Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T15767 |
LLY-283
|
Histone Methyltransferase | Chromatin/Epigenetic |
LLY-283 是一种有效的,选择性的,可口服的蛋白精氨酸甲基转移酶 5 (PRMT5) 抑制剂,对 PRMT5:MEP50 复合物的作用很强,IC50 和 Kd 值分别为 22 nM 和 6 nM,具有抗肿瘤活性。 | |||
T22356 |
LLY-284
|
Others | Others |
LLY-284 is the diastereomer of LLY-283, which is a selective and potent SAM-competitive chemical probe for PRMT5. LLY-284 is much less active than LLY-283 and can be used as a negative control for LLY-283. |