59
27
5
30
3
Cat. No. | Product Name | ||
---|---|---|---|
L2193 | 抗肝癌化合物库 | 1787 compounds | |
1787 种与肝癌相关的化合物,可以用于抗肝癌药物研发和药理研究; | |||
L5510 | 肝脏毒性化合物库 | 1001 compounds | |
1001 个肝脏毒性化合物的特有集合,可用于高通量、高内涵筛选,是毒理学研究的良好工具; | |||
L1120 | AMPK靶向分子库 | 80 compounds | |
80 个靶向AMPK 的分子集合,可用于高通量和高内涵筛选; | |||
L2550 | 谷氨酰胺代谢化合物库 | 565 compounds | |
565 种谷氨酰胺代谢相关的分子,可以用于高通量和高内涵筛选; | |||
L4600 | 植物来源化合物库 | 3048 compounds | |
3048 个植物来源天然产物的独特集合,来自277类植物的精心之选; |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
TP2333 |
cyclo(L-Pro-L-Tyr)
|
Others | Others |
cyclo(L-Pro-L-Tyr) 是真菌和细菌的次生代谢产物。 | |||
T10904 |
CWP232228
|
Wnt/beta-catenin | Cytoskeletal Signaling; Stem Cells |
CWP232228 是一种高效的、选择性的Wnt/β-catenin 信号通路抑制剂,在细胞核中,拮抗 β-catenin 与 T 细胞因子结合。它能够抑制乳腺癌和肝癌干细胞的生长,抑制肿瘤的形成和转移,且没有毒性。 | |||
T8505 |
SC-236
4-(5-(4-氯苯基)-3-(三氟甲基)-1H-,Sc 236 |
Apoptosis; COX; PPAR | Apoptosis; DNA Damage/DNA Repair; Immunology/Inflammation; Metabolism; Neuroscience |
SC-236 (Sc 236) 是一种具有口服活性的COX-2特异性抑制剂和PPARγ激动剂。它可通过 c-Jun 氨基端抑制激活蛋白-1活性,在小鼠模型中通过抑制 ERK 的磷酸化发挥抗炎作用。 | |||
T1090 |
Perphenazine
Perphenazin,Etaperazine,Trilafon,奋乃静 |
CaMK; Dopamine Receptor; 5-HT Receptor; Adrenergic Receptor; Histamine Receptor | GPCR/G Protein; Immunology/Inflammation; Neuroscience |
Perphenazine (Trilafon) 是吩噻嗪衍生物和多巴胺拮抗剂,具有止吐和抗精神病特性。它能够抑制5-HT2A 受体,α1A 肾上腺素能受体,多巴胺D2、D3、D2L 受体,以及组胺H1受体,对应的Ki 值分别为5.6、10、0.765、0.13、3.4 和 8 nM。 | |||
T22443 |
Triglycidyl isocyanurate
Tris(2,3-epoxypropyl) Isocyanurate,Teroxirone,TGIC,1,3,5-三缩水甘油-S-三嗪三酮,TGI |
Apoptosis | Apoptosis |
Triglycidyl isocyanurate (Teroxirone) 是一种三氮烯三环氧化合物,可通过 p53的激活抑制非小细胞肺癌细胞的生长。它诱导细胞凋亡,具有抗血管生成和抗肿瘤活性,用于癌症研究。 | |||
T1406 |
Amantadine hydrochloride
盐酸金刚烷胺,1-adamantanamine HCl,1-Adamantanamine hydrochloride,Symmetrel,CI-719,Amantadine HCl,1-Adamantylamine hydrochloride |
Dopamine Receptor; Influenza Virus | GPCR/G Protein; Microbiology/Virology; Neuroscience |
Amantadine hydrochloride (CI-719) 是一种抗病毒药物,用于预防或对症治疗甲型流感和帕金森病。它阻断质子流通过 M2 离子通道,从而阻止病毒 RNA 释放到感染细胞的细胞质中。 | |||
T23867 |
Cdc7-IN-7c
Cdc7 inhibitor-7c,Cdc7 inhibitor 7c,Cdc7 IN 7c |
CDK | Cell Cycle/Checkpoint |
Cdc7-IN-7c (Cdc7 inhibitor-7c) 具有抗肿瘤活性,对肝癌,肺癌,肾癌,脑癌,宫颈癌有抑制作用。 | |||
T60226 |
CT52923
|
PDGFR | Angiogenesis; Tyrosine Kinase/Adaptors |
CT52923 is a selective, orally active antagonist of platelet-derived growth factor receptor (PDGFR), functioning as an ATP-competitive inhibitor. It has versatile applications for researching an array of pathological diseases such as atherosclerosis, glomerulonephritis, liver cirrhosis, pulmonary fibrosis, and cancer. | |||
T22136 |
PRL-3 Inhibitor I
PRL-3 Inhibitor,BR-1 |
Phosphatase; Others | Metabolism; Others |
PRL-3 Inhibitor I (BR-1) 是 PRL-3 抑制剂,IC50=0.9 μM。它在细胞检测中显示降低侵袭性。 | |||
T27133 |
DCLX069
DCLX 069,DCLX-069 |
Histone Methyltransferase | Chromatin/Epigenetic |
DCLX069 是一种选择性蛋白精氨酸甲基转移酶 1 抑制剂,IC50值为 17.9 µM,对 PRMT4 和 PRMT6 的活性较低。它可有效阻断乳腺癌、肝癌和急性髓性白血病细胞系中的细胞增殖。 | |||
T9939 |
JMJD6 inhibitor WL12
2H-1-Benzopyran-2-one, 3-(3H-imidazo[4,5-c]pyridin-2-yl)-6-methyl-,ZINC6733033 |
Others | Others |
JMJD6 inhibitor WL12 (ZINC6733033) 是一种JMJD6 抑制剂,能够抑制JMJD6依赖的癌细胞增殖,包括宫颈癌细胞和肝癌细胞,为研究JMJD6在癌症发展中的生物学功能提供了一个小分子探针。 | |||
T9945 |
MNK8
3-methyl-6-(naphthalen-1-yl)pyrimidine-2,4(1H,3H)-dione |
STAT | JAK/STAT signaling; Stem Cells |
MNK8 (3-methyl-6-(naphthalen-1-yl)pyrimidine-2,4(1H,3H)-dione) 是一种有效的STAT3抑制剂,降低STAT3与DNA 结合的能力,对肝癌细胞也有良好的生长抑制作用。 | |||
T18957 |
D-Ala-Lys-AMCA hydrochloride
|
Others | Others |
D-Ala-Lys-AMCA hydrochloride 是发射蓝色荧光的质子偶联寡肽转运蛋白 1 (PEPT1) 的已知底物。 D-Ala-Lys-AMCA 可能被转运到 Caco-2 细胞和肝癌细胞中。 | |||
TQ0141 |
Taltobulin
HTI-286,SPA-110 |
Apoptosis; Microtubule Associated; ADC Cytotoxin | Antibody-drug Conjugate/ADC Related; Apoptosis; Cytoskeletal Signaling |
Taltobulin (HTI-286) 是一种三肽半胱氨酸的合成类似物,是一种微管蛋白抑制剂,在体外抑制肝肿瘤细胞增殖和体内肿瘤生长。Taltobulin 具有细胞毒性,诱导有丝分裂停滞以及凋亡 (apoptosis),可用于研究乳腺癌和与微管组织相关的疾病。 | |||
T62491 |
STAT3-IN-13
|
STAT | JAK/STAT signaling; Stem Cells |
STAT3-IN-13 是一种有效的 STAT3 抑制剂。STAT3-IN-13 具有抗增殖和抗癌活性,通过与 STAT3 SH2 结构域结合发挥作用。STAT3-IN-13 抑制 STAT3 Y705 的磷酸化,诱导细胞凋亡 ,抑制肿瘤细胞的生长和转移。STAT3-IN-13 可用于研究乳腺癌和肝癌。 | |||
T0078L |
Lapatinib ditosylate monohydrate
Lapatinib ditosylate monohydrate,Lapatinib ditoluenesulfonate monohydrate,Lapatinib tosilate hydrate,Lapatinib tosilate,Tykerb,二甲苯磺酸拉帕替尼单水合物,Tyverb |
EGFR; Ferroptosis; Autophagy | Angiogenesis; Apoptosis; Autophagy; JAK/STAT signaling; Tyrosine Kinase/Adaptors |
Lapatinib ditosylate (Lapatinib tosilate) monohydrate 是一种有效的 EGFR 和 ErbB2 抑制剂,对 EGFR 和 ErbB2的 IC50值分别为 10.8 和 9.2 nM。它用于治疗晚期乳腺癌和其他实体瘤。 | |||
T83658 |
SQLE-IN-1
|
Antifungal | Microbiology/Virology |
SQLE-IN-1 是一种角鲨烯环氧化酶 (SQLE) 抑制剂,具有抗肿瘤活性,可抑制肝癌细胞系 Huh7 的增殖和迁移能力,抑制细胞胆固醇的生成,增加抑癌基因PTEN的表达,抑制PI3K和AKT的蛋白表达。 | |||
T0189L |
Pemetrexed disodium
培美曲塞二钠盐,LY-231514,LY231514 disodium,培美曲塞二钠,Pemetrexed |
Apoptosis; DHFR; DNA/RNA Synthesis; Antifolate; Autophagy | Apoptosis; Autophagy; Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Metabolism |
Pemetrexed disodium (LY-231514) 是一种叶酸拮抗剂,用于治疗非小细胞肺癌和恶性间皮瘤。它抑制胸苷酸合成酶,二氢叶酸还原酶和甘氨酰胺核苷酸甲酰转移酶的Ki 分别为 1.3 nM,7.2 nM 和 65 nM。 | |||
T14091 |
AC-73
|
Autophagy | Autophagy |
AC-73 是一种可口服的 Cluster of Differentiation 147 (CD147) 抑制剂,具有很高的生物利用,可选择性破坏 CD147 的二聚化 (结合位点在 CD147 的 N 端 IgC2 域中包括 Glu64 和 Glu73),从而对 CD147/ERK1/2/STAT3/MMP-2 途径产生抑制,并抑制肝癌细胞的运动和侵袭。AC-73 具有抗增殖活性,诱导白血病细胞自噬。 | |||
