402
48
1
5
573
9
Cat. No. | Product Name | ||
---|---|---|---|
VM1400 | 多样性核心库Part2 | 25920 compounds | |
分子量<500,主要集中于250-450之间,方便后续的改造优化; |
Cat. No. | Product Name | Form | Specificity Of Inhibition |
---|---|---|---|
C0072 |
Mag Beads COOH (2 μm)
羧基磁珠 (2 μm) |
Suspension in bottle | 蛋白纯化、免疫检测、细胞分选、特异性核酸分离、生物传感器、药物筛选和输送 |
C0100 |
Mag Beads NHS (2 μm)
NHS 磁珠 (2 μm) |
Suspension in bottle | 体外诊断、免疫检测、细胞分选、免疫沉淀/共沉淀、蛋白/抗体分离纯化 |
C0077 |
Mag Beads NH2 (2 μm)
氨基磁珠 (2 μm) |
Suspension in bottle | 蛋白纯化、免疫检测、细胞分选、特异性核酸分离、生物传感器、药物筛选和输送 |
C0099 |
Mag Beads NHS Kit (2 μm)
NHS 磁珠试剂盒 (2 μm) |
Suspension in bottle | 体外诊断、免疫检测、细胞分选、免疫沉淀/共沉淀、蛋白/抗体分离纯化 |
C0091 |
Mag Beads Streptavidin (2 μm)
链霉亲和素磁珠 (2 μm) |
Suspension in bottle | 免疫检测、分离蛋白;分离核酸、制备核酸探针;DNA-蛋白质相互作用研究;细胞分选与激活 |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T18184 |
m-PEG3-SH
M-PEG3-Thiol,2-(2-(2-Methoxyethoxy)Ethoxy)Ethanethiol |
Others; PROTAC Linker | Others; PROTAC |
m-PEG3-SH (M-PEG3-Thiol) 是一种属于 PEG 类的 PROTAC linker,可用于 PROTAC 分子的合成。 | |||
T18161 |
m-PEG2-Br
1-溴-2-(2-甲氧基乙氧基)乙烷 |
Others; PROTAC Linker | Others; PROTAC |
m-PEG2-Br 是一种属于 PEG 类的 PROTAC linker,可用于 PROTAC 分子的合成。 | |||
T8607 |
M084
正丁基-1H-苯并[D]咪唑基-2-胺,M-084 hydrochloride,1H-Benzimidazol-2-amine,N-butyl-(9CI),N-Butyl-1H-benzimidazol-2-amine |
TRP/TRPV Channel | Membrane transporter/Ion channel |
M084 (N-Butyl-1H-benzimidazol-2-amine) 是 TRPC4/5 通道的阻断剂,具有抗抑郁和抗焦虑作用。 | |||
T33131 |
m-(2-Phenoxyethoxy)phenol
|
Others | Others |
m-(2-Phenoxyethoxy)phenol is a biaoctive chemical. | |||
T15887 |
m-PEG5-2-methylacrylate
|
Others | Others |
m-PEG5-2-methylacrylate is a polyethylene glycol (PEG)- and alkyl/ester-based PROTAC linker employed for the synthesis of proteolysis-targeting chimeras (PROTACs)[1]. | |||
T29351 |
2-Hexyl-m-cresol
|
Others | Others |
2-Hexyl-m-cresol is a bioactive chemical. | |||
T15904 |
m-PEG6-2-methylacrylate
|
Others | Others |
m-PEG6-2-methylacrylate is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells. | |||
T33141 |
m-Acetanisidide, 2-iodo-
|
Others | Others |
m-Acetanisidide, 2-iodo- is a bioactive chemical. | |||
T33147 |
m-Acetophenetidide, 2-iodo-
|
Others | Others |
m-Acetophenetidide, 2-iodo- is a bioactive chemical. | |||
T33146 |
m-Acetophenetidide, 2-chloro-
|
Others | Others |
m-Acetophenetidide, 2-chloro- is a bioactive chemical. | |||
T30063 |
Aniline, m-(2-(2-(diethylamino)ethoxy)ethyl)-
|
Others | Others |
Aniline, m-(2-(2-(diethylamino)ethoxy)ethyl)- is a bioactive chemical. | |||
T8741 |
MitoBloCK-10
3-fluoro-N'-[(E)-(5-nitrothiophen-2-yl)m |
Others | Others |
MitoBloCK-10 (3-fluoro-N'-[(E)-(5-nitrothiophen-2-yl)m) 是第一个能够减弱PAM 复合体活性的小分子调节剂,对 C 末端结构域的Tim44与前体和 Hsp70 结合具有抑制作用。 | |||
T18571 |
m-PEG12-2-methylacrylate
Propargyl-PEG13-alcohol |
Others | Others |
Propargyl-PEG13-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. | |||
T34003 |
Phenol, m-(2-(methylamino)ethyl)-, hydrochloride
|
Others | Others |
Phenol, m-(2-(methylamino)ethyl)-, hydrochloride is a biaoctive chemical. | |||
T33140 |
m-Acetanisidide, 2-chloro-N-(2-ethoxyethyl)-
|
Others | Others |
m-Acetanisidide, 2-chloro-N-(2-ethoxyethyl)- is a bioactive chemical. | |||
T33253 |
m-Dioxan-5-ol, 2-(2-furyl)-
|
Others | Others |
m-Dioxan-5-ol, 2-(2-furyl)- is a bioactive chemical. | |||
T40754 |
m-PEG2-O-Ph-NH2
m-PEG2-O-Ph-NH2 |
Others | Others |
m-PEG2-O-Ph-NH2 is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells. | |||
T33149 |
m-Acetotoluidide, 2-chloro-N-(2-ethoxyethyl)-
|
Others | Others |
m-Acetotoluidide, 2-chloro-N-(2-ethoxyethyl)- is a bioactive chemical. | |||
T34002 |
Phenol, m-(2-(dipropylamino)ethyl)-, hydrobromide
|
Others | Others |
Phenol, m-(2-(dipropylamino)ethyl)-, hydrobromide is a bioactive chemical. | |||
T29370 |
2-Propynyl m-hydroxycarbanilate methylcarbamate
|
Others | Others |
2-Propynyl m-hydroxycarbanilate methylcarbamate is a bioactive chemical. | |||
T10198 |
8-M-PDOT
8-Methoxy-2-propionamidotetralin,AH-002 |
MT Receptor | Neuroscience |
8-M-PDOT (AH-002) 是一种具有选择性和有效性的褪黑激素 MT2 受体激动剂,对 MT1 受体也具有抑制作用。8-M-PDOT 具有抗焦虑活性,可用于研究由 MT2 诱导的神经疼痛。 | |||
T33990 |
Phenol, m-(1,3-dithiolan-2-yl)-
|
Others | Others |
Phenol, m-(1,3-dithiolan-2-yl)- is a bioactive chemical. | |||
T34001 |
Phenol, m-(2-(dimethylaminomethyl)-1-hydroxycyclopentyl)-
|
Others | Others |
Phenol, m-(2-(dimethylaminomethyl)-1-hydroxycyclopentyl)- is a bioactive chemical. | |||
T4282 |
S-methyl-KE-298
|
MMP; Drug Metabolite | Metabolism; Proteases/Proteasome |
S-methyl-KE-298 是 KE-298 的活性代谢物。KE-298 抑制类风湿关节炎滑膜细胞产生基质金属蛋白酶。 | |||
T33150 |
m-Acetotoluidide, 2-fluoro-N-methyl-
|
Others | Others |
m-Acetotoluidide, 2-fluoro-N-methyl- is a bioactive chemical. | |||
T34006 |
Phenol, m-(2-(phenethylamino)ethyl)-, hydrochloride
|
Others | Others |
Phenol, m-(2-(phenethylamino)ethyl)-, hydrochloride 可用于生命科学领域的相关研究。其产品编号为 T34006,CAS号为 70045-20-4。 | |||
T38671 |
m-PEG2-O-Ph-3-NH2
m-PEG2-O-Ph-3-NH2 |
Others | Others |
m-PEG2-O-Ph-3-NH2 is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells. | |||
T29432 |
4-Chloro-2-nitro-m-cresol
|
Others | Others |
4-Chloro-2-nitro-m-cresol is a biaoctive chemical. | |||
T33139 |
m-Acetanisidide, 2-(diethylamino)-4'-(octyloxy)-
|
Others | Others |
m-Acetanisidide, 2-(diethylamino)-4'-(octyloxy)- is a bioactive chemical. | |||
T10220 |
LSN2839567
Abemaciclib metabolite M2 |
CDK | Cell Cycle/Checkpoint |
LSN2839567 (Abemaciclib metabolite M2) 是 Abemaciclib 的活性代谢物,是一种强效的 CDK4 和 CDK6 抑制剂(IC50s:1-3 nM),具有抗癌活性。LSN2839567 抑制 CDK9。LSN2839567 以浓度依赖性方式抑制细胞生长和细胞周期进程,可用于研究乳腺癌和肺癌。 | |||
T33254 |
m-Dioxane, 2-hexyl-2,4-dimethyl-
|
Others | Others |
m-Dioxane, 2-hexyl-2,4-dimethyl- is a bioactive chemical. | |||
T30403 |
Benzoic acid, m-iodo-, 2-phenylhydrazide
|
Others | Others |
Benzoic acid, m-iodo-, 2-phenylhydrazide is a bioactive chemical. | |||
T33195 |
m-Anisidine, 4-(2-ethylbutoxy)-, hydrobromide
|
Others | Others |
m-Anisidine, 4-(2-ethylbutoxy)-, hydrobromide is a bioactive chemical. | |||
T34005 |
Phenol, m-(2-(N-methylphenethylamino)ethyl)-, hydrobromide
|
Others | Others |
Phenol, m-(2-(N-methylphenethylamino)ethyl)-, hydrobromide is a bioactive chemical. | |||
T33249 |
m-Dioxan-5-amine, 2-(p-chlorophenyl)-
|
Others | Others |
m-Dioxan-5-amine, 2-(p-chlorophenyl)- is a bioactive chemical. | |||
T30721 |
Carbanilic acid, m-(2-methoxyethoxy)-, 2-(diethylamino)ethyl ester
|
Others | Others |
Carbanilic acid, m-(2-methoxyethoxy)-, 2-(diethylamino)ethyl ester is a bioactive chemical. | |||
T33256 |
m-Dioxane, 5-ethyl-2-(2-furyl)-4-propyl-
|
Others | Others |
m-Dioxane, 5-ethyl-2-(2-furyl)-4-propyl- is a bioactive chemical. | |||
T50077 |
