Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
TP1992L |
M40 acetate(143896-17-7 free base)
|
Neuropeptide Y Receptor | GPCR/G Protein; Neuroscience |
M40 acetate(143896-17-7 free base) 是一种有效的、非选择性的甘丙肽受体拮抗剂(GAL1 和 GAL2 的 Ki 值分别为 1.82 和 5.1 nM),在体外抑制大鼠脑中甘丙肽 (1-29) 的结合 (IC50 = 3 - 15 nM)。减弱氟西汀的抗抑郁作用并阻止甘丙肽诱导的体内食物摄入。在剂量 > 100 nM 时,对外周 GAL2 受体也表现出较弱的部分激动剂活性。 | |||
TP1992 |
M40
|
||
Potent, non-selective galanin receptor antagonist (Ki values are 1.82 and 5.1 nM at GAL1 and GAL2 respectively) that inhibits galanin (1-29) binding in rat brain in vitro (IC50 = 3 - 15 nM). Attenuates the antidepressant effects of fluoxetine and blocks galanin-induced food intake in vivo. Also exhibits weak partial agonist activity at peripheral GAL2 receptors at doses > 100 nM. |