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Search Results for " lovo "

Targets Recommended: Microtubule Associated

14

抑制剂 & 化合物

2

天然产物

1

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T41248	Thiocolchicine	Microtubule Associated	Cytoskeletal Signaling
	Thiocolchicine 是一种有效的微管蛋白聚合抑制剂，IC50 为 2.5 µM，Ki 为 0.7 µM。 Thiocolchicine 诱导细胞凋亡。 Thiocolchicine 可用作 ADC 技术中的 ADC 细胞毒素。
T4435	E7820 ER68203-00	Integrin	Cytoskeletal Signaling
	E7820 (ER68203-00) 是具有口服活性芳香族磺酰胺衍生物，是一种血管生成抑制剂，可抑制内皮上整合素 α2 亚基的表达。它调节 α1，α2，α3 和 α5 整联素 mRNA 表达，具有抗血管生成和抗肿瘤活性。它抑制大鼠主动脉血管生成，IC50为 0.11 μg/ml。
T27047	Clovoxamine DU 23811,DU-23811,DU23811	5-HT Receptor; Serotonin Transporter; Norepinephrine	GPCR/G Protein; Neuroscience
	Clovoxamine (DU 23811) 是一种 5-羟色胺再摄取、血清素和去甲肾上腺素抑制剂，具有抗抑郁和抗惊厥活性。
T61808	ATR-IN-14	Others	Others
	ATR-IN-14 (compound 1) is a powerful ATR kinase inhibitor that significantly inhibits ATR signaling pathways following CHKI protein phosphorylation, demonstrating a remarkable inhibition rate of 98.03% at 25 nM. Moreover, ATR-IN-14 exhibits notable anticancer efficacy in LoVo cells, displaying an IC50 value of 64 nM [1].
T61432	ATR-IN-16	Others	Others
	ATR-IN-16 (compound 46) is a highly effective ATR kinase inhibitor, exhibiting considerable anticancer activity in LoVo cells, as demonstrated by its IC 50 value of 410 nM [1].
T62548	ATR-IN-17	Others	Others
	ATR-IN-17 是一种 ATR 激酶的有效抑制剂，在 LoVo 细胞中具有良好的抗癌效果 (IC50: 1 nM)。
T63604	ATR-IN-18	Others	Others
	ATR-IN-18 是口服具有活力的 ATR 激酶抑制剂 (IC50: 0.69 nM)。ATR-IN-18 在 LoVo 细胞中表现出抗增殖效果 (IC50: 37.34 nM)。ATR-IN-18 显示出抗肿瘤作用。
T74771	Diaporthein B	Others	Others
	Diaporthein B 是氧化程度极高的 pimarane 二萜之一。Diaporthein B 表现出抗结核分枝杆菌的活性，MIC 为 3.1 μg/mL。Diaporthein B 显示对 HCT 116 和 LoVo 结肠癌细胞的 IC50为 1.5-3 μM/L。
T22490	2,3-DCPE hydrochloride	Others	Others
	Induces p21 expression and S-phase arrest in cancer cells via ERK-mediated pathways. IC50 values are 0.89 and 12.6 μM for LoVo human colon cancer cell line and normal human fibroblasts respectively.
T78959	ATR-IN-23	ATM/ATR	DNA Damage/DNA Repair; PI3K/Akt/mTOR signaling
	ATR-IN-23 (Compound 34) 是一种选择性ATR抑制剂，其IC50为 1.5 nM。该化合物对LoVo细胞表现出抗增殖活性，并对HT-29细胞产生合成致死效果，适用于研究DNA损伤反应(DDR)缺陷癌症。
T61587	ATR-IN-15	Others	Others
	ATR-IN-15 (compound 1) is a highly potent and orally active inhibitor of ATR kinase with an IC50 of 8 nM. Additionally, ATR-IN-15 demonstrates inhibitory activity against several targets, including human colon tumor cells LoVo, DNA-PK, and PI3K, with IC50 values of 47, 663, and 5131 nM, respectively [1].
T63521	Bcl-2-IN-7	Others	Others
	Bcl-2-IN-7 是 Bcl-2(b 细胞淋巴瘤 -2) 的有效抑制剂，能够下调 Bcl-2 的表达，提高 p53、Bax、caspase-7 mRNA 的表达，能够诱导乳腺癌 MCF-7 细胞周期阻滞和凋亡。Bcl-2-IN-7 对 MCF-7 细胞 (IC50: 20.17 μM)、LoVo 细胞 (IC50: 22.64 μM)、HepG2 细胞 (IC50:45.57 μM) 和 A549 细胞 (IC50: 51.50 μM)均表现出良好的抗肿瘤活性。
T63676	Bcl-2-IN-6	Others	Others
	Bcl-2-IN-6 是 Bcl-2 (b 细胞淋巴瘤-2) 的有效抑制剂，可下调 Bcl-2 的表达，并提高 p53、Bax、caspase-7 mRNA 的表达。Bcl-2-IN-7 能够诱导乳腺癌 MCF-7 细胞周期阻滞和凋亡。Bcl-2-IN-7 能够作用于 MCF-7 细胞 (IC50: 20.91 μM)、LoVo 细胞 (IC50: 22.30 μM)、HepG2 细胞 (IC50: 42.29 μM) 和 A549 细胞 (IC50: 48.00 μM) 均显示出良好的抗肿瘤效果。
T35897	ASK120067	Others	Others
	ASK120067 is a potent and orally active inhibitor of EGFRT790M (IC50:0.3 nM) with selectivity over EGFRWT (IC50:6.0 nM). ASK120067 is a third-generation EGFR-TKI for the research of non-small cell lung cancer (NSCLC)[1]. In the in vitro kinase assay ASK120067 potently inhibits the EGFR L858R/T790M and EGFR T790M resistant mutants with IC50 values of 0.3 nM and 0.5 nM, respectively, as well as the EGFRexon19del sensitizing mutant (IC50= 0.5 nM). The 50 of ASK120067 against wild-type EGFR (EGFRWT...