m-Nisoldipine
3-methyl 5-(2-methylpropyl) 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate |
Others | Others |
m-Nisoldipine (3-methyl 5-(2-methylpropyl) 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate) 是一种二氢吡啶类钙通道阻滞剂,尼索地平的衍生物,阻断心脏和平滑肌细胞中的 L-型钙通道,用于治疗高血压和心绞痛。 | |||
T33156 |
m-Acetotoluidide, N-benzyl-2-(diethylamino)-, monohydrochloride
|
Others | Others |
m-Acetotoluidide, N-benzyl-2-(diethylamino)-, monohydrochloride is a bioactive chemical. | |||
T33255 |
m-Dioxane, 5,5-bis(chloromethyl)-2-phenyl-
|
Others | Others |
m-Dioxane, 5,5-bis(chloromethyl)-2-phenyl- is a bioactive chemical. | |||
T33252 |
m-Dioxan-5-amine, 5-benzylaminomethyl-2-phenyl-
|
Others | Others |
m-Dioxan-5-amine, 5-benzylaminomethyl-2-phenyl- is a bioactive chemical. | |||
T30396 |
Benzoic acid, m-(2-methyl-5-phenylpyrrol-1-yl)-
|
Others | Others |
Benzoic acid, m-(2-methyl-5-phenylpyrrol-1-yl)- is a bioactive chemical. | |||
T33257 |
m-Dioxane, 5-ethyl-5-nitro-2-propyl-
|
Others | Others |
m-Dioxane, 5-ethyl-5-nitro-2-propyl- is a bioactive chemical. | |||
T33251 |
m-Dioxan-5-amine, 2-(p-chlorophenyl)-5-methyl-
|
Others | Others |
m-Dioxan-5-amine, 2-(p-chlorophenyl)-5-methyl- is a bioactive chemical. | |||
T30392 |
Benzoic acid, m-(2-(p-bromophenyl)-5-methylpyrrol-1-yl)-
|
Others | Others |
Benzoic acid, m-(2-(p-bromophenyl)-5-methylpyrrol-1-yl)- is a bioactive chemical. | |||
T11929 |
M2N12
|
Phosphatase | Metabolism |
M2N12 是一种高度选择性的细胞分裂周期蛋白磷酸酶 25C 抑制剂,IC50值为 0.09 μM。它还抑制 Cdc25A 和 Cdc25B 的活性,IC50值分别为 0.53 μM 和 1.39 μM。它具有抗肿瘤活性,可研究癌症。 | |||
T33250 |
m-Dioxan-5-amine, 2-(p-chlorophenyl)-5-ethyl-
|
Others | Others |
m-Dioxan-5-amine, 2-(p-chlorophenyl)-5-ethyl- is a bioactive chemical. | |||
T34004 |
Phenol, m-(2-(N-ethylphenethylamino)ethyl)-, fumarate (1:1)
|
Others | Others |
Phenol, m-(2-(N-ethylphenethylamino)ethyl)-, fumarate (1:1) is a bioactive chemical. | |||
T4647 |
M2I-1
M2I 1 |
Others | Others |
M2I-1 是Mad2抑制剂,靶向的 Mad2 与 Cdc20 的结合,该结合是纺锤体装配检查点内必不可少的蛋白-蛋白相互作用。 | |||
T37088L |
pep2m aceate
|
Others | Others |
pep2m aceate 是 GluR2 亚基 C 端与 N-乙基马来酰亚胺敏感融合蛋白相互作用的肽抑制剂。 |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T13535 |
Aflatoxin M2
黄曲霉毒素 M2 |
Others | Others |
Aflatoxin M2 is a major metabolite of Aflatoxin B1. It is a mycotoxin produced by the fungi Aspergillus flavus and Aspergillus parasiticus. | |||
TN1708 |
Gomisin M2
五味子脂素 M2 |
HIV Protease | Microbiology/Virology; Proteases/Proteasome |
Gomisin M2 is an anti-HIV agent. | |||
T2764 |
(S)-10-Hydroxycamptothecin
10-羟喜树碱,10-羟基喜树碱,10-Hydroxycamptothecin,10-HCPT |
Apoptosis; Topoisomerase | Apoptosis; DNA Damage/DNA Repair |
(S)-10-Hydroxycamptothecin (10-HCPT) 是一种从喜树中分离的 DNA 拓扑异构酶 I 抑制剂。它显著诱导细胞凋亡,可研究肝癌、胃癌、结肠癌和白血病。 | |||
TL0016 |
Sulforaphene
油菜 |
Apoptosis; ERK; EGFR; NF-κB | Angiogenesis; Apoptosis; JAK/STAT signaling; MAPK; NF-κB; Tyrosine Kinase/Adaptors |
Sulforaphene 是从萝卜种子中分离出来的天然产物,对鹿茸幼苗的 ED50 约为 2 x 10 -4 M。它通过抑制 EGFR、p-ERK1/2、NF-κB 和其他信号促进癌细胞凋亡并抑制迁移。 | |||
T4709 |
(2S,3R,4S,5R)-2-Amino-3,4,5,6-tetrahydroxyhexanal hydrochloride
盐酸 D-甘露糖胺,D-Mannosamine hydrochloride |
Others; Endogenous Metabolite | Metabolism; Others |
(2S,3R,4S,5R)-2-Amino-3,4,5,6-tetrahydroxyhexanal hydrochloride (D-Mannosamine hydrochloride) 是内源性代谢产物的一种。 | |||
T6S0109 |
Sipeimine
Kashmirine,西贝母碱,Imperialine,西贝碱 |
Others | Others |
Sipeimine (Kashmirine) 是一种天然产物,从平贝母中分离得到。 | |||
T78479 |
Manool
|
Others | Others |
Manool 是一种来自丹参的二萜,在小鼠黑色素瘤模型中显示出抗肿瘤活性。Manool 可使癌细胞细胞周期停滞在的 G(2)/M 期,降低预防染色体损伤和癌前病变。Manool 促使大鼠主动脉中由 NO/cGMP 信号通路介导的内皮依赖性血管松弛和血压降低。 | |||
T4S1335 |
Daphnoretin
Dephnoretin,西瑞香素,Thymelol |
Influenza Virus; Caspase; PKC | Apoptosis; Chromatin/Epigenetic; Cytoskeletal Signaling; Microbiology/Virology; Proteases/Proteasome |
Daphnoretin (Thymelol) 是从了哥王中提取得到的一种天然产物,具有抗癌和抗病毒活性。它通过在 G2/M 期连续阻断细胞并激活 caspase-3 通路导致 HOS 细胞死亡。 | |||
TN2254 |
Taccalonolide A
根薯酮内酯A,根薯酮内酯 A |
Apoptosis; Microtubule Associated | Apoptosis; Cytoskeletal Signaling |
Taccalonolide A 是从水田七根茎中分离得到的一种类固醇,具有细胞毒性和抗疟活性。它在体外对过表达 p 糖蛋白、多药耐药蛋白 7 细胞系有抑制作用,抑制 SK-OV-3 细胞生长的 IC50值为 622 nM。它是微管稳定剂,能引起 G2-M 期滞留、Bcl-2 磷酸化,并引发细胞凋亡。 | |||
T6S0071 |
Fraxinellone
|
HIF/HIF Prolyl-Hydroxylase; STAT; PD-1/PD-L1 | Apoptosis; Cell Cycle/Checkpoint; Chromatin/Epigenetic; Immunology/Inflammation; JAK/STAT signaling; Metabolism; Stem Cells |
Fraxinellone 是从白鲜的根皮中分离出来的一种天然产物,是PD-L1抑制剂,可抑制HIF-1α蛋白质合成。它通过靶向 PD-L1,有用于癌症免疫的潜力。 | |||
T3S0081 |
Oxypeucedanin
(+-)-Oxypeucedanin,氧化前胡素,Oxypeucadanin |
Potassium Channel | Membrane transporter/Ion channel |
Oxypeucedanin ((+-)-Oxypeucedanin) 是呋喃香豆素衍生物,分离自Angelica dahurica。它是选择性开放通道阻滞剂,可抑制hKv1.5通道电流,IC50值为 76 nM。它延长心脏动作电位持续时间,是潜在的抗心律失常试剂。它通过抑制癌细胞迁移来诱导细胞凋亡。 | |||
T5S1607 |
Morusin
Mulberrochromene,桑辛素 |
NF-κB; Antibacterial; STAT | JAK/STAT signaling; Microbiology/Virology; NF-κB; Stem Cells |
Morusin (Mulberrochromene) 是从M. australis 分离的去乙烯基化黄酮,可抑制NF-κB 和STAT3的活性,具有抗菌、抗肿瘤、抗氧化等各种生物活性。 | |||
T5S0106 |
Peimisine
贝母辛,Ebeiensine |
RAAS; AChR | Endocrinology/Hormones; Neuroscience |
Peimisine (Ebeiensine) 非竞争性拮抗气管平滑肌 M 受体,抑制 Ach 引起的平滑肌收缩。它兴奋 β 受体和拮抗内钙释放,促进一氧化氮释放,可舒张气管平滑肌,有平喘作用。 | |||
T3824 |
Jaceosidin
|
Apoptosis; BCL; COX; UGT | Apoptosis; Immunology/Inflammation; Metabolism; Neuroscience |
Jaceosidin 是从毛莲蒿中得到的一种黄酮类天然产物,可激活Bax,下调 Mcl-1 和 c-FLIP 的表达,诱导癌细胞凋亡。它能够降低炎性因子水平,激活 NF-κB,抑制COX-2的表达,具有抗癌和抗炎作用。 | |||
T2966 |
Beta-Sitosterol
Cupreol,谷甾醇,Beta-Sitosterol,β-Sitosterol,Azuprostat,SKF 14463,beta-谷甾醇,22,23-Dihydrostigmasterol,Betaprost |
Apoptosis; Lipase; Endogenous Metabolite | Apoptosis; Metabolism |
Beta-Sitosterol (SKF 14463) 属于天然产物,是一种植物甾醇,广泛存在于植物界。Beta-Sitosterol 的摄人量与许多慢性病的发生率有关系,比如具有明显降低血清胆固醇的功效。 | |||
T5S0055 |
Chelidonine
Helidonine,Khelidonin,白屈菜碱,Stylophorin |
Apoptosis; Others; Influenza Virus | Apoptosis; Microbiology/Virology; Others |
Chelidonine (Stylophorin) 是白屈菜中的一种异喹啉生物碱,有抗肿瘤和抗病毒作用。它可导致细胞周期 G2/M 停滞,诱导 caspase 依赖和非依赖性的细胞凋亡。 | |||
T3895 |
Polyphyllin I
重楼皂苷I,重楼皂甙 |
Apoptosis; Akt; JNK; PDK; mTOR; Autophagy | Apoptosis; Autophagy; Cytoskeletal Signaling; MAPK; PI3K/Akt/mTOR signaling |
Polyphyllin I 是从七叶一枝花中提取的生物活性成分,具有很强的抗肿瘤活性。它是 JNK 信号通路的激活剂,也是 PDK1/Akt/mTOR 信号传导的抑制剂。它诱导自噬,G2/M 期阻滞和细胞凋亡。 | |||
T0186 |
Docetaxel trihydrate
RP-56976 (Trihydrate),RP56976 (NSC 628503) Trihydrate,多西他赛三水合物 |
Apoptosis; BCL; Microtubule Associated | Apoptosis; Cytoskeletal Signaling |
Docetaxel trihydrate (RP-56976 Trihydrate) 是一种抗肿瘤试剂,抑制微管解聚的IC50值为 0.2 μM。它是紫杉醇的半合成类似物,能减弱 bcl-2 和 bcl-xL 基因表达的影响。它阻滞G2/M 细胞周期,导致细胞凋亡。 | |||
T5S0661 |
Koumine
|
Others | Others |
Koumine 是一种从钩吻中得到的生物碱,具有高效抗肿瘤活性,在肿瘤细胞中能够提高 Bax/Bcl-2 的蛋白比例和 caspase-3 的表达。在类风湿性关节炎动物模型中,它能够预防关节炎的发展。它具有抗焦虑、抗应激、抗银屑病作用,也可用于缓解疼痛的研究。 | |||
