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Search Results for " lewis "

Targets Recommended: Others

19

抑制剂 & 化合物

5

天然产物

3

重组蛋白

1

同位素标记化合物

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Cat. No.	Product Name	Target	Signaling Pathways
T72319	Lewis y tetrasaccharide Lewis y	Others	Others
	Lewis Y tetrasaccharide (Lewis Y, LeY) 是Lewis X trisaccharide 的四糖衍生物。Lewis Y tetrasaccharide 是一种与恶性卵巢癌转移和预后不良相关的抗原。
T35884	Sialyl-Lewis X	Others	Others
	Sialyl-Lewis X (sLeX), a sialylated fucosylated tetrasaccharide and endogenous antigen, serves as a high-affinity ligand for selectins (E-, P-, and L-selectin)[1]. It interacts with ELAM-1 and CD62, consequently inhibiting CD62-mediated neutrophil recruitment to inflammation sites[2].
T77243	Sialyl lewis x-lactose	Others	Others
	Sialyl Lewis X-Lactose 是一种生化试剂，可作为生物材料或有机化合物，用于生命科学相关研究。
T9616	PD-1/PD-L1-IN-10	PD-1/PD-L1	Apoptosis; Cell Cycle/Checkpoint; Immunology/Inflammation
	PD-1/PD-L1-IN-10 是一种口服有效的PD-1/PD-L1抑制剂 (IC50of 2.7 nM)，显示出抗肿瘤活性。
T73592	N′-(2-Chloroethyl)-N-(4-methylcyclohexyl)-N-nitrosourea	Others	Others
	N′-(2-Chloroethyl)-N-(4-methylcyclohexyl)-N-nitrosourea 具有抗肿瘤活性，可用于治疗 Lewis 肺癌和结肠肿瘤。
TP1358L	Peptide M acetate Peptide M acetate(110652-62-5 free base),Peptide M 醋酸盐	Others	Others
	Peptide M acetate 是一种合成多肽 (长度为 18 个氨基酸，对应于牛 S 抗原的氨基酸位置303-322: DTNLASSTIIKEGIDKTV)，能够在猴子和 Hartley 豚鼠以及 Lewis 大鼠中诱导实验性自身免疫性葡萄膜炎。
T40925	Peripheral Myelin Protein P2 (53-78), bovine Peripheral Myelin Protein P2 (53-78), bovine
	Bovine Peripheral Myelin Protein P2 (53-78) is a derivative composed of amino acid residues 53 to 78 from the peripheral myelin P2 protein of bovine origin. It acts as a T cell epitope and is used to induce experimental autoimmune neuritis (EAN) in Lewis rats.
T37542	Anguinomycin A	Others	Others
	Anguinomycin A is an antibiotic first isolated from a Streptomyces sp. and analog of leptomycin B that is highly cytotoxic to mouse P388 leukemia cells in vitro (IC50 = 0.1-0.2 ng/ml). It also demonstrates antitumor activity at 62.5 μg/kg/day against Lewis lung carcinoma in mice.
T83334	4-(Phenylazo)diphenylamine
	4-(Phenylazo)diphenylamine 是一种用于准确测定强碱、路易斯酸和氢化物还原剂浓度的优异比色指示剂。
T36040	16,16-dimethyl Prostaglandin A1 16,16-dimethyl Prostaglandin A1	Others	Others
	16,16-dimethyl Prostaglandin A1 是一种前列腺素类似物，可以抑制 Lewis 肺癌和 B 16无黑色素瘤细胞中的 DNA 合成 (DNA synthesis)，以及抑制 HSV 和 HIV-1的病毒复制。
TP1974	Obtustatin
	Highly potent integrin α1β1 inhibitor (IC50 = 0.8 nM for α1β1 binding to type IV collagen). Selective for α1β1 over α2β1, αIIbβ3, αvβ3, α4β1, α5β6, α9β1 and α4β7. Inhibits FGF2-stimulated angiogenesis in the chicken chorioallantoic model. Displays antitum
T36497	CAY10735 CAY10735	Others	Others
	CAY10735 is an anticancer compound.1 It inhibits proliferation in a panel of melanoma and breast, pancreatic, and lung cancer cell lines (IC50s = 0.674-11.56 μM). CAY10735 inhibits migration of and the epithelial-to-mesenchymal transition (EMT) in A375 and B16/F10 melanoma cells in vitro in a concentration-dependent manner. It reduces the viability of spheroid A375 and B16/F10 cells (IC50s = 3.04 and 1.24 μM, respectively) and increases production of reactive oxygen species (ROS) in these cells ...
T68631	Carbetimer	Others	Others
	Carbetimer is a partially imidized copolymer of ethylene & maleic anhydride with average MW approx 1,200 daltons; capable of specific stimulation of immune response. Carbetimer is a low molecular weight polymer derived from ethylene and maleic anhydride with potent antineoplastic activity. Preclinical studies have shown antitumor effects against many tumor cell lines including B 16 melanoma. Its antitumor actions are felt to include both reduction of uridine and cytidine nucleoside triphosphate ...
