341
74
5
46
7
Cat. No. | Product Name | ||
---|---|---|---|
L2190 | 抗肺癌化合物库 | 1702 compounds | |
1702 种与肺癌相关的化合物,可以用于抗肺癌药物研发和药理研究; | |||
L2192 | 抗胰腺癌化合物库 | 2238 compounds | |
2238 种与胰腺癌相关的化合物,可以用于高通量和高内涵筛选; | |||
L4300 | Wnt/Hedgehog/Notch 通路化合物库 | 237 compounds | |
237 个Wnt & Hedgehog & Notch 靶点相关的生物活性小分子化合物的特有集合,用于相关通路的研究及药物的筛选,可用于高通量、高内涵筛选。 | |||
L2191 | 抗乳腺癌化合物库 | 1939 compounds | |
1939 种与乳腺癌相关的化合物,可以用于抗乳腺癌药物研发和药理研究; | |||
L4600 | 植物来源化合物库 | 3048 compounds | |
3048 个植物来源天然产物的独特集合,来自277类植物的精心之选; |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T9929 |
Ramucirumab
|
VEGFR | Angiogenesis; Tyrosine Kinase/Adaptors |
Ramucirumab 是一种人 VEGFR-2 拮抗剂,具有抗实体瘤活性。它是人源化单克隆抗体,能够与 VEGFR-2 结合,阻碍 VEGFR 配体 VEGF-A,VEGF-C 和 VEGF-D 结合。 | |||
T9552 |
BAZ1A-IN-1
|
Epigenetic Reader Domain | Chromatin/Epigenetic |
BAZ1A-IN-1 是BAZ1A(含溴结构域蛋白)抑制剂(Kd:0.52 μM)。它对低表达BAZ1A 的癌细胞表现出弱活性或无活性,但对高表达BAZ1A 的癌细胞系显示出良好的抗生存作用。 | |||
T8466 |
BC-DXI-843
|
Others | Others |
BC-DXI-843 是特异性 AIMP2-DX2抑制剂(IC50:0.92 μM),比作用于 AIMP2 (IC50 >100 μM) 选择性高 100 倍以上。它具有用于 AIMP2-DX2 肺癌的研究潜力。 | |||
T2455 |
PFK-015
PFK15,PFK 015 |
Glucokinase; Autophagy | Autophagy; Metabolism |
PFK-015 (PFK15) 是一种有效的 PFKFB3 抑制剂,对重组PFKFB3的IC50为110 nM。它能抑制 Y 细胞中的 PFKFB3 活性,IC50为20 nM。 | |||
T10777 |
CG347B
|
HDAC | Chromatin/Epigenetic; DNA Damage/DNA Repair |
CG347B 是一种选择性HDAC6抑制剂。 | |||
T6778 |
BDA-366
|
BCL | Apoptosis |
BDA-366 是一种有效的 Bcl2 拮抗剂,以高亲和力和选择性 (Ki = 3.3 nM) 结合 Bcl2-BH4 结构域。 BDA-366 诱导 Bcl2 的构象变化,从而消除其抗凋亡功能,将其从存活分子转变为细胞死亡诱导剂。 BDA-366 抑制肺癌细胞的生长。 | |||
T2325 |
Neratinib
HKI-272,来那替尼 |
EGFR; HER | Angiogenesis; JAK/STAT signaling; Tyrosine Kinase/Adaptors |
Neratinib (HKI-272) 是一种酪氨酸激酶受体抑制剂,可以抑制 HER2 和 EGFR (IC50=59/92 nM),具有不可逆性和口服活性。Neratinib 具有抗肿瘤活性,可以用于治疗乳腺癌。 | |||
T8310 |
MMP-9-IN-1
|
MMP | Proteases/Proteasome |
MMP-9-IN-1 是特异性的基质金属蛋白酶-9 抑制剂,选择性靶向 MMP-9 的血红素域,对其他 MMP 无影响。 | |||
T23384 |
SR 11302
|
DNA/RNA Synthesis | Cell Cycle/Checkpoint; DNA Damage/DNA Repair |
SR 11302 是一种类视黄醇,是一种激活蛋白-1 转录因子抑制剂,能够特异性抑制 AP-1 活性,而不会激活视黄酸反应元件 (RARE) 的转录。 | |||
T8320 |
J14
J-14 |
Reactive Oxygen Species | Immunology/Inflammation; Metabolism; NF-κB |
J14 是一种可逆的 sulfiredoxin 抑制剂,IC50=8.1 μM。它能够抑制sulfiredoxin 诱导氧化应激,使细胞内ROS 积累,导致细胞毒性和癌细胞死亡。 | |||
T2345 |
PTC-209
PTC209,PTC 209 |
BMI-1; Autophagy | Autophagy; Cell Cycle/Checkpoint; DNA Damage/DNA Repair |
PTC-209 是特定的BMI-1抑制剂,不可逆转地损害结直肠癌起始细胞,在 HEK293T 细胞系中的IC50为 0.5 μM。它有抗骨髓瘤活性并损害肿瘤微环境。 | |||
T14371 |
Barasertib
巴拉塞替,AZD1152 |
Apoptosis; Aurora Kinase | Apoptosis; Cell Cycle/Checkpoint; Chromatin/Epigenetic |
Barasertib (AZD1152) 是 Barasertib-hQPA 的前体药物,在癌细胞中诱导生长停滞和凋亡。它是高度选择性的Aurora B 抑制剂,IC50值为 0.37 nM。 | |||
T28410 |
PHPS1
PHPS-1,PHPS 1 |
Phosphatase | Metabolism |
PHPS1 是 Shp2的选择性抑制剂,对 Shp2,Shp2-R362K,Shp1,PTP1B 和 PTP1B-Q 的 Ki 分别为 0.73,5.8,10.7,5.8 和 0.47 μM。 | |||
T20533 |
NNK
Nicotine-derived nitrosamine ketone |
Lipoxygenase | Metabolism |
NNK (Nicotine-derived nitrosamine ketone) 是尼古丁亚硝化衍生物。它可以激活 ERK1/2和 PKCα,并在 Ser70 激活 Bcl2磷酸化,以及在 Thr58和 Ser62激活 c-Myc。它可用于构建肺癌小鼠模型,以及诱导人肺癌细胞的增殖和存活。 | |||
T21588 |
Olomoucine
|
ERK; CDK | Cell Cycle/Checkpoint; MAPK |
Olomoucine 是 Cdk2/cyclin A、Cdc2/CyclinB、CDK2/CyclinE、CDK5/p35 和 ERK1/p44 MAP 激酶的 ATP 竞争性抑制剂,IC50 分别为 7、7、7、3 和 25 µM。 Olomoucine 调节细胞周期并表现出抗黑色素肿瘤活性。 | |||
T9497 |
Niraparib tosylate monohyrate
|
PARP | Chromatin/Epigenetic; DNA Damage/DNA Repair |
Niraparib tosylate monohyrate 也称为 MK-4827,是一种聚 (ADP-核糖) 聚合酶 (PARP) 抑制剂,具有潜在的抗肿瘤活性。 MK4827 抑制 PARP 活性,增强 DNA 链断裂的积累,促进基因组不稳定性和细胞凋亡。 PARP 蛋白家族通过碱基切除修复 (BER) 途径检测和修复单链 DNA 断裂。 | |||
T14496 |
BAMB-4
ITPKA-IN-C14 |
Others | Others |
BAMB-4 (ITPKA-IN-C14) 是一种新型的膜渗透型ITPKA 抑制剂,在ADP-Glo 实验中的IC50值为37uM。 | |||
T39275 |
Befotertinib
D-0316,Befotertinib |
EGFR | Angiogenesis; JAK/STAT signaling; Tyrosine Kinase/Adaptors |
Befotertinib (D-0316) 是一种 EGFR 酪氨酸激酶抑制剂,可用于 EGFR T790M 阳性非小细胞肺癌的研究。 | |||
T13044 |
Mevociclib
SY-1365 |
CDK | Cell Cycle/Checkpoint |
Mevociclib (SY-1365) 是一种高效选择性 CDK7抑制剂,Ki 值为 17.4 nM。它具有抗血液肿瘤和侵袭性实体肿瘤作用,有抗增殖和凋亡活性。 | |||
T9865 |
Almonertinib mesylate
|
EGFR | Angiogenesis; JAK/STAT signaling; Tyrosine Kinase/Adaptors |
Almonertinib mesylate 是一种不可逆的 EGFR 酪氨酸激酶抑制剂,对 EGFR 敏感突变和 T790M 耐药突变具有高选择性。 它可用于非小细胞肺癌研究。 | |||
T3231 |
Niraparib
尼拉帕尼,MK-4827 |
Apoptosis; Others; PARP | Apoptosis; Chromatin/Epigenetic; DNA Damage/DNA Repair; Others |
Niraparib (MK-4827) 是一种 PARP 抑制剂,可以抑制 PARP1 和 PARP2 (IC50=3.8/2.1 nM),具有选择性。Niraparib 具有抗肿瘤活性,可以抑制 DNA 损伤修复、诱导细胞凋亡。 | |||
T8327 |
ONO-7475
|
Trk receptor; TAM Receptor | Tyrosine Kinase/Adaptors |
ONO-7475 是一种选择性的、有效的、具有口服活性的Axl/Mer 抑制剂。它使 AXL 过表达的EGFR 突变型 NSCLC 细胞对 EGFR-TKIs 敏感,抑制耐药细胞的产生和耐药性的维持。它与 Osimertinib 联合使用,具有用于 EGFR 突变非小细胞肺癌的潜力。 | |||
T2542 |
Prucalopride
R-93877,普芦卡必利,普卡必利 |
5-HT Receptor | GPCR/G Protein; Neuroscience |
Prucalopride (R-93877) 是一种选择性、高亲和力的 5-HT4A/4B 受体激动剂,Ki 为2.5和 8 nM。它对 5-HT4A/4B 受体的选择性是其他 5-HT 受体亚型的 290 倍以上。 | |||
T8756 |
KRAS inhibitor-9
DUN09716 |
Apoptosis; Ras | Apoptosis; GPCR/G Protein; MAPK |
KRAS inhibitor-9 (DUN09716) 是一种 KRAS 抑制剂,阻止 GTP-KRAS 的形成和 KRAS 下游激活。它以中等的结合亲和力与 KRAS G12D、KRAS G12C 和 KRAS Q61H 蛋白结合,选择性抑制具有 KRAS 突变的 NSC-LC 细胞的增殖。它可导致 G2/M 细胞周期停滞并诱导凋亡。 | |||
T16996 |
TAS6417
|
Apoptosis; EGFR | Angiogenesis; Apoptosis; JAK/STAT signaling; Tyrosine Kinase/Adaptors |
TAS6417 是一种高效的、具有口服活性的 EGFR 突变型抑制剂,可独特的结合到 EGFR 铰链区的 ATP 结合位点,其 IC50值为 1.1-8.0 nM。 | |||
T60076 |
Oritinib
SH-1028 |
EGFR | Angiogenesis; JAK/STAT signaling; Tyrosine Kinase/Adaptors |
Oritinib (SH-1028) 是一种 EGFR 抑制剂,对 EGFR (wt)、EGFR (L858R)、EGFR (L861Q)、EGFR (L858R/T790M)、EGFR (d746-750) 的 IC50 分别为 18、0.7、4、0.1、1.4 和 0.89 nM , EGFR (d746-750/T790M), 分别。奥瑞替尼可用于治疗非小细胞肺癌的研究。 | |||
T5462 |
Almonertinib
HS-10296,阿美替尼 |
EGFR | Angiogenesis; JAK/STAT signaling; Tyrosine Kinase/Adaptors |
Almonertinib (HS-10296) 是EGFR 激活突变抑制剂和EGFR T790M 耐受突变抑制剂,对 EGFR 致敏和 T790M 耐药突变具有高选择性,用于非小细胞肺癌的研究。它对 T790M、T790M/L858R 和 T790M/Del19 表现出较强的抑制活性,对野生型的抑制作用较弱。 | |||
T0459 |
Sulindac
Arthrocine,MK-231,舒林酸,Clinoril,Sulindac sulfoxide |
COX; Autophagy | Autophagy; Immunology/Inflammation; Neuroscience |
Sulindac (Sulindac sulfoxide) 是一种非甾体类抗炎剂,可抑制COX-2的活性,也可抑制 COX-2 的过表达。它是一种亚磺酰基茚衍生物前药,具有潜在的抗肿瘤活性。 | |||
T16545 |
Pivanex
Pivalyloxymethyl butyrate,AN-9 |
Apoptosis; HDAC; Bcr-Abl | Angiogenesis; Apoptosis; Chromatin/Epigenetic; Cytoskeletal Signaling; DNA Damage/DNA Repair; Tyrosine Kinase/Adaptors |
Pivanex (Pivalyloxymethyl butyrate) 是丁酸的一种衍生物,是具有口服活性的 HDAC 抑制剂。Pivanex 通过下调 bcr-abl 蛋白增强凋亡。Pivanex 显示出抗转移和抗血管生成的活性。 | |||
T8656 |
CAY10404
3-(4-METHYLSULPHONYLPHENYL)-4-PHENYL-5-T |
Apoptosis; Akt; COX | Apoptosis; Cytoskeletal Signaling; Immunology/Inflammation; Neuroscience; PI3K/Akt/mTOR signaling |
CAY10404 (3-(4-METHYLSULPHONYLPHENYL)-4-PHENYL-5-T) 是一种有效且高度选择性的 COX-2 和 COX-1 抑制剂。 它还是 PKB/Akt 和 MAPK 信号通路的有效抑制剂,可诱导 NSC-LC 细胞凋亡,具有镇痛、抗炎和抗癌活性。 | |||
