | HEK293 Cells |
FGFR1 Protein, Human, Recombinant (alpha (IIIb), hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 65.7 kDa and the accession number is P11362-7. | |||
TMPK-00395 |
FGFR1 alpha (IIIc) Protein, Human, Recombinant (His & Avi), Biotinylated
FGF R1a,FGFR1 α,FGFR1 alpha,FGFR1 α (IIIc) |
Human | HEK293 Cells |
FGFR1 alpha (IIIc) Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 42 kDa and the accession number is P11362-7. | |||
TMPK-00393 |
FGFR1 alpha (IIIc) Protein, Human, Recombinant (His & Avi)
FGFR1 α,FGFR1 alpha,FGF R1a,FGFR1 α (IIIc) |
Human | HEK293 Cells |
FGFR1 alpha (IIIc) Protein, Human, Recombinant (His & Avi) is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 42 kDa and the accession number is P11362-7. |
Cat. No. | Product Name | Target | Signaling Pathways |
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T71293 |
Nifuroxazide-d4
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Nifuroxazide-d4 is intended for use as an internal standard for the quantification of nifuroxazide by GC- or LC-MS. Nifuroxazide is a nitrofuran antibiotic. It is active against strains of the enteropathogenic bacteria C. jejuni, Salmonella, Y. enterocolitica, Shigella, and E. coli. It inhibits quorum sensing and virulence factor production in P. aeruginosa. Nifuroxazide inhibits STAT3 activity in a reporter assay and decreases viability of U266 and INA-6 myeloma cells, which have constitutive S... | |||
TMIJ-0244 |
Fulvestrant-d3
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Fulvestrant-d3 是 Fulvestrant 的氘代化合物。Fulvestrant 的 CAS 号为 129453-61-8。Fulvestrant是纯抗雌激素,也是一种雌激素受体拮抗剂,IC50为 9.4 nM。它抑制ER阳性 MCF-7 细胞的生长,IC50为 0.29 nM。它还是一种GPR30的激动剂。它可诱导细胞自噬和凋亡,有抗肿瘤作用。 |