T36460	CAY10736 CAY10736	Others	Others
	CAY10736 is an anticancer compound.1 It inhibits proliferation in a panel of melanoma and breast, pancreatic, and lung cancer cell lines (IC50s = 0.827-9.89 μM). CAY10736 inhibits migration and epithelial-to-mesenchymal transition (EMT) of A375 and B16/F10 melanoma cells in vitro in a concentration-dependent manner. It reduces the viability of spheroid A375 and B16/F10 cells (IC50s = 2.4 and 1.59 μM, respectively) and increases the production of reactive oxygen species (ROS) in these cells in a ...
T37631	tetranor-12(S)-HETE	Others	Others
	12(S)-HETE is a product of arachidonic acid metabolism through the 12-lipoxygenase pathway. It is primarily found in platelets, leukocytes, and to a lesser extent in smooth muscle cells. It enhances tumor cell adhesion to endothelial cells, fibronectin, and the subendothelial matrix. tetranor-12(S)-HETE is the major β-oxidation product resulting from peroxisomal metabolism of 12(S)-HETE in numerous tissues, and Lewis lung carcinoma cells. No biological function has yet been determined for tetran...
T36695	TAS-103	Others	Others
	TAS-103 is a dual inhibitor of DNA topoisomerase I/II, used for cancer research. TAS-103 is a dual inhibitor of DNA topoisomerase I/II. TAS-103 (0.1-10 μM) is active on CCRF-CEM cells, with an IC50 value of 5 nM. TAS-103 (0.1 μM) significantly increases levels of topo IIα FITC immunofluorescence in individual CCRF-CEM cells[1]. TAS-103 (0.01-1 μM) is highly cytotoxic to Lewis lung carcinoma (LLC) cells, and Liposomal TAS-103 is almost as active as free TAS-103[2]. TAS-103 inhibits the viability ...
T36053	D-Lysine lactam	Others	Others
	D-Lysine lactam is a chiral building block.1,2It has been used in the synthesis of a chiral antibiotic synthetic intermediate, as well as in the stereoselective synthesis of neurokinin (NK) receptor antagonists. 1.Kumar, A., Bhashkar, B., Bhavsar, J., et al.Catalytic reduction: Efficient synthesis of chiral key intermediate of besifloxacin hydrochlorideDer Pharma Chemica7(9)297-3000(2015) 2.Gerspacher, M., Lewis, C., Ball, H.A., et al.Stereoselective preparation of N-[(R,R)-(E)-1-(3,4-dichlorobe...
T36373	Urocortin II (mouse) (trifluoroacetate salt)
	Urocortin II is a neuropeptide hormone and member of the corticotropin-releasing factor (CRF) family which includes mammalian CRF , urocortin , urocortin III , frog sauvagine, and piscine urotensin I.1 Mouse urocortin II shares 34 and 42% sequence homology with rat CRF and urocortin . It is expressed in mouse paraventricular, supraoptic, and arcuate nuclei of the hypothalamus, the locus coeruleus, and in motor nuclei of the brainstem and spinal ventral horn. Urocortin II selectively binds to CRF...
T35814	Urocortin III (human) (trifluoroacetate salt)
	Urocortin III is a neuropeptide hormone and member of the corticotropin-releasing factor (CRF) family which includes mammalian CRF , urocortin , urocortin II , frog sauvagine, and piscine urotensin I.1 Human urocortin III shares 90, 40, 37, and 21% identity to mouse urocortin III , mouse urocortin II , human urocortin , and mouse urocortin, respectively. Urocortin III selectively binds to type 2 CRF receptors (Kis = 21.7, 13.5, and >100 nM for rat CRF2α, rat CRF2β, and human CRF1, respectively)....