T1602 |
Valproic acid sodium salt
丙戊酸钠,Sodium Valproate |
Mitophagy; Gamma-secretase; HIV Protease; GABA Receptor; HDAC; Autophagy | Autophagy; Chromatin/Epigenetic; DNA Damage/DNA Repair; Membrane transporter/Ion channel; Microbiology/Virology; Neuroscience; Proteases/Proteasome; Stem Cells |
Valproic acid sodium salt (Sodium Valproate) 是一种HDAC 抑制剂,可抑制HDAC1的活性,诱导HDAC2的降解。它激活Notch1信号并抑制小细胞肺癌细胞的增殖。它可研究癫痫、偏头痛和双相情感障碍等。 | |||
T3353 |
Niraparib hydrochloride
尼拉帕利盐酸盐,MK-4827 hydrochloride,MK-4827 (hydrochloride) |
Apoptosis; Others; PARP | Apoptosis; Chromatin/Epigenetic; DNA Damage/DNA Repair; Others |
Niraparib hydrochloride (MK-4827 hydrochloride) 是一种具有口服活性的PARP1和PARP2抑制剂,IC50值分别为 3.8 nM 和 2.1 nM。它抑制 DNA 损伤修复,诱导凋亡并具有抗肿瘤活性。 | |||
T9533 |
BC-LI-0186
4-(2,3-dimethyl-5-oxo-4-propan-2-ylpyrazol-1-yl)-N-(2-phenoxyethyl)benzenesulfonamide |
Others | Others |
BC-LI-0186 (4-(2,3-dimethyl-5-oxo-4-propan-2-ylpyrazol-1-yl)-N-(2-phenoxyethyl)benzenesulfonamide) 是选择性抑制亮氨酸 tRNA 合成酶与 Ras 相关的 GTP 结合蛋白 D 相互作用(IC50=46.11 nM)。BC-LI-0186能有效抑制肿瘤相关 MTOR 突变体的特性和雷帕霉素耐药癌细胞的生长,能够用于肺癌的相关研究。 | |||
T2602 |
Barasertib-HQPA
1H-Pyrazole-3-acetamide,Barasertib,AZD1152-HQPA,AZD2811,AZD1152-HQPA|AZD2811 |
Apoptosis; Aurora Kinase | Apoptosis; Cell Cycle/Checkpoint; Chromatin/Epigenetic |
Barasertib-HQPA (AZD2811) 是一种高度选择性的极光激酶B 抑制剂,在非细胞试验中IC50值为0.37 nM。它可阻滞癌细胞生长,诱导凋亡。 | |||
T0373 |
Erlotinib
OSI-744,NSC 718781,CP358774,埃罗替尼,R1415 |
EGFR; Autophagy | Angiogenesis; Autophagy; JAK/STAT signaling; Tyrosine Kinase/Adaptors |
Erlotinib (CP358774) 是一种 EGFR 一代抑制剂,抑制 EGFR 19 Del 和 L858R 突变。Erlotinib 具有抗肿瘤活性,用于治疗 EGFR 突变的非小细胞肺癌。Erlotinib 用药会产生 EGFR C797S 耐药突变。 | |||
T6474 |
Divalproex Sodium
Valproate semisodium,Epival,双丙戊酸钠 |
HDAC | Chromatin/Epigenetic; DNA Damage/DNA Repair |
Divalproex Sodium (Valproate semisodium) 结合并抑制 γ-氨基丁酸 (GABA) 转氨酶,其抗惊厥活性可通过增加 GABA 脑浓度和抑制分解 GABA 或阻止 GABA 再摄取到神经胶质和神经末梢的酶来发挥。它也是一种 HDAC 抑制剂。由丙戊酸钠和丙戊酸组成,具有抗惊厥和抗癫痫活性。 Divalproex 还可以通过抑制电压敏感的钠通道来抑制重复的神经元放电。 | |||
T21312 |
Afatinib
阿法替尼,Afatinib free base,BIBW 2992 |
EGFR; Autophagy | Angiogenesis; Autophagy; JAK/STAT signaling; Tyrosine Kinase/Adaptors |
Afatinib (BIBW 2992) 是一种不可逆的 EGFR 家族抑制剂,抑制 EGFRwt、EGFRL858R、EGFRL858R/T790M 和 HER2的 IC50分别为0.5 nM、0.4 nM、10 nM 和 14 nM。 | |||
T9003 |
CVT-11127
N-[2-[6-[[(3,4-二氯苯基)甲基]氨基]-2-(4-甲氧基苯基)-3-氧代-3,4-二氢吡啶并[2,3-B]吡嗪-4-基]乙基]乙酰胺 |
Dehydrogenase | Metabolism |
CVT-11127 是 SCD 抑制剂。它将细胞周期阻滞在 G1/S 期,诱导细胞凋亡。它可用于肺癌的研究。 | |||
T6892 |
Niraparib tosylate
尼拉帕利,MK-4827 (tosylate),MK 4827 tosylate,Niraparib (MK-4827) tosylate,尼拉帕尼对苯甲磺酸盐 |
Apoptosis; PARP | Apoptosis; Chromatin/Epigenetic; DNA Damage/DNA Repair |
Niraparib tosylate (MK-4827(tosylate)) 是一种高效的,具有生物口服利用度的PARP1和PARP2抑制剂,IC50分别为 3.8 和 2.1 nM。它抑制 DNA 损伤修复,诱导凋亡并具有抗肿瘤活性。 | |||
T1773 |
Afatinib Dimaleate
马来酸阿法替尼,双马来酸盐阿法替尼,BIBW2992,Afatinib,BIBW 2992MA2,Afatinib (BIBW2992) Dimaleate |
EGFR; HER; Autophagy | Angiogenesis; Autophagy; JAK/STAT signaling; Tyrosine Kinase/Adaptors |
Afatinib Dimaleate (BIBW 2992MA2) 是一种可口服的苯胺基-喹唑啉衍生物和受体酪氨酸激酶表皮生长因子受体家族的抑制剂,具有抗肿瘤活性。它抑制 EGFRwt、EGFRL858R、EGFRL858R/T790M 和 HER2的 IC50分别为0.5 nM、0.4 nM、10 nM 和 14 nM。 | |||
T9304 |
(S)-Sunvozertinib
N-[5-[[4-[5-Chloro-4-fluoro-2-(2-hydroxypropan-2-yl)anilino]pyrimidin-2-yl]amino]-2-[(3S)-3-(dimethylamino)pyrrolidin-1-yl]-4-methoxyphenyl]prop-2-enamide,DZD9008 |
EGFR; HER | Angiogenesis; JAK/STAT signaling; Tyrosine Kinase/Adaptors |
(S)-Sunvozertinib (DZD9008) 是 Sunvozertinib 的 S-对映体,能够抑制EGFR 外显子 20 NPH 和 ASV 插入、EGFR L858R/T790M 突变及 Her2 外显子 20 YVMA 插入,也能够抑制BTK。 | |||
T6178 |
PTC-209 hydrobromide
PTC-209 HBr |
BMI-1; Autophagy | Autophagy; Cell Cycle/Checkpoint; DNA Damage/DNA Repair |
PTC-209 hydrobromide (PTC-209 HBr) 是一种特定的BMI-1抑制剂,能不可逆转地损害结直肠癌起始细胞,也可损害肿瘤微环境,有抗骨髓瘤活性。它在 HEK293T 细胞系中的IC50为 0.5 μM。 | |||
T5675 |
Almonertinib hydrochloride
HS-10296 hydrochloride,盐酸阿美替尼 |
EGFR | Angiogenesis; JAK/STAT signaling; Tyrosine Kinase/Adaptors |
Almonertinib hydrochloride (HS-10296 hydrochloride) 是一种 EGFR 激活突变和 T790M 耐药突变的小分子抑制剂,用于非小细胞肺癌的研究,对 T790M、T790M/L858R 和 T790M/Del19 表现出较强的抑制活性,对野生型的抑制作用较弱。 | |||
T1758 |
ABT-751
E7010 |
Microtubule Associated; Autophagy | Autophagy; Cytoskeletal Signaling |
ABT-751 (E7010) 是一种新型的生物相容性的微管蛋白结合剂,用于治疗肺癌、非小细胞肺癌和非小细胞肺癌。它是磺胺类抗有丝分裂抑制剂,对神经母细胞瘤细胞株和非神经母细胞瘤细胞株的IC50分别为1.5 和 3.4 μM。 | |||
T7351 |
3-Methylcytidine
|
Nucleoside Antimetabolite/Analog | Cell Cycle/Checkpoint; DNA Damage/DNA Repair |
3-Methylcytidine 是一种尿核苷,作为四种不同类型癌症的生物标志物:肺癌、胃癌、结肠癌和乳腺癌。 | |||
T23867 |
Cdc7-IN-7c
Cdc7 inhibitor-7c,Cdc7 inhibitor 7c,Cdc7 IN 7c |
CDK | Cell Cycle/Checkpoint |
Cdc7-IN-7c (Cdc7 inhibitor-7c) 具有抗肿瘤活性,对肝癌,肺癌,肾癌,脑癌,宫颈癌有抑制作用。 | |||
T15390 |
Glufosfamide
D 19575,Glucosylifosfamide mustard |
Others | Others |
Glufosfamide 是一种新型噁唑磷胺化合物,具有抗癌活性,可用于研究晚期非小细胞肺癌。 | |||
T13602 |
CDDO-2P-Im
CDDO-2-P-Im |
Others | Others |
CDDO-2P-Im 在小鼠肺癌模型中显示出化学预防作用并降低了肺肿瘤的大小和严重程度。 | |||
T67934 |
MRT-2359
|
Others | Others |
MRT-2359 是一种有效的且可口服的 GSPT1 降解剂,具有抗肿瘤活性。MRT-2359 对耐药非小细胞肺癌 (NSCLC) 和小细胞肺癌 (SCLC) 细胞的生长具有抑制作用。MRT-2359 在 MYC 驱动的细胞系中表现出优先活性。 | |||
T11770 |
KRAS G12C inhibitor 16
|
Ras | GPCR/G Protein; MAPK |
KRAS G12C inhibitor 16 是一种高效的 KRAS G12C 抑制剂,具有潜在的抗癌抗肿瘤活性,抑制癌细胞增殖,可用于研究肺癌。 |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T3862 |
Irigenin
|
NF-κB; Integrin | Cytoskeletal Signaling; NF-κB |
Irigenin 可通过特异性和选择性地阻断 Extra Domain A 域的 C-C 环上α9β1和α4β1整合素结合位点,介导其抗转移作用。可通过增强胃癌细胞中促凋亡分子的表达来敏化 TRAIL 诱导的凋亡,具有抗癌作用。 | |||
TN1153 |
Polyporenic acid C
猪苓酸C,聚孔酸C |
Apoptosis; PARP; Caspase; PI3K | Apoptosis; Chromatin/Epigenetic; DNA Damage/DNA Repair; PI3K/Akt/mTOR signaling; Proteases/Proteasome |
Polyporenic acid C 是从茯苓中分离出的一种羊毛甾烷型三萜,可通过死亡受体介导的凋亡途径诱导细胞凋亡,有用于肺癌的研究潜力。 | |||
T5739 |
Paederosidic acid
鸡屎藤苷酸,异戊二酸 紫草酸 |
Apoptosis; BCL | Apoptosis |
Paederosidic acid 是从鸡矢藤分离出的一种天然产物,通过诱导线粒体介导的凋亡抑制肺癌细胞,具有显着的抗肿瘤、抗惊厥和镇静作用。 | |||
T5061 |
Lumichrome
7,8-Dimethylalloxazine,光色素 |
Apoptosis; Endogenous Metabolite | Apoptosis; Metabolism |
Lumichrome 是人类体内的内源性化合物,由核黄素光降解产生。它利用p53 依赖机制抑制人肺癌细胞生长并诱导凋亡。 | |||
T4S1173 |
Agrimol B
仙鹤草酚B,仙鹤草酚 B |
Sirtuin; PPAR | Chromatin/Epigenetic; DNA Damage/DNA Repair; Metabolism |
Agrimol B 是从仙鹤草中分离得到的一种多酚衍生物,可抑制脂肪形成,降低PPARγ的表达,诱导SIRT1易位和表达。 | |||
T1181 |
Gefitinib
ZD1839,吉非替尼 |
EGFR; Tyrosine Kinases; Autophagy | Angiogenesis; Autophagy; JAK/STAT signaling; Tyrosine Kinase/Adaptors |
Gefitinib (ZD1839) 是一种 EGFR 一代抑制剂,具有口服活性,抑制 EGFR 19 Del 和 L858R 突变。Gefitinib 具有抗肿瘤活性,用于治疗 EGFR 突变的非小细胞肺癌。Gefitinib 用药会产生 EGFR C797S 耐药突变。 | |||
T2870 |
Matrine
Vegard,苦参碱,Matridin-15-one,Matrinium,α-Matrine,(+)-Matrine |
Mitophagy; Ferroptosis; Opioid Receptor; Autophagy | Apoptosis; Autophagy; Endocrinology/Hormones; GPCR/G Protein; Neuroscience |