T0976 |
Propoxur
残杀威,Aprocarb,Propoxure,Baygon |
AChR; Antifungal | Microbiology/Virology; Neuroscience |
Propoxur (Propoxure) 是一种氨基甲酸酯类杀虫剂,用于控制蟑螂、苍蝇、蚊子以及草坪和草坪昆虫。 | |||
T69201 |
Lophenol
|
Others | Others |
Lophenol has potent inhibitory activity against human cancer cell lines such as liver cancer, nasopharyngeal and colon cancer cells. | |||
T11264 |
FAPI-4
DOTA-fapi-04,FAPI 4 |
Others | Others |
FAPI-4 是一种成纤维细胞激活蛋白 (FAP) 抑制剂,是FAPI配体,在原发性肝癌肝细胞癌(HCC)的PET成像中显示出强烈的肝脏摄取作用,常用于 PET 成像,可用于研究癌症。 | |||
T34757 |
Symphytine
|
Others | Others |
Symphytine is a natural inducer of hepatic tumors. Symphytine interacts with DNA in liver endothelial cells and hepatocytes, resulting in DNA damage, mutation induction, and cancer development. | |||
T72740 |
n-Octyl caffeate
|
Others | Others |
n-Octyl caffeate 具有抗癌、诱导凋亡活性。 | |||
T18958 |
D-Ala-Lys-AMCA TFA (375822-19-8 free base)
D-Ala-Lys-AMCA TFA |
Others | Others |
D-Ala-Lys-AMCA TFA is a known substrate of proton-coupled oligopeptide transporter 1 (PEPT1) that emits blue fluorescence. D-Ala-Lys-AMCA TFA may be transported into Caco-2 cells and liver cancer cells. | |||
T61243 |
MAT2A-IN-5
|
Others | Others |
MAT2A-IN-5, a potent inhibitor of MAT2A, effectively targets the abnormally elevated expression of MAT2A found in various tumor types such as gastric, colon, liver, and pancreatic cancers. By reducing the proliferative activity of MTAP-deficient cancer cells, MAT2A-IN-5 exhibits potential in cancer research applications [1]. | |||
T61672 |
MAT2A-IN-7
|
Others | Others |
MAT2A-IN-7, a potent inhibitor of the enzyme MAT2A, demonstrates efficacy in targeting the abnormally elevated expression of MAT2A observed in gastric, colon, liver, and pancreatic cancers. Furthermore, MAT2A-IN-7 effectively reduces the proliferative activity specifically in MTAP-deficient cancer cells, thus highlighting its potential for cancer research applications [1]. | |||
T25611 |
Lanatoside
Lantoside,ABC lanatoside complex |
Others | Others |
Lanatoside 是一种 FDA 批准的强心苷,已被确定为候选的抗登革热化合物。它也被发现可以促进脉粥样硬化,还具有抗肿瘤活性,可抑制结直肠癌细胞、肝癌细胞的生长。 | |||
T37584 |
Tryptoquivaline D
|
Others | Others |
Tryptoquivaline D is a fungal metabolite that has been found inNeosartorya siamensisand has anticancer activity.1,2It induces nuclear chromatin condensation, a marker of apoptosis, in HCT116 colon and HepG2 liver cancer cells when used at a concentration of 150 μM.1Tryptoquivaline D (1-100 μM), alone or in combination with doxorubicin , reduces the viability of A549 lung cancer cells.2 | |||
T18959 |
D-Ala-Lys-AMCA
|
Others | Others |
D-Ala-Lys-AMCA is a known substrate of proton-coupled oligopeptide transporter 1 (PEPT1) that emits blue fluorescence. D-Ala-Lys-AMCA may be transported into Caco-2 cells and liver cancer cells. | |||
T27816 |
Leucinostatin
A 20668,A20668,A-20668 |
Others | Others |
Leucinostatin is a peptide mycotoxins that have some potent effects on liver cells after oral administration. Leucinostatin is used as both antimicrobial and antitumor agents through interactions with the membrane phospholipids. Leucinostatin has shown ef | |||
T82458 |
Epigenetic factor-IN-1
|
Sirtuin | Chromatin/Epigenetic; DNA Damage/DNA Repair |
Epigenetic factor-IN-1(40569Z)是一种针对SIRT7显示出强效结合能力的表观遗传因子抑制剂,常用于肝癌的研究领域。 | |||
T63975 |
MAT2A-IN-1
|
Others | Others |
MAT2A-IN-1 是 MAT2A 的有效抑制剂,能够 MTAP 缺陷型癌细胞的增殖活性。其中 MAT2A 在几种类型肿瘤中表达水平异常高,包括胃癌、结肠癌、肝癌和胰腺癌。MAT2A-IN-1 对癌症疾病表现出研究潜力。 | |||
T83433 |
1D228
|
c-Met/HGFR | Tyrosine Kinase/Adaptors |
1D228为c-Met/TRK抑制剂,显示出抗肿瘤活性。该化合物通过抑制细胞周期蛋白D1,诱导G0/G1停滞,进而抑制癌细胞的增殖和迁移。该化合物适用于胃肿瘤、肝肿瘤和血管肿瘤研究领域。 | |||
T61801 |
HIV-1 inhibitor-35
|
Others | Others |
HIV-1 inhibitor-35 (compound 74) is a highly potent inhibitor of the HIV-1 virus, exhibiting EC50 values of 80 nM and 70 nM for LTR and CMV, respectively, in HEK293 cells. Additionally, HIV-1 inhibitor-35 demonstrates inhibitory activity against HepG2 liver cancer cells, with a CC50 value of 40 nM. Moreover, HIV-1 inhibitor-35 shows promise as a potential HIV-1 latency reversing agent [1]. | |||
T35809 |
C20 Sphingomyelin (d18:1/20:0)
|
Others | Others |
C20 Sphingomyelin is a naturally occurring sphingolipid. Levels of C20 sphingomyelin are upregulated in the hippocampus of rats with diabetes induced by streptozotocin and in human plasma where it is positively correlated with insulin resistance in obese humans. C20 sphingomyelin is also upregulated in the liver of a mouse model of Niemann-Pick type C1 disease, a neurodegenerative cholesterol-sphingolipid lysosomal storage disorder. The plasma concentration of C20 sphingomyelin is decreased in m... | |||
T79594 |
COX-1/2-IN-5
|
COX | Immunology/Inflammation; Neuroscience |
COX-1/2-IN-5 (compound 2a) 为 COX1/2 双抑制剂,IC50 分别为 2.650 μM 和 0.958 μM,展现抗癌功效。针对肝癌细胞株 HepG2,其抑制作用的 IC50 值为 60.75 μM。 | |||
T84968 |
Indium (III) thiosemicarbazone 5b
|
Others | Others |
Indium (III) thiosemicarbazone 5b is an anticancer compound demonstrating cytotoxicity against various cancer cell lines including A549, MCF-7 breast, cisplatin-resistant MCF-7/DDP breast, and Hl 7702 liver cancer cells, with IC50 values of 2.41, 1.97, 2.11, and 8.95 µM, respectively. It effectively lowers PI3K, Akt, mTOR, P-gp, and GSH levels in MCF-7/DDP cells. In vivo studies show that at a dosage of 2.5 µmol/kg, indium (III) thiosemicarbazone 5b significantly reduces tumor weight and volume ... | |||
