20
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28
Cat. No. | Product Name | Target | Signaling Pathways |
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TP1702L |
Laminin (925-933) acetate
Laminin (925-933) acetate (110590-60-8 free base) |
Others | Others |
Laminin (925-933) acetate 源自与层粘连蛋白受体结合的层粘连蛋白 B1 链。 | |||
TP1671 |
Laminin (925-933)
Laminin 925-933 |
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Laminin 925-933 is a peptide originating from residues 925-933 of the laminin B1 chain, known for its binding affinity to the laminin receptor. | |||
TP1702 |
Laminin (925-933)(TFA) (110590-60-8 free base)
Laminin (925-933)(TFA) |
||
Laminin (925-933) (TFA) is a peptide derived from residues 925-933 of the Laminin B1 chain that binds to the laminin receptor. | |||
T32548 |
Laminin B1 (1363-1383)
Yosh4,Yosh 4,Yosh-4 |
Others | Others |
Laminin B1 (1363-1383) is the Residue 1363-1383 of the laminin B1 chain. | |||
TP2389 |
Laminin B1 octapeptide P-8
Asp-pro-gln-tyr-ile-gln-ser-arg,Dpgyigsr |
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Laminin B1 octapeptide P-8 is a synthetic laminin B1 chain octapeptide with laminin receptor binding ability. | |||
T77997 |
Laminin (925-933)TFA
|
||
Laminin (925-933) (TFA)是层粘连蛋白B1链残基925-933的肽段,源于层粘连蛋白受体结合区。 | |||
T81576 |
PA22-2
IKVAV sequence,Laminin A-chain fragment |
||
PA22-2(IKVAV序列;层粘连蛋白A链片段)为一生物活性肽,源于小鼠层粘连蛋白a1氨基酸2110至2127残基。构成的细胞外基质能够促进神经突生长。 | |||
T81575 |
PA22-2 free acid
Cys-Laminin A chain 2091-2108 |
||
PA22-2 (free acid) (Cys-Laminin A chain 2091-2108) 为促进神经突生长和神经元样过程形成的多肽。该化合物适用于人腺样囊性癌细胞培养和肽功能化磷脂双层制备<sup>[3]。 | |||
T34842 |
Thialaminine
4Thialaminine,4-Thialaminine |
Others | Others |
Thialaminine is a type of strongly basic chemical modification of cysteine. | |||
TP2384L |
Hexapeptide-10 Acetate
Hexapeptide-10 Acetate(146439-94-3 Free base) |
Integrin | Cytoskeletal Signaling |
Hexapeptide-10 Acetate (Hexapeptide-10 Acetate) 是一种合成肽。它增加层粘连蛋白 V 和 α6-整合素的合成以促进细胞结合,具有非凡的可见皮肤重组和紧致能力。 | |||
TP2488 |
Palmitoyl Tripeptide-38 Acetate
Palmitoyl Tripeptide-38 Acetate(1447824-23-8 Free base),醋酸棕榈酰三肽 38 |
Others | Others |
Palmitoyl Tripeptide-38 Acetate (Palmitoyl Tripeptide-38 Acetate (1447824-23-8 Free base)) 由三个氨基酸组成,是一种二氧化脂肽。该肽的灵感来自于胶原蛋白 VI 和层粘连蛋白中天然存在的三肽。它从内部重建需要的皮肤,抚平皱纹并舒缓皮肤,尤其是前额纹、鱼尾纹、前额纹和领口。 | |||
T67961 |
Safironil
|
Others | Others |
safironil 是一种新型抗纤维化化合物,是胶原蛋白合成的竞争性抑制剂。safironil 在体外实验中对由胶原蛋白I mRNA 或平滑肌α-actin 水平监测的成纤维细胞的激活,以及由I 型和III 型胶原蛋白和层粘连蛋白生产判断的纤维生成有抑制作用。safironil 在不改变总羟脯氨酸的情况下对肝脏肉芽肿的大小没有影响,但通过增加III 型和减少I 型胶原的沉积改变了纤维化的模式。 | |||
T28205 |
NSC47924
NSC 47924,NSC-47924 |
Others | Others |
NSC47924 is a laminin receptor (LR) inhibitor. | |||
TP2384 |
Hexapeptide-10
Serilesine |
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Hexapeptide-10 is a synthetic peptide. It increases the synthesis of laminin V and α6-integrin to promote cell binding, with extraordinary visible skin restructuring and firming abilities. | |||
T82780 |
Caprooyl-tetrapeptide-3 acetate
|
||
Caprooyl-tetrapeptide-3 acetate 旨在减少细纹与皱纹。该化合物能够在皮质激素诱导的皮肤老化模型中刺激VII型胶原蛋白及层粘连蛋白5的表达。 | |||
T82633 |
Cys-Asp-Pro-Gly-Tyr-Ile-Gly-Ser-Arg-NH2
|
||
Cys-Asp-Pro-Gly-Tyr-Ile-Gly-Ser-Arg-NH2是源自层粘连蛋白B1链的线性肽,能够干预肿瘤细胞对基底膜的附着与侵袭,且表现出抗血管生成活性。 | |||
T76583 |
H-Ile-Lys-Val-Ala-Val-OH
|
||