Matrine (Vegard) 是一种从槐属植物中分离出来的生物碱,可作为一种κ阿片受体激动剂,有抗肿瘤活性。 | |||
T7064 |
Valproic Acid
Sodium valproate,2-Propylpentanoic Acid,丙戊酸,VPA,Depakine,2-Propylvaleric Acid |
Mitophagy; Gamma-secretase; HIV Protease; GABA Receptor; Sodium Channel; HDAC; Autophagy | Autophagy; Chromatin/Epigenetic; DNA Damage/DNA Repair; Membrane transporter/Ion channel; Microbiology/Virology; Neuroscience; Proteases/Proteasome; Stem Cells |
Valproic Acid (2-Propylpentanoic Acid) 是一种 HDAC 抑制剂,可抑制 HDAC1 活性,诱导 HDAC2 降解,具有口服活性。Valproic Acid 可以用于癫痫和躁郁症的研究。 | |||
T2S0618 |
β-Elemonic Acid
3-oxo Tirucallic Acid,β-岚香酮酸,Beta-Elemonic acid,3-Oxotirucallenoic Acid,β-榄香酮酸,Elemadienonic Acid |
Apoptosis; Reactive Oxygen Species; COX | Apoptosis; Immunology/Inflammation; Metabolism; Neuroscience; NF-κB |
β-Elemonic Acid (3-Oxotirucallenoic Acid) 是从乳香树中分离得到的一种三萜,具有抗癌和抗炎作用。它抑制脯氨酰内肽酶,诱导细胞凋亡,活性氧和COX-2表达。 | |||
T19581 |
Tiglyl carnitine
|
Endogenous Metabolite | Metabolism |
Tiglyl carnitine 与肺癌和肉碱和甘氨酸对3-酮硫解酶缺乏症有关 。 | |||
T3425 |
Polyphyllin G
重楼皂苷VII,Polyphyllin VII,Polyphyllin VII,Y-0166,重楼皂苷G |
Others | Others |
Polyphyllin G (Polyphyllin VII) 是从Paris yunnanensis 的根茎中分离出来的,具有抗菌活性,抑制革兰氏阳性和革兰氏阴性细菌的生长。它是polyphyllin 家族的主要成员,对肺癌、乳腺癌、结直肠癌、宫颈癌、肝细胞癌和骨肉瘤等多种癌症具有很强的抗癌活性。 | |||
T7849 |
Norspermine
|
Others | Others |
Norspermine 是一种多胺类似物,用于治疗非小细胞肺癌和乳腺癌。 | |||
T25192 |
Butyrolactone I
Olomoucin,丁酸内酯I |
CDK | Cell Cycle/Checkpoint |
Butyrolactone I (Olomoucin) 是 CDK 和 cdc2 激酶家族的 ATP 竞争性抑制剂。 Butyrolactone I 在非小细胞肺、小细胞肺和前列腺癌细胞系中显示出抗肿瘤作用。 | |||
TJS0339 |
Coumarin-3-carboxylic acid
香豆素-3-羧酸,3-Carboxycoumarin |
VEGFR | Angiogenesis; Tyrosine Kinase/Adaptors |
Coumarin-3-carboxylic acid (3-Carboxycoumarin) 是一种合成香豆素的重要起始化合物。其中香豆素是具有多种生物活性的天然产物。它的镧系复合物对 K-562 细胞具有抗增殖活性。 | |||
T7990 |
9-hydroxy-4-androstene-3,17-dione
|
Others | Others |
9-hydroxy-4-androstene-3,17-dione 是一种类固醇激素,具有抗肿瘤活性,可以抑制多种癌症细胞的生长,包括乳腺癌、前列腺癌和肺癌细胞。 | |||
TN6771 |
Malabaricone B
|
Others | Others |
Malabaricone B 是一种源自香料的酚类物质,它通过不依赖 p53 的途径诱导肺癌细胞中的线粒体损伤。 | |||
T6S1010 |
Allomatrine
槐定碱,别苦参碱 |
Others | Others |
Allomatrine 是一种来源槐花树皮的生物碱。它能够激活 κ-阿片受体,进而产生缓解疼痛的作用。 | |||
TJP2872 |
Acevaltrate
Acevaltratum,乙酰缬草三酯,Acetoxyvaltrate |
ATPase; Others | Membrane transporter/Ion channel; Others |
Acevaltrate (Acevaltratum) 对人小细胞肺癌细胞系 GLC(4) 和人结肠直肠癌细胞系 COLO 320 具有高细胞毒性,IC50 值为 1-6 uM。它抑制大鼠肾和脑半球中 Na+/K+-ATP 酶活性,IC50分别为 22.8 和 42.3 μM。 | |||
T5S1982 |
Periplocin
Periplocoside,杠柳毒苷 |
Apoptosis; Others | Apoptosis; Others |
Periplocin (Periplocoside) 是从黑龙骨中分离出的一种强心类固醇。它可促进肿瘤细胞凋亡并抑制肿瘤生长。它通过激活 Na/K-ATPase 介导的 Src/ERK 和 PI3K/Akt 途径,具有促进伤口愈合的潜力。 | |||
T5646 |
Cinnamic acid
3-Phenylacrylic acid,β-Phenylacrylic acid,肉桂酸 |
Endogenous Metabolite | Metabolism |
Cinnamic acid (β-Phenylacrylic acid) 在癌症干预中具有潜在的应用价值,对胶质母细胞瘤,黑色素瘤,前列腺癌,肺癌细胞的IC50=1-4.5 mM。 | |||
TN5254 |
Wighteone
Erythrinin B,6-Isopentenylgenistein |
Antifungal | Microbiology/Virology |
Wighteone (Erythrinin B) 是一种从 Genista ephedroides 中提取出来的小分子化合物,具有潜在的抗真菌和抗癌活性,对 EGFR L858R/T790M 突变非小细胞肺癌具有抗肿瘤作用。。 | |||
T4S0998 |
Trifolirhizin
红车轴草根甙/三叶豆紫檀苷,三叶豆紫檀苷 |
TNF; Tyrosinase | Apoptosis; Proteases/Proteasome |
Trifolirhizin 是一种从苦参根中分离出的 pterocarpan 黄酮类化合物。它具有酪氨酸酶高抑制活性,IC50=506 μM。它具有抗炎和抗癌的潜能。 | |||
TMA2474 |
δ-Tocotrienol
Delta-Tocotrienol,δ-生育三烯酚 |
ERK; BCL; VEGFR; Akt; PI3K; PDK; p53 | Angiogenesis; Apoptosis; Cytoskeletal Signaling; MAPK; PI3K/Akt/mTOR signaling; Tyrosine Kinase/Adaptors |
δ-Tocotrienol (Delta-Tocotrienol) 是一种维生素 E,存在于蔬菜,水果,种子,坚果,谷物和油等。维生素 E 是抗氧化剂、神经保护剂和抗癌剂,可以降低胆固醇和其他脂质,保护心血管疾病。 | |||
TN1393 |
(-)-Anonaine
番荔枝碱 |
Apoptosis; Antioxidant; Parasite; Antifungal | Apoptosis; Microbiology/Virology; oxidation-reduction |
(-)-Anonaine 可从木兰科和安妮科的几个物种中提取出来,具有抗疟、抗菌、抗真菌、抗氧化、抗癌、抗抑郁和血管舒张的活性。(-)-Anonaine 通过 Bax 和 caspase 依赖性途径诱导人类宫颈癌(HeLa)细胞的凋亡,诱导 DNA 损伤并抑制人类肺癌 h1299细胞的生长和迁移。 | |||
TN1721 |
Gypenoside L
|
ERK; p38 MAPK; Calcium Channel; NF-κB; ROS | Immunology/Inflammation; MAPK; Membrane transporter/Ion channel; Metabolism; NF-κB |
Gypenoside L 是存在于绞股蓝中的一种皂苷,可增加 SA-β-半乳糖苷酶活性,促进衰老相关分泌细胞因子的产生。它还可以激活p38和ERK MAPK 通路和NF-κB 通路以诱导衰老,具有抗肿瘤和抗炎活性。 | |||
T7027 |
EURYCOMANONE
东革阿里提取物,Pasakbumin A |
Others | Others |
Eurycomanone (Pasakbumin A) 能够抑制雌激素生成过程中磷酸二酯酶和芳香酶的活性,促进精子生成。它对 HepG2 细胞具有细胞毒性,能够上调 p53 和 Bax 以及下调 Bcl-2 ,诱导细胞凋亡。它具有抗癌活性,在浓度范围内以剂量依赖性方式抑制 A549 肺癌细胞增殖 从 5 到 20 微克/毫升。 | |||
T75643 |
Isoxanthohumol
|
HSV | Microbiology/Virology |
Isoxanthohumol 是一种从啤酒花和啤酒中提取的一种前黄酮类化合物,对几种人类癌细胞株具有抗增殖活性。Isoxanthohumol对肿瘤细胞肺转移灶的转移或侵袭有抑制作用。Isoxanthohumol具有抗病毒活性,对疱疹病毒(HSV1和HSV2)和牛病毒性腹泻病毒(BVDV)具有抑制作用。 | |||
T1660 |
Silibinin
水飞蓟宾 A,水飞蓟宾,Silibinin A,Silybin,Silymarin I |
Reactive Oxygen Species; Autophagy | Autophagy; Immunology/Inflammation; Metabolism; NF-κB |
Silibinin (Silybin) 是水飞蓟的主要活性成分,具有抗癌和化疗预防作用,能抑制细胞增殖和迁移。 | |||
T5679 |
(E)-Ferulic acid
trans-Ferulic acid,反式阿魏酸,(E)-Coniferic acid |
BCL; Ferroptosis; Wnt/beta-catenin; Endogenous Metabolite | Apoptosis; Cytoskeletal Signaling; Metabolism; Stem Cells |
(E)-Ferulic acid ((E)-Coniferic acid) 是阿魏酸的异构体,阿魏酸是在植物细胞壁中丰富存在的芳香族天然产物。 它引起 β-catenin 的磷酸化,导致其蛋白酶体降解,增加促凋亡因子 Bax 的表达,降低促生存因子的表达。它在人肺癌细胞系 H1299 中发挥抗增殖和抗迁移作用。 | |||
T0186 |
Docetaxel trihydrate
RP-56976 (Trihydrate),RP56976 (NSC 628503) Trihydrate,多西他赛三水合物 |
Apoptosis; BCL; Microtubule Associated | Apoptosis; Cytoskeletal Signaling |
Docetaxel trihydrate (RP-56976 Trihydrate) 是一种抗肿瘤试剂,抑制微管解聚的IC50值为 0.2 μM。它是紫杉醇的半合成类似物,能减弱 bcl-2 和 bcl-xL 基因表达的影响。它阻滞G2/M 细胞周期,导致细胞凋亡。 | |||
TN3972 |
Epimedokoreanin B
|
Apoptosis; Others; Antibacterial | Apoptosis; Microbiology/Virology; Others |
Epimedokoreanin B (EKB) 是一种从韩国淫羊藿中分离出的异戊烯化类黄酮,在人非小细胞肺癌(NSCLC)A549和NCI-H292细胞中展现出抗癌活性。Epimedokoreanin B 还具有抗炎和抗菌活性,可有清除 DPPH 自由基的活性,能以剂量依赖的方式抑制 MCF-7 和 HepG2 的增殖。Epimedokoreanin B 能显著抑制 N (δ) -(羧甲基)赖氨酸(CML)和 N (Ï) -(羧甲基)精氨酸(CMA)的形成,可通过抑制高级糖化终产物(AGEs)预防糖尿病的临床并发症。 | |||
T15011 | Creatine riboside | Others | Others |
Creatine riboside, a urinary metabolite, is a diagnostic and prognostic biomarker of lung cancer. | |||
TN1889 |
Lupalbigenin
|
ERK; Akt; Topoisomerase | Cytoskeletal Signaling; DNA Damage/DNA Repair; MAPK; PI3K/Akt/mTOR signaling |
Lupalbigenin sensitizes detachment-induced cell death in human lung cancer cell through down-regulation of pro-survival proteins. | |||
TN5684 |
5,6-Desmethylenedioxy-5-methoxyaglalactone
|
||
5,6-Desmethylenedioxy-5-methoxyaglalactone is cytotoxic to small cell lung cancer (NCI-H187) cell line. It has antimycobacterial activity against Mycobacterium tuberculosis H(37)Ra. | |||
TN4603 |
Myricanol
|
BCL; VEGFR; Caspase; HIF | Angiogenesis; Apoptosis; Chromatin/Epigenetic; Proteases/Proteasome; Tyrosine Kinase/Adaptors |
Myricanol can elicit growth inhibitory and cytotoxic effects on lung cancer cells, it can significantly decelerate tumor growth in vivo by inducing apoptosis. | |||
