3
2
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T3461 |
Losartan Carboxylic Acid
EXP-3174,E-3174 |
RAAS | Endocrinology/Hormones |
Losartan Carboxylic Acid (E-3174) 是 Losartan 的活性羧酸代谢产物,是血管紧张素Ⅱ受体 1 型(AT1)拮抗剂。它能够阻断血管紧张素 II 诱导的血管平滑肌细胞反应,可以提高血浆肾素活性,降低平均动脉压。 | |||
T0215L |
Losartan
DuP-753,氯沙坦,洛沙坦 |
RAAS | Endocrinology/Hormones |
Losartan (DuP-753) 是一种血管紧张素II 受体拮抗剂,能够与血管紧张素II 竞争性结合AT1受体(IC50:20 nM)。 | |||
T0215 |
Losartan potassium
DuP-753 potassium,洛沙坦钾,氯沙坦钾,MK 954,DuP 753 |
RAAS | Endocrinology/Hormones |
Losartan potassium (DuP-753 potassium) 是一种血管紧张素 II 受体 1 型(AT1)拮抗剂,能够与血管紧张素 II 与 AT1 的结合竞争,其 IC50=20 nM。 |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T11869 |
Losartan (D4 Carboxylic Acid)
E-3174 D4,氯沙坦羧酸 D4,EXP-3174 D4 |
Others | Others |
Losartan D4 Carboxylic Acid is the deuterium labeled Losartan, which is an angiotensin II receptor antagonist. | |||
T11870 |
Losartan D4
氯沙坦 D4,DuP-753 D4 |
Others | Others |
Losartan D4, the deuterium-labeled version of Losartan, functions as an angiotensin II receptor antagonist. It inhibits the interaction between angiotensin II and AT1 receptors by competing for binding, achieving an IC50 value of 20 nM. |