T3779 |
Crocin II
Crocin 2,西红花苷II,Crocetin gentiobiosylglucosyl ester,藏红花,Tricrocin,Crocin B |
Caspase; COX; NO Synthase | Apoptosis; Immunology/Inflammation; Neuroscience; Proteases/Proteasome |
Crocin II (Crocetin gentiobiosylglucosyl ester) 是从栀子果实中分离出来的一种天然产物,具有抗氧化、抗癌和抗抑郁活性。它抑制 iNOS 和 COX-2的蛋白质和 m-RNA 的表达,还抑制NO 产生,IC50值为 31.1 μM。 | |||
T38019 |
Nybomycin
|
Others | Others |
Nybomycin is a fungal metabolite originally isolated from Streptomyces sp. A717 and has antibacterial activity. It is active against B. subtilis, B. cereus, B. mycoides, M. smegmatis, and K. pneumoniae (MICs = 0.025, 2, 0.8, 0.2, and 0.003 μg/ml, respectively). Nybomycin is also active against M. tuberculosis and M. bovis (MICs = 4.5 and 1 μg/ml, respectively). | |||
TN2116 |
Pteropodine
|
BCL; Calcium Channel; 5-HT Receptor | Apoptosis; GPCR/G Protein; Membrane transporter/Ion channel; Metabolism; Neuroscience |
Pteropodine acts as a positive modulator of muscarinic M(1) and 5-HT(2) receptors. Pteropodine shows antigenotoxic, antioxidant and lymphocyte induction effects, it also shows strong apoptotic effect on acute leukaemic lymphoblasts. | |||
T79947 |
10-Hydroxyaloin A
|
SARS-CoV | Microbiology/Virology |
10-Hydroxyaloin A有效抑制SARS-CoV-2,与SARS-CoV-2 Mpro活性位点显著结合。 | |||
T72581 |
SARS-CoV MPro-IN-2
|
Others | Others |
SARS-CoVMPro-IN-2 是一种有效的SARS-CoV-2 Mpro 抑制剂,IC50sub>值为 72.07 nM。病毒的主要蛋白酶 Mpro 作为加工病毒多蛋白的主要酶,有助于 SARS-CoV-2 在宿主细胞中的复制和转录,并已被定性为药物发现的有吸引力的靶点。SARS-CoVMPro-IN-2 具有研究 COVID-19 的潜力。 | |||
T81991 |
Kaempferol-3-O-[2″,6″-di-O-E-p-coumaroyl]-β-D-glucopyranoside
|
||
Kaempferol-3-O-[2″,6″-di-O-E-p-coumaroyl]-β-D-glucopyranoside为一种从O. dentata叶中提取的酰化坎氨酚葡萄糖苷,用作污染生物(蓝贻贝M. edulis)的驱虫剂。 | |||
TN6059 |
Demethoxyfumitremorgin C
|
||
Demethoxyfumitremorgin C and tryprostatin B are fungal inhibitors of mammalian cell cycle progression at the G(2)/M transition. Demethoxyfumitremorgin C inhibits the proliferation of PC3 human prostate cancer cells via the intrinsic (mitochondrial) and ex | |||
T36931 |
Penicillide
|
Others | Others |
Penicillide is a fungal metabolite originally isolated from Penicillium that has diverse biological activities. It is an inhibitor of calpain 2/m-calpain (IC50 = 7.1 μM) and acyl-coenzyme A:cholesterol acyltransferase (ACAT; IC50 = 22.9 μM). It is also an antagonist of oxytocin receptors (IC50 = 67 μM). Penicillide inhibits RNA synthesis in P388 murine leukemia cells. | |||
T75602 |
Albanol B
|
Others | Others |
Albanol B 是一种芳基苯并呋喃衍生物,可从桑葚中分离得到。Albanol B 具有抗阿尔茨海默病、抗菌和抗氧化活性。Albanol B 抑制癌细胞增殖,下调 CDK1表达。Albanol B 还会诱导细胞周期停滞在 G2/M 期,诱导细胞凋亡 (apoptosis)。Albanol B 诱导线粒体 ROS 产生并增加 AKT 和 ERK1/2的磷酸化水平。 | |||
T14121 |
Actinonin
(-)-Actinonin |
Aminopeptidase | Metabolism |
Actinonin ((-)-Actinonin) is a naturally occurring antibacterial agent produced by Actinomyces and a potent reversible peptide deformylase (PDF) inhibitor with a Ki of 0.28 nM, it also is an apoptosis inducer. Actinonin inhibits aminopeptidase M, aminopeptidase N and leucine aminopeptidase, it also inhibits MMP-1, MMP-3, MMP-8, MMP-9, and hmeprin α with Ki values of 300 nM, 1,700 nM, 190 nM, 330 nM, and 20 nM, respectively. Actinonin has antiproliferative and antitumor activities[1][2][3][4][5]. | |||
TN7502 |
1-Isothiocyanato-6-(methylsulfenyl)-hexane
Lesquerellin |
Others | Others |
1-Isothiocyanato-6-(methylsulfenyl)-hexane, identified in wasabi (W. japonica), exhibits multifaceted biological activities. This isothiocyanate compound demonstrates antibacterial properties by inhibiting B. subtilis growth in an agar diffusion assay at 25 µmol/disc, and antifungal effectiveness against T. mentagrophytes with a minimum inhibitory concentration (MIC) of 25 µg/ml. Additionally, it acts as a repellent in the blue mussel (M. edulis) assay and shows antifouling capabilities on polyv... | |||
T35609 |
19-O-Acetylchaetoglobosin A
|
Others | Others |
19-O-Acetylchaetoglobosin A is a fungal metabolite originally isolated fromC. globosumthat has actin polymerization inhibitory and cytotoxic activities.1,2It inhibits actin polymerization in a cell-free assay when used at a concentration of 2 μM.219-O-Acetylchaetoglobosin A (3.2, 10, and 32 μg/ml) is cytotoxic to HeLa cervical cancer cells.1 1.Umeda, M., Ohtsubo, K., Saito, M., et al.Cytotoxicity of new cytochalasans from Chaetomium globosumExperientia31(4)435-438(1975) 2.Sekita, S., Yoshihira, ... | |||
T38330 |
Collinin
|
Others | Others |
Collinin is a coumarin that has been found in Z. schinifolium and has diverse biological activities.1,2,3,4 It is active against drug-susceptible and -resistant strains of M. tuberculosis (MIC50s = 3.13-6.25 μg/ml).1 Collinin inhibits LPS-induced nitric oxide (NO) production (IC50 = 5.9 μM) and reduces COX-2 protein levels in RAW 264.7 cells.2 It completely inhibits aggregation of isolated rabbit platelets induced by arachidonic acid , collagen, or platelet activating factor (PAF) when used at a... | |||
TN7266 |
Harzianopyridone
(-)-Harzianopyridone |
Others | Others |
Harzianopyridone is an atpenin-like compound that functions as an inhibitor of mammalian and nematode mitochondrial complex II, also known as succinate:ubiquinone oxidoreductase (SQR), demonstrating IC50 values of 0.017, 0.2, and 2 μM against bovine, rat, and nematode complex II, respectively. Additionally, it inhibits nematode quinol-fumarate reductase (QFR) with an IC50 value of 0.36 μM. Significantly selective for complex II over complexes I and III in rats and cattle, as well as complex I in... | |||
T35667 |
Napyradiomycin A1
Napyradiomycin A1 |
Others | Others |
Napyradiomycin A1is a fungal metabolite originally isolated fromC. rubraand has diverse biological activities.1,2It is active againstS. aureus,M. luteus,B. anthracis,C. bovis, andM. smegmatis(MICs = 1.56-12.5 μg/ml).1Napyradiomycin A1is an estrogen receptor antagonist (IC50= 4.2 μM in rat uterine homogenates).2It also inhibits mitochondrial NADH:ubiquinone oxidoreductase (complex I) and succinate:ubiquinone oxidoreductase (complex II) activities in bovine heart homogenates (IC50s = 20 and 9.7 μM... | |||
T36417 |
Nargenicin
Antibiotic 47444 |
Others | Others |
Nargenicin is a macrolide antibiotic that selectively inhibits the growth of S. aureus, methicilin resistant S. aureus (MRSA), and M. luteus (MICs = 0.6, 0.3, and 2.5 μg/ml, respectively) over a panel of 11 Gram-positive and Gram-negative bacteria (MICs = >80 μg/ml). [1] It dose-dependently inhibits S. aureus DnaE in the presence of DNase I-activated DNA and E. coli DnaE when used at concentrations of 0.00001-0.1 and 0.01-100 μg/mL, respectively. [2] In murine BV-2 microglial cells, nargenicin (... | |||