TN4352 |
Jatamanvaltrate B
|
Others | Others |
Jatamanvaltrate B shows cytotoxicity against lung adenocarcinoma (A549), metastatic prostate cancer (PC-3M), colon cancer (HCT-8),and hepatoma (Bel7402) cell lines. | |||
T40708 |
Neoanhydropodophyllol
|
Others | Others |
Neoanhydropodophyllol, a cyclolignan derivative, exhibits potent antineoplastic activity by exerting cytotoxic effects on various cancer cell lines including leukemia, lung carcinoma, and colon carcinoma. | |||
TN4261 |
Isoaltenuene
|
Antifection | Microbiology/Virology |
Isoaltenuene shows antibiotic activity against Gram-positive bacteria; it also shows a minor phytotoxic activity on tomato leaves at level of 20 ug/spot . Isoaltenuene exhibits cytotoxic activity against lung cancer cell line A549, breast cancer cell line | |||
TN3355 |
Agatharesinol acetonide
|
Antifection | Microbiology/Virology |
Agatharesinol acetonide shows anticancer activity towards the A549 non-small-cell lung-cancer cell line (IC50 = 27.1 microM). | |||
TN3424 |
Antiquorin
|
Others | Others |
Antiquorin exhibits moderate cytotoxic activities against the human lung cancer 95-D cell line with the IC50 value of 34.5 uM. | |||
TN3646 |
Chlorovaltrate K
|
Others | Others |
Chlorovaltrate K shows moderate cytotoxicity against lung adenocarcinoma (A 549), metastatic prostate cancer (PC-3M), colon cancer (HCT-8) and hepatoma (Bel 7402) cell lines with IC50 values of 0.89-9.76 uM. | |||
TN3560 |
Cabralealactone
|
Antifection | Microbiology/Virology |
Cabralealactone displays antimycobacterial activity against Mycobacterium tuberculosis, it is weakly cytotoxic to a breast cancer (BC) cell line, it is moderately active against a small-cell lung cancer (NCI-H187) cell line. | |||
TN5249 |
Volvaltrate B
|
Others | Others |
Volvaltrate B shows cytotoxic activity against the lung adenocarcinoma (A549), metastatic prostate cancer (PC-3M), colon cancer (HCT-8), and hepatoma (Bel7402) cell lines, with IC50 values of 8.5, 2.0, 3.2, and 6.1 uM, respectively. | |||
TN6062 |
1,3,9-Trimethyluric acid
|
||
1,3,9-Trimethyluric acid exhibits in vitro cytotoxic activity against breast cancer (MCF-7), human neuroblastoma (SHSY5Y), human non-small cell lung cancer (A549) and human liver cancer (HEPG2) with IC50 value in the range of 1-3 uM. 1,3,9-Trimethyluric a | |||
TN1642 |
Ferruginol
铁锈罗汉柏醇 |
BCL; PARP; Caspase | Apoptosis; Chromatin/Epigenetic; DNA Damage/DNA Repair; Proteases/Proteasome |
Ferruginol has anti-plasmodial, leishmanicidal, anti-ulcerogenic, cardioprotective, anticancer, anti-oxidative and anti-inflammatory activities, it can induce apoptosis in non-small cell lung cancer (NSCLC) cells. | |||
TN2492 |
1,4,5,6-Tetrahydroxy-7,8-diprenylxanthone
|
Others | Others |
1,4,5,6-Tetrahydroxy-7,8-diprenylxanthone has moderate cytotoxicities against breast cancer (MDA-MB-435S) and lung adenocarcinoma (A549) cell lines, but lacks antifungal activity against Candida albicans. | |||
T83110 |
Angulatin K
|
||
Angulatin K为Celastrus angulatus根皮中发现的天然倍半萜多元醇酯。 | |||
TN2493 | 1,4,5,6-Tetrahydroxy-7-prenylxanthone | Others | Others |
1,4,5,6-Tetrahydroxy-7-prenylxanthone has anti-cancer activity, it shows moderate cytotoxicities against breast cancer (MDA-MB-435S) and lung adenocarcinoma (A549) cell lines; it also exhibits moderate activities with GI50 (Growth inhibitory) values of 2. | |||
TN4355 |
Jolkinol A
|
Others | Others |
Jolkinol A can inhibit both MCF-7 (breast adenocarcinoma), NCI-H460 (non-small cell lung cancer) cell lines, with GI50 values ranging between 40.9 microM and 95.3 microM. | |||
T81951 |
Lanosta-7,9(11),24-trien-3α-hydroxy-26-oic acid
|
||
Lanosta-7,9(11),24-trien-3α-hydroxy-26-oic acid,亦称为灵芝酸24,展现了强大的细胞毒性能,能够抑制多种癌细胞株的增殖,包括人肺癌细胞CH27、黑色素瘤细胞M21和口腔癌细胞HSC-3。 | |||
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Cat. No. | Product Name | Species | Expression System |
---|---|---|---|
TMPH-01594 |
CT83 Protein-VLP, Human, Recombinant (His)
CXorf61,KK-LC-1,Cancer/testis antigen 83,Kita-kyush... |
Human | HEK293 Cells |
CT83 Protein-VLP, Human, Recombinant (His) is expressed in HEK293. | |||
TMPH-01593 |
CT83 Protein, Human, Recombinant (E. coli, His)
CXorf61,Kita-kyushu lung cancer antigen 1,... |
Human | E. coli |
CT83 Protein, Human, Recombinant (E. coli, His) is expressed in E. coli. | |||
TMPH-01357 |
ALDOA Protein, Human, Recombinant (His)
Muscle-type aldolase,Lung cancer antigen N... |
Human | E. coli |
Plays a key role in glycolysis and gluconeogenesis. In addition, may also function as scaffolding protein. ALDOA Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 45.3 kDa and the accession number is P04075. | |||
TMPH-01498 |
HJURP Protein, Human, Recombinant (His & SUMO)
14-3-3-associated AKT substrate,Up-regulated in lung |
Human | E. coli |
HJURP Protein, Human, Recombinant (His & SUMO) is expressed in E. coli. | |||
TMPJ-00281 |
CADM1 Protein, Mouse, Recombinant (hFc)
IgSF4,NECL-2,Nectin-like protein 2,Immunoglobulin superfamil... |
Mouse | HEK293 Cells |
Cell adhesion molecule 1(CADM1) is a single-pass type I membrane protein and belongs to the nectin family. It contains 2 Ig-like C2-type (immunoglobulin-like) domains and 1 Ig-like V-type (immunoglobulin-like) domain. CADM1 acts as a tumor suppressor in non-small-cell lung cancer (NSCLC) cells. Interaction with CRTAM promotes natural killer (NK) cell cytotoxicity and interferon-gamma (IFN-gamma) secretion by CD8+ cells in vitro as well as NK cell-mediated rejection of tumors expressing CADM3 in... | |||
TMPY-03958 |
TGF alpha Protein, Human, Recombinant
transforming growth factor α,转化生长因子,transforming growth fact... |
Human | E. coli |
The miR-137 served as a tumor suppressor in non-small cell lung cancer (NSCLC) and its suppressive effect is mediated by repressing TGFA expression. TGFA gene expression was significantly higher in tumor tissues compared to adjacent normal tissue and high TGFA gene expression strongly correlated with poor survival in patients with lung adenocarcinoma, and miR-374a suppresses lung adenocarcinoma cell proliferation and invasion via targeting TGFA gene expression. Transforming growth factor alpha (... | |||
TMPY-02869 |
MMP-12 Protein, Human, Recombinant (catalytic domain)
HME,ME,MMP-12,MME,matrix metallopeptidase 12 |
Human | E. coli |
Matrix metalloproteinases (MMPs) are a family of zinc-dependent endopeptidases that degrade components of the extracellular matrix (ECM) and play essential roles in various physiological processes such as morphogenesis, differentiation, angiogenesis, and tissue remodeling, as well as pathological processes including inflammation, arthritis, cardiovascular diseases, pulmonary diseases, and tumor invasion. Macrophage Metalloelastase, also known as Matrix metalloproteinase-12, Macrophage elastase, ... | |||
