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Search Results for " luteinizing hormone releasing hormone "
Targets Recommended: Reductase

44

抑制剂 & 化合物

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Cat. No. Product Name Target Signaling Pathways
T5015 Gonadorelin Acetate (33515-09-2 free base)

醋酸戈那瑞林,Luteinizing Hormone Releasing Hormone (LH-RH),Luteinizing Hormone Releasing Hormone (LH-RH), human,Gonadorelin Acetate

 Reductase Endocrinology/Hormones; Metabolism
Gonadorelin Acetate (33515-09-2 free base) (Luteinizing Hormone Releasing Hormone (LH-RH)) 是下丘脑神经肽，在控制生殖功能中起关键作用。
TP1112 Luteinizing Hormone Releasing Hormone (LH-RH), salmon

LH-RH, salmon
Luteinizing Hormone Releasing Hormone (LH-RH) is a pituitary Hormone synthesized in the hypothalamus and plays a crucial role in the control of reproductive function.
TP1112L LH-RH, salmon acetate(86073-88-3 free base)

Luteinizing Hormone Releasing Hormone (LH-RH), salmon acetate

 Others Others
LH-RH, salmon acetate(86073-88-3 free base) (Luteinizing Hormone Releasing Hormone (LH-RH), salmon acetate) 是一种在下丘脑中合成的垂体激素，在控制生殖功能中起着至关重要的作用。
T3538 Sufugolix

TAK-013

 LHRH Endocrinology/Hormones
Sufugolix (TAK-013) 是一种高效的、有口服活性的黄体激素释放激素(LHRH) 受体拮抗剂(IC50:0.1 nM)。
T5520L Cetrorelix diacetate

NS-75A,醋酸西曲瑞克,SB-075 acetate,SB-075 diacetate,Cetrorelix acetate,NS-75A diacetate

 GNRH Receptor GPCR/G Protein
Cetrorelix diacetate (NS-75A) 是GnRH 受体的强效拮抗剂(IC50:1.21 nM)。
T3630 Relugolix

RVT-601,瑞卢戈利,TAK-385

 GNRH Receptor GPCR/G Protein
Relugolix (RVT-601) 是口服有活性的非肽性促性腺激素释放激素的拮抗剂。同 TAK-013 相比，它对人和猴子的受体具有高亲和力和强拮抗活性，它们的 IC50值分别为0.33 nM 和0.32 nM。它可用于研究性激素依赖性疾病，如子宫肌瘤、子宫内膜异位症、前列腺癌等。
TP2107L Histrelin acetate

Histrelin acetate(76712-82-8 free base),醋酸组氨瑞林

 GNRH Receptor GPCR/G Protein
Histrelin acetate 是促性腺激素释放激素 (GnRH) 的九肽类似物，具有增加的效力。当存在于血流中时，它作用于称为促性腺激素的垂体特定细胞。 Histrelin 刺激这些细胞释放促黄体激素和促卵泡激素。因此，它被认为是促性腺激素释放激素激动剂或 GnRH 激动剂。
T34055 Phtstllap

Others Others
Phtstllap is a luteinizing hormone-releasing factor
T28954 Teverelix

Teverelix is a water-soluble antagonist of luteinizing hormone-releasing hormone (LHRH).
T25715 LHRH, Ala(6)-

L 1868,L-1868,L1868

 Others Others
LHRH, Ala(6)- is a synthetic luteinizing hormone-releasing hormone agonist agent.
T26040 Ramorelix

HOE 013,HOE013,HOE-013

 Others Others
Ramorelix is an antagonist of luteinizing hormone-releasing hormone (LHRH).
T70819 Argtide

Others Others
Argtide is an luteinizing hormone releasing hormone (LHRH) antagonist.
T68700 Avorelin acetate

Others Others
Avorelin acetate is a luteinizing hormone releasing hormone (LH-RH) agonist.
T26692 Avorelin

