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Search Results for " lipa "

Targets Recommended: Lipase Phospholipase PARP Autophagy

19

抑制剂 & 化合物

2

天然产物

8

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T2591	Veliparib ABT-888,NSC 737664,维利帕尼	PARP; Autophagy	Autophagy; Chromatin/Epigenetic; DNA Damage/DNA Repair
	Veliparib (ABT-888) 是一种可口服的 PARP 抑制剂，抑制PARP1和PARP2的Ki 分别为 5.2 和 2.9 nM。它增强细胞凋亡和自噬。
T2105	Veliparib dihydrochloride 维利帕尼二盐酸盐,ABT-888 dihydrochloride	PARP; Autophagy	Autophagy; Chromatin/Epigenetic; DNA Damage/DNA Repair
	Veliparib dihydrochloride (ABT-888 dihydrochloride) 是一种PARP1和PARP2抑制剂，Ki 分别为5.2 nM 和2.9 nM。
T11199	Endothelial lipase inhibitor-1	Lipase	Metabolism
	Endothelial lipase inhibitor-1是有效，选择性的内皮脂肪酶抑制剂，IC50为 49 nM。
T67991	Iliparcil	Others	Others
	Iliparcil 是一种具有口服活性的抗血栓化合物。
T65529	Lipase, triacylglycerol	Others	Others
	Lipase, triacylglycerol 是一种有用的有机化合物，可用于生命科学领域的相关研究。其产品编号为 T65529，CAS号为 9001-62-1。
T69004	Falipamil hydrochloride	Others	Others
	Falipamil hydrochloride is a calcium channel antagonist potentially for the treatment of ischaemic heart disorder and sinus.
T76120	Phospholipase D	Others	Others
	PhospholipaseD (PLD) ，即磷脂酶 D，是磷脂酶超家族的一种酶，广泛存在于细菌、酵母、植物、动物和病毒中，常用于生化研究。PhospholipaseD 可以催化甘油磷脂的磷酸二酯键水解，产生磷脂酸和可溶性胆碱。PhospholipaseD 参与了多种疾病相关过程，包括糖尿病、动脉粥样硬化形成、肥胖、肿瘤发生、免疫反应和神经内分泌功能。
T76182	Phospholipase A2
	PhospholipaseA2 (PLA2) 催化膜磷脂质在 sn-2 位置的水解作用，释放出花生四烯酸 (AA)。该酶为钙依赖型且热稳定，广泛应用于生化实验中。
T27302	Falipamil AQ-A 39,AQ-A-39,AQ-A39	Others	Others
	Falipamil is a verapamil derivative and a calcium channel antagonist. Falipamil exerts antitachycardic effects by a direct action on the sinus node. Falipamil decreases HR at exercise in normal subjects and may exert antianginal effects in patients with m
T63015	Pancreatic lipase/Carboxylesterase 1-IN-1	Others	Others
	Pancreatic lipase/Carboxylesterase 1-IN-1 (Compound 39) 是一种有效的、双重的胰脂酶 (PL) 和人羧酸酯酶 1A (hCES1A) 抑制剂，作用于 PL (IC50: 2.13 μM) 和 hCES1A (IC50: 0.055 μM)。
T61294	Monoacylglycerol lipase inhibitor 1	Others	Others
	Monoacylglycerol lipase inhibitor 1 是一种有效的单酰基甘油脂肪酶 (MGL) 抑制剂 (化合物 13)。
T29865	Alipamide CI-546,D-1721,CN 38474,Alipamidum,CN-38,474	Others	Others
	Alipamide is a bio-active chemical.
TP2467	Plipastatin B 1
	Plipastatin B 1 is a lipopeptide.
T39383	Lipase Substrate	Others	Others
	Lipase Substrate is a substrate of lipase to detect activity.
T125927	Folipastatin	Others	Others
	Folipastatin 是一种有用的有机化合物，可用于生命科学领域的相关研究。其产品编号为 T125927，CAS号为 139959-71-0。
T73610	Lipoprotein lipase	Others	Others
	Lipoprotein lipase 是来自于脂肪组织、心肌和骨骼肌、胰岛和巨噬细胞的多功能酶。Lipoprotein lipase 促进正常脂蛋白代谢、组织特异性底物的输送和利用。Lipoprotein lipase 催化脂质在血液循环的限速步骤。
T126497	Plipastatin A2	Others	Others
	Plipastatin A2 是一种有用的有机化合物，可用于生命科学领域的相关研究。其产品编号为 T126497，CAS号为 103955-72-2。
T126496	Plipastatin B2	Others	Others
	Plipastatin B2 是一种有用的有机化合物，可用于生命科学领域的相关研究。其产品编号为 T126496，CAS号为 103955-74-4。
T78528	ERX-41	Others	Others
	ERX-41是一种口服活性的立体特异性小分子，靶向溶酶体酸性脂肪酶A (LIPA)。该化合物通过诱导内质网(ER)应激从而导致细胞死亡，这一作用表明ERX-41功能独立于LIPA，但依赖于其在内质网的定位。ERX-41主要用于实体瘤靶向研究。