H-Ile-Lys-Val-Ala-Val-OH 是层纤蛋白-1 有效的活性位点之一。H-Ile-Lys-Val-Ala-Val-OH 可促进细胞粘附、神经突生长和肿瘤生长。H-Ile-Lys-Val-Ala-Val-OH 通过激活 MAPK/ERK1/2和 PI3K/Akt 信号通路,刺激 BMMSC 细胞生长和增殖。 | |||
T35613 |
Cytostatin (sodium salt)
|
Others | Others |
Cytostatin (sodium salt) is a natural antitumor inhibitor of cell adhesion to extracellular matrix, blocking adhesion of B16 melanoma cells to laminin and collagen type IV in vitro (IC50s = 1.3 and 1.4 μg/ml, respectively) and B16 cells metastatic activity in mice. It induces apoptosis of FS3 mouse fibrosarcoma cells (IC50 = 3.1 μg/ml). Cytostatin (sodium salt) potently and selectively inhibits protein phosphatase 2A (PP2A; IC50 = 29 nM against the catalytic subunit), while having no effect agai... | |||
T38363 |
MeOSuc-AAPV-pNA
|
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Proteinase 3 (PR3, myeloblastin) is a polymorphonuclear leukocyte serine proteinase that degrades matrix proteins including fibronectin, laminin, vitronectin, and collagen type IV to generate antimicrobial peptides. Neutrophil elastase is a serine proteinase that is secreted by neutrophils during inflammation to destroy pathogens. Evaluating these enzymes is helpful to understanding inflammatory autoimmune processes. MeOSuc-AAPV-pNA is a highly sensitive peptide substrate that is hydrolyzed by b... | |||
T82379 |
FN-A208 fusion peptide
|
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FN-A208 是源自鼠层粘连蛋白 a1 的 A208 与纤连蛋白 (GRGDS) 活性位点和甘氨酸间隔区融合形成的生物活性肽。该肽能形成淀粉样原纤维,并有助于促进肌动蛋白应力纤维的形成,进而介导成纤维细胞附着,显示出其在组织再生和工程生物粘合剂方面的应用潜力。FN-A208 与 IKVAV 受体和整合素发生相互作用,而在 EDTA 存在下,其活性则会被破坏。 |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T37055 |
Cytostatin
|
Others | Others |
Cytostatin is a natural antitumor inhibitor of cell adhesion to extracellular matrix, blocking adhesion of B16 melanoma cells to laminin and collagen type IV in vitro (IC50s = 1.3 and 1.4 μg/ml, respectively) and B16 cells metastatic activity in mice. It induces apoptosis of FS3 mouse fibrosarcoma cells (IC50 = 3.1 μg/ml). Cytostatin potently and selectively inhibits protein phosphatase 2A (PP2A; IC50 = 29 nM against the catalytic subunit), while having no effect against PP1, PP2B, or PP5. |
Cat. No. | Product Name | Species | Expression System |
---|---|---|---|
TMPH-00838 |
LAMB1 Protein, Human, Recombinant (His & SUMO)
LAMB1,Laminin-1 subunit beta,Laminin-12 su... |
Human | E. coli |
LAMB1 Protein, Human, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 44.3 kDa and the accession number is P07942. | |||
TMPH-01602 |
LAMA5 Protein, Human, Recombinant (His & SUMO)
LAMA5,Laminin subunit alpha-5,Laminin-15 s... |
Human | E. coli |
Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. | |||
TMPH-00856 |
RPSA Protein, Human, Recombinant (His & Myc)
67 kDa laminin receptor,RPSA,Laminin-bindi... |
Human | E. coli |
RPSA Protein, Human, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 37.7 kDa and the accession number is P08865. | |||
TMPH-03296 |
Galectin-3/LGALS3 Protein, Rat, Recombinant (His)
Lgals3,IgE-binding protein,Carbohydrate-binding protein 35,L... |
Rat | E. coli |
Galactose-specific lectin which binds IgE. May mediate with the alpha-3, beta-1 integrin the stimulation by CSPG4 of endothelial cells migration. In the nucleus: acts as a pre-mRNA splicing factor. Involved in acute inflammatory responses including neutrophil activation and adhesion, chemoattraction of monocytes macrophages, opsonization of apoptotic neutrophils, and activation of mast cells. Together with TRIM16, coordinates the recognition of membrane damage with mobilization of the core autop... | |||