T37690 |
Phenylpyropene A
|
Others | Others |
Phenylpyropene A is a fungal metabolite originally isolated from P. griseofulvum that has enzyme inhibitory and insecticidal activities.1,2,3 It inhibits acyl-coenzyme A:cholesterol acyltransferase (ACAT; IC50 = 0.8 μM).1 Phenylpyropene A inhibits diacylglycerol acyltransferase (DGAT) in rat liver microsomes (IC50 = 78.7 μM). It induces mortality in 100% of M. persicae when used at a concentration of 5 ppm.3 |1. Kwon, O.E., Rho, M.C., Song, H.Y., et al. Phenylpyropene A and B, new inhibitors of ... | |||
T36791 |
Lysophosphatidylcholine 18:2
|
Others | Others |
1-Linoleoyl-2-hydroxy-sn-glycero-3-PC (LGPC) is a lysophospholipid containing linoleic acid at thesn-1 position that has been found in mouse heart, lung, liver, spleen, kidney, plasma, and serum.1Serum levels of LGPC decrease with increasing insulin resistance and dysglycemia in humans.2 1.Okudaira, M., Inoue, A., Shuto, A., et al.Separation and quantification of 2-acyl-1-lysophospholipids and 1-acyl-2-lysophospholipids in biological samples by LC-MS/MSJ. Lipid Res.55(10)2178-2192(2014) 2.Gall, ... | |||
T37451 |
Stachybotrysin B
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Others | Others |
Stachybotrysin B is a fungal metabolite originally isolated from S. chartarum and has antiviral and anticancer activities.1,2 It has antiviral activity against HIV in SupT1 cells (IC50 = 19.2 μM).1 Stachybotrysin B is cytotoxic to K562, HeLa, and HL-60 cells (IC50s = 21.72, 39.63, and 18.5 μM, respectively).2 |1. Zhao, J., Feng, J., Tan, Z., et al. Stachybotrysins A-G, phenylspirodrimane derivatives from the fungus Stachybotrys chartarum. J. Nat. Prod. 80(6), 1819-1826 (2017).|2. Ma, X.-h., Zhen... | |||
T35752 |
Xanthoquinodin A1
Xanthoquinodin A1 |
Others | Others |
Xanthoquinodin A1 is a fungal metabolite that has been found inHumicolaand has diverse biological activities.1,2It inhibitsE. tenellaschizont formation in BHK-21 cells with a minimum effective concentration (MEC) value of 0.02 μg/ml.1Xanthoquinodin A1 is active againstB. subtilis,M. luteus,S. aureus,A. laidlawii, andB. fragilisin a disc assay when used at a concentration of 1 mg/ml. It is also active againstB. cereus(MIC = 0.44 μM).2Xanthoquinodin A1 is cytotoxic to KB, MCF-7, and NCI H187 cance... | |||
T36915 |
21-Deoxycortisol
|
Others | Others |
21-Deoxycortisol is a corticosteroid metabolite of 17-hydroxyprogesterone produced in the adrenal glandvia11-hydroxylation by 11β-hydroxylase.1,2Serum levels of 21-deoxycortisol are elevated in patients with congenital adrenal hyperplasia that are heterozygous for mutations inCYP2A21, the gene encoding steroid 21-hydroxylase, and have been used as a biomarker for the detection of 21-hydroxylase deficiencies. 1.Fiet, J., Villette, J.-M., Galons, H., et al.The application of a new highly-sensitive... | |||
T36295 |
Echistatin TFA
|
Others | Others |
Echistatin TFA, the smallest active RGD protein belonging to the family of disintegrins that are derived from snake venoms, is a potent inhibitor of platelet aggregation. Echistatin is a potent inhibitor of bone resorption in culture. Echistatin is a potent antagonist of αIIbβ3, αvβ3 and α5β1[1][2][3][4]. [1]. J Musial, et al. Inhibition of platelet adhesion to surfaces of extracorporeal circuits by disintegrins. RGD-containing peptides from viper venoms. Circulation. 1990 Jul;82(1):261-73.[2]. ... | |||
T35741 |
Gliovirin
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Others | Others |
Gliovirin is a fungal metabolite that has been found inT. harzianumand has fungicidal, antimicrobial and anti-inflammatory activities.1It is active against the plant pathogenic fungusP. ultimum(MIC = 60 ng/ml) and the parasiteT. brucei brucei(IC50= 90 ng/ml), but has no effect on the plant pathogenic fungiR. solani,P. omnivorum,T. basicola,R. arrhizus, andV. dahliaeor the bacteriaB. thuringiensis,P. fluorescens, andX. malvacearumwhen used at concentrations up to 1,000 ng/ml.2,3Gliovirin decrease... | |||
T36179 |
Aspulvinone O
|
Others | Others |
Aspulvinone O is a fungal metabolite that has been found in P. variotti and has antioxidant and anticancer activities.1,2 It scavenges 2,2-diphenyl-1-picrylhydrazyl radicals in a cell-free assay (IC50 = 11.6 μM).1 Aspulvinone O inhibits aspartate transaminase 1 (GOT1; Kd = 3.32 μM) and is cytotoxic to PANC-1, AsPC-1, and SW1990 pancreatic cancer cells (IC50s = 20.54-26.8 μM).2 It reduces the oxygen consumption rate (OCR) and induces apoptosis in SW1990 cells. Aspulvinone O (2.5 and 5 mg/kg) redu... | |||
T36563 |
(E)-Guggulsterone
|
Others | Others |
Bile acids are essential for solubilization and transport of dietary lipids, are the major products of cholesterol catabolism, and are physiological ligands for farnesoid X receptor (FXR), a nuclear receptor that regulates genes involved in lipid metabolism.1They are also inherently cytotoxic, as physiological imbalance contributes to increased oxidative stress.2,3Bile acid-controlled signaling pathways are promising novel targets to treat such metabolic diseases as obesity, type II diabetes, hy... | |||
T37272 |
9(S),12(S),13(S)-TriHOME
|
Others | Others |
9(S),12(S),13(S)-TriHOME is a linoleic acid-derived oxylipin that has diverse biological activities.1,2,3,4It has been found in various plants and is produced in human eosinophils in a 15-lipoxygenase-dependent, soluble epoxide hydrolase-independent manner.1,59(S),12(S)13(S)-TriHOME inhibits antigen-induced β-hexosaminidase release from RBL-2H3 mast cells (IC50= 28.7 μg/ml).2It inhibits LPS-induced nitric oxide (NO) production in BV-2 microglia (IC50= 40.95 μM).3In vivo, 9(S),12(S),13(S)-TriHOME... | |||
T38069 |
Aquastatin A
|
Others | Others |
Aquastatin A is a fungal metabolite originally isolated fromF. aquaeductuumthat has diverse biological activities.1It is active againstS. aureus(MIC = 32 μg/ml) and inhibits enoyl-acyl carrier protein reductase (Fabl; IC50= 3.2 μM) andS. aureusfatty acid synthesis (IC50= 3.5 μM).2Aquastatin A also inhibits the Na+/K+-ATPase and H+/K+-ATPase (IC50s = 7.1 and 6.2 μM, respectively), as well as protein tyrosine phosphatase 1B (PTP1B; IC50= 0.19 μM).1,3 1.Hamano, K., Kinoshita-Okami, M., Minagawa, K.... | |||
T36348 |
Cerebroside C
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Others | Others |
