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Search Results for " mapkk "

Targets Recommended: MEK

32

抑制剂 & 化合物

3

天然产物

1

化合物库

9

重组蛋白

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Cat. No.	Product Name
L1400	MAPK 抑制剂库		365 compounds
	365 种与MAPK 信号通路相关的生物活性小分子化合物的特有集合，可用于高通量筛选和高内涵筛选；

化合物库

MAPK 抑制剂库

Cat.No: L1400

Compounds: 365

Cat. No.	Product Name	Target	Signaling Pathways
T6152	PD318088	MEK	MAPK
	PD318088 是非 ATP 竞争性的MEK1/2变构抑制剂，是 PD184352 的结构类似物。它在MEK1 活性位点与 ATP 结合位点相邻的区域与 ATP 同时结合，可用于癌症研究。
T6785	BI-847325	Apoptosis; MEK; Aurora Kinase	Apoptosis; Cell Cycle/Checkpoint; Chromatin/Epigenetic; MAPK
	BI847325是MEK 和极光激酶 (AK)的一种选择性双重抑制剂，对人类MEK2和AK-C 的IC50值分别为4和15 nM。
T6692	TAK-733 TAK733,TAK 733	MEK	MAPK
	TAK-733 是选择性 MEK 抑制剂，IC50为 3.2 nM。
T2708	SL327 SL 327,SL-327	MEK; DNA/RNA Synthesis	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; MAPK
	SL327 是能通过血脑屏障运输的选择性 MEK1/2 抑制剂，IC50 分别为 0.18 和 0.22 μM。
T21295	BIX02189 BIX 02189	ERK; MEK	MAPK
	BIX02189 是一种有效的选择性 MEK5 和 ERK5 抑制剂，IC50分别为 1.5 和 59 nM。
T21635	PD184161	MEK	MAPK
	PD 184161 是一种口服有效的，时间和浓度依赖的 MEK 抑制剂，IC50为10-100 nM。它诱导抑郁样行为，抑制细胞增殖并诱导细胞凋亡。
T6971	Ro 5126766 CH5126766,Avutometinib,VS-6766,RO5126766	Raf; MEK	MAPK
	Ro 5126766 (CH5126766) 是双重MEK/RAF 抑制剂，抑制BRAFV600E、CRAF、MEK 和 BRAF，IC50分别为 8.2、56、160 和 190 nM。
T2623	PD98059 PD 98059	ERK; Aryl Hydrocarbon Receptor; MEK; Autophagy	Autophagy; Immunology/Inflammation; MAPK
	PD98059 是一种 MEK 抑制剂，抑制 MEK1 和 MEK2 (IC50=2/50 μM)，具有非 ATP 竞争性。PD98059 也是一种 AHR 的配体而起拮抗作用。PD98059 可以抑制细胞自噬。
T2443	CI-1040 PD 184352	Apoptosis; MEK	Apoptosis; MAPK
	CI-1040 (PD 184352) 是一种有口服活性的高度特异性MEK 小分子抑制剂，对 MEK1 的IC50值为 17 nM 。
T7610	GW284543 UNC10225170	MEK	MAPK
	GW284543 (UNC10225170) 是一个选择性的MEK5抑制剂，可降低 pERK5，并下调内源性 MYC 蛋白。
T6189	Mirdametinib PD325901,PD0325901	Apoptosis; MEK; Autophagy	Apoptosis; Autophagy; MAPK
	Mirdametinib (PD325901) 是一种 MEK 抑制剂 (IC50=0.33 nM)，具有选择性、非 ATP 竞争性和口服活性。Mirdametinib 具有抗肿瘤活性，可以抑制 p-ERK1/2 的表达并诱导细胞凋亡。
T21980	PD 198306	MEK	MAPK
	PD 198306 是一种具有抗痛觉过敏作用的 MAPK/ERK 激酶 (MEK) 选择性抑制剂。 PD 198306 可降低链脲佐菌素诱导的活性 ERK1 水平升高。
T6218	Selumetinib ARRY-142886,司美替尼,AZD6244	Apoptosis; ERK; MEK	Apoptosis; MAPK