T79919 |
S-Adenosyl-L-methionine (1,4-butanedisulfonate)
Ademetionine (1,4-butanedisulfonate),S-Adenosyl methionine (1,4-butanedisulfonate),AdoMet (1,4-butanedisulfonate) |
Endogenous Metabolite | Metabolism |
S-Adenosyl-L-methionine (S-Adenosyl methionine) 1,4-butanedisulfonate 作为一种口服活性的甲基供体,它是一种膳食补充剂,对抗抑郁和缓解疼痛具有显著功效。此化合物在癌症治疗中显示了抗增殖、促进凋亡和阻止转移的潜在作用。同时,S-Adenosyl-L-methionine 1,4-butanedisulfonate 也用于肝病和骨关节炎的相关研究。 | |||
T82617 |
D-Ala-Lys-AMCA TFA
|
||
D-Ala-Lys-AMCA是一个已知的PEPT1底物,具有发射蓝色荧光的性质。该化合物可被转运至肝癌细胞及Caco-2细胞。D-Ala-Lys-AMCA能够作为工具用于评估PEPT1的特异性底物或其抑制剂。 | |||
T35978 |
Benastatin A
|
Others | Others |
Benastatin A is a polyketide synthase-derived benastatin that has been found inStreptomycesand has diverse biological activities.1,2,3It inhibits glutathione S-transferase (GST; Ki= 5 μM for the rat liver enzyme).2Benastatin A is active against several bacteria, including methicillin-resistantS. aureus(MRSA; MIC = 3.12 μg/ml). It induces apoptosis and cell cycle arrest at the G1/G0phase in Colon 26 mouse colon cancer cells when used at concentrations of 20 and 16 μM, respectively.3 1.Xu, Z., Sch... | |||
T79373 |
A3AR agonist 2
|
Adenosine Receptor | GPCR/G Protein; Neuroscience |
A3AR agonist 2 (Compound 19) 是高选择性A3AR激动剂,Ki为22.1 nM。本化合物有效促进β-arrestin2募集,展现出EC50为4.36 nM。A3AR agonist 2 主要用于研究炎症性疾病、缺血、癌症、神经性疼痛、肝脏病以及其他慢性病态。 | |||
T72861 |
(6R)-ML753286
|
Others | Others |
(6R)-ML753286 是 ML753286 的异构体。ML753286 是一种口服活性和选择性 BCRP(抗乳腺癌蛋白) 抑制剂,IC50为 0.6 μM。 ML753286 在啮齿动物和人类肝脏 S9 组分中具有高渗透性和低至中等清除率,并且在不同物种中都具有血浆稳定性。 | |||
T71097 |
DC-120
|
Others | Others |
DC-120 is an ATP competitive AKT kinase inhibitor that suppressed proliferation and induced apoptosis in liver cancer cells both in vitro and in vivo. DC120 blocked the phosphorylation of downstream molecules in the AKT signal pathway in dose- and time-dependent manners both in vitro and in vivo. DC120 inhibits AKT activity in vitro with an EC(50) of 153 nM. DC120 at 20 mg/kg/day inhibited the CNE2 xenograft tumor growth with a treated group/control group ratio of 38.1%, accompanied by increas... | |||
T69035 |
Camostat free base
|
Others | Others |
Camostat, also known as FOY 305, is a serine protease inhibitor. Camostat is used in the treatment of some forms of cancer and is also effective against some viral infections, as well as inhibiting fibrosis in liver or kidney disease or pancreatitis. It is an inhibitor of the enzyme transmembrane protease, serine 2 (TMPRSS2). Inhibition of TMPRSS2 partially blocked infection by SARS-CoV and Human coronavirus NL63 in HeLa cell cultures. In vitro study showed that camostat significantly reduces... | |||
T61990 |
Topoisomerase I/II inhibitor 3
|
Others | Others |
Topoisomerase I/II inhibitor 3 (化合物7) 是拓扑异构酶 I (Topo I)和 II (Topo II)的有效双抑制剂。 通过抑制 PI3K/Akt/mTOR 信号通路,Topoisomerase I/II inhibitor 3抑制细胞增殖、侵袭和迁移,诱导细胞凋亡(apoptosis)。Topoisomerase I/II inhibitor 3 在肝癌中具有研究价值。 | |||
T72997 |
HIF-2α-IN-7
|
Others | Others |
HIF-2α-IN-7 是一种缺氧诱导因子 2α(HIF-2α)抑制剂。HIF-2α-IN-7 抑制 HIF-2α,EC50值为 6 nM。HIF-2α-IN-7 可用于多种疾病的研究,包括癌症、肝病、炎性疾病、肺病和铁负荷紊乱。 | |||
T79359 |
Anticancer agent 147
|
Ferroptosis | Apoptosis |
Anticanceragent 147(化合物6j),作为槐定碱的衍生物,功能为铁死亡(Ferroptosis)诱导剂。该化合物能促进Fe2+、活性氧(ROS)及丙二醛(MDA)在细胞内的积累,并通过增加内质网(ER)应激和上调转录因子ATF3的表达发挥作用。在体外及体内实验中,Anticanceragent 147展现了出色的抗肝癌活性。 | |||
T79798 |
PHD-IN-2
|
HIF/HIF Prolyl-Hydroxylase | Chromatin/Epigenetic; Metabolism |
PHD-IN-2(Compound 91)是一种高效的PHD拮抗剂,具有IC50值小于5 nM,能在HEP3B细胞中诱导促红细胞生成素的合成,EC50值小于2.5 μM。此化合物主要用于心血管、代谢、血液、肺部、肾脏、肝脏疾病、伤口愈合以及癌症等研究领域。 | |||
T79372 |
A3AR agonist 1
|
Adenosine Receptor | GPCR/G Protein; Neuroscience |
A3AR拮抗剂1(化合物12)是一种选择性的A3AR激动剂,其Ki值为25.8 nM。该化合物能有效促进β-arrestin2的募集,表现出EC50为5.17 nM的高亲和力。A3AR拮抗剂1主要用于炎症性疾病、缺血、癌症、神经性疼痛和肝脏疾病等方面的科研。 |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T5S1923 |
Schisandrin C
五味子丙素,Schizandrin-C,Wuweizisu-C |
Apoptosis; Others; Virus Protease | Apoptosis; Microbiology/Virology; Others |
Schisandrin C (Wuweizisu-C) 是从五味子中分离得到的一种植物化学木脂素。它具有抗癌、抗炎和抗氧化等多种生物活性,可研究癌症、阿尔茨海默病、肝病。 | |||
T3673 |
Mollugin
大叶茜草素,Rubimaillin |
HER; JAK | Angiogenesis; Chromatin/Epigenetic; JAK/STAT signaling; Stem Cells; Tyrosine Kinase/Adaptors |
Mollugin (Rubimaillin) 是Rubia cordifolia L.中主要的生物活性成分。它能通过 p38-Smad 信号通路增强 BMP-2 的成骨作用。它通过抑制 TNF-α 诱导的 NF-κB 激活起抗癌疗效。 | |||
T3324 |
Lycorine
Galanthidine,Narcissine,石蒜碱,Amarylline,Belamarine,Licorine,番石榴碱 |
Apoptosis; Virus Protease; Antibacterial; AChR; Fatty Acid Synthase | Apoptosis; Metabolism; Microbiology/Virology; Neuroscience |
Lycorine (Narcissine) 是从金眼科植物科中提取的一种天然生物碱。它是一种具有口服活性的SCAP 抑制剂,Kd 值 15.24 nM。它也是黑色素瘤血管生成抑制剂,有用于前列腺癌和代谢疾病的研究潜力。 | |||
T7060 |
Amantadine
1-Aminoadamantane,1-金刚烷胺,金刚烷胺,1-Adamantanamine,1-Adamantylamine |
Others | Others |
Amantadine (1-Aminoadamantane) 是抗病毒药物,也是是 NMDA 型谷氨酸受体的弱拮抗剂,能促进高多巴胺的释放,并阻断多巴胺的再摄取。 | |||
TN1599 |
Eburicoic acid
Eburicoicacid,MFCD00238594,ZINC4655149,齿孔菌酸 |
Antioxidant; TNF; NOS; NO Synthase; CCR; Immunology/Inflammation related | Apoptosis; Immunology/Inflammation; Microbiology/Virology; oxidation-reduction |