Cerebroside C is a fungal metabolite and glycosphingolipid that has been found in the rice pathogenic fungusM. grisea.1It induces production of the phytoalexin momilactone A when applied to wounded rice leaves, indicating that cerebroside C is an elicitor of the hypersensitive response in rice. Cerebroside C increases germination rate and reduces germination time in wheat seeds in a concentration-dependent manner at 4°C.2It also increases root length, fresh weight, and dry weight of wheat seedli... | |||
T35779 |
Oosporein
|
Others | Others |
Oosporein is a mycotoxin that has been found inBeauveriaand has diverse biological activities.1,2It is cytotoxic to Sf9 and Sf21 insect cells with 50% cytotoxic concentration (CC50) values of 4.23 and 10.43 μM, respectively.3Oosporin induces lethality in day-old cockerels (LD50= 6.12 mg/kg).4It inhibits Na+/K+-, Ca2+-, and Mg2+-ATPase activities by 27, 52, and 100%, respectively, in equine erythrocyte ghosts when used at a concentration of 200 μg/ml.2Oosporein inhibits herpes simplex 1 (HSV-1), ... |
Cat. No. | Product Name | Species | Expression System |
---|---|---|---|
TMPH-01031 |
CAPN2 Protein, Human, Recombinant (His)
Calpain-2 catalytic subunit,Millimolar-calpain,Calp... |
Human | E. coli |
Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. Proteolytically cleaves MYOC at 'Arg-226'. Proteolytically cleaves CPEB3 following neuronal stimulation which abolishes CPEB3 translational repressor activity, leading to translation of CPEB3 target mRNAs. CAPN2 Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 82... | |||
TMPH-03474 |
Beta-lactamase CTX-M-2 Protein, Salmonella typhimurium, Recombinant
bla,Beta-lactamase CTX-M-2,Cefotaximase 2 |
Salmonella typhimurium | E. coli |
Has cefotaxime-hydrolyzing activity. Beta-lactamase CTX-M-2 Protein, Salmonella typhimurium, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 28.4 kDa and the accession number is P74841. | |||
TMPY-02630 |
B2M/beta 2-Microglobulin Protein, Mouse, Recombinant (His)
beta2-m,β2-m,β-2 microglobulin,be... |
Mouse | HEK293 Cells |
B2M/beta 2-Microglobulin Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 13 kDa and the accession number is P01887. | |||
TMPY-01037 |
CSF1R Protein (Met1-Glu512), Human, Recombinant (His)
CSF-1R,CD115,HDLS,FIM2,M-CSF-R,MCSF Receptor,colony... |
Human | HEK293 Cells |
CSF1R Protein (Met1-Glu512), Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 56 kDa and the accession number is P07333-1. | |||
TMPH-02200 |
TXNIP Protein, Human, Recombinant (B2M & His)
Vitamin D3 up-regulated protein 1,Thioredoxin-interacting pr... |
Human | E. coli |
TXNIP Protein, Human, Recombinant (B2M & His) is expressed in E. coli expression system with N-6xHis-B2M tag. The predicted molecular weight is 57.7 kDa and the accession number is Q9H3M7. | |||
TMPY-01686 |
B2M/beta 2-Microglobulin Protein, Human, Recombinant (His)
β-2 microglobulin,beta-2 microglobulin |
Human | HEK293 Cells |
B2M/beta 2-Microglobulin Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 13.2 kDa and the accession number is P61769. | |||
TMPH-02305 |
VCAN Protein, Human, Recombinant (B2M & His & Myc)
VCAN,Glial hyaluronate-binding protein,Versican core protein... |
Human | E. coli |
May play a role in intercellular signaling and in connecting cells with the extracellular matrix. May take part in the regulation of cell motility, growth and differentiation. Binds hyaluronic acid. | |||
TMPY-02811 |
FCGRT & B2M Heterodimer Protein, Mouse, Recombinant (His)
Fc fragment of IgG, receptor, transporter, alpha,FcRn,Fc fra... |
Mouse | HEK293 Cells |
FCGRT & B2M Heterodimer Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 43.5 kDa and the accession number is Q61559&P01887. | |||
TMPY-02830 |
FCGRT & B2M Heterodimer Protein, Cynomolgus, Recombinant (His)
Fc fragment of IgG, receptor, transporter, alpha,Fc fragment... |
Cynomolgus | HEK293 Cells |
FCGRT & B2M Heterodimer Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 43.5 kDa and the accession number is Q8SPV9&Q8SPW0. | |||
TMPY-02082 |
FCGRT & B2M Heterodimer Protein, Human, Recombinant (His)
Fc fragment of IgG, receptor, transporter, alpha,alpha-chain... |
Human | HEK293 Cells |
FCGRT & B2M Heterodimer Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 43.5 kDa and the accession number is P55899-1&P61769. | |||
TMPY-02829 |
FCGRT & B2M Heterodimer Protein, Rat, Recombinant (His)
Fc fragment of IgG, receptor, transporter, alpha,Fc fragment... |
Rat | HEK293 Cells |
FCGRT & B2M Heterodimer Protein, Rat, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 44 kDa and the accession number is P13599&P07151. | |||
TMPY-05539 |
FCGRT & B2M Heterodimer Protein, Human, Recombinant (His), Biotinylated
Fc fragment of IgG, receptor, transporter, α,FCRN,α-chain,Fc... |
Human | HEK293 Cells |
FCGRT & B2M Heterodimer Protein, Human, Recombinant (His), Biotinylated is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 43.5 kDa and the accession number is P55899&P61769. | |||
TMPY-05650 |
FCGRT & B2M Heterodimer Protein, Cynomolgus, Recombinant (His & Avi), Biotinylated
Fc fragment of IgG, receptor, transporter, alpha,Fc fragment... |
Cynomolgus | HEK293 Cells |
FCGRT & B2M Heterodimer Protein, Cynomolgus, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with His and Avi tag. The predicted molecular weight is 45.3 kDa and the accession number is Q8SPV9&Q8SPW0. | |||
TMPY-02854 |
CD1D & B2M Heterodimer Protein, Human, Recombinant (His)
CD1D & B2M Heterodimer |
Human | HEK293 Cells |
CD1D & B2M Heterodimer Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 45 kDa and the accession number is P15813&P61769. | |||
TMPY-04764 |
PCK2 Protein, Human, Recombinant (His & GST)
PEPCK-M,PEPCK2,PEPCK,phosphoenolpyruvate carboxykin... |
Human | Baculovirus Insect Cells |
PCK2 promotes tumor initiation by lowering acetyl-CoA level through reducing the mitochondrial tricarboxylic acid (TCA) cycle. The levels of phosphoenolpyruvate carboxykinase isoform 2 (PCK2) are critical for the metabolic switch and the maintenance of TICs in prostate cancer. PCK2 is a potential therapeutic target for aggressive prostate tumors. | |||
TMPK-01414 |
Qa-1b&B2M&Qdm (AMAPRTLLL) Monomer Protein, Mouse, MHC (His & Avi)
Qa-1b,Qdm,MHC,H2-T23 |
Mouse | HEK293 Cells |
Qa-1b binds a peptide (AMAPRTLLL), referred to as Qdm (for Qa-1 determinant modifier), derived from the signal sequence of murine class Ia molecules. This peptide binds with high affinity and accounts for almost all of the peptides associated with this molecule. Human histocompatibility leukocyte antigen (HLA)-E, a homologue of Qa-1b, binds similar peptides derived from human class Ia molecules and interacts with CD94/NKG2 receptors on natural killer cells. | |||
TMPY-01563 |
PMP2 Protein, Human, Recombinant (His)