TMPJ-00563 |
LGALS3 Protein, Human, Recombinant (His)
Galactose-Specific Lectin 3,LGALS3,35 kDa Lectin,Gal-3,MAC2,... |
Human | HEK293 Cells |
Galectin-3(LGALS3) is also known as Galactose-specific lectin 3, Mac-2 antigen, Carbohydrate-binding protein 35, Laminin-binding protein and Galactoside-binding protein. LGALS3 is highly expressed in early stages of papillary carcinoma, and lowly during tumor progression. LGALS3 is probably forms homo- or heterodimers and secreted by a non-classical secretory pathway and associates with the cell surface. LGALS3 plays an important role during the acquisition of vasculogenic mimicry and angiogenic... | |||
TMPJ-00021 |
LGALS1 Protein, Human, Recombinant (His)
HPL,S-Lac Lectin 1,Lactose-Binding Lectin 1,14 kDa Lectin,Be... |
Human | E. coli |
Galectin-1 is a member of growing family of evolutionary conserved animal lectins. Galectin-1 is widely expressed in many cells and tissues. Galectins consists of a Galectin domain and two Beta-galactoside binding domains. Galectin-1 can binds LGALS3BP and interacts with CD2, CD3, CD4, CD7, CD43 and CD45. Galectin-1 may act as an autocrine negative growth factor which regulates apoptosis, cell proliferation and cell differentiation. In addition, Galectin-1 plays improtant roles in immunosuppress... | |||
TMPY-05716 |
Integrin alpha V beta 3 Protein, Human, Recombinant (His)
Integrin α V β 3,Integrin alpha V β3 |
Human | HEK293 Cells |
Integrin alpha-V & beta-3 (ITGAV/ITGB3) is a receptor for cytotactin, fibronectin, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin, vitronectin and von Willebrand factor. | |||
TMPH-01258 |
DAG1 Protein, Human, Recombinant (His & Myc)
Dystrophin-associated glycoprotein 1,Dystroglycan,Dystroglyc... |
Human | Baculovirus Insect Cells |
The dystroglycan complex is involved in a number of processes including laminin and basement membrane assembly, sarcolemmal stability, cell survival, peripheral nerve myelination, nodal structure, cell migration, and epithelial polarization.; Extracellular peripheral glycoprotein that acts as a receptor for extracellular matrix proteins containing laminin-G domains. Receptor for laminin-2 (LAMA2) and agrin in peripheral nerve Schwann cells. Also acts as a receptor for laminin LAMA5.; Transmembra... | |||
TMPJ-01402 |
NTNG1 Protein, Human, Recombinant (His)
KIAA0976,Netrin-G1,Laminet-1,NTNG1,LMNT1 |
Human | HEK293 Cells |
Netrin-G1 (NTNG1) is a member of a conserved family of proteins that act as axon guidance cues during vertebrate nervous system development. Netrin-G1 contains one laminin EGF-like domain and one laminin N-terminal domain, Netrin-G1 is highly expressed in the thalamus, lowly in other tissue. Netrin-G1 localizes to the cell membrane. Netrin-G1 interacts with NGL1 and is glycosylated in the N-terminal. In addition, Netrin-G1 can promotesneurite outgrowth of both axons and dendrites. NTNG1 Protein,... | |||
TMPH-02145 |
MMP-3 Protein, Human, Recombinant (His & SUMO)
Transin-1,Matrix metalloproteinase-3,MMP3,Stromelysin-1 |
Human | E. coli |
Can degrade fibronectin, laminin, gelatins of type I, III, IV, and V; collagens III, IV, X, and IX, and cartilage proteoglycans. Activates procollagenase. | |||