化合物

Lewis y tetrasaccharide

Cat.No: T72319

Synonym: Lewis y

Target: Others

Sialyl-Lewis X

Cat.No: T35884

Target: Others

Sialyl lewis x-lactose

Cat.No: T77243

Target: Others

PD-1/PD-L1-IN-10

Cat.No: T9616

Target: PD-1/PD-L1

N′-(2-Chloroethyl)-N-(4-methylcyclohexyl)-N-nitrosourea

Cat.No: T73592

Target: Others

Peptide M acetate

Cat.No: TP1358L

Synonym: Peptide M acetate(110652-62-5 free base),Peptide M 醋酸盐

Target: Others

Peripheral Myelin Protein P2 (53-78), bovine

Cat.No: T40925

Synonym: Peripheral Myelin Protein P2 (53-78), bovine

Cat.No: T37542

Target: Others

4-(Phenylazo)diphenylamine

Cat.No: T83334

16,16-dimethyl Prostaglandin A1

Cat.No: T36040

Synonym: 16,16-dimethyl Prostaglandin A1

Target: Others

Cat.No: TP1974

Cat.No: T36497

Synonym: CAY10735

Target: Others

Cat.No: T68631

Target: Others

Cat.No: T36460

Synonym: CAY10736

Target: Others

tetranor-12(S)-HETE

Cat.No: T37631

Target: Others

Cat.No: T36695

Target: Others

D-Lysine lactam

Cat.No: T36053

Target: Others

Urocortin II (mouse) (trifluoroacetate salt)

Cat.No: T36373

Urocortin III (human) (trifluoroacetate salt)

Cat.No: T35814

Cat. No.	Product Name	Target	Signaling Pathways
T81937	Lewis a trisaccharide Lewis a
	Lewis a trisaccharide 是精子聚糖结构和 HL-60 细胞表面聚糖结构的主要组分。
T7203	Oglufanide 奥谷法奈,L-Glutamyl-L-tryptophan,H-Glu-Trp-OH	VEGFR; HCV Protease; Endogenous Metabolite	Angiogenesis; Metabolism; Microbiology/Virology; Proteases/Proteasome; Tyrosine Kinase/Adaptors
	Oglufanide (H-Glu-Trp-OH) 是一种从小牛胸腺中分离出来的二肽免疫调节剂，可抑制血管内皮生长因子，可刺激细胞内细菌感染和对丙型肝炎病毒的免疫反应。
TN4455	Lucialdehyde B	Integrase; HSV	Microbiology/Virology
	Lucialdehyde B exhibits potent inhibitory activity against herpes simplex virus. It shows cytotoxic effects on Lewis lung carcinoma (LLC), T-47D, Sarcoma 180, and Meth-A tumor cell lines.
T81961	Lacto-N-difucohexaose I LDFH I
	LNDFH I是一种连接子，它能够将含Lewis b糖链的寡糖有效结合形成水不溶性多糖。
T75670	Lacto-N-fucopentaose II	Others	Others
	Lacto-N-fucopentaose II (LNFP II)作为人Lewis血型决定因子的半抗原，其单唾液神经节苷/糖脂以及唾液酰衍生物CA 19-9，都是胆胰恶性肿瘤中的分子肿瘤标记物(TM)。