MF-6001,EP 23904,EP-23904,EP23904,MF6001

 Others Others
Avorelin, a luteinizing hormone releasing hormone (LH-RH) agonist, is used potentially for the treatment of prostate.
T76351 [D-Ala6]-LH-RH

Others Others
[D-Ala6]-LH-RH，一种黄体激素释放激素(LHRH)模拟物，充当GnRH受体的激动剂。
T76350 [D-Glp1,D-Phe2,D-Trp3,6]-LH-RH

[D-Glp1,D-Phe2,D-Trp3,6]-LH-RH 是一种黄体激素释放激素 (LHRH) 类似物，可作为 GnRH 受体拮抗剂。
T76617 (D-Trp6)-LHRH free acid

(D-Trp6)-LHRH free acid 是促黄体生成素释放激素 (LHRH) 激动剂。
TP1648 [Gln8]-C517 (LH-RH), chicken

[Gln8] Luteinizing hormone releasing hormone ([Gln8] LH-RH), Avian hypothalamic peptide that stimulates release of gonadotropins from anterior pituitary, thus regulating reproductive functions.
T83499 [D-Phe2,6, Pro3]-LH-RH

[D-Phe2,6, Pro3]-LH-RH是一种促黄体生成素释放激素(LHRH)的高效拮抗剂，具有特定氨基酸序列变异。
T76348 [D-Lys6]-LH-RH

[D-Lys6]-LH-RH 是一种黄体激素释放激素 (LHRH) 类似物，可作为GnRH 受体激动剂。
T76620 (D-Tyr5,D-Ser(tBu)6,Azagly10)-LHRH

(D-Ser4,D-Ser(tBu)6,Azagly10)-LHRH 是黄体生成素释放激素 (LHRH) 的类似物。LHRH 通过刺激垂体黄体生成素 (LH) 和促卵泡激素 (FSH) 的释放，在控制生殖中发挥核心作用。
T76615 (D-Ser(tBu)6,D-Leu7,Azagly10)-LHRH

(D-Ser(tBu)6,D-Leu7,Azagly10)-LHRH是一种LHRH(黄体生成素释放激素)的类似物，主要通过激活垂体分泌黄体生成素(LH)和促卵泡激素(FSH)来在生殖调控中发挥核心作用。
T80116 LHRH

GNRH Receptor GPCR/G Protein
LHRH是一种调节生殖功能的下丘脑神经肽，常用于癌症研究。
T76616 (D-Ser4,D-Ser(tBu)6,Azagly10)-LHRH

(D-Ser4,D-Ser(tBu)6,Azagly10)-LHRH 是一种黄体生成素释放激素 (LHRH) 的类似物，主要通过促进垂体分泌黄体生成素 (LH) 和促卵泡激素 (FSH) 来在生殖调控中发挥关键作用。
T82162 Human follicular gonadotropin releasing peptide

hF-GRP
Human follicular gonadotropin releasing peptide (hF-GRP)是一种刺激垂体分泌促黄体激素(LH)及促卵泡激素(FSH)的激素类多肽，其作用可在体外实现。
T83498 [D-Phe2,D-Ala6]-LH-RH

Wy 18185
[D-Phe2,D-Ala6]-LH-RH 为有效LH-RH拮抗剂，展现了显著的抗LH/FSH-RH及抗排卵活性。
T76324 GnRH Associated Peptide (1-24), human

GnRH Associated Peptide (GAP) (1-24), human 是人类的一个化合物，具体为促性腺激素释放激素相关肽(GAP)的第1至24个氨基酸片段(hGAP-1-24)。该化合物通过3个氨基酸加工位点与黄体生成素释放激素(LH-RH)序列连接。
T75991 Ganirelix

Ganirelix为一种竞争性且选择性的促性腺激素释放激素(GnRH)拮抗剂，其主要作用机制为抑制内源性GnRH，从而抑制黄体生成素(LH)及促卵泡激素的释放。
TP1342 GnRH-I