TMPH-02934 |
Thrombospondin-3/THBS3 Protein, Mouse, Recombinant (GST)
Thrombospondin-3,Thbs3 |
Mouse | E. coli |
Adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. Can bind to fibrinogen, fibronectin, laminin and type V collagen. Thrombospondin-3/THBS3 Protein, Mouse, Recombinant (GST) is expressed in E. coli expression system with N-GST tag. The predicted molecular weight is 62.7 kDa and the accession number is Q05895. | |||
TMPH-02812 |
Nidogen-1 Protein, Mouse, Recombinant (His)
Nid1,Nidogen-1,Entactin |
Mouse | P. pastoris (Yeast) |
Sulfated glycoprotein widely distributed in basement membranes and tightly associated with laminin. Also binds to collagen IV and perlecan. It probably has a role in cell-extracellular matrix interactions. | |||
TMPH-02915 |
MMP-3 Protein, Mouse, Recombinant (His)
Stromelysin-1,Mmp3,Transin-1,Matrix metalloproteinase-3,EMS-... |
Mouse | E. coli |
Can degrade fibronectin, laminin, gelatins of type I, III, IV, and V; collagens III, IV, X, and IX, and cartilage proteoglycans. Activates procollagenase. MMP-3 Protein, Mouse, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 46.2 kDa and the accession number is P28862. | |||
TMPJ-01400 |
NTNG1 Protein, Human, Recombinant (Avi & His), Biotinylated
LMNT1,NTNG1,KIAA0976,Netrin-G1,Laminet-1 |
Human | HEK293 Cells |
Netrin-G1 (NTNG1) is a member of a conserved family of proteins that act as axon guidance cues during vertebrate nervous system development. Netrin-G1 contains one laminin EGF-like domain and one laminin N-terminal domain, Netrin-G1 is highly expressed in the thalamus, lowly in other tissue. Netrin-G1 localizes to the cell membrane. Netrin-G1 interacts with NGL1 and is glycosylated in the N-terminal. In addition, Netrin-G1 can promotesneurite outgrowth of both axons and dendrites. NTNG1 Protein,... | |||
TMPH-02813 |
Nidogen-1 Protein, Mouse, Recombinant (E. coli, His)
Nid1,Nidogen-1,Entactin |
Mouse | E. coli |
Sulfated glycoprotein widely distributed in basement membranes and tightly associated with laminin. Also binds to collagen IV and perlecan. It probably has a role in cell-extracellular matrix interactions. Nidogen-1 Protein, Mouse, Recombinant (E. coli, His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 30.3 kDa and the accession number is P10493. | |||
TMPH-01536 |
ITGB4 Protein, Human, Recombinant (His & Myc)
GP150,ITGB4,Integrin beta-4 |
Human | E. coli |
Integrin alpha-6/beta-4 is a receptor for laminin. Plays a critical structural role in the hemidesmosome of epithelial cells. Is required for the regulation of keratinocyte polarity and motility. ITGA6:ITGB4 binds to NRG1 (via EGF domain) and this binding is essential for NRG1-ERBB signaling. ITGA6:ITGB4 binds to IGF1 and this binding is essential for IGF1 signaling. ITGA6:ITGB4 binds to IGF2 and this binding is essential for IGF2 signaling. | |||
TMPK-00558 |
BCAM Protein, Cynomolgus, Recombinant (His)
CD239,MSK19,Lutheran,Gplu,LU |
Cynomolgus | HEK293 Cells |
Lutheran/basal cell adhesion molecule (Lu/BCAM) is a transmembrane adhesion molecule expressed by erythrocytes and endothelial cells that can interact with the extracellular matrix protein laminin-α5. In sickle cell disease, Lu/BCAM is thought to contribute to adhesion of sickle erythrocytes to the vascular wall, especially during vaso-occlusive crises. | |||