化合物

Cat.No: T2591

Synonym: ABT-888,NSC 737664,维利帕尼

Target: PARP, Autophagy

Veliparib dihydrochloride

Cat.No: T2105

Synonym: 维利帕尼二盐酸盐,ABT-888 dihydrochloride

Target: PARP, Autophagy

Endothelial lipase inhibitor-1

Cat.No: T11199

Target: Lipase

Cat.No: T67991

Target: Others

Lipase, triacylglycerol

Cat.No: T65529

Target: Others

Falipamil hydrochloride

Cat.No: T69004

Target: Others

Phospholipase D

Cat.No: T76120

Target: Others

Phospholipase A2

Cat.No: T76182

Cat.No: T27302

Synonym: AQ-A 39,AQ-A-39,AQ-A39

Target: Others

Pancreatic lipase/Carboxylesterase 1-IN-1

Cat.No: T63015

Target: Others

Monoacylglycerol lipase inhibitor 1

Cat.No: T61294

Target: Others

Cat.No: T29865

Synonym: CI-546,D-1721,CN 38474,Alipamidum,CN-38,474

Target: Others

Plipastatin B 1

Cat.No: TP2467

Lipase Substrate

Cat.No: T39383

Target: Others

Cat.No: T125927

Target: Others

Lipoprotein lipase

Cat.No: T73610

Target: Others

Cat.No: T126497

Target: Others

Cat.No: T126496

Target: Others

Cat.No: T78528

Target: Others

Cat. No.	Product Name	Target	Signaling Pathways
T5320	Tulipalin A α-methylene-γ-butyrolactone,2-Methylenebutyrolactone,2-甲烯基丁内酯	Others; Drug Metabolite	Metabolism; Others
	Tulipalin A (α-methylene-γ-butyrolactone) 是来源于郁金香鳞茎的有毒糖苷。Tulipalin A 是引起过敏性接触皮炎的致敏性致敏物 (causative allergen)，在低剂量影响免疫细胞的功能，例如 Jurkat T 细胞。
T83864	Plipastatin A1 SNA-60-367-3,Fengycin IX	Others	Others
	Plipastatin A1是一种在B. cereus中发现的脂肽类化合物，具有酶抑制活性和免疫抑制活性。它能抑制磷脂酶A2（PLA2）、PLC和PLD（IC50分别为2.9、1.3和1.4 µM）。Plipastatin A1（100 µg/ml）能抑制LPS诱导的B细胞爆发生成和Concanavalin A诱导的T细胞爆发生成。在体内，Plipastatin A1（0.1 mg/动物）能抑制小鼠的迟发型超敏反应。