化合物

Cat.No: T41248

Target: Microtubule Associated

Cat.No: T4435

Synonym: ER68203-00

Target: Integrin

Cat.No: T27047

Synonym: DU 23811,DU-23811,DU23811

Target: 5-HT Receptor, Serotonin Transporter, Norepinephrine

Cat.No: T61808

Target: Others

Cat.No: T61432

Target: Others

Cat.No: T62548

Target: Others

Cat.No: T63604

Target: Others

Cat.No: T74771

Target: Others

2,3-DCPE hydrochloride

Cat.No: T22490

Target: Others

Cat.No: T78959

Target: ATM/ATR

Cat.No: T61587

Target: Others

Cat.No: T63521

Target: Others

Cat.No: T63676

Target: Others

Cat.No: T35897

Target: Others

Cat. No.	Product Name	Target	Signaling Pathways
TN3920	Effusanin A	Raf; Antifection	MAPK; Microbiology/Virology
	Effusanin A 是一种存在于Isodon rugosus 之中的天然产物。它具有 DNA 损伤和抗菌作用。
T36886	Pestalotin	Others	Others
	Pestalotin is a fungal metabolite originally isolated from P. cryptomeriaecola with diverse biological activities. It induces reducing sugar release in embryoless rice endosperms when used at concentrations ranging from 3 to 100 mg/L and enhances growth of rice seedlings (O. sativa) when used in combination with gibberellin A3 at concentrations ranging from 30 to 500 mg/L. Pestalotin has antifungal activity, reducing the growth of C. albicans, C. neoformans, T. rubrum, and A. fumigatus (MICs = 1...

天然产物

Cat.No: TN3920

Target: Raf, Antifection

Cat.No: T36886

Target: Others

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPH-00552	Lpp Protein, Erwinia amylovora, Recombinant (His & SUMO) Major outer membrane lipoprotein Lpp,lpp	Erwinia amylovora	E. coli
	A highly abundant outer membrane lipoprotein that controls the distance between the inner and outer membranes. The only protein known to be covalently linked to the peptidoglycan network (PGN). Also non-covalently binds the PGN. The link between the cell outer membrane and PGN contributes to maintenance of the structural and functional integrity of the cell envelope, and maintains the correct distance between the PGN and the outer membrane.

重组蛋白

Lpp Protein, Erwinia amylovora, Recombinant (His & SUMO)

Cat.No: TMPH-00552

Species: Erwinia amylovora

Expression System: E. coli

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