天然产物

Lewis a trisaccharide

Cat.No: T81937

Synonym: Lewis a

Cat.No: T7203

Synonym: 奥谷法奈,L-Glutamyl-L-tryptophan,H-Glu-Trp-OH

Target: VEGFR, HCV Protease, Endogenous Metabolite

Cat.No: TN4455

Target: Integrase, HSV

Lacto-N-difucohexaose I

Cat.No: T81961

Synonym: LDFH I

Lacto-N-fucopentaose II

Cat.No: T75670

Target: Others

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPJ-00382	P-selectin Protein, Mouse, Recombinant (Avi & His), Biotinylated PADGEM,CD62 antigen-like family member P,Granule membrane pr...	Mouse	HEK293 Cells
	P-selectin/CD62P is a single-pass type I membrane protein which is a member of the Selectin family. It consists 768 amino acid (aa). P-selectin is a cell surface glycoprotein expressed by activated platelets and endothelial cells. It induced expression in lung, liver, kidney and heart after endotoxin treatment. Ca2+-dependent receptor for myeloid cells that binds to carbohydrates on neutrophils and monocytes. It mediates the interaction of activated endothelial cells or platelets with leukocytes...
TMPJ-01217	Mgl2 Protein, Mouse, Recombinant (His) Macrophage Galactose-type C-lectin 2,Mgl2,CD301b,Macrophage ...	Mouse	HEK293 Cells
	Macrophage galactose N-acetyl-galactosamine-specific lectin 2(Mgl2), also known as CD301b, is a 38 kDa member that belongs to the C-type lectin family. Two MGL proteins are encoded by separate genes in the mouse, but share 91% amino acid (aa) identity in the extracellular domain (ECD). Only one MGL occurs in human and rat and this MGL is structurally more similar to mouse MGL1 than MGL2. However, human MGL and mouse MGL2 both bind specifically to terminal GalNAc residues, in contrast with mouse...
TMPY-03397	TPPP3 Protein, Human, Recombinant (His) CGI-38,TPPP3,p25gamma,tubulin polymerization-promoting prote...	Human	E. coli
	TPPP3, a member of the Tubulin polymerization-promoting protein family, is an intrinsically unstructured protein that induces tubulin polymerization. TPPP3 is a marker in the developing musculoskeletal system. In tendons, Tppp3 is expressed in cells at the circumference of the developing tendons, likely the progenitors of connective tissues that surround tendons: the tendon sheath, epitenon, and paratenon. Tppp3 is also expressed in forming synovial joints. The onset of Tppp3 expression in joint...

重组蛋白

P-selectin Protein, Mouse, Recombinant (Avi & His), Biotinylated

Cat.No: TMPJ-00382

Species: Mouse

Expression System: HEK293 Cells

Mgl2 Protein, Mouse, Recombinant (His)

Cat.No: TMPJ-01217

Species: Mouse

Expression System: HEK293 Cells

TPPP3 Protein, Human, Recombinant (His)

Cat.No: TMPY-03397

Species: Human

Expression System: E. coli

Cat. No.	Product Name	Target	Signaling Pathways
T69966	Roxadustat-d5
	Roxadustat-d5 is intended for use as an internal standard for the quantification of roxadustat by GC- or LC-MS. Roxadustat is an inhibitor of hypoxia-inducible factor prolyl hydroxylase (HIF-PH; IC50s = 1.4, 1.26, and 1.32 µM for HIF-PH1, HIF-PH2, and HIF-PH3, respectively). It is selective for HIF-PH over other 2-oxoglutarate-dependent dioxygenases, including lysine-specific demethylase 5A (KDM5A), KDM5B, -5C, -5D, and -6B (IC50s = >100 µM for all). Roxadustat (10-200 µM) stabilizes HIF-1α and ...

同位素标记化合物

Cat.No: T69966

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