Eburicoic acid (ZINC4655149) 具有抗炎和抗氧化活性,从而保护肝脏免受 CCl4 引起的肝损伤,可用于抗肝癌研究。 | |||
TQ0065 |
Pseudobufarenogin
伪异沙蟾毒精,ψ-Bufarenogin |
Others | Others |
Pseudobufarenogin (ψ-Bufarenogin) 是一种蟾蜍毒素提取物,活性背景未知。 | |||
TN1143 |
1-O-Acetyl britannilactone
|
Apoptosis; Antibiotic | Apoptosis; Microbiology/Virology |
1-O-Acetyl britannilactone 是一种农用杀菌剂,可诱导细胞凋亡,可用于研究肝损伤和癌症。 | |||
TN5770 |
Gingerenone A
|
Nrf2 | Immunology/Inflammation |
Gingerenone A 是一种有效的 Nrf2-Gpx4 激活剂,是从生姜里面分离出来的小分子化合物,具有抗癌活性,可延长癌细胞的细胞周期,可抑制右旋糖酐硫酸钠 (DSS) 诱导的结肠炎小鼠继发性肝损伤 (SLI) 中的铁死亡。 | |||
T5S0018 |
Betulonic acid
路路通酸,(+)-Betulonic acid,Betunolic acid,Liquidambaric acid |
Parasite; HSV | Microbiology/Virology |
Betulonic acid (Liquidambaric acid) 是一种在许多植物中存在的三萜类天然产物,具有抗肿瘤,抗炎,抗寄生虫和抗病毒的活性。 | |||
TN2272 |
Tigloylgomisin H
|
Nrf2 | Immunology/Inflammation |
Tigloylgomisin H 是分离自S. chinensis 果实中的木酚素。Tigloylgomisin H 能诱导小鼠肝癌细胞 Hepa1c1c7 中醌还原酶活性。Tigloylgomisin H 是单功能诱导剂,通过 Nrf2-ARE 途径特异性上调 II 期解毒酶 NQO1。Tigloylgomisin H 是潜在的肝癌预防剂。 | |||
T1660 |
Silibinin
水飞蓟宾 A,水飞蓟宾,Silibinin A,Silybin,Silymarin I |
Reactive Oxygen Species; Autophagy | Autophagy; Immunology/Inflammation; Metabolism; NF-κB |
Silibinin (Silybin) 是水飞蓟的主要活性成分,具有抗癌和化疗预防作用,能抑制细胞增殖和迁移。 | |||
TWS1977 |
Kamebakaurin
尾叶香茶菜丙素,Kamebakaurine |
NF-κB | NF-κB |
Kamebakaurin (Kamebakaurine) 是一种提取自Isodon japonicus 中的天然产物,是一种NF-κB 的抑制剂,能够抑制 p50 的 DNA 结合活性。 | |||
T4S0797 |
Berberine
小檗碱,Berberin,Umbellatine,黄连素 |
Reactive Oxygen Species; Topoisomerase; Endogenous Metabolite; Antibacterial; Antibiotic; Autophagy | Autophagy; DNA Damage/DNA Repair; Immunology/Inflammation; Metabolism; Microbiology/Virology; NF-κB |
Berberine (Umbellatine) 属于生物碱类天然产物,可以激活 AMPK、抑制 DNA 拓扑异构酶、诱导 ROS 生成。Berberine 具有抗肿瘤、抗菌、降血糖、降血脂等生物学活性。 | |||
T5S0754 |
Isoquercetin
3-Glucosylquercetin,Hirsutrin,Isoquercitrin,异槲皮苷,Quercetin 3-o-glucopyranoside,槲皮素-3-葡萄糖苷 |
NF-κB; Wnt/beta-catenin; NO Synthase | Cytoskeletal Signaling; Immunology/Inflammation; NF-κB; Stem Cells |
Isoquercetin (3-Glucosylquercetin) 是天然存在的多酚,具有抗氧化,抗增殖和抗炎特性。它通过调节核因子-κB 转录调节系统调节一氧化氮合酶 2 的表达。它通过 Nrf2/ARE 抗氧化剂信号传导途径减轻乙醇诱导的肝毒性,氧化应激和炎症反应。它具有高生物利用度和低毒性,是预防糖尿病妊娠出生缺陷的有希望的候选药物。 | |||
T37067 |
9-hydroxy Stearic Acid
|
HDAC | Chromatin/Epigenetic; DNA Damage/DNA Repair |
9-hydroxy Stearic Acid 是一种羟基脂肪酸,是9-PAHSA 的活性代谢物。9-hydroxy Stearic Acid 是由9-PAHSA 通过肝脏和胰腺的羧基酯脂肪酶形成的。9-hydroxy Stearic Acid (5 μM)抑制HT-29结肠癌细胞裂解物中组蛋白去乙酰化酶1 (HDAC1)的表达。3 .当浓度为100 μM.1时,可抑制HT-29细胞的增殖,并诱导细胞周期阻滞于G0/ g1期。 | |||
T6677 |
Sophocarpine
|
ERK; p38 MAPK; NF-κB; TLR; COX; HER; JNK; STAT | Angiogenesis; Immunology/Inflammation; JAK/STAT signaling; MAPK; Neuroscience; NF-κB; Stem Cells; Tyrosine Kinase/Adaptors |
Sophocarpine 是一种从传统草药苦参中提取的重要生物碱。苦参具有抗病毒、抗肿瘤和抗炎等多种药理作用。它通过多种机制显著抑制癌细胞的生长,具有抗肿瘤活性。 | |||
TN2507 |
1,6,7-Trihydroxyxanthone
|
DNA/RNA Synthesis | Cell Cycle/Checkpoint; DNA Damage/DNA Repair |
1,6,7-Trihydroxyxanthone has anti-cancer activity ,at least in part, through the activation of miR-218 and suppression of Bmi-1 expression; can suppress cell growth and induce apoptosis in liver cancer cells. | |||
T2S2104 |
Sinigrin hydrate
黑芥子苷,Sinigrin monohydrate,芥子甙单水合物,Allylglucosinolate monohydrate |
Antibacterial | Microbiology/Virology |
Sinigrin hydrate (Allylglucosinolate monohydrate) 是一种天然脂肪族芥子油苷,存在于十字花科植物中。它具有消炎、抗癌、抗真菌、抗菌、抗氧化作用。 | |||
TN6062 |
1,3,9-Trimethyluric acid
|
||
1,3,9-Trimethyluric acid exhibits in vitro cytotoxic activity against breast cancer (MCF-7), human neuroblastoma (SHSY5Y), human non-small cell lung cancer (A549) and human liver cancer (HEPG2) with IC50 value in the range of 1-3 uM. 1,3,9-Trimethyluric a | |||
TN4291 |
Isofuranodiene
|
IL Receptor; NOS | Immunology/Inflammation |
Isofuranodiene protects GalN/LPS-induced liver injury in SD rats, it may be a potential functional food ingredient for the prevention and treatment of liver diseases. Isofuranodiene has anticancer activity, by inhibiting the proliferation and inducing apo | |||
TN2308 |
Wilfortrine
|
BCL | Apoptosis |
Wilfortrine can induce liver cancer cell HepG2 apoptosis, but with no effect on the cell cycle, mainly by promoting Bax expression and inhibiting anti-apoptotic protein Bcl-2 expression. | |||
TN5013 |
Shizukaol D
|
AMPK | Chromatin/Epigenetic; PI3K/Akt/mTOR signaling |
Shizukaol D exerts a growth inhibition effect on liver cancer cells in a dose- and time-dependent manner by modulating wnt signalling pathway. Shizukaol D may be used to treat metabolic syndrome, it induces mitochondrial dysfunction by depolarizing the mitochondrial membrane and suppressing energy production, which may result in AMPK activation. | |||
TN4194 |
Heliangin
|
IL Receptor; TNF; NF-κB; MAPK; Prostaglandin Receptor | Apoptosis; GPCR/G Protein; Immunology/Inflammation; MAPK; NF-κB |
Heliangin shows anti-inflammatory effects, it can inhibit lipopolysaccharide-induced inflammation through signaling NF-κB pathway on LPS-induced RAW 264.7 cells. Heliangin has anti-cancer activity, it exhibits cytotoxicity against human oral epidermoid ( | |||
TN5901 |
Cudratricusxanthone A
|
||
Cudratricusxanthone A has potent anti-proliferative, antioxidative, and monoamine oxidase inhibitory effects, it also possesses anti-cancer activities and provide a basis for developing effective therapeutic agents to inhibit growth and metastasis of brea | |||