	Selumetinib (AZD6244) 是一种高效选择性的，非 ATP 竞争性的MEK1/2抑制剂，抑制 MEK1 的IC50为14 nM。它抑制 MEK1/2 磷酸化水平。
T1144L	Lidocaine Hydrochloride hydrate	EGFR; Sodium Channel	Angiogenesis; JAK/STAT signaling; Membrane transporter/Ion channel; Tyrosine Kinase/Adaptors
	Lidocaine Hydrochloride hydrate 是一种酰胺类局部麻醉剂，具有抗炎作用。
T5412	RO4987655 CH4987655,RG7167	MEK	MAPK
	RO4987655 (RG7167) 是一种具有口服活性和高选择性的 MEK 抑制剂，抑制MEK1/MEK2，IC50为 5.2 nM。
T6760	APS-2-79 hydrochloride APS-2-79 HCl,APS-2-79	MEK; MAPK	MAPK
	APS-2-79 hydrochloride (APS-2-79 HCl) 是一种 KSR 依赖性的MEK 拮抗剂，可与 ATPbiotin 竞争性地结合到 KSR2-MEK1 复合物内的KSR2。它与 KSR 结合可将 KSR 处于非活性状态，使其无法再结合 RAF 和激活 MEK，从而阻断 Ras-MAPK 信号通路。
T6083	AZD8330 ARRY-424704,ARRY-704	ERK; MEK	MAPK
	AZD8330 (ARRY-704) 是非竞争性的 MEK1/MEK2抑制剂，IC50为 7 nM。
T0468	Lidocaine Lignocaine,Alphacaine,Xylocaine,利多卡因	Apoptosis; ERK; NF-κB; MEK; Sodium Channel; Histamine Receptor	Apoptosis; GPCR/G Protein; Immunology/Inflammation; MAPK; Membrane transporter/Ion channel; Neuroscience; NF-κB
	Lidocaine (Alphacaine) 是一种酰胺衍生物，抑制涉及复杂电压和依赖性的钠通道，可用于研究室性心律失常。它通过调节 miR-145 表达和进一步抑制 MEK/ERK 和 NF-κB 信号通路来减少胃癌细胞的生长，迁移和侵袭。
T6843	GDC-0623 G-868,GDC0623,RG 7421,MEK inhibitor 1	Apoptosis; MEK	Apoptosis; MAPK
	GDC-0623 (RG 7421) 是一种 ATP 竞争性的MEK1抑制剂，Ki 值为 0.13 nM。它对 A375 细胞中 BRAFV600E 的 EC50值为 7 nM，而对 HCT116 细胞中 KRAS (G13D)的 EC50值为 42 nM。
T6223	U0126-EtOH U0126 Ethanol,U0126	Mitophagy; Influenza Virus; MEK; Autophagy	Autophagy; MAPK; Microbiology/Virology
	U0126-EtOH (U0126 Ethanol) 是一种非 ATP 竞争性的选择性MEK1和MEK2抑制剂，IC50分别为 72 nM 和 58 nM。U0126-EtOH 可抑制自噬和线粒体自噬。
T2125	Trametinib GSK1120212,曲美替尼,JTP-74057	Apoptosis; MEK; Autophagy	Apoptosis; Autophagy; MAPK
	Trametinib (GSK1120212) 是一种 MEK 抑制剂，抑制 MEK1 和 MEK2 (IC50=0.7/0.9 nM)，具有 ATP 非竞争性和口服活性。Trametinib 可以激活自噬，诱导凋亡。
T1144	Lidocaine hydrochloride Lidocaine HCL,盐酸利多卡因,Lignocaine hydrochloride,Xyloneural,Lidothesin	Apoptosis; ERK; NF-κB; MEK; Sodium Channel	Apoptosis; MAPK; Membrane transporter/Ion channel; NF-κB
	Lidocaine hydrochloride (Lignocaine hydrochloride) 抑制涉及复杂电压和依赖性的钠通道。它通过调节 miR-145 表达和进一步抑制 MEK/ERK 和 NF-κB 信号通路来减少胃癌细胞的生长，迁移和侵袭。Lidocaine 是一种酰胺衍生物，是一种研究室性心律失常的药物和有效的肿瘤抑制剂。