GnRH-I is a small 10 amino acid long peptide (decapeptide) from the hypothalamus,It is also known as luteinizing hormone releasing hormone (LHRH), is a key molecule in the regulation of reproduction in vertebrates. GnRH, a decapeptide, is produced by neur
T84706 DCOIT

Kathon 930

 Others Others
DCOIT是一种典型的异噻唑啉酮，能激活促性腺激素释放激素受体(GnRHR)在大脑中引发卵泡刺激素和黄体生成素的合成。此外，DCOIT干扰了G蛋白偶联受体、MAPK和Ca2+信号传递途径。
T76322 LH-RH II (chicken)

LH-RH II (chicken) 为家鸡下丘脑黄体生成素释放激素(LHRH)两种形式之一，亦为哺乳动物LHRH的结构变体。该化合物促进家鸡促性腺激素释放。
T76323 GnRH Associated Peptide (25-53), human

GnRH Associated Peptide (GAP) (25-53), human 是来源于人的促性腺激素释放激素相关肽（GAP）的一个特定片段，具体为第25至第53位氨基酸（hGAP-25-53）。本片段可用作免疫原，用以产生含有MC-1、MC-2和MC-3等抗体的抗血清。GAP通过其内含的三个氨基酸加工位点，能与黄体生成素释放激素（LH-RH）序列进行有效连接。
T85273 Gonadorelin acetate

Others Others
Gonadorelin, a gonadotropin-releasing hormone receptor (GNRHR; Ki= 13 nM in CHO cells expressing the human receptor) agonist and tropic hormone, effectively stimulates the release of luteinizing hormone (LH) and follicle-stimulating hormone (FSH) from rat anterior pituitary cultures at 0.1 μg doses. Additionally, it triggers LH release from bovine anterior pituitary cultures at a 1 μM concentration. In vivo, gonadorelin induces ovulation in rats pretreated with fluphenazine (ED50= 610.3 ng/kg). ...
T76602 (D-Phe12,Nle21,38,α-Me-Leu37)-CRF (12-41) (human, rat)

(D-Phe12,Nle21,38,α-Me-Leu37)-CRF (12-41) (human, rat) 作为一种CRF拮抗剂，能有效阻断IL-1a诱发的黄体生成素 (LH) 抑制作用。
T71149 Triptorelin pamoate

Others Others
Triptorelin, a decapeptide (pGlu-His-Trp-Ser-Tyr-D-Trp-Leu-Arg-Pro-Gly-NH2), is a gonadotropin-releasing hormone agonist (GnRH agonist) used as the acetate or pamoate salts. By causing constant stimulation of the pituitary, it decreases pituitary secretion of gonadotropins luteinizing hormone (LH) and follicle stimulating hormone (FSH). Like other GnRH agonists, triptorelin may be used in the treatment of hormone-responsive cancers such as prostate cancer or breast cancer, precocious puberty, es...
T76558 Onvitrelin ucalontide

Onvitrelin ucalontide ([Phor18-LHRH (338613)]) 是一种 LHRH (黄体生成素释放激素) 的类似物，展现出抗肿瘤特性。这一化合物是一个具备序列 KFAKFAKKFAKFAKKFAKQHWSYGLRPG 的肽，能在小鼠模型上有效地抑制乳腺癌、卵巢癌和前列腺癌的异种移植物生长。
T76353 LH-RH (7-10)

LH-RH (7-10)，一种由性腺激素释放激素 (LHRH) 在垂体和下丘脑降解过程中形成的主要四肽降解产物之一，存在于巨噬细胞、I 型样及II 型肺细胞中。
T70309 Dicetrorelix pamoate

Others Others
Dicetrorelix pamoate is a synthetic decapeptide with gonadotropin-releasing hormone (GnRH) antagonistic activity. GnRH induces the production and release of luteinizing hormone (LH) and follicle stimulating hormone (FSH) from the gonadotrophic cells of the anterior pituitary. Due to a positive estradiol (E2) feedback at midcycle, GnRH liberation is enhanced resulting in an LH-surge. This LH-surge induces the ovulation of the dominant follicle, resumption of oocyte meiosis and subsequently lutein...
T68701 Abarelix acetate