TN4223 |
Homopterocarpin
|
Antifection | Microbiology/Virology |
Homopterocarpin and Pterocarpus extract offer gastroprotection against indomethacin- induced ulcer by antioxidative mechanism and the modulation of gastric homeostasis, homopterocarpin may be responsible for, or contribute to the antiulcerogenic property | |||
T36000 |
3-Hydroxyterphenyllin
|
Others | Others |
3-Hydroxyterphenyllin is a p-terphenyl fungal metabolite originally isolated from A. candidus that has diverse biological activities, including antioxidant, antiproliferative, antibacterial, and antiviral properties.1,2,3,4 It has a 96% scavenging effect on 2,2-diphenyl-1-picrylhydrazyl radicals when used at a concentration of 100 μg/ml.2 3-Hydroxyterphenyllin inhibits the growth of HeLa cervical, A549 lung, and HepG2 liver cancer cells (IC50s = 23, 36, and 32 μM, respectively), as well as methi... | |||
T35624 |
Ajoene
|
Others | Others |
Ajoene is a disulfide that has been found inA. sativumand has diverse biological activities, including antibacterial, anticancer, antiplatelet, and antioxidant properties.1,2,3,4It is active against Gram-positive (MICs = 5-160 µg/ml) and Gram-negative bacteria (MICs = 136-200 µg/ml), as well as yeasts (MICs = 10-20 µg/ml).1Ajoene is cytotoxic to mouse melanoma cells (IC50= 18 µM), as well as human colon, lung, mammary, and pancreatic cancer cells (IC50s = 7-41 µM).2It reduces... |
Cat. No. | Product Name | Species | Expression System |
---|---|---|---|
TMPH-01091 |
CHD1L Protein, Human, Recombinant (His & SUMO)
Amplified in liver cancer protein 1,CHD1L,... |
Human | E. coli |
DNA helicase which plays a role in chromatin-remodeling following DNA damage. Targeted to sites of DNA damage through interaction with poly(ADP-ribose) and functions to regulate chromatin during DNA repair. Able to catalyze nucleosome sliding in an ATP-dependent manner. Helicase activity is strongly stimulated upon poly(ADP-ribose)-binding. CHD1L Protein, Human, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 37.3 kDa an... | |||
TMPH-01498 |
HJURP Protein, Human, Recombinant (His & SUMO)
14-3-3-associated AKT substrate,Up-regulated in lung can... |
Human | E. coli |
HJURP Protein, Human, Recombinant (His & SUMO) is expressed in E. coli. | |||
TMPY-02869 |
MMP-12 Protein, Human, Recombinant (catalytic domain)
HME,ME,MMP-12,MME,matrix metallopeptidase 12 |
Human | E. coli |
Matrix metalloproteinases (MMPs) are a family of zinc-dependent endopeptidases that degrade components of the extracellular matrix (ECM) and play essential roles in various physiological processes such as morphogenesis, differentiation, angiogenesis, and tissue remodeling, as well as pathological processes including inflammation, arthritis, cardiovascular diseases, pulmonary diseases, and tumor invasion. Macrophage Metalloelastase, also known as Matrix metalloproteinase-12, Macrophage elastase, ... | |||
TMPJ-00412 |
VEGFR1/FLT-1 Protein, Human, Recombinant (hFc)
Vascular endothelial growth factor receptor 1,Vascular perme... |
Human | HEK293 Cells |
Human Vascular endothelial growth factor receptor 1(VEGFR-1, FLT-1) is a member of the the class III subfamily of receptor tyrosine kinases (RTKs) and Tyr protein kinase family and CSF-1/PDGF receptor subfamily. VEGFR-1 is widely expressed in human tissues including normal lung, placenta, liver, kidney, heart and brain tissues. It is specifically expressed in most of the vascular endothelial cellsand peripheral blood monocytes. VEGFR-1 contains seven Ig-like C2-type domains and one protein kinas... | |||
TMPK-01482 |
HLA-A*02:03&B2M&AFP (FMNKFIYEI) Tetramer Protein, Human, MHC (His & Avi)
MHC,AFPD,Alpha-fetoprotein,FETA,Alpha-1-fetoprotein,AFP,HPAF... |
Human | HEK293 Cells |
Alpha-fetoprotein (AFP), a specific liver cancer marker, T cells expressing AFP-CAR selectively degranulated, released cytokines, and lysed liver cancer cells that were HLA-A*02:01 /AFP while sparing cells from multiple tissue types that were negative for either expressed proteins.CAR T-cell immunotherapy targeting intracellular/secreted solid tumor antigens can elicit a potent antitumor response. | |||
TMPK-01519 |
HLA-A*02:01&B2M&AFP (FMNKFIYEI) Tetramer Protein, Human, MHC (His & Avi)
MHC,FETA,AFP,Alpha-feto,AFPD,Alpha-1-fetoprotein,HPAFP,Alpha... |
Human | HEK293 Cells |
Alpha-fetoprotein (AFP), a specific liver cancer marker, T cells expressing AFP-CAR selectively degranulated, released cytokines, and lysed liver cancer cells that were HLA-A*02:01 /AFP while sparing cells from multiple tissue types that were negative for either expressed proteins.CAR T-cell immunotherapy targeting intracellular/secreted solid tumor antigens can elicit a potent antitumor response. | |||
TMPK-01520 |
HLA-A*02:01&B2M&AFP (PLFQVPEPV) Tetramer Protein, Human, MHC (His & Avi)
Alpha-1-fetoprotein,AFP,HPAFP,FETA,AFPD,MHC,Alpha-fetoprotei... |
Human | HEK293 Cells |
Alpha-fetoprotein (AFP), a specific liver cancer marker, T cells expressing AFP-CAR selectively degranulated, released cytokines, and lysed liver cancer cells that were HLA-A*02:01 /AFP while sparing cells from multiple tissue types that were negative for either expressed proteins.CAR T-cell immunotherapy targeting intracellular/secreted solid tumor antigens can elicit a potent antitumor response. | |||