T2378	RGB-286638 free base	GSK-3; MEK; JAK; CDK	Angiogenesis; Cell Cycle/Checkpoint; Chromatin/Epigenetic; JAK/STAT signaling; MAPK; PI3K/Akt/mTOR signaling; Stem Cells
	RGB-286638 free base 是一种新型 CDK 抑制剂，抑制cyclin T1-CDK9、cyclin B1-CDK1、cyclin E-CDK2、cyclin D1-CDK4、cyclin E-CDK3和p35-CDK5活性，IC50分别为 1、2、3、4、5 和 5 nM。它也抑制 GSK-3β、TAK1、Jak2 和 MEK1，IC50值分别为 3、5、50和 54 nM。
T2508	Binimetinib ARRY-438162,ARRY-162,MEK162	MEK; Autophagy	Autophagy; MAPK
	Binimetinib (ARRY-162) 是一种可口服的选择性 MEK1/2抑制剂，抑制MEK 的IC50为 12 nM。
T3623	Cobimetinib 可美替尼,考比替尼,RG7420,XL518,GDC-0973	Apoptosis; MEK	Apoptosis; MAPK
	Cobimetinib (GDC-0973) 是一种可口服的 MEK1选择性抑制剂，抑制MEK1的IC50为4.2 nM。
T6131	Pimasertib AS703026,MSC1936369B,N-[(2S)-2,3-二羟基丙基]-3-[(2-氟-4-碘苯基)氨基]-4-吡啶甲酰胺,SAR 245509	MEK	MAPK
	Pimasertib (AS703026) 是一种高效选择性和ATP 非竞争性的MEK1/2抑制剂，可用于癌症研究。
T6636	Refametinib BAY 86-97661,瑞法替尼//瑞美替尼,BAY 869766,RDEA119	MEK	MAPK
	Refametinib (RDEA119) 是可口服的、非 ATP 竞争和选择性的 MEK1/MEK2变构抑制剂，IC50分别为 19 和 47 nM。
T5857	Trametinib (DMSO solvate) Trametinib DMSO solvate,GSK-1120212 (DMSO solvate),Trametinib dimethyl sulfoxide,JTP-74057 (DMSO solvate)	Apoptosis; MEK	Apoptosis; MAPK
	Trametinib (DMSO solvate) (GSK-1120212 (DMSO solvate)) 是一种口服有效的 MEK 抑制剂，抑制 MEK1 和 MEK2 的 IC50分别为 2 nM。它还能激活自噬，诱导凋亡。
T9321	zapnometinib ATR-002,3,4-difluoro-2-(2-chloro-4-iodophenylaMino)-benzoic acid,PD0184264,2-(2-chloro-4-iodoanilino)-3,4-difluorobenzoic acid	Influenza Virus; MEK; Antibacterial	MAPK; Microbiology/Virology
	Zapnometinib (ATR-002) 是 CI-1040 的活性代谢物，是一种 MEK 抑制剂，IC50值为 5.7 nM，有抗流感病毒的抗病毒和抗菌活性。
T21332	U0126 U 0126,U-0126	Mitophagy; MEK; Autophagy	Autophagy; MAPK
	U0126 是一种有效的特异性非竞争性 MAP 激酶抑制剂，抑制 MEK-1 和 MEK-2，IC50 值分别为 0.07 和 0.06 μM。 U0126 抑制自噬和线粒体自噬。
T22677	Cobimetinib racemate Cobimetinib (racemate),考比替尼 (外消旋体)	MEK	MAPK
	Cobimetinib racemate (Cobimetinib (racemate)) 是 Cobimetinib 的外消旋体，是一种选择性 MEK 抑制剂。
T70317	BIBU-1361 dihydrochloride	Others	Others
	BIBU-1361 dihydrochloride is an inhibitor of epidermal growth factor receptor (EGFR) tyrosine kinase that blocks downstream EGFR signaling events such as MAPKK/MAPK activation.

