Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T69629 |
M‑89 MLL inhibitor
|
Others | Others |
M‑89 is a Highly Potent Inhibitor of the Menin-Mixed Lineage Leukemia (Menin-MLL) Protein−Protein Interaction (Kd = 1.4 nM; IC50 = 25nM). M-89 binds to menin with a Kd value of 1.4 nM and effectively engages cellular menin protein at low nanomolar concentrations. M-89 inhibits cell growth in the MV4;11 and MOLM-13 leukemia cell lines carrying MLL fusion with IC50 values of 25 and 55 nM, respectively, and demonstrates >100-fold selectivity over the HL-60 leukemia cell line lacking MLL fusion. | |||
T69628 |
Iptacopan hydrochloride hydrate
|
Others | Others |
Iptacopan hydrochloride hydrate is a highly potent and highly selective factor B inhibitor. | |||
T11925 |
M‑89
|
Epigenetic Reader Domain; Histone Methyltransferase | Chromatin/Epigenetic |
M-89 可抑制 Menin-MLL 蛋白之间的相互作用,有研究混合谱系白血病的潜力。它是一种强特异性 menin 抑制剂,结合到 menin 的Kd 值为 1.4 nM。 |