TMPK-01417 |
HLA-A*02:03&B2M&AFP (FMNKFIYEI) Tetramer Protein, Human, MHC (His & Avi), PE-Labeled
Alpha-1-fetoprotein,HPAFP,AFPD,AFP,Alpha-feto,MHC,FETA,Alpha... |
Human | HEK293 Cells |
Alpha-fetoprotein (AFP), a specific liver cancer marker, T cells expressing AFP-CAR selectively degranulated, released cytokines, and lysed liver cancer cells that were HLA-A*02:01 /AFP while sparing cells from multiple tissue types that were negative for either expressed proteins.CAR T-cell immunotherapy targeting intracellular/secreted solid tumor antigens can elicit a potent antitumor response. | |||
TMPK-01477 |
HLA-A*02:01&B2M&AFP (FMNKFIYEI) Monomer Protein, Human, MHC (His & Avi), Biotinylated
HPAFP,FETA,Alpha-1-fetoprotein,AFPD,AFP,Alpha-feto,MHC,Alpha... |
Human | HEK293 Cells |
Alpha-fetoprotein (AFP), a specific liver cancer marker, T cells expressing AFP-CAR selectively degranulated, released cytokines, and lysed liver cancer cells that were HLA-A*02:01 /AFP while sparing cells from multiple tissue types that were negative for either expressed proteins.CAR T-cell immunotherapy targeting intracellular/secreted solid tumor antigens can elicit a potent antitumor response. | |||
TMPK-01484 |
HLA-A*02:03&B2M&AFP (FMNKFIYEI) Monomer Protein, Human, MHC (His & Avi)
HPAFP,FETA,AFP,AFPD,Alpha-1-fetoprotein,MHC,Alpha-fetoprotei... |
Human | HEK293 Cells |
Alpha-fetoprotein (AFP), a specific liver cancer marker, T cells expressing AFP-CAR selectively degranulated, released cytokines, and lysed liver cancer cells that were HLA-A*02:01 /AFP while sparing cells from multiple tissue types that were negative for either expressed proteins.CAR T-cell immunotherapy targeting intracellular/secreted solid tumor antigens can elicit a potent antitumor response. | |||
TMPK-01483 |
HLA-A*02:03&B2M&AFP (FMNKFIYEI) Monomer Protein, Human, MHC (His & Avi), Biotinylated
AFPD,AFP,Alpha-fetoprotein,HPAFP,MHC,FETA,Alpha-1-fetoprotei... |
Human | HEK293 Cells |
Alpha-fetoprotein (AFP), a specific liver cancer marker, T cells expressing AFP-CAR selectively degranulated, released cytokines, and lysed liver cancer cells that were HLA-A*02:01 /AFP while sparing cells from multiple tissue types that were negative for either expressed proteins.CAR T-cell immunotherapy targeting intracellular/secreted solid tumor antigens can elicit a potent antitumor response. | |||
TMPK-01515 |
HLA-A*02:01&B2M&AFP (FMNKFIYEI) Monomer Protein, Human, MHC (His & Avi)
HPAFP,Alpha-fetoprotein,MHC,FETA,Alpha-feto,Alpha-1-fetoprot... |
Human | HEK293 Cells |
Alpha-fetoprotein (AFP), a specific liver cancer marker, T cells expressing AFP-CAR selectively degranulated, released cytokines, and lysed liver cancer cells that were HLA-A*02:01 /AFP while sparing cells from multiple tissue types that were negative for either expressed proteins.CAR T-cell immunotherapy targeting intracellular/secreted solid tumor antigens can elicit a potent antitumor response. | |||
TMPK-01521 |
HLA-A*02:01&B2M&AFP (PLFQVPEPV) Monomer Protein, Human, MHC (His & Avi)
MHC,Alpha-feto,AFPD,Alpha-1-fetoprotein,Alpha-fetoprotein,FE... |
Human | HEK293 Cells |
Alpha-fetoprotein (AFP), a specific liver cancer marker, T cells expressing AFP-CAR selectively degranulated, released cytokines, and lysed liver cancer cells that were HLA-A*02:01 /AFP while sparing cells from multiple tissue types that were negative for either expressed proteins.CAR T-cell immunotherapy targeting intracellular/secreted solid tumor antigens can elicit a potent antitumor response. | |||
TMPK-01436 |
HLA-A*02:01&B2M&AFP (FMNKFIYEI) Tetramer Protein, Human, MHC (His & Avi), PE-Labeled
Alpha-1-fetoprotein,FETA,MHC,Alpha-feto,AFPD,Alpha-fetoprote... |
Human | HEK293 Cells |
Alpha-fetoprotein (AFP), a specific liver cancer marker, T cells expressing AFP-CAR selectively degranulated, released cytokines, and lysed liver cancer cells that were HLA-A*02:01 /AFP while sparing cells from multiple tissue types that were negative for either expressed proteins.CAR T-cell immunotherapy targeting intracellular/secreted solid tumor antigens can elicit a potent antitumor response. | |||
TMPK-01478 |
HLA-A*02:01&B2M&AFP (PLFQVPEPV) Monomer Protein, Human, MHC (His & Avi), Biotinylated
AFP,FETA,Alpha-feto,HPAFP,Alpha-1-fetoprotein,MHC,Alpha-feto... |
Human | HEK293 Cells |
Alpha-fetoprotein (AFP), a specific liver cancer marker, T cells expressing AFP-CAR selectively degranulated, released cytokines, and lysed liver cancer cells that were HLA-A*02:01 /AFP while sparing cells from multiple tissue types that were negative for either expressed proteins.CAR T-cell immunotherapy targeting intracellular/secreted solid tumor antigens can elicit a potent antitumor response. | |||
TMPK-01132 |
PRL-1/PTP4A1 Protein, Human, Recombinant (His)
PTPCAAX1,PRL1,PRL-1,PTP(CAAXI),PTP4A1 |
Human | E. coli |
Phosphatases of regenerating liver (PRL-1, PRL-2, and PRL-3, also known as PTP4A1, PTP4A2, and PTP4A3) control magnesium homeostasis through an association with the CNNM magnesium transport regulators. PRL-1 (PTP4A1) is a key molecule that activates tyrosine phosphorylation, which is important for cancer progression and metastasis. | |||