MP2,FABP8,peripheral myelin protein 2,P |
Human | E. coli |
Myelin P2 protein, also known as PMP2, is a cytosolic protein found primarily in peripheral nerves. It Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. PMP2 is a small, basic, and cytoplasmic lipid binding protein of peripheral myelin. It is similar in amino acid sequence and tertiary structure to fatty acid binding proteins found in the liver, adipocytes, and intestine, its expression is limited to the nervous system. PMP2 is detected only in myelin-producing cells ... | |||
TMPH-03088 |
Arginine kinase/AK Protein, Penaeus monodon, Recombinant (His & SUMO)
Pen m 2,AK,Arginine kinase |
Penaeus monodon | E. coli |
N/A. Arginine kinase/AK Protein, Penaeus monodon, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 56.0 kDa and the accession number is C7E3T4. | |||
TMPK-00414 |
M-CSFR/CSF1R/CD115 Protein, Human, Recombinant (His & Avi)
FMSFIM2,FMS,M-CSF R,HDLS,M-CSFR,CSF1R,CSF-1-R,FIM |
Human | HEK293 Cells |
M-CSFR/CSF1R/CD115 Protein, Human, Recombinant (His & Avi) is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 57.4 kDa and the accession number is P07333-1. | |||
TMPY-04192 |
HIV-1 (group M, subtype B, strain HXB2) p24 Protein (His)
Gag-p24 |
HIV | E. coli |
HIV-1 (group M, subtype B, strain HXB2) p24 Protein (His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 26.5 kDa and the accession number is P04591. | |||
TMPH-02348 |
Influenza A H1N1 (strain A/Puerto Rico/8/1934) Matrix protein 2 (His & Myc)
Matrix protein 2,M,Proton channel protein M2 |
H1N1 | E. coli |
Forms a proton-selective ion channel that is necessary for the efficient release of the viral genome during virus entry. After attaching to the cell surface, the virion enters the cell by endocytosis. Acidification of the endosome triggers M2 ion channel activity. The influx of protons into virion interior is believed to disrupt interactions between the viral ribonucleoprotein (RNP), matrix protein 1 (M1), and lipid bilayers, thereby freeing the viral genome from interaction with viral proteins ... | |||
TMPY-01833 |
CSF1R Protein, Mouse, Recombinant (His)
Fim-2,M-CSF-R,CD115,Csfmr,CSF-1R,colony stimulating... |
Mouse | HEK293 Cells |
CSF1R Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 56.8 kDa and the accession number is P09581. | |||
TMPK-00656 |
M-CSFR/CSF1R/CD115 Protein, Cynomolgus, Recombinant (His)
M-CSF R,M-CSFR,HDLS,C-FMS,CSF1R,CSFR,CD115,MCSFR,FMS,CSF-1-R... |
Cynomolgus | HEK293 Cells |
M-CSFR/CSF1R/CD115 Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells with C-His tag. The predicted molecular weight is 56.3 kDa and the accession number is G7P8P1. | |||
TMPK-00415 |
M-CSFR/CSF1R/CD115 Protein, Human, Recombinant (His & Avi), Biotinylated
CSF-1-R,M-CSF R,C-FMS,FMSFIM2,CSFR,CD115,M-CSFR,FMS... |
Human | HEK293 Cells |
M-CSFR/CSF1R/CD115 Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 57.4 kDa and the accession number is P07333-1. | |||
TMPY-05436 |
CSF1R Protein, Mouse, Recombinant (hFc)
AI323359,Csfmr,Fim-2,Fms,colony stimulatin... |
Mouse | HEK293 Cells |
CSF1R Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 81.9 kDa and the accession number is P09581. | |||
TMPY-04938 |
CSF1R Protein, Mouse, Recombinant (His), Biotinylated
CD115,M-CSFR,colony stimulating factor 1 receptor,AI32 |
Mouse | HEK293 Cells |
CSF1R Protein, Mouse, Recombinant (His), Biotinylated is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 56.8 kDa and the accession number is P09581. | |||
TMPH-02347 |
Influenza A H1N1 (strain A/USA:Phila/1935) Matrix protein 2 (His)
Matrix protein 2,Proton channel protein M2... |
H1N1 | E. coli |
Forms a proton-selective ion channel that is necessary for the efficient release of the viral genome during virus entry. After attaching to the cell surface, the virion enters the cell by endocytosis. Acidification of the endosome triggers M2 ion channel activity. The influx of protons into virion interior is believed to disrupt interactions between the viral ribonucleoprotein (RNP), matrix protein 1 (M1), and lipid bilayers, thereby freeing the viral genome from interaction with viral proteins ... | |||
TMPH-00066 |
Phospholipase A2 Protein, Apis mellifera, Recombinant (His)
Allergen Api m I,Phospholipase A2,Phosphatidylcholi... |
Apis mellifera | E. coli |
PLA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides. | |||
TMPK-01062 |
RGMC Protein, Mouse, Recombinant (His)
HJV,DL-M,JH,Rgmc,RGM-C,Hemojuvelin,HFE2,HFE2 |
Mouse | HEK293 Cells |
RGM gene family ('Repulsive Axonal Guidance molecules' A, B and C),both RGM A and B are mostly expressed in central nervous system, while RGM C is exclusively expressed in all striated muscle and in the myocardium. RGM A and B appear at every level of the developing neural axis, where they colocalize to a large extent in the mantle layer, although only RGM A appears in the neuroepithelium, and only RGM B in the peripheral nervous system. | |||
TMPY-02128 |
Serpin B1 Protein, Human, Recombinant (His)
HEL57,serpin peptidase inhibitor, clade B (ovalbumin), membe... |
Human | Baculovirus Insect Cells |
SerpinB1 is an endogenous inhibitor of serine proteases recognized for its anti-inflammatory and host-protective properties. Serum SerpinB1 levels are elevated in patients with type 2 diabetes compared with that in healthy subjects and are negatively correlated with serum LDL-C. serpinB1 as an endogenous protein that can potentially be harnessed to enhance functional beta cell mass in patients with diabetes. | |||
TMPJ-00395 |
SEMA4D Protein, Mouse, Recombinant (hFc)
Semacl2,Sema J,Semaphorin-C-like 2,Semaj,C... |
Mouse | HEK293 Cells |
SEMA4D is a member of the semaphorin family,contains one Ig-like C2-type domain, one PSI domain and one Sema domain. SEMA4D is strongly expressed in lymphoid tissues, especially in the thymus, as well as in the nervous tissues. However, SEMA4D is expressed at lower levels in testes, brain, kidney, small intestine, prostate, heart, placenta, lung and pancreas, but not in colon and liver. SEMA4D is a cell surface receptor for PLXN1B and PLXNB2 that plays an important role in cell-cell signaling. S... | |||
TMPH-02969 |
VCAN Protein, Mouse, Recombinant (His & Myc)
Chondroitin sulfate proteoglycan core protein 2,Ver... |
Mouse | E. coli |
May play a role in intercellular signaling and in connecting cells with the extracellular matrix. May take part in the regulation of cell motility, growth and differentiation. Binds hyaluronic acid. VCAN Protein, Mouse, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 20.9 kDa and the accession number is Q62059. | |||