Others Others
Abarelix acetate is a synthetic third generation gonadotropin-releasing hormone receptor (GnRHR) antagonist. It increases histamine release from rat peritoneal mast cells in vitro and from a human skin model ex vivo. In vivo, abarelix decreases plasma luteinizing hormone (LH) levels six hours post-treatment in castrated rats, with levels returning to baseline within 24 hours.3 Abarelix (2 mg/kg) also transiently decreases plasma testosterone levels in intact rats, with levels returning to baseli...
T36912 17α,20β-Dihydroxy-4-pregnen-3-one

17α,20β-dihydroxy Progesterone,17α,20β-DHP,17α,20β-Dihydroxy-4-pregnen-3-one

 Others Others
17α,20β-Dihydroxy-4-pregnen-3-one (17α,20β-DHP) is an endogenous, maturation-inducing steroid that stimulates oocyte maturation in females of several teleost species. For example, 1 μg/ml of 17α,20β-DHP applied to Persian sturgeon oocytes has been shown to effectively induce germinal vesicle breakdown, an essential step during oocyte maturation.1 Gonadotropin-releasing hormone and the gonadotropins, follicle-stimulating hormone and luteinizing hormone, have been shown to stimulate the production...
T72990 BAY 1214784

Others Others
BAY 1214784是一种针对人促性腺激素释放激素受体(hGnRH-R)的高效、选择性口服活性拮抗剂，属于螺二氢吲哚衍生物化合物。该化合物能显著降低血浆促黄体激素水平，最高可达49%，同时显示出较低的药代动力学变异性和良好的耐受性，表现出研究子宫肌瘤的潜力。
T76047 TAK-683 TFA

TAK-683 TFA是一种高效的全KISS1R激动剂(IC50=170 pM)，拥有较好的代谢稳定性，是九肽metastin的类似物，对KISS1R有激动效应，其对人和大鼠EC50值分别为0.96 nM和1.6 nM。TAK-683 TFA能够降低下丘脑GnRH水平，进而减少血浆FSH、LH、睾酮的浓度，显示出对激素依赖性前列腺癌研究的可能性。
T68525 Nafarelin acetate hydrate

Others Others
Nafarelin is a gonadotropin-releasing hormone agonist (GnRH agonist) which acts as an analog of GnRH. Nafarelin increases the release of FSH and LH by the anterior pituitary, which in turn leads to an increase of estrogen/progesterone. When administered, Nafarelin has the purpose of causing increase estrogen that will negatively feed back upon hypothalamus to decrease GnRH ( negative feedback loop ) Through negative feedback, Nafarelin causes a decrease in pituitary secretion of gonadotropins lu...
T35794 Kisspeptin-54 (human) (trifluoroacetate salt)

Kisspeptin-54 is a peptide ligand of the orphan G protein-coupled receptor GPR54 (Kis = 1.81 and 1.45 nM for rat and human receptors, respectively).1 It is a 54 amino acid peptide encoded by the metastasis suppressor gene KISS-1. Kisspeptin-54 induces calcium mobilization in CHO-K1 cells expressing rat and human receptors (EC50s = 1.39 and 5.47 nM, respectively). It also induces arachidonic acid release in CHO cells expressing rat and human GPR54 in a concentration-dependent manner. Kisspeptin-5...