TMPY-02028 |
RON/CD136 Protein, Human, Recombinant (His)
CD136,macrophage stimulating 1 receptor,CDw136,PTK8,RON |
Human | HEK293 Cells |
The tyrosine kinase receptor, macrophage-stimulating 1 receptor (MST1R), a c-met-related tyrosine kinase, also known as the Ron receptor or CD136, controls cell survival and motility programs related to invasive growth. As the tyrosine kinase receptor is comprised of an extracellular domain, MST1R protein contains the ligand-binding pocket and an intracellular region where the kinase domain is located. MST1R signaling may be involved in the regulation of macrophage and T-lymphocyte activation in... | |||
TMPY-00539 |
GSTA1 Protein, Human, Recombinant (His)
glutathione S-transferase alpha 1,GTH1,GST2,glutathione S-tr... |
Human | HEK293 Cells |
GSTA1 (Glutathione S-Transferase Alpha 1) is a Protein Coding gene. This gene encodes a member of a family of enzymes that function to add glutathione to target electrophilic compounds. Glutathione S-transferases (GSTs) are involved in the detoxification of carcinogens and may be linked to carcinogenesis. As a vital component of GSTs, GSTA1 plays an important role in carcinogenesis. GSTA1 expression may be a target molecule in the early diagnosis and treatment of lung cancer. Human colonic adeno... | |||
TMPJ-00412 |
VEGFR1/FLT-1 Protein, Human, Recombinant (hFc)
Vascular endothelial growth factor receptor 1,Vascular perme... |
Human | HEK293 Cells |
Human Vascular endothelial growth factor receptor 1(VEGFR-1, FLT-1) is a member of the the class III subfamily of receptor tyrosine kinases (RTKs) and Tyr protein kinase family and CSF-1/PDGF receptor subfamily. VEGFR-1 is widely expressed in human tissues including normal lung, placenta, liver, kidney, heart and brain tissues. It is specifically expressed in most of the vascular endothelial cellsand peripheral blood monocytes. VEGFR-1 contains seven Ig-like C2-type domains and one protein kinas... | |||
TMPY-03856 |
SEZ6L2 Protein, Human, Recombinant (His)
PSK-1,seizure related 6 homolog (mouse)-like 2 |
Human | HEK293 Cells |
SEZ6L2, also known as PSK-1, belongs to the SEZ6 family. It contains 3 CUB domains and 5 Sushi (CCP/SCR) domains. SEZ6L2 may contribute to specialized endoplasmic reticulum functions in neurons.SEZ6L2 presents on the surface of lung cancer cells. SEZ6L2 should be a useful prognostic marker of lung cancers. Increased expression of this gene has been found in lung cancers, and the protein is therefore considered to be a novel prognostic marker for lung cancer. | |||
TMPY-04321 |
CHRNA5 Protein, Human, Recombinant (His)
cholinergic receptor, nicotinic, α5 (neuronal),cholinergic r... |
Human | HEK293 Cells |
Genetic variation in the cluster on chromosome 15, encoding the nicotinic acetylcholine receptor subunits (CHRNA5-CHRNA3-CHRNB4), has shown strong associations with tobacco consumption and an additional risk increase in smoking-related diseases such as chronic obstructive pulmonary disease (COPD), peripheral artery disease and lung cancer. CHRNA5 may influence susceptibility to lung cancer among Han smokers. Genetic variation in nicotinic receptor alpha 5 (CHRNA5) has been associated with increa... | |||
TMPK-01188 |
CHODL Protein, Human, Recombinant (hFc)
PRED12,C21orf68,CHODL,MT75,Chondrolectin,3110074E07Rik,FLJ12... |
Human | HEK293 Cells |
chondrolectin (CHODL) is commonly overexpressed in the majority of lung cancers, indicating a possible correlation between CHODL and metastasis of lung cancer cells. the expression of CHODL is significantly decreased in HCC clinical samples and in HCC cell lines. Overexpression of CHODL in SMMC7721 cells with a lentiviral vector increased SMMC7721 cell migration and invasion. | |||
TMPK-00906 |
PSCA Protein, Mouse, Recombinant (hFc)
UNQ206,PSCA,PRO232 |
Mouse | HEK293 Cells |
Gastric cancer is a deadly malignancy and is a prognostically unfavorable entity with restricted therapeutic strategies available. Prostate stem cell antigen (PSCA) is a glycosylphosphatidylinositol (GPI)-anchored cell surface protein widely expressed in bladder, prostate, and pancreatic cancers. Existing studies have thoroughly recognized the availability of utilizing anti-PSCA CAR-T cells in the treatment of metastatic prostate cancer and non-small-cell lung cancer. PSCA Protein, Mouse, Recomb... | |||
TMPK-00728 |
PSCA Protein, Human, Recombinant (hFc)
UNQ206,PRO232,PSCA |
Human | HEK293 Cells |
Gastric cancer is a deadly malignancy and is a prognostically unfavorable entity with restricted therapeutic strategies available. Prostate stem cell antigen (PSCA) is a glycosylphosphatidylinositol (GPI)-anchored cell surface protein widely expressed in bladder, prostate, and pancreatic cancers. Existing studies have thoroughly recognized the availability of utilizing anti-PSCA CAR-T cells in the treatment of metastatic prostate cancer and non-small-cell lung cancer. PSCA Protein, Human, Recomb... | |||
TMPJ-01288 |
KLF6 Protein, Human, Recombinant
CPBP,GC-Rich Sites-Binding Factor GBF,Suppressor of Tumorige... |
Human | E. coli |
Krueppel-Like Factor 6 (KLF6) belongs to the krueppel C2H2-type zinc-finger protein family. KLF6 contains three C2H2-type zinc fingers and localizes in the nucleus. KLF6 expression is highest in the placenta followed by spleen, thymus, prostate, testis, small intestinem and colon. However, it is weakly expressed in the pancreas, lung, liver, heart, and skeletal muscle. KLF6 functions as a transcriptional activator and could play a role in B-cell growth and development. Defects in KLF6 will resul... | |||
TMPK-01203 |
TNFRSF19 Protein, Human, Recombinant (hFc)
AW123854,TRADE,TAJ α,AL023044,TAJ-α,Taj,TAJ alpha,Toxicity a... |
Human | HEK293 Cells |
A novel susceptibility gene TNFRSF19, which encodes an orphan member of the TNF receptor superfamily known to be associated with nasopharyngeal carcinoma (NPC) and lung cancer risk. TNFRSF19, a susceptibility gene for nasopharyngeal carcinoma and other cancers, functions as a potent inhibitor of the TGFβ signaling pathway. TNFRSF19 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with C-hFc tag. The predicted molecular weight is 42.22 kDa and the accession number is Q9NS6... | |||
TMPK-01204 |
TNFRSF19 Protein, Human, Recombinant (His)
Taj,TAJ-α,Toxicity and JNK inducer,TAJ-alpha,TRADE,Troy,AW12... |
Human | HEK293 Cells |
A novel susceptibility gene TNFRSF19, which encodes an orphan member of the TNF receptor superfamily known to be associated with nasopharyngeal carcinoma (NPC) and lung cancer risk. TNFRSF19, a susceptibility gene for nasopharyngeal carcinoma and other cancers, functions as a potent inhibitor of the TGFβ signaling pathway. TNFRSF19 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with C-His tag. The predicted molecular weight is 16.55 kDa and the accession number is Q9NS6... | |||