化合物

Cat.No: T6152

Target: MEK

Cat.No: T6785

Target: Apoptosis, MEK, Aurora Kinase

Cat.No: T6692

Synonym: TAK733,TAK 733

Target: MEK

Cat.No: T2708

Synonym: SL 327,SL-327

Target: MEK, DNA/RNA Synthesis

Cat.No: T21295

Synonym: BIX 02189

Target: ERK, MEK

Cat.No: T21635

Target: MEK

Cat.No: T6971

Synonym: CH5126766,Avutometinib,VS-6766,RO5126766

Target: Raf, MEK

Cat.No: T2623

Synonym: PD 98059

Target: ERK, Aryl Hydrocarbon Receptor, MEK, Autophagy

Cat.No: T2443

Synonym: PD 184352

Target: Apoptosis, MEK

Cat.No: T7610

Synonym: UNC10225170

Target: MEK

Cat.No: T6189

Synonym: PD325901,PD0325901

Target: Apoptosis, MEK, Autophagy

Cat.No: T21980

Target: MEK

Cat.No: T6218

Synonym: ARRY-142886,司美替尼,AZD6244

Target: Apoptosis, ERK, MEK

Lidocaine Hydrochloride hydrate

Cat.No: T1144L

Target: EGFR, Sodium Channel

Cat.No: T5412

Synonym: CH4987655,RG7167

Target: MEK

APS-2-79 hydrochloride

Cat.No: T6760

Synonym: APS-2-79 HCl,APS-2-79

Target: MEK, MAPK

Cat.No: T6083

Synonym: ARRY-424704,ARRY-704

Target: ERK, MEK

Cat.No: T0468

Synonym: Lignocaine,Alphacaine,Xylocaine,利多卡因

Target: Apoptosis, ERK, NF-κB, MEK, Sodium Channel, Histamine Receptor

Cat.No: T6843

Synonym: G-868,GDC0623,RG 7421,MEK inhibitor 1

Target: Apoptosis, MEK

Cat.No: T6223

Synonym: U0126 Ethanol,U0126

Target: Mitophagy, Influenza Virus, MEK, Autophagy

Cat.No: T2125

Synonym: GSK1120212,曲美替尼,JTP-74057

Target: Apoptosis, MEK, Autophagy

Lidocaine hydrochloride

Cat.No: T1144

Synonym: Lidocaine HCL,盐酸利多卡因,Lignocaine hydrochloride,Xyloneural,Lidothesin

Target: Apoptosis, ERK, NF-κB, MEK, Sodium Channel

RGB-286638 free base

Cat.No: T2378

Target: GSK-3, MEK, JAK, CDK

Cat.No: T2508

Synonym: ARRY-438162,ARRY-162,MEK162

Target: MEK, Autophagy

Cat.No: T3623

Synonym: 可美替尼,考比替尼,RG7420,XL518,GDC-0973

Target: Apoptosis, MEK

Cat.No: T6131

Synonym: AS703026,MSC1936369B,N-[(2S)-2,3-二羟基丙基]-3-[(2-氟-4-碘苯基)氨基]-4-吡啶甲酰胺,SAR 245509

Target: MEK

Cat.No: T6636

Synonym: BAY 86-97661,瑞法替尼//瑞美替尼,BAY 869766,RDEA119

Target: MEK

Trametinib (DMSO solvate)

Cat.No: T5857

Synonym: Trametinib DMSO solvate,GSK-1120212 (DMSO solvate),Trametinib dimethyl sulfoxide,JTP-74057 (DMSO solvate)

Target: Apoptosis, MEK

Cat.No: T9321

Synonym: ATR-002,3,4-difluoro-2-(2-chloro-4-iodophenylaMino)-benzoic acid,PD0184264,2-(2-chloro-4-iodoanilino)-3,4-difluorobenzoic acid

Target: Influenza Virus, MEK, Antibacterial

Cat.No: T21332

Synonym: U 0126,U-0126

Target: Mitophagy, MEK, Autophagy

Cobimetinib racemate

Cat.No: T22677

Synonym: Cobimetinib (racemate),考比替尼 (外消旋体)