TMPY-02609 |
UBE2M Protein, Human, Recombinant
UBC12,UBC-RS2,ubiquitin-conjugating enzyme... |
Human | E. coli |
UBE2M is a member of the ubiquitin-conjugating E2 family whose members perform the second step in the ubiquitination reaction. Initially identified as the main process for protein degradation, ubiquitination is believed nowadays to be crucial for a wider range of cellular processes. The outcome of the ubiquitin-conjugation reaction, and thereby the fate of the substrate, is heavily dependent on the number of ubiquitin molecules attached and how these ubiquitin molecules are inter-connected. To d... | |||
TMPY-06384 |
CSF1R Protein, Human, Recombinant (His & Avi), Biotinylated
HDLS,FMS,colony stimulating factor 1 receptor,MCSF Receptor,... |
Human | HEK293 Cells |
CSF1R Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with His and Avi tag. The predicted molecular weight is 57.76 kDa and the accession number is P07333-1. | |||
TMPY-05429 |
CSF1R Protein, Human, Recombinant (hFc)
FIM2,C-FMS,FMS,MCSF Receptor,CD115,HDLS,CSF-1R,colo... |
Human | HEK293 Cells |
CSF1R Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 81.2 kDa and the accession number is P07333-1. | |||
TMPY-00881 |
CSF1R Protein, Human, Recombinant
FIM2,C-FMS,CD115,CSFR,MCSF Receptor,FMS,CSF-1R,colo... |
Human | HEK293 Cells |
CSF1R Protein, Human, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 55.1 kDa and the accession number is P07333-1. | |||
TMPK-01534 |
Chimeric HLA-A*02:01 (mα3) &B2M&LMP2 (CLGGLLTMV) Monomer Protein, Human&Mouse, MHC (His & Avi)
RING12,PSMB9,Proteasome chain 7,RMF,LMP-2,... |
Human & Mouse | HEK293 Cells |
The immunoproteasome, having been linked to neurodegenerative diseases and hematological cancers, has been shown to play an important role in MHC class I antigen presentation. The development of molecular probes that selectively inhibit the major catalytic subunit, LMP2, of the immunoproteasome,LMP2-rich cancer cells compared to LMP2-deficient cancer cells are more sensitive to growth inhibition by the LMP2-specific inhibitor, implicating an important role of LMP2 in regulating cell growth of ma... | |||
TMPK-01535 |
Chimeric HLA-A*02:01 (mα3) &B2M&LMP2 (CLGGLLTMV) Tetramer Protein, Human&Mouse, MHC (His & Avi)
Macropain chain 7,LMP2,Proteasome chain 7,RING1... |
Human & Mouse | HEK293 Cells |
The immunoproteasome, having been linked to neurodegenerative diseases and hematological cancers, has been shown to play an important role in MHC class I antigen presentation. The development of molecular probes that selectively inhibit the major catalytic subunit, LMP2, of the immunoproteasome,LMP2-rich cancer cells compared to LMP2-deficient cancer cells are more sensitive to growth inhibition by the LMP2-specific inhibitor, implicating an important role of LMP2 in regulating cell growth of ma... | |||
TMPY-05045 |
CSF1R Protein, Human, Recombinant (Domain I&II&III, His)
M-CSF-R,colony stimulating factor 1 receptor,HDLS,C-FMS,FMS,... |
Human | HEK293 Cells |
CSF1R Protein, Human, Recombinant (Domain I&II&III, His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 31.1 kDa and the accession number is P07333-1. | |||
TMPY-05513 |
CSF1R Protein (Ala299-Glu512), Human, Recombinant (His)
M-CSF-R,HDLS,C-FMS,CSFR,CSF-1R,CD115,FMS,colony stimulating ... |
Human | HEK293 Cells |
CSF1R Protein (Ala299-Glu512), Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 25.3 kDa and the accession number is P07333-1. | |||
TMPY-06389 |
CSF1R Protein, Human, Recombinant (hFc & Avi), Biotinylated
FMS,CD115,FIM2,MCSF Receptor,colony stimulating fac... |
Human | HEK293 Cells |
CSF1R Protein, Human, Recombinant (hFc & Avi), Biotinylated is expressed in HEK293 mammalian cells with hFc and Avi tag. The predicted molecular weight is 83.04 kDa and the accession number is P07333-1. | |||
TMPY-05264 |
CSF1R Protein, Human, Recombinant (mFc)
CD115,FIM2,FMS,CSF-1R,colony stimulating factor 1 r... |
Human | HEK293 Cells |
CSF1R Protein, Human, Recombinant (mFc) is expressed in HEK293 mammalian cells with mFc tag. The predicted molecular weight is 81.5 kDa and the accession number is P07333-1. | |||
TMPY-04358 |
CSF1R Protein, Human, Recombinant (His & GST)
MCSF Receptor,FMS,colony stimulating factor 1 receptor,FIM |
Human | Baculovirus Insect Cells |
CSF1R Protein, Human, Recombinant (His & GST) is expressed in Baculovirus insect cells with His and GST tag. The predicted molecular weight is 76 kDa and the accession number is P07333-1. | |||
TMPH-01652 |
MLANA Protein, Human, Recombinant (B2M & His)
Antigen LB39-AA,Protein Melan-A,MLANA,Melanoma antigen recog... |
Human | E. coli |
Involved in melanosome biogenesis by ensuring the stability of GPR143. Plays a vital role in the expression, stability, trafficking, and processing of melanocyte protein PMEL, which is critical to the formation of stage II melanosomes. MLANA Protein, Human, Recombinant (B2M & His) is expressed in E. coli expression system with N-6xHis-B2M tag. The predicted molecular weight is 27.2 kDa and the accession number is Q16655. | |||
TMPH-03111 |
Erythropoietin Protein, Pig, Recombinant (B2M & His)
EPO,Erythropoietin |
Sus scrofa (Pig) | E. coli |
Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3. Erythropoietin Protein, Pig, Recombinant (B2M & His) is expressed in E. coli expression system with N-6xHis-B2M tag. The predicted molecular weight is 32.6 kDa and the accession number is P49157. | |||
TMPH-01350 |
FOxM1 Protein, Human, Recombinant (GST)
M-phase phosphoprotein 2,Hepatocyte nuclear factor ... |
Human | E. coli |
Transcriptional factor regulating the expression of cell cycle genes essential for DNA replication and mitosis. Plays a role in the control of cell proliferation. Plays also a role in DNA breaks repair participating in the DNA damage checkpoint response. FOxM1 Protein, Human, Recombinant (GST) is expressed in E. coli expression system with N-GST tag. The predicted molecular weight is 43.8 kDa and the accession number is Q08050. | |||
TMPH-01351 |
FOxM1 Protein, Human, Recombinant (His & Myc & SUMO)
Forkhead-related protein FKHL16,MPM-2 reactive phos... |
Human | E. coli |
Transcriptional factor regulating the expression of cell cycle genes essential for DNA replication and mitosis. Plays a role in the control of cell proliferation. Plays also a role in DNA breaks repair participating in the DNA damage checkpoint response. FOxM1 Protein, Human, Recombinant (His & Myc & SUMO) is expressed in E. coli expression system with N-10xHis-SUMO and C-Myc tag. The predicted molecular weight is 31.2 kDa and the accession number is Q08050. | |||