TMPK-01299 |
CEACAM5 Protein, Cynomolgus, Recombinant (aa 35-685, His)
Carcinoembryonic,CEA,CEACD66e,DKFZp781M2392,CEACAM-5,CD66e,M... |
Cynomolgus | HEK293 Cells |
Carcinoembryonic antigen-related cell adhesion molecule 5 (CEACAM5) was identified as a metastatic driver. CEACAM5 overproduction enriched for an epithelial gene expression pattern and facilitated tumor outgrowth at metastatic sites. Tissues from patients with metastatic breast cancer confirmed elevated levels of CEACAM5 in lung metastases relative to breast tumors, and an inverse correlation between CEACAM5 and the mesenchymal marker vimentin was demonstrated. | |||
TMPY-03398 |
FHIT Protein, Human, Recombinant (His)
FRA3B,AP3Aase,fragile histidine triad |
Human | E. coli |
Fragile histidine triad, also known as FHIT, may play a key role in differentiating humans from apes. Fragile histidine triad gene belongs to the histidine triad gene family. It has been shown that fragile histidine triad synergizes with VHL, another tumor suppressor, in protecting against chemically - induced lung cancer. Fragile histidine triad gene works as a tumor suppressor as it has been demonstrated in animal studies. The exact molecular function of FHIT is still partially unclear. It als... | |||
TMPK-01034 |
SEMA4B Protein, Mouse, Recombinant (His)
SEMA4B,SemC,Semaphorin-C,MGC131831,Semaphorin-4B,KIAA1745,SE... |
Mouse | HEK293 Cells |
Semaphorin 4B (SEMA4B) inhibits the invasion of non-small cell lung cancer (NSCLC) through PI3K-dependent suppression of MMP9 activation. SEMA4B may induce FoxO1 nuclear retention through suppressing PI3K/Akt signaling pathway, which subsequently inhibited cell growth through the direct nuclear target of FoxO1, p21. A role of SEMA4B in suppressing NSCLC growth, besides its role in inhibiting cell metastasis, and highlights SEMA4B as a promising therapeutic target for NSCLC. | |||
TMPY-03416 |
TNFAIP8 Protein, Human, Recombinant (His)
GG2-1,tumor necrosis factor, alpha-induced protein 8,SCCS2,S... |
Human | E. coli |
Tumor necrosis factor (TNF)-alpha-induced protein 8 (TNFAIP8) family is a newly identified protein with vital roles in maintaining immune homeostasis. Tumor necrosis factor-alpha-inducible protein 8 (TNFAIP8) is a TNF-alpha inducible anti-apoptotic protein with multiple roles in tumor growth and survival. by the creation of cellular autophagy events, TNFAIP8 promotes cell survival and drug resistance in prostate cancer cells. TNFAIP8 regulates Hippo pathway through interacting with LATS1 to prom... | |||
TMPK-00341 |
ALCAM Protein (Primary Amine Labeling), Human, Recombinant (His), Biotinylated
ALCAM,KG-CAM,MEMD,CD166,CD6L |
Human | HEK293 Cells |
Brain metastasis (BM) in non-small-cell lung cancer (NSCLC) has a very poor prognosis. Recent studies have demonstrated the importance of cell adhesion molecules in tumor metastasis.Elevated levels of ALCAM expression promote BM formation in NSCLC through increased tumor cell dissemination and interaction with the brain endothelial cells. Therefore, ALCAM could be targeted to reduce the occurrence of BM. ALCAM Protein (Primary Amine Labeling), Human, Recombinant (His), Biotinylated is expressed ... | |||
TMPJ-01262 |
UPRT Protein, Human, Recombinant (His)
UPRT,UPP,FUR1,Uracil phosphoribosyltransferase homolog |
Human | E. coli |
UPRT is a cytoplasmic enzyme which belongs to the UPRTase family. UPRT is highly expressed in leukocytes, liver, spleen and thymus, with lower expression in brain, lung and skeletal muscle. UPRTcatalyzes the conversion of uracil and 5-phosphoribosyl-1-R-diphosphate to uridine monophosphate (UMP). This reaction is an important part of nucleotide metabolism, specifically the pyrimidine salvage pathway. UPRT is a potential target for rational design of drugs to treat parasitic infections and cancer | |||
TMPY-04686 |
SHISA3 Protein, Human, Recombinant (mFc)
shisa family member 3,hShisa3 |
Human | HEK293 Cells |
SHISA3(high)CLL are characterized by a restrained activation of Wnt signaling and sensibility to lenalidomide-induced apoptosis. SHISA3 promoter hypermethylation might increase the risk of LSCC through regulation of gene expression and is a potential diagnostic and prognostic biomarker for LSCC. Shisa3 is a novel tumor suppressor identified in lung cancer. SHISA3 gene is epigenetically inactivated in a substantial fraction of CRC, and its hypermethylation is of prognostic significance in predict... | |||
TMPK-00340 |
ALCAM Protein, Human, Recombinant (His & Avi), Biotinylated
CD166,CD6L,KG-CAM,ALCAM,MEMD |
Human | HEK293 Cells |
Brain metastasis (BM) in non-small-cell lung cancer (NSCLC) has a very poor prognosis. Recent studies have demonstrated the importance of cell adhesion molecules in tumor metastasis.Elevated levels of ALCAM expression promote BM formation in NSCLC through increased tumor cell dissemination and interaction with the brain endothelial cells. Therefore, ALCAM could be targeted to reduce the occurrence of BM. ALCAM Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian... | |||
TMPK-00339 |
ALCAM Protein, Mouse, Recombinant (His & Avi), Biotinylated
CD6L,ALCAM,MEMD,KG-CAM,CD166 |
Mouse | HEK293 Cells |
Brain metastasis (BM) in non-small-cell lung cancer (NSCLC) has a very poor prognosis. Recent studies have demonstrated the importance of cell adhesion molecules in tumor metastasis.Elevated levels of ALCAM expression promote BM formation in NSCLC through increased tumor cell dissemination and interaction with the brain endothelial cells. Therefore, ALCAM could be targeted to reduce the occurrence of BM. ALCAM Protein, Mouse, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian... | |||
TMPY-03601 |
PDRG1 Protein, Human, Recombinant (His)
PDRG,p53 and DNA-damage regulated 1,C20orf126 |
Human | E. coli |
PDRG1, also known as C2orf126, belongs to the prefoldin subunit beta family. It is predominantly expressed in normal testis and exhibits reduced but detectable expression in other organs. PDRG1 may play a role in chaperone-mediated protein folding. PDRG1 is overexpressed in tumors relative to normal tissues. Its expression is upregulated in multiple malignancies including cancers of the colon, rectum, ovary, lung, stomach, breast and uterus when compared to their respective matched normal tissue... | |||
TMPY-03287 |
RRM1 Protein, Human, Recombinant (His & GST)
ribonucleotide reductase M1,R1,RR1,RIR1 |
Human | Baculovirus Insect Cells |