Target: MEK

BIBU-1361 dihydrochloride

Cat.No: T70317

Target: Others

Cat. No.	Product Name	Target	Signaling Pathways
TMS2181	trans-Zeatin (E)-Zeatin,玉米素	ERK; MEK; Endogenous Metabolite	MAPK; Metabolism
	trans-Zeatin ((E)-Zeatin) 是植物细胞分裂素，可抑制紫外线诱导的MEK/ERK 的活化，在细胞生长、分化和分裂中起着重要的作用。
T7030	anemarsaponin B 知母皂苷B,知母皂苷 B	p38 MAPK; NF-κB; MEK; COX; NO Synthase	Immunology/Inflammation; MAPK; Neuroscience; NF-κB
	Anemarsaponin B 是一种甾体皂苷，可降低iNOS 和COX-2的蛋白和 mRNA 水平，减少促炎细胞因子的表达和产生。它通过阻断 IκBα 的磷酸化来抑制NF-κB 的 p65 亚基的核转位，还抑制 MAP 激酶激酶 3/6 (MKK3/6) 和混合谱系激酶 3 的磷酸化。
T2836	Isorhamnetin 3-methylquercetin,3'-Methylquercetin,Isorhamnetol,异鼠李素,3'-Methoxyquercetin	MEK; PI3K; Endogenous Metabolite	MAPK; Metabolism; PI3K/Akt/mTOR signaling
	Isorhamnetin (3-methylquercetin) 是从中草药沙棘中提取的一种类黄酮，可通过抑制MEK1和PI3K 来抑制皮肤癌。

天然产物

Cat.No: TMS2181

Synonym: (E)-Zeatin,玉米素

Target: ERK, MEK, Endogenous Metabolite

anemarsaponin B

Cat.No: T7030

Synonym: 知母皂苷B,知母皂苷 B

Target: p38 MAPK, NF-κB, MEK, COX, NO Synthase

Cat.No: T2836

Synonym: 3-methylquercetin,3'-Methylquercetin,Isorhamnetol,异鼠李素,3'-Methoxyquercetin