化合物

Gonadorelin Acetate (33515-09-2 free base)
Cat.No: T5015
Synonym: 醋酸戈那瑞林,Luteinizing Hormone Releasing Hormone (LH-RH),Luteinizing Hormone Releasing Hormone (LH-RH), human,Gonadorelin Acetate
Target: Reductase
Luteinizing Hormone Releasing Hormone (LH-RH), salmon
Cat.No: TP1112
Synonym: LH-RH, salmon
Target:
LH-RH, salmon acetate(86073-88-3 free base)
Cat.No: TP1112L
Synonym: Luteinizing Hormone Releasing Hormone (LH-RH), salmon acetate
Target: Others
Sufugolix
Cat.No: T3538
Synonym: TAK-013
Target: LHRH
Cetrorelix diacetate
Cat.No: T5520L
Synonym: NS-75A,醋酸西曲瑞克,SB-075 acetate,SB-075 diacetate,Cetrorelix acetate,NS-75A diacetate
Target: GNRH Receptor
Relugolix
Cat.No: T3630
Synonym: RVT-601,瑞卢戈利,TAK-385
Target: GNRH Receptor
Histrelin acetate
Cat.No: TP2107L
Synonym: Histrelin acetate(76712-82-8 free base),醋酸组氨瑞林
Target: GNRH Receptor
Phtstllap
Cat.No: T34055
Synonym:
Target: Others
Teverelix
Cat.No: T28954
Synonym:
Target:
LHRH, Ala(6)-
Cat.No: T25715
Synonym: L 1868,L-1868,L1868
Target: Others
Ramorelix
Cat.No: T26040
Synonym: HOE 013,HOE013,HOE-013
Target: Others
Argtide
Cat.No: T70819
Synonym:
Target: Others
Avorelin acetate
Cat.No: T68700
Synonym:
Target: Others
Avorelin
Cat.No: T26692
Synonym: MF-6001,EP 23904,EP-23904,EP23904,MF6001
Target: Others
[D-Ala6]-LH-RH
Cat.No: T76351
Synonym:
Target: Others
[D-Glp1,D-Phe2,D-Trp3,6]-LH-RH
Cat.No: T76350
Synonym:
Target:
(D-Trp6)-LHRH free acid
Cat.No: T76617
Synonym:
Target:
[Gln8]-C517 (LH-RH), chicken
Cat.No: TP1648
Synonym:
Target:
[D-Phe2,6, Pro3]-LH-RH
Cat.No: T83499
Synonym:
Target:
[D-Lys6]-LH-RH
Cat.No: T76348
Synonym:
Target:
(D-Tyr5,D-Ser(tBu)6,Azagly10)-LHRH
Cat.No: T76620
Synonym:
Target:
(D-Ser(tBu)6,D-Leu7,Azagly10)-LHRH
Cat.No: T76615
Synonym:
Target:
LHRH
Cat.No: T80116
Synonym:
Target: GNRH Receptor
(D-Ser4,D-Ser(tBu)6,Azagly10)-LHRH
Cat.No: T76616
Synonym:
Target:
Human follicular gonadotropin releasing peptide
Cat.No: T82162
Synonym: hF-GRP
Target:
[D-Phe2,D-Ala6]-LH-RH
Cat.No: T83498
Synonym: Wy 18185
Target:
GnRH Associated Peptide (1-24), human
Cat.No: T76324
Synonym:
Target:
Ganirelix
Cat.No: T75991
Synonym:
Target:
GnRH-I
Cat.No: TP1342
Synonym:
Target:
DCOIT
Cat.No: T84706
Synonym: Kathon 930
Target: Others
LH-RH II (chicken)
Cat.No: T76322
Synonym:
Target:
GnRH Associated Peptide (25-53), human
Cat.No: T76323
Synonym:
Target:
Gonadorelin acetate
Cat.No: T85273
Synonym:
Target: Others
(D-Phe12,Nle21,38,α-Me-Leu37)-CRF (12-41) (human, rat)
Cat.No: T76602
Synonym:
Target:
Triptorelin pamoate
Cat.No: T71149
Synonym:
Target: Others
Onvitrelin ucalontide
Cat.No: T76558
Synonym:
Target:
LH-RH (7-10)
Cat.No: T76353
Synonym:
Target:
Dicetrorelix pamoate
Cat.No: T70309
Synonym:
Target: Others
Abarelix acetate
Cat.No: T68701
Synonym:
Target: Others
17α,20β-Dihydroxy-4-pregnen-3-one
Cat.No: T36912
Synonym: 17α,20β-dihydroxy Progesterone,17α,20β-DHP,17α,20β-Dihydroxy-4-pregnen-3-one
Target: Others
BAY 1214784
Cat.No: T72990
Synonym:
Target: Others
TAK-683 TFA
Cat.No: T76047
Synonym:
Target:
Nafarelin acetate hydrate
Cat.No: T68525
Synonym:
Target: Others
Kisspeptin-54 (human) (trifluoroacetate salt)
Cat.No: T35794
Synonym:
Target:
Species：
Human (2)
Mouse (1)
Expression System：
HEK293 Cells (2)
Baculovirus Insect Cells (1)
Tag：
C-6xHis (1)
N-His (1)
N-hFc (1)
Cat. No. Product Name Species Expression System
TMPJ-00017 GNRH2 Protein, Human, Recombinant (His)