RRM1 is a subunit of ribonucleoside-diphosphate reductase which is constituted by two subunits. Ribonucleoside-diphosphate reductase is an enzyme essential for the production of deoxyribonucleotides prior to DNA synthesis in S phase of dividing cells. RRM1 is one of several genes located in the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocort... | |||
TMPJ-00160 |
EMMPRIN/CD147 Protein, Human, Recombinant (His)
5F7,TCSF,OK Blood Group Antigen,Tumor Cell-Derived Collagena... |
Human | HEK293 Cells |
Extracellular Matrix Metalloproteinase Inducer (EMMPRIN) belongs to the immunoglobulin superfamily, which has the homology to both the immunoglobulin V domain and MHC class II antigen β-chain. EMMPRIN is a transmembrane glycoprotein with different forms, resulting from different modes of glycosylation and N-terminal sequence variants. EMMPRIN can be expressed in breast cancer, oral squamous cell carcinoma, glioma, lymphoma, lung, bladder, and melanoma carcinomas cells. EMMPRIN promotes invasion,... | |||
TMPY-01033 |
IL-32 Protein, Human, Recombinant (isoform alpha, His)
IL-32δ,IL-32beta,IL32,TAIFc,IL-32γ,白介素,IL-32 Protein(isoform... |
Human | HEK293 Cells |
IL-32 is a recently discovered cytokine that induces various proinflammatory cytokines (TNF-alpha, IL-1beta, IL-6) and chemokines in both human and mouse cells through the NF-kappaB and p38 MAPK inflammatory signal pathways. It is regulated robustly by other major proinflammatory cytokines and is crucial to inflammation and immune responses. Four of the IL-32 isoforms (alpha, beta, gamma, and delta) are the most representative IL-32 transcripts, and the gamma isoform of IL-32 is the most active,... | |||
TMPJ-01209 |
BTNL9 Protein, Mouse, Recombinant (hFc)
BTNL9,Butyrophilin-like protein 9 |
Mouse | HEK293 Cells |
Butyrophilin-Like Protein 9 (BTNL9) is single-pass type I membrane protein member of the BTN/MOG family that belongs to the immunoglobulin superfamily. BTNL9 consists of two domains: one B30.2/SPRY domain and one Ig-like V-type (immunoglobulin-like) domain. Human BTNL9 mRNA has been identified in adipose, lung, thymus, spleen, colon, and cardiac tissues, but its highest levels of expression were found in B cells. BTNL9 expression has also been found to be down-regulated in colon cancer tumors. B... | |||
TMPJ-01195 |
BTNL9 Protein, Human, Recombinant (His)
BTNL9,Butyrophilin-like protein 9 |
Human | HEK293 Cells |
Butyrophilin-Like Protein 9 (BTNL9) is single-pass type I membrane protein member of the BTN/MOG family that belongs to the immunoglobulin superfamily. BTNL9 consists of two domains: one B30.2/SPRY domain and one Ig-like V-type (immunoglobulin-like) domain. Human BTNL9 mRNA has been identified in adipose, lung, thymus, spleen, colon, and cardiac tissues, but its highest levels of expression were found in B cells. BTNL9 expression has also been found to be down-regulated in colon cancer tumors. B... | |||
TMPJ-01194 |
BTNL9 Protein, Human, Recombinant (hFc)
BTNL9,Butyrophilin-like protein 9 |
Human | HEK293 Cells |
Butyrophilin-Like Protein 9 (BTNL9) is single-pass type I membrane protein member of the BTN/MOG family that belongs to the immunoglobulin superfamily. BTNL9 consists of two domains: one B30.2/SPRY domain and one Ig-like V-type (immunoglobulin-like) domain. Human BTNL9 mRNA has been identified in adipose, lung, thymus, spleen, colon, and cardiac tissues, but its highest levels of expression were found in B cells. BTNL9 expression has also been found to be down-regulated in colon cancer tumors. B... | |||
TMPY-02399 |
TRF1 Protein, Human, Recombinant (His)
TRF,telomeric repeat binding factor (NIMA-interacting) 1,hTR... |
Human | Baculovirus Insect Cells |
Telomeric repeat binding factor 1 (TRF1), also known as TERF1, the shelterin complex, which modulates the telomere structures. TRF1 protein structure contains a C-terminal Myb motif, a dimerization domain near its N-terminus and an acidic N-terminus. Pin2/TRF1 was originally identified as a protein bound to telomeric DNA (TRF1) and as a protein involved in mitotic regulation (Pin2). Pin2/TRF1 negatively regulates telomere length and importantly, its function is tightly regulated during the cell ... | |||
TMPY-04375 |
Casein Kinase 1 alpha Protein, Human, Recombinant (GST)
CKIa,casein kinase 1, alpha 1,casein kinase 1, α1,CK1a,Casei... |
Human | Baculovirus Insect Cells |
Casein kinase I isoform alpha, also known as CKI-alpha, CK1 and CSNK1A1, is a cytoplasm protein which belongs to theprotein kinase superfamily, CK1 Ser/Thr protein kinase family and casein kinase I subfamily. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. High expression of CSNK2A1, or concomitantly high expression of CSNK2A1, are independent prognostic factors of poor survival in NSCLC patients. CSNK2A1 are use... | |||
TMPY-04484 |
ACK1 Protein, Human, Recombinant (GST)
ACK-1,ACK1,p21cdc42Hs,ACK,tyrosine kinase, non-receptor, 2 |
Human | Baculovirus Insect Cells |
ACK1 (also known as ACK, TNK2, or activated Cdc42 kinase) is a structurally unique non-receptor tyrosine kinase that is expressed in diverse cell types. This downstream effector of CDC42 mediates CDC42-dependent cell migration via phosphorylation of BCAR1. The ACK1 protein may be involved in a regulatory mechanism that sustains the GTP-bound active form of Cdc42Hs and which is directly linked to a tyrosine phosphorylation signal transduction pathway. ACK1 integrates signals from plethora of liga... | |||
TMPY-03397 |
TPPP3 Protein, Human, Recombinant (His)
CGI-38,TPPP3,p25gamma,tubulin polymerization-promoting prote... |
Human | E. coli |
TPPP3, a member of the Tubulin polymerization-promoting protein family, is an intrinsically unstructured protein that induces tubulin polymerization. TPPP3 is a marker in the developing musculoskeletal system. In tendons, Tppp3 is expressed in cells at the circumference of the developing tendons, likely the progenitors of connective tissues that surround tendons: the tendon sheath, epitenon, and paratenon. Tppp3 is also expressed in forming synovial joints. The onset of Tppp3 expression in joint... | |||
TMPY-02100 |
TEM7 Protein, Human, Recombinant (His)
TEM3,plexin domain containing 1,TEM7 |
Human | HEK293 Cells |
Plexin domain-containing protein 1, also known as tumor endothelial marker 3, tumor endothelial marker 7 and PLXDC1 and TEM3, is a secreted, cytoplasm and single-pass type I membrane protein that belongs to the plexin family. PLXDC1 / TEM3 is detected in endothelial cells from colorectal cancer, and in endothelial cells from primary cancers of the lung, liver, pancreas, breast and brain. It is expressed in fibrovascular membrane with increased expression in individuals with proliferative diabeti... | |||