Target: MEK, PI3K, Endogenous Metabolite

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-04544	MEK2 Protein, Human, Recombinant (GST) mitogen-activated protein kinase kinase 2,FLJ26075,MKK2,CFC4...	Human	Baculovirus Insect Cells
	Dual specificity mitogen-activated protein kinase kinase 2, also known as MAP kinase kinase 2, MAPKK2, ERK activator kinase 2, MAPK / ERK kinase 2, MEK2 and MAP2K2, is a member of the protein kinase superfamily, STE Ser/Thr protein kinase family and MAP kinase kinase subfamily. MAP2K2 / MEK2 contains one protein kinase domain. MEK1 and MEK2 (also known as MAP2K1 and MAP2K2, respectively) are evolutionarily conserved, dual-specificity kinases that mediate Erk1 and Erk2 activation during adhesion ...
TMPY-04569	MEK1 Protein, Mouse, Recombinant (His & GST) MEKK1,mitogen-activated protein kinase kinase 1,Prkmk1,M...	Mouse	Baculovirus Insect Cells
	MEK1 Protein, Mouse, Recombinant (His & GST) is expressed in Baculovirus insect cells with His and GST tag. The predicted molecular weight is 71.3 kDa and the accession number is P31938.
TMPY-04756	MEK1 Protein, Mouse, Recombinant Prkmk1,MAPKK1,mitogen-activated protein kinase kina...	Mouse	Baculovirus Insect Cells
	MEK1 Protein, Mouse, Recombinant is expressed in Baculovirus insect cells. The predicted molecular weight is 43.6 kDa and the accession number is P31938.
TMPY-04364	MKK6 Protein, Human, Recombinant (His & GST) MKK6,mitogen-activated protein kinase kinase 6,SAPKK3,MA...	Human	Baculovirus Insect Cells
	MKK6 Protein, Human, Recombinant (His & GST) is expressed in Baculovirus insect cells with His and GST tag. The predicted molecular weight is 65.3 kDa and the accession number is P52564-1.
TMPY-04365	MKK6 Protein, Human, Recombinant (S207D, T211D, His & GST) SAPKK3,mitogen-activated protein kinase kinase 6,MKK6,MA...	Human	Baculovirus Insect Cells
	MKK6 Protein, Human, Recombinant (S207D, T211D, His & GST) is expressed in Baculovirus insect cells with His and GST tag. The predicted molecular weight is 65.3 kDa and the accession number is P52564-1.
TMPY-04749	MKK6 Protein, Human, Recombinant (S207D, T211D) MAPKK6,PRKMK6,MKK6,MEK6,mitogen-activated protein k...	Human	Baculovirus Insect Cells
	MKK6 Protein, Human, Recombinant (S207D, T211D) is expressed in Baculovirus insect cells. The predicted molecular weight is 37.7 kDa and the accession number is P52564-1.
TMPY-04748	MKK6 Protein, Human, Recombinant MKK6,MAPKK6,SAPKK-3,SAPKK3,PRKMK6,MEK6,mitogen-acti...	Human	Baculovirus Insect Cells
	MKK6 Protein, Human, Recombinant is expressed in Baculovirus insect cells. The predicted molecular weight is 37.6 kDa and the accession number is A8K3Y2.
TMPY-04572	MKK4 Protein, Mouse, Recombinant (His & GST) MKK4,MEK4,PRKMK4,Sek1,JNKK1,Serk1,mitogen-activated protein ...	Mouse	Baculovirus Insect Cells
	Dual specificity mitogen-activated protein kinase kinase 4, also known as MAP kinase kinase 4, MAPKK4, JNK-activating kinase 1, MAPK/ERK kinase 4, SAPK/ERK kinase 1, c-Jun N-terminal kinase kinase 1, JNKK, and MAP2K4, is a protein that belongs to the protein kinase superfamily, STE Ser/Thr protein kinase family and MAP kinase kinase subfamily. MAP2K4 / JNKK1 is a protein kinase that is a direct activator of MAP kinases in response to various environmental stresses or mitogenic stimuli. MAP2K4 / ...
TMPY-04547	PBK/TOPK Protein, Human, Recombinant (His) HEL164,Nori-3,CT84,TOPK,PDZ binding kinase,SPK	Human	Baculovirus Insect Cells
	PDZ binding kinase (PBK), also known as TOPK (T-LAK cell-originated protein kinase), is a serine/threonine kinase related to the dual specific mitogen-activated protein kinase kinase (MAPKK) family, and has all the characteristic protein kinase subdomains and a C-terminal PDZ-binding T/SXV motif. PBK is expressed in the testis restrictedly expressed in outer cell layer of seminiferous tubules, as well as placenta. PBK may be enrolled in the activation of lymphoid cells and support testicular fun...

重组蛋白

MEK2 Protein, Human, Recombinant (GST)

Cat.No: TMPY-04544

Species: Human

Expression System: Baculovirus Insect Cells

MEK1 Protein, Mouse, Recombinant (His & GST)

Cat.No: TMPY-04569

Species: Mouse

Expression System: Baculovirus Insect Cells

MEK1 Protein, Mouse, Recombinant

Cat.No: TMPY-04756

Species: Mouse

Expression System: Baculovirus Insect Cells

MKK6 Protein, Human, Recombinant (His & GST)

Cat.No: TMPY-04364

Species: Human

Expression System: Baculovirus Insect Cells

MKK6 Protein, Human, Recombinant (S207D, T211D, His & GST)

Cat.No: TMPY-04365

Species: Human

Expression System: Baculovirus Insect Cells

MKK6 Protein, Human, Recombinant (S207D, T211D)

Cat.No: TMPY-04749

Species: Human

Expression System: Baculovirus Insect Cells

MKK6 Protein, Human, Recombinant

Cat.No: TMPY-04748

Species: Human

Expression System: Baculovirus Insect Cells

MKK4 Protein, Mouse, Recombinant (His & GST)

Cat.No: TMPY-04572

Species: Mouse

Expression System: Baculovirus Insect Cells

PBK/TOPK Protein, Human, Recombinant (His)

Cat.No: TMPY-04547

Species: Human

Expression System: Baculovirus Insect Cells

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