TMPJ-01288 |
KLF6 Protein, Human, Recombinant
CPBP,GC-Rich Sites-Binding Factor GBF,Suppressor of Tumorige... |
Human | E. coli |
Krueppel-Like Factor 6 (KLF6) belongs to the krueppel C2H2-type zinc-finger protein family. KLF6 contains three C2H2-type zinc fingers and localizes in the nucleus. KLF6 expression is highest in the placenta followed by spleen, thymus, prostate, testis, small intestinem and colon. However, it is weakly expressed in the pancreas, lung, liver, heart, and skeletal muscle. KLF6 functions as a transcriptional activator and could play a role in B-cell growth and development. Defects in KLF6 will resul... | |||
TMPY-04205 |
AGR3 Protein, Human, Recombinant (mFc)
hAG-3,AG3,HAG3,anterior gradient 3,PDIA18,BCMP11,AG-3 |
Human | HEK293 Cells |
Anterior gradient protein (AGR) 3 is a highly related homologue of pro-oncogenic AGR2 and belongs to the family of protein disulfide isomerases. AGR3 was found in breast, ovary, prostate, and liver cancer, it is associated with the level of differentiation, slowly proliferating tumors, and more favorable prognosis of breast cancer patients. AGR3 is a specialized member of the PDI family that plays an unexpected role in the regulation of CBF and mucociliary clearance in the airway. AGR3 had been... | |||
TMPY-02622 |
Aldolase B Protein, Human, Recombinant (GST)
aldolase B, fructose-bisphosphate,ALDO2,ALDB |
Human | E. coli |
The aldolase family members involved in metabolism and glycolysis are present in three isoforms: ALDOA, ALDOB, and ALDOC. Aldolases are differentially expressed in human tissues, and aberrant expression has been observed in several human diseases and cancer types. Via GATA6, metastatic cells in the liver upregulate the enzyme aldolase B (ALDOB), which enhances fructose metabolism and provides fuel for major pathways of central carbon metabolism during tumor cell proliferation. Targeting ALDOB or... | |||
TMPY-02386 |
PTP4A2 Protein, Human, Recombinant (GST)
HNMT-S2,PRL-2,HNMT-S1,protein tyrosine phosphatase type IVA,... |
Human | E. coli |
PRL-2 (Protein-tyrosine phosphatase of regenerating liver 2), also known as PTP4A2 (Protein tyrosine phosphatase type IVA, member 2), is a member of PTP family and has an important function in controlling cell growth. PRL-2 phosphatases may be multifunctional enzymes with diverse roles in a variety of tissue and cell types. The phosphatase of regenerating liver (PRL) family, comprising PRL-1, PRL-2 and PRL-3, is a group of prenylated phosphatases that are candidate cancer biomarkers and therapeu... | |||
TMPK-00336 |
GPC3 Protein-VLP, Human, Recombinant
Glypican 3,SGB,SGBS1SDYS,DGSX,OCI-5,OCI5,GTR2-2,GPC3,SGBS1,S... |
Human | E. coli |
Glypican-3 is a protein ,which is encoded by the GPC3 gene in humans.The protein core of GPC3 consists of two subunits, where the N-terminal subunit has a size of ~40 kDa and the C-terminal subunit is ~30 kDa.Glypican 3 is a potential therapeutic target for treating liver cancer and other cancers. Several therapeutic anti-GPC3 antibodies have been developed. GPC3 Protein-VLP, Human, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 14 kDa and the accession ... | |||
TMPY-06226 |
SLC39A6/LIV-1 Protein, Cynomolgus, Recombinant (His)
solute carrier family 39 member 6 |
Cynomolgus | HEK293 Cells |
Along with the SLC30 family, SLC39 family members regulate zinc movement in cells. SLC39 metal ion transporters accumulate zinc into the cytosol. SLC39A6, also known as LIV-1, belongs to a new subfamily of Zrt, Irt-like protein zinc transporters (LZTs). It is involved in maintaining the intracellular homeostasis of zinc, an ion that is essential in the control of cellular growth and differentiation. SLC39A6 plays a critical role in maintaining zinc homeostasis, and was originally identified as a... | |||
TMPY-02426 |
UBE2D1 Protein, Human, Recombinant (His)
UBC4/5,E2(17)KB1,ubiquitin-conjugating enzyme E2D 1,UBCH5,UB... |
Human | E. coli |
Ubiquitin-conjugating enzyme E2 D1 (UBE2D1), a member of human E2 ubiquitin-conjugating enzymes, is closely related to SFT, which is short for stimulator of iron (Fe) transport. In other words, UbcH5A is significantly up-regulated in the liver of iron-overloaded patients with hereditary hemochromatosis, as previously published for SFT. Moreover, a complex of UBE2D1 is critical in maintaining KRAS protein stability and propose that targeting such complex may be a unique strategy to degrade mutant... | |||
TMPJ-01262 |
UPRT Protein, Human, Recombinant (His)
UPRT,UPP,FUR1,Uracil phosphoribosyltransferase homolog |
Human | E. coli |
UPRT is a cytoplasmic enzyme which belongs to the UPRTase family. UPRT is highly expressed in leukocytes, liver, spleen and thymus, with lower expression in brain, lung and skeletal muscle. UPRTcatalyzes the conversion of uracil and 5-phosphoribosyl-1-R-diphosphate to uridine monophosphate (UMP). This reaction is an important part of nucleotide metabolism, specifically the pyrimidine salvage pathway. UPRT is a potential target for rational design of drugs to treat parasitic infections and cancer | |||
TMPK-00337 |
GPC3 Protein-VLP, Human, Recombinant (aa 438-554)