TMPY-04417 |
DAPK1 Protein, Human, Recombinant (aa 1-363, His & GST)
DAPK,death-associated protein kinase 1,ROCO3 |
Human | Baculovirus Insect Cells |
Death-associated protein kinase 1, also known as DAP kinase 1, DAPK1 and DAPK, is a cytoplasm protein which belongs to theprotein kinase superfamily, CAMK Ser / Thr protein kinase family and DAP kinase subfamily. DAPK1 contains tenANK repeats, onedeath domain and oneprotein kinase domain. DAPK1 is a calcium / calmodulin-dependent serine/threonine kinase which acts as a positive regulator of apoptosis. DAPK1 gene is a candidate tumor suppressor (TSG) and the abnormal methylation of DAPK1 g... | |||
TMPY-04084 |
ANGPTL1 Protein, Canine, Recombinant (hFc)
angiopoietin-like 1 |
Canine | HEK293 Cells |
Angiopoietin-like protein 1 (ANGPTL1) has been reported to suppress migration and invasion in lung and breast cancer, acting as a novel tumor suppressor candidate. Downregulation of tumor suppressor signaling plays an important role in the pathogenesis of hepatocellular carcinoma (HCC).The downregulation of the angiopoietin-like protein ANGPTL1 is associated with vascular invasion, tumor thrombus, metastasis, and poor prognosis in HCC. Ectopic expression of ANGPTL1 in HCC cells effectively decre... | |||
TMPJ-01212 |
ULBP-1 Protein, Mouse, Recombinant (His)
RAET1I,ULBP1,NKG2DL1 |
Mouse | HEK293 Cells |
Mouse ULBP1, also known as RAET1I and NKG2DL1, is a member of the ULBP/RAET1 gene family. ULBP1 plays an important role in immune responses, especially in cancer and infectious diseases, and is well-known to bind to NKG2D together with at least ULBP 2 and 3. These proteins are distantly related to major histocompatibility class I (MHC I) molecules, possessing the alpha 1 and alpha 2 Ig-like domains, but lacking the alpha 3 domain. Unlike MHC Class I, they have no capacity to bind peptide or inte... | |||
TMPY-02757 |
TWEAKR/TNFRSF12A Protein, Human, Recombinant (hFc)
FN14,CD266,TWEAKR,tumor necrosis factor receptor superfamily... |
Human | HEK293 Cells |
Fn14 (tumor necrosis factor receptor superfamily, member 12A), also known as TNFRSF12A, is the receptor for TNFSF12/TWEAK. Fn14 shares 82% amino acid identity with the mouse sequence. It contains a signal peptide, an extracellular domain, a membrane-anchoring domain, and a cytoplasmic domain. In response to FGF1, calf serum, or phorbol ester stimulation of human quiescent fibroblasts in vitro, the level of Fn14 is increased. A 1.2-kb FN14 transcript was expressed at high levels in heart, placent... | |||
TMPY-02796 |
KIAA0101 Protein, Human, Recombinant (His)
L5,NS5ATP9,p15PAF,OEATC1,p15(PAF),OEATC,PAF,p15/PAF,OEATC-1,... |
Human | E. coli |
KIAA11, also known as p15(PAF), is a proliferating cell nuclear antigen-associated factor that interacts with proliferating cell nuclear antigen(PCNA). It was initially isolated in a yeast two-hybrid screen for PCNA binding partners and was shown to bind PCNA competitively with the cell cycle regulator p21(WAF). KIAA11 is localized primarily in the nucleus. It shares the conserved PCNA binding motif with several other PCNA binding proteins including CDK inhibitor p21. KIAA11 is involved in cell ... | |||
TMPY-02228 |
p53 Protein, Cynomolgus, Recombinant
tumor protein p53,p53,TP53 |
Cynomolgus | E. coli |
p53, also known as Tp53, is a DNA-binding protein which belongs to the p53 family. It contains transcription activation, DNA-binding, and oligomerization domains. p53 protein is expressed at low level in normal cells and at a high level in a variety of transformed cell lines, where it's believed to contribute to transformation and malignancy. p53 (TP53) is a transcription factor whose protein levels and post-translational modification state alter in response to cellular stress (such as DNA damag... | |||
TMPH-03753 |
MYLK Protein, Human, Recombinant (His)
MYLK,Myosin light chain kinase, smooth muscle,Telokin,Kinase... |
Human | E. coli |
Calcium/calmodulin-dependent myosin light chain kinase implicated in smooth muscle contraction via phosphorylation of myosin light chains (MLC). Also regulates actin-myosin interaction through a non-kinase activity. Phosphorylates PTK2B/PYK2 and myosin light-chains. Involved in the inflammatory response (e.g. apoptosis, vascular permeability, leukocyte diapedesis), cell motility and morphology, airway hyperreactivity and other activities relevant to asthma. Required for tonic airway smooth muscl... |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T11067 |
VX-984
M9831 |
DNA-PK | DNA Damage/DNA Repair; PI3K/Akt/mTOR signaling |
VX-984 (M9831) 是一种可口服的、具有选择性的的、可透过血脑屏障的 DNA-PK 抑制剂。VX-984 对非同源性末端 NHEJ 的接合具有抑制作用,可作用于 DSBs 使 DNA 双链断裂。VX-984常见于对胶质母细胞瘤 (GBM) 和非小细胞肺癌 (NSC-LC) 的研究。 | |||
TMIH-0089 |
Androstenedione-d7
|
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Androstenedione-d7 是 Androstenedione 的氘代化合物。Androstenedione 的 CAS 号为 560-62-3。9-hydroxy-4-androstene-3,17-dione 是一种类固醇激素,具有抗肿瘤活性,可以抑制多种癌症细胞的生长,包括乳腺癌、前列腺癌和肺癌细胞。 | |||
T72818 |
Dosimertinib-d3
|
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Dosimertinib-d3是一种有效的口服活性EGFR 抑制剂。Dosimertinib-d3降低 p-EGFR 和 p-ERK 蛋白水平的表达。Dosimertinib-d3显示出抗增殖和抗肿瘤活性。Dosimertinib-d3具有非小细胞肺癌 (NSCLC) 研究的潜力。 | |||
TMIH-0413 |
Osimertinib-d6
|
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Osimertinib-d6 是 Osimertinib 的氘代化合物。Osimertinib 的 CAS 号为 1421373-65-0。Osimtinib 是一种小分子酪氨酸激酶受体抑制剂和抗肿瘤剂,用于治疗选定形式的晚期非小细胞肺癌,其有效抑制 L858R 和 L858R/T790M EGFR,IC50 为 12 和 1 nM。 | |||
TMIH-0521 |
Silibinin-d3
|
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Silibinin-d3 是 Silibinin 的氘代化合物。Silibinin 的 CAS 号为 22888-70-6。Silibinin 是水飞蓟的主要活性成分,具有抗癌和化疗预防作用,能抑制细胞增殖和迁移。 | |||
T71141 |
Fenspiride-d5
|
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Fenspiride-d5 is intended for use as an internal standard for the quantification of fenspiride by GC- or LC-MS. Fenspiride is an antagonist of histamine H1 receptors and a non-steroidal anti-inflammatory drug (NSAID). It inhibits histamine-induced contraction of isolated guinea pig trachea but not histamine-induced inotropy of isolated guinea pig heart. It also inhibits phosphodiesterase 4 (PDE4), PDE5, and PDE3 (IC50s = 69, ~158, and 363 µM, respectively, in isolated human bronchi derived from ... | |||
T35915 |
Erlotinib-13C6
Erlotinib-13C6 |
||
Erlotinib-13C6 (CP-358774-13C6) is a 13C-labeled Erlotinib. Erlotinib is a directly acting EGFR tyrosine kinase inhibitor, with an IC50 of 2 nM for human EGFR[1]. Erlotinib reduces EGFR autophosphorylation in intact tumor cells with an IC50 of 20 nM. Erlotinib is used for the treatment of non-small cell lung cancer[1].Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process[2]... |