TMPJ-00447 |
MMP-3 Protein, Human, Recombinant (His)
Transin-1,Stromelysin-1,MMP-3,Matrix metalloproteinase-3,MMP... |
Human | HEK293 Cells |
MMP3 is a member of the matrix metalloproteinase (MMP) family whose members are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, tissue remodeling, and disease processes including arthritis and metastasis. The MMP-3 enzyme degrades collagen types II, III, IV, IX, and X, proteoglycans, fibronectin, laminin, and elastin. In addition, MMP-3 can also activate other MMPs such as MMP-1, MMP-7, and MMP-9, rendering MMP-3 c... | |||
TMPJ-00523 |
SAA2 Protein, Human, Recombinant (His)
SAA2,SAA,Serum Amyloid A2 |
Human | E. coli |
Serum amyloid A-2 protein (SAA2) belongs to the SAA family. It expressed by the liver and secreted in plasma. SAA2 functions as major acute phase reactant and could works as apolipoprotein of the HDL complex. Increased levels of A-SAA in serum are indicative of inflammatory disease. When highly expressed, SAA can displace ApoA1 as the major apolipoprotein in HDL complexes, weakening the function of HDL as a reverse (lipid clearing) cholesterol transporter. A highly charged region of SAA2 and SAA... | |||
TMPJ-00810 |
ITGA5 Protein, Human, Recombinant (His)
FNRA,Integrin α-5,Integrin Alpha-F,Fibronectin Receptor Subu... |
Human | HEK293 Cells |
Integrin α-5 belongs to the Integrin α chain family and contains 7 FG-GAP repeats. Integrin α-5 joins with Integrin-β1 to form a fibronectin and laminin receptor which recognizes the sequence R-G-D in its ligands. In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions. It is expressed on fibroblasts, endothelial cells, peripheral T cells and platelets. Integrin α-5 undergoes post-translational cleavage in the ext... | |||
TMPJ-01005 |
Lumican Protein, Mouse, Recombinant (His)
KSPG lumican,Lumican,Keratan sulfate proteoglycan lumican |
Mouse | HEK293 Cells |
Keratan sulfate proteoglycan lumican, mostly known as lumican, belongs to the SLRP class II subfamily and the small leucine-rich proteoglycan (SLRP) family. Lumican binds to laminin. It has positive regulation of transcription from RNA polymerase II promoter and transforming growth factor beta1 production. Lumican is expressed in a variety of tissues, including skin, artery, lung, cornea, kidney, bone, aorta, and articular cartilage. The abnormal connective tissue phenotype seen in the Lumican n... | |||
TMPJ-00802 |
THBS1 Protein, Human, Recombinant (His)
TSP,TSP1,Thrombospondin-1,THBS1 |
Human | HEK293 Cells |
Thrombospondin-1 (TSP-1) is a 150-180kDa calcium-sensitive protein that is secreted as a disulfide-linked homotrimer. TSP-1 regulates a wide range of cellular functions including their interactions with other cells and with the extracellular matrix (ECM). TSP-1 contains an N-terminal Laminin G-like globular domain, an extended central region with one vWFC domain, 3 TSP type 1domains, 2 EGF-like domains, and 8 TSP type3 domains, and a globular TSP C-terminal domain. Distinct regions of TSP-1 have... | |||
TMPJ-01137 |
MIA Protein, Human, Recombinant (His)
MIA,Melanoma Inhibitory Activity Protein,Melanoma-Derived Gr... |
Human | E. coli |