OCI-5,SDYS,SGB,OCI5,MXR7,GTR2-2,GPC3,Glypican 3,SGBS,SGBS1SD... |
Human | HEK293 Cells |
Glypican-3 is a protein ,which is encoded by the GPC3 gene in humans.The protein core of GPC3 consists of two subunits, where the N-terminal subunit has a size of ~40 kDa and the C-terminal subunit is ~30 kDa.Glypican 3 is a potential therapeutic target for treating liver cancer and other cancers. Several therapeutic anti-GPC3 antibodies have been developed. GPC3 Protein-VLP, Human, Recombinant (aa 438-554) is expressed in HEK293 mammalian cells. The predicted molecular weight is 21.5 kDa and th... | |||
TMPY-02757 |
TWEAKR/TNFRSF12A Protein, Human, Recombinant (hFc)
FN14,CD266,TWEAKR,tumor necrosis factor receptor superfamily... |
Human | HEK293 Cells |
Fn14 (tumor necrosis factor receptor superfamily, member 12A), also known as TNFRSF12A, is the receptor for TNFSF12/TWEAK. Fn14 shares 82% amino acid identity with the mouse sequence. It contains a signal peptide, an extracellular domain, a membrane-anchoring domain, and a cytoplasmic domain. In response to FGF1, calf serum, or phorbol ester stimulation of human quiescent fibroblasts in vitro, the level of Fn14 is increased. A 1.2-kb FN14 transcript was expressed at high levels in heart, placent... | |||
TMPY-06821 |
THRB Protein, Human, Recombinant (His)
THRB1,GRTH,THR1,ERBA2,C-ERBA-2,THRB2,thyroid hormone recepto... |
Human | E. coli |
Thyroid hormone receptor beta (THRB), also known as TRbeta and NR1A2, belongs to the nuclear hormone receptor family. Featuring an N-terminal transactivation domain, a central DNA-binding domain, and a hormone/ligand-binding domain, THRB isoform 1/2 expression localizes predominately to the liver and pituitary, respectively. THRB regulates the feedback of T3-dependent thyrotropin-stimulating hormone (TSH) transcription in the pituitary by binding to thyroid hormone (TH) response elements present... | |||
TMPY-02100 |
TEM7 Protein, Human, Recombinant (His)
TEM3,plexin domain containing 1,TEM7 |
Human | HEK293 Cells |
Plexin domain-containing protein 1, also known as tumor endothelial marker 3, tumor endothelial marker 7 and PLXDC1 and TEM3, is a secreted, cytoplasm and single-pass type I membrane protein that belongs to the plexin family. PLXDC1 / TEM3 is detected in endothelial cells from colorectal cancer, and in endothelial cells from primary cancers of the lung, liver, pancreas, breast and brain. It is expressed in fibrovascular membrane with increased expression in individuals with proliferative diabeti... | |||
TMPY-02796 |
KIAA0101 Protein, Human, Recombinant (His)
L5,NS5ATP9,p15PAF,OEATC1,p15(PAF),OEATC,PAF,p15/PAF,OEATC-1,... |
Human | E. coli |
KIAA11, also known as p15(PAF), is a proliferating cell nuclear antigen-associated factor that interacts with proliferating cell nuclear antigen(PCNA). It was initially isolated in a yeast two-hybrid screen for PCNA binding partners and was shown to bind PCNA competitively with the cell cycle regulator p21(WAF). KIAA11 is localized primarily in the nucleus. It shares the conserved PCNA binding motif with several other PCNA binding proteins including CDK inhibitor p21. KIAA11 is involved in cell ... | |||
TMPJ-01212 |
ULBP-1 Protein, Mouse, Recombinant (His)
RAET1I,ULBP1,NKG2DL1 |
Mouse | HEK293 Cells |
Mouse ULBP1, also known as RAET1I and NKG2DL1, is a member of the ULBP/RAET1 gene family. ULBP1 plays an important role in immune responses, especially in cancer and infectious diseases, and is well-known to bind to NKG2D together with at least ULBP 2 and 3. These proteins are distantly related to major histocompatibility class I (MHC I) molecules, possessing the alpha 1 and alpha 2 Ig-like domains, but lacking the alpha 3 domain. Unlike MHC Class I, they have no capacity to bind peptide or inte... |
Cat. No. | Product Name | Target | Signaling Pathways |
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T69758 |
Flutamide-d7
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Flutamide-d7 is intended for use as an internal standard for the quantification of flutamide by GC- or LC-MS. Flutamide is an androgen receptor antagonist and prodrug form of 2-hydroxy flutamide. Flutamide is converted to 2-hydroxy flutamide by the cytochrome P450 (CYP) isoform CYP1A2 in human liver microsomes. It is cytotoxic to PC3 and LNCaP prostate cancer cells with IC50 values of 98.8 and 81.8 µM, respectively. Flutamide (50 mg/kg per day) reduces tumor growth in a PC-82 mouse xenograft mo... | |||
TMIH-0521 |
Silibinin-d3
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Silibinin-d3 是 Silibinin 的氘代化合物。Silibinin 的 CAS 号为 22888-70-6。Silibinin 是水飞蓟的主要活性成分,具有抗癌和化疗预防作用,能抑制细胞增殖和迁移。 | |||
T71055 |
Albendazole-d7
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Albendazole-d7 is intended for use as an internal standard for the quantification of albendazole by GC- or LC-MS. Albendazole is an orally bioavailable benzimidazole anthelmintic that is active against a variety of helminths, including liver flukes, tapeworms, and roundworms. It eliminates Trichostrongylus in the fourth stomach of cattle and sheep when orally administered at doses ranging from 2.5 to 10 mg/kg as well as other species in the fourth stomach and the small and large intestine. Alben... |