天然产物

Cat.No: T5320

Synonym: α-methylene-γ-butyrolactone,2-Methylenebutyrolactone,2-甲烯基丁内酯

Target: Others, Drug Metabolite

Cat.No: T83864

Synonym: SNA-60-367-3,Fengycin IX

Target: Others

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPH-03323	LIPA Protein, Rat, Recombinant (His) Lysosomal acid lipase/cholesteryl ester hydrolase,<...	Rat	E. coli
	Catalyzes the deacylation of triacylglyceryl and cholesteryl ester core lipids of endocytosed low density lipoproteins to generate free fatty acids and cholesterol. LIPA Protein, Rat, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 48.6 kDa and the accession number is Q64194.
TMPH-01626	LIPA Protein, Human, Recombinant (GST) Lysosomal acid lipase/cholesteryl ester hydrolase,<...	Human	E. coli
	Catalyzes the deacylation of triacylglyceryl and cholesteryl ester core lipids of endocytosed low density lipoproteins to generate free fatty acids and cholesterol. LIPA Protein, Human, Recombinant (GST) is expressed in E. coli expression system with N-GST tag. The predicted molecular weight is 70.0 kDa and the accession number is P38571.
TMPH-01625	LIPA Protein, Human, Recombinant (His) Cholesteryl esterase,Lysosomal acid lipase/choleste...	Human	P. pastoris (Yeast)
	Catalyzes the deacylation of triacylglyceryl and cholesteryl ester core lipids of endocytosed low density lipoproteins to generate free fatty acids and cholesterol. LIPA Protein, Human, Recombinant (His) is expressed in yeast with N-6xHis tag. The predicted molecular weight is 45.0 kDa and the accession number is P38571.
TMPH-00066	Phospholipase A2 Protein, Apis mellifera, Recombinant (His) Allergen Api m I,Phospholipase A2,Phosphatidylcholi...	Apis mellifera	E. coli
	PLA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides.
TMPH-00449	Phospholipase A2 Protein, Crotalus atrox, Recombinant (His & Myc) Phospholipase A2,Phosphatidylcholine 2-acylhydrolas...	Crotalus atrox	Baculovirus Insect Cells
	Phospholipase A2 Protein, Crotalus atrox, Recombinant (His & Myc) is expressed in Baculovirus.
TMPH-02829	Phospholipase D3/PLD3 Protein, Mouse, Recombinant (His) Phosphatidylcholine-hydrolyzing phospholipase D3,Pl...	Mouse	E. coli
	5'->3' DNA exonuclease which digests single-stranded DNA (ssDNA). Regulates inflammatory cytokine responses via the degradation of nucleic acids, by reducing the concentration of ssDNA able to stimulate TLR9, a nucleotide-sensing receptor in collaboration with PLD4. May be important in myotube formation. Plays a role in lysosomal homeostasis. Involved in the regulation of endosomal protein sorting.
TMPH-00421	Phospholipase C Protein, Clostridium perfringens, Recombinant (His) Phospholipase C,plc,Alpha-toxin,Hemolysin,Phosphati...	C.perfringens	E. coli
	Phospholipase C Protein, Clostridium perfringens, Recombinant (His) is expressed in E. coli.
TMPH-03568	Phospholipase C Protein, S. aureus, Recombinant (His) hlb,Beta-hemolysin,Phospholipase C,Beta-toxin,Sphin...	Staphylococcus aureus	P. pastoris (Yeast)
	Bacterial hemolysins are exotoxins that attack blood cell membranes and cause cell rupture. Beta-hemolysin is a phospholipase C with specific activity toward sphingomyelins. Has a high specificity for sphingomyelin, hydrolyzes lysophosphatidylcholine at a much lower rate, but has no activity towards phosphatidylcholine, phosphatidylethanolamine, or phosphatidylserine. Phospholipase C Protein, S. aureus, Recombinant (His) is expressed in yeast with N-6xHis tag. The predicted molecular weight is 3...

重组蛋白

LIPA Protein, Rat, Recombinant (His)

Cat.No: TMPH-03323

Species: Rat

Expression System: E. coli

LIPA Protein, Human, Recombinant (GST)

Cat.No: TMPH-01626

Species: Human

Expression System: E. coli

LIPA Protein, Human, Recombinant (His)

Cat.No: TMPH-01625

Species: Human

Expression System: P. pastoris (Yeast)

Phospholipase A2 Protein, Apis mellifera, Recombinant (His)

Cat.No: TMPH-00066

Species: Apis mellifera

Expression System: E. coli

Phospholipase A2 Protein, Crotalus atrox, Recombinant (His & Myc)

Cat.No: TMPH-00449

Species: Crotalus atrox

Expression System: Baculovirus Insect Cells

Phospholipase D3/PLD3 Protein, Mouse, Recombinant (His)

Cat.No: TMPH-02829

Species: Mouse

Expression System: E. coli

Phospholipase C Protein, Clostridium perfringens, Recombinant (His)

Cat.No: TMPH-00421

Species: C.perfringens

Expression System: E. coli

Phospholipase C Protein, S. aureus, Recombinant (His)

Cat.No: TMPH-03568

Species: Staphylococcus aureus

Expression System: P. pastoris (Yeast)

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