TMPH-02677 |
GPI Protein, Mouse, Recombinant (B2M & His)
Gpi,Phosphohexose isomerase,Phosphoglucose isomerase,Neurole... |
Mouse | E. coli |
In the cytoplasm, catalyzes the conversion of glucose-6-phosphate to fructose-6-phosphate, the second step in glycolysis, and the reverse reaction during gluconeogenesis. Besides it's role as a glycolytic enzyme, also acts as a secreted cytokine: acts as an angiogenic factor (AMF) that stimulates endothelial cell motility. Acts as a neurotrophic factor, neuroleukin, for spinal and sensory neurons. It is secreted by lectin-stimulated T-cells and induces immunoglobulin secretion. | |||
TMPY-02791 |
B2M/beta 2-Microglobulin Protein, Rat, Recombinant (His)
beta-2 microglobulin,β-2 microglobulin |
Rat | HEK293 Cells |
B2M/beta 2-Microglobulin Protein, Rat, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 13 kDa and the accession number is P07151. | |||
TMPJ-01235 |
B2M/beta 2-Microglobulin Protein, Cynomolgus, Recombinant (hFc)
B2M,Beta-2-Microglobulin,β-2-Micr... |
Cynomolgus | HEK293 Cells |
B2M/beta 2-Microglobulin Protein, Cynomolgus, Recombinant (hFc) is expressed in HEK293 mammalian cells with C-Fc tag. The predicted molecular weight is 40 KDa and the accession number is Q8SPW0. | |||
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Cat. No. | Product Name | Target | Signaling Pathways |
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TMIJ-0272 |
Sarpogrelate-d3 HCl
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Sarpogrelate-d3 HCl 是 Sarpogrelate HCl 的氘代化合物。Sarpogrelate HCl 的 CAS 号为 135159-51-2。Sarpogrelate hydrochloride 是一种选择性5-HT2R拮抗剂,可用于研究与血栓形成有关的血管疾病,对 5-HT2A、5-HT2B 和 5-HT2C 受体的pKi值分别为 8.52、6.57 和 7.43。 | |||
T36055 |
Nitisinone-13C6
Nitisinone-13C6 |
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Nitisinone-13C6is intended for use as an internal standard for the quantification of nitisinone by GC- or LC-MS. Nitisinone is an inhibitor of 4-hydroxyphenylpyruvate dioxygenase (HPPD), which converts 4-hydroxyphenylpyruvate (HPPA) to homogentisate in the tyrosine catabolic pathway.1Nitisinone increases urinary levels of HPPA and 4-hydroxyphenyllactate (HPLA) in rats when administered at a dose of 10 mg/kg. Nitisinone (3 mg/kg) prevents the neonatal lethality of fumarylacetoacetate hydrolase (F... | |||
T37847 |
Zonisamide-13C2,15N
Zonisamide-13C2,15N |
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Zonisamide-13C2,15N is intended for use as an internal standard for the quantification of zonisamide by GC- or LC-MS. Zonisamide is an antiepileptic agent.1 It selectively inhibits the repeated firing of sodium channels (IC50 = 2 μg/ml) in mouse embryo spinal cord neurons and inhibits spontaneous channel firing when used at concentrations greater than 10 μg/ml.2 In rat cerebral cortex neurons, zonisamide (1-1,000 μM) inhibits T-type calcium channels with a maximum reduction of 60% of the calcium... | |||
T35775 |
HT-2 Toxin-13C22
HT-2 Toxin-13C22 |
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HT-2 toxin-13C22is intended for use as an internal standard for the quantification of HT-2 toxin by GC- or LC-MS. HT-2 toxin is a type A trichothecene mycotoxin and an active, deacetylated metabolite of the trichothecene mycotoxin T-2 toxin .1,2Like T-2 toxin, HT-2 toxin inhibits protein synthesis and cell proliferation in plants.2HT-2 toxin also reduces viability of HepG2, A549, HEp-2, Caco-2, A-204, U937, Jurkat, and RPMI-8226 cancer cells with IC50values ranging from 3.1 to 23 ng/ml and human... | |||
T35789 |
Palmitic acid-1-13C
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Palmitic acid-13C is intended for use as an internal standard for the quantification of palmitic acid by GC- or LC-MS. Palmitic acid is a 16-carbon saturated fatty acid. It comprises approximately 25% of human total plasma lipids.1 It increases protein levels of COX-2 in RAW 264.7 cells when used at a concentration of 75 μM.2 Palmitic acid is involved in the acylation of proteins to anchor membrane-bound proteins to the lipid bilayer.2,3,4,5,6 |1. Santos, M.J., López-Jurado, M., Llopis, J., et a... | |||
T38297 |
Ribavirin-13C5
Ribavirin-13C5 |
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Ribavirin-13C5is intended for use as an internal standard for the quantification of ribavirin by GC- or LC-MS. Ribavirin is an antiviral guanosine nucleoside analog.1,2Upon entry into cells, ribavirin is metabolized to an active triphosphate form that induces viral RNA chain termination and inhibits viral polymerases. It reduces replication in a panel of seven RNA and four DNA viruses in Vero cells (EC50s = 2-95 μg/ml).3Ribavirin also reduces replication of severe acute respiratory syndrome coro... | |||
T35791 |
Palmitic acid-13C
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Palmitic acid-13C is intended for use as an internal standard for the quantification of palmitic acid by GC- or LC-MS. Palmitic acid-13C contains 13C at the C2 position and has been used in the study of free fatty acid incorporation into phospholipid fatty acids in soil microbes.1 Palmitic acid is a 16-carbon saturated fatty acid. It comprises approximately 25% of human total plasma lipids.2 It increases protein levels of COX-2 in RAW 264.7 cells when used at a concentration of 75 μM.3 Palmitic ... | |||
T35519 |
Aflatoxin B2-13C17
Aflatoxin B2-13C17 |
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Aflatoxin B2-13C17(AFB2-13C17) is intended for use as an internal standard for the quantification of AFB2by GC- or LC-MS. AFB2is a mycotoxin that has been found inA. terricola.1It induces hepatic autophagy and apoptosis in broiler chickens when administered at doses of 0.2, 0.4, and 0.8 mg/kg.2AFB2(0.5 and 1 mg/animal) also induces parenchymal cell hyperplasia in rats.3 1.Moubasher, A.H., el-Kady, I.A., and Shoriet, A.Toxigenic Aspergilli isolated from different sources in EgyptAnn. Nutr. Alimen... | |||
T35790 |
Palmitic acid-1,2,3,4-13C4
Palmitic Acid-13C (C1, C2, C3, and C4 labeled) |
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Palmitic acid-13C (C1, C2, C3, and C4 labeled) is intended for use as an internal standard for the quantification of palmitic acid by GC- or LC-MS. Palmitic acid is a common 16-carbon saturated fat that represents 10-20% of human dietary fat intake and comprises approximately 25 and 65% of human total plasma lipids and saturated fatty acids, respectively.1,2Acylation of palmitic acid to proteins facilitates anchoring of membrane-bound proteins to the lipid bilayer and trafficking of intracellula... |