Melanoma Inhibitory Activity Protein (MIA) is an autocrine growth regulatory protein secreted from chondrocytes and malignant melanoma cells, which was the first discovered member of a family of secreted cytokines termed the MIA/OTOR family. The four known members of this family: MIA, MIA2, OTOR and TANGO each contain a Src homology-3 (SH3)-like domain. MIA acts as a potent tumor cell growth inhibitor for malignant melanoma cells and some other neuroectodermal tumors, including gliomas, in an au... | |||
TMPY-02759 |
Kallikrein 6/KLK6 Protein, Human, Recombinant (His)
kallikrein-related peptidase 6,PRSS18,PRSS9,Klk7,Bssp,SP59,h... |
Human | HEK293 Cells |
KLK6 (kallikrein-related peptidase 6), also known as Klk7, belongs to the peptidase S1 family, Kallikrein subfamily. Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. KLK6 is a serine protease that exhibits a preference for Arg over Lys in the substrate P1 position and for Ser or Pro in the P2 position. Klk7 sh... | |||
TMPY-02689 |
MMP-3 Protein, Human, Recombinant
STMY,MMP-3,matrix metallopeptidase 3,CHDS6,STMY1,SL-1,STR1 |
Human | E. coli |
Matrix metallopeptidase 3 (abbreviated as MMP3) is also known as stromelysin 1 and progelatinase. MMP3 is a member of the matrix metalloproteinase (MMP) family whose members are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, tissue remodeling, and disease processes including arthritis and metastasis. As a secreted zinc-dependent endopeptidase, MMP3 exerts its functions mainly in the extracellular matrix. This prot... | |||
TMPJ-00605 |
GPVI Protein, Mouse, Recombinant (His)
Glycoprotein 6,GP6,glycoprotein VI (platelet),GPVI,GPIV,MGC1... |
Mouse | HEK293 Cells |
Glycoprotein VI (GPVI) is a 63 kDa platelet/megakaryocyte-specific type I transmembrane glycoprotein of the immunoglobulin superfamily that is an important collagen receptor and initiator of platelet activation, aggregation and thrombin generation. GPVI is also a secondary receptor required for platelet spreading on laminin. GPVI associates with the Fc receptor gamma -chain via charged aa in the TM domains of GPVI (arginine) and the FcR gamma (aspartic acid). Collagen binding by the GPVI Ig-like... | |||
TMPY-01695 |
CASPR2 Protein, Mouse, Recombinant (His)
5430425M22Rik,Caspr2,contactin associated protein-like 2,mKI... |
Mouse | HEK293 Cells |
CNTNAP2/CASPR2 is a member of the neurexin family which functions in the vertebrate nervous system as cell adhesion molecules and receptors. This protein, like other neurexin proteins, contains epidermal growth factor repeats and laminin G domains. In addition, it includes an F5/8 type C domain, discoidin/neuropilin- and fibrinogen-like domains, thrombospondin N-terminal-like domains and a putative PDZ binding site. CNTNAP2/CASPR2 is localized at the juxtaparanodes of myelinated axons, and media... | |||
TMPJ-01188 |
CORO6 Protein, Human, Recombinant (His)
Coronin-6,Clipin-E,CORO6 |
Human | E. coli |
Coronin 6, a newly identified member of the coronin family, is highly enriched at adult NMJs and regulates AChR clustering via modulating the interaction between receptors and the actin cytoskeletal network. Coronins are a family of conserved actin-binding proteins originally identified in the actin-rich structure of the amoeba Dictyostelium discoideum . To date, seven members of coronins have been identified in mammals, and most exhibit tissue-specific distribution patterns. Coronin 6 is promin... |