GnRH-Associated Peptide 2,LH-RH II,Gonadoliberin-2,GnRH II,L...

 Human HEK293 Cells
Progonadoliberin-2, also known as Progonadoliberin II and GNRH2, belongs to the gonadotropin-releasing hormone family. GNRH2 is specially expressed in midbrain, at significantly higher levels outside the brain (up to 30-fold). GNRH2 can be cleaved into two chains, gonadoliberin-2 and GnRH-associated peptide 2. gonadoliberin-2 regulates reproduction in females by stimulating the secretion of both luteinizing- and follicle-stimulating hormones. The proproteins produce three transcript variants, bu...
TMPY-03269 Prolyl Endopeptidase Protein, Mouse, Recombinant (His)

PEP,AI450383,AI047692,D10Wsu136e,prolyl endopeptidase,Pop

 Mouse Baculovirus Insect Cells
Prolyl endopeptidase, also known as PREP, belongs to a distinct class of serine peptidases. It is a large cytosolic enzyme which was first described in the cytosol of rabbit brain as an oligopeptidase. Prolyl endopeptidase degrades the nonapeptide bradykinin at the Pro-Phe bond. It is involved in the maturation and degradation of peptide hormones and neuropeptides such as alpha-melanocyte-stimulating hormone, luteinizing hormone-releasing hormone (LH-RH), thyrotropin-releasing hormone, angiotens...
TMPY-04307 GNRH2 Protein, Human, Recombinant (hFc)

LH-RHII,gonadotropin releasing hormone...

 Human HEK293 Cells
GNRH2 (Gonadotropin-Releasing Hormone 2) is a Protein Coding gene. This gene is a member of the gonadotropin-releasing hormone (GnRH) gene family. Proteins encoded by members of this gene family are proteolytically cleaved to form neuropeptides which, in part, regulate reproductive functions by stimulating the production and release of the gonadotropins follicle-stimulating hormone (FSH) and luteinizing hormone (LH). 3 alternatively spliced human isoforms have been reported. The second mammalian...

重组蛋白

GNRH2 Protein, Human, Recombinant (His)
Cat.No: TMPJ-00017
Species: Human
Expression System: HEK293 Cells
Prolyl Endopeptidase Protein, Mouse, Recombinant (His)
Cat.No: TMPY-03269
Species: Mouse
Expression System: Baculovirus Insect Cells
GNRH2 Protein, Human, Recombinant (hFc)
Cat.No: TMPY-04307
Species: Human
Expression System: HEK293 Cells
Cat. No. Product Name Target Signaling Pathways
TMIJ-0268 Relugolix-d6

Relugolix-d6 是 Relugolix 的氘代化合物。Relugolix 的 CAS 号为 737789-87-6。Relugolix 是口服有活性的非肽性促性腺激素释放激素的拮抗剂。同 TAK-013 相比，它对人和猴子的受体具有高亲和力和强拮抗活性，它们的IC50值分别为0.33 nM和0.32 nM。它可用于研究性激素依赖性疾病，如子宫肌瘤、子宫内膜异位症、前列腺癌等。

同位素标记化合物

Relugolix-d6
Cat.No: TMIJ-0268
Synonym:
Target:
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