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Cat. No. | Product Name | Target | Signaling Pathways |
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T32810 |
LL-C 10037alpha
LLC 10037alpha,LL-c10037alpha |
Others | Others |
LL-C 10037alpha is a gamma-aminoepoxysemiquinone isolated from Streptomyces. | |||
T12580 |
PTUPB
|
COX; Epoxide Hydrolase | Immunology/Inflammation; Metabolism; Neuroscience |
PTUPB 是强效的sEH(IC50:0.9 μM)和COX-2(IC50:1.26 μM)的双向抑制剂。 | |||
T0463 |
Loxoprofen
Loxoprofene,洛索洛芬,Loxoprofeno,Koloxo |
COX | Immunology/Inflammation; Neuroscience |
Loxoprofen (Koloxo) 是一种非甾体类抗炎药,具有解热作用,可用于缓解疼痛的研究。它是非选择性COX 抑制剂,对 COX-1 和 COX-2 的IC50分别为 6.5 和 13.5 μM。 | |||
T9616 |
PD-1/PD-L1-IN-10
|
PD-1/PD-L1 | Apoptosis; Cell Cycle/Checkpoint; Immunology/Inflammation |
PD-1/PD-L1-IN-10 是一种口服有效的PD-1/PD-L1抑制剂 (IC50of 2.7 nM),显示出抗肿瘤活性。 | |||
T6835 |
Fenoldopam mesylate
Fenoldopam methanesulfonate,SKF-82526 mesylate,Corlopam mesylate,mesylate,SKF 82526,非诺多泮甲磺酸盐 |
Dopamine Receptor | GPCR/G Protein; Neuroscience |
Fenoldopam mesylate (Corlopam mesylate) 是一种多巴胺受体D1选择性激动剂。 | |||
T39195 |
YM-244769 dihydrochloride
|
Calcium Channel | Membrane transporter/Ion channel; Metabolism |
YM-244769 dihydrochloride 是一种有效的 Na+/Ca2+ exchange 3 (NCX3) 抑制剂,IC50 为 18 nM。 YM-244769 dihydrochloride 对神经元和肾脏具有有效的保护作用。 | |||
T9888 |
YM-244769
3-Pyridinecarboxamide, N-[(3-aminophenyl)methyl]-6-[4-[(3-fluorophenyl)methoxy]phenoxy]- |
Calcium Channel | Membrane transporter/Ion channel; Metabolism |
YM-244769 (3-Pyridinecarboxamide, N-[(3-aminophenyl)methyl]-6-[4-[(3-fluorophenyl)methoxy]phenoxy]-) 是一种有效的 Na+/Ca2+ exchange 3 (NCX3) 抑制剂,IC50 为 18 nM。 YM-244769 对神经元和肾脏具有有效的保护作用。 | |||
T11719 |
JMV 2959 hydrochloride (925238-89-7 free base)
JMV 2959 hydrochloride |
GHSR | GPCR/G Protein |
JMV 2959 hydrochloride (925238-89-7 free base) 是一种生长激素促分泌素受体 1a 型 (GHS-R1a) 拮抗剂,在 LLC-PK1 细胞中的 IC50 为 32±3 nM。 | |||
T85171 |
9(E),11(E)-Conjugated Linoleic Acid methyl ester
Methyl 9(E),11(E)-Octadecadienoate |
Others | Others |
9(E),11(E)-Conjugated Linoleic Acid Methyl Ester, identified in thermally stressed cooking oils, can serve as an indicator for the adulteration of olive oils with lower quality oils. [Matreya, LLC. Catalog No. 1257] | |||
T85178 |
22-hydroxy Docosanoic Acid
ω-hydroxy Behenic Acid,22-hydroxy DCA,ω-hydroxy Docosanoic Acid,ω-hydroxy DCA |
Others | Others |
22-Hydroxy docosanoic acid, a hydroxylated fatty acid identified within the suberin component of silver birch (B. pendula) outer bark, along with the leaves, roots, and wood of Q. ilex from Cala Violina and Colognole, Italy. [Matreya, LLC. Catalog No. 1818] | |||
T85261 |
10-methyl Palmitic Acid methyl ester
Methyl 10-methyl Hexadecanoic Acid |
Others | Others |
10-Methyl palmitic acid methyl ester is a methylated derivative of fatty acid methyl ester, identified in glycolipid analogs with cyclitol from P. crassa. [Matreya, LLC. Catalog No. 1792] | |||
T85173 |
15-hydroxy Pentadecanoic Acid methyl ester
Methyl 15-hydroxy Pentadecanoate |
Others | Others |
15-Hydroxy Pentadecanoic Acid Methyl Ester is a hydroxylated fatty acid methyl ester (FAME) crucial for synthesizing musk-odored macrocyclic lactones, specifically cyclopentadecanolide and exaltolide [Matreya, LLC. Catalog No. 1882]. | |||
T85268 |
10(E),12(Z)-Conjugated Linoleic Acid methyl ester
Methyl 10(E),12(Z)-Octadecadienoate methyl ester,10E,12Z-CLA methyl ester |
Others | Others |
10(E),12(Z)-Conjugated linoleic acid methyl ester serves as a standard for quantifying 10(E),12(Z)-conjugated linoleic acid in L. plantarum culture samples. [Matreya, LLC. Catalog No. 1254] | |||
T85142 |
1,2-Dilauroyl-sn-glycero-3-phospho-(2R)-glycerol sodium
1,2-Dilauroyl-sn-glycero-3-phosphorylglycerol,DLPG,PG(12:0/12:0),1,2-Didodecanoyl-sn-glycero-3-phospho-(2R)-glycerol |
Others | Others |
1,2-Dilauroyl-sn-glycero-3-phospho-(2R)-glycerol is a type of phosphoglycerol characterized by the presence of lauric acid at the sn-1 and sn-2 positions. [Matreya, LLC. Catalog No. 1443] | |||
T85172 |
9(Z),11(Z)-Conjugated Linoleic Acid methyl ester
9Z,11Z-CLA |
Others | Others |
9(Z),11(Z)-Conjugated Linoleic Acid Methyl Ester serves as a standard in the quantification of conjugated linoleic acid methyl esters via GC-MS, according to Matreya, LLC. Catalog No. 1256. | |||
T85177 |
17-hydroxy Heptadecanoic Acid
ω-hydroxy Heptadecanoic Acid |
Others | Others |
17-Hydroxyheptadecanoic acid, a hydroxylated fatty acid identified in aeolian particles from the Frioul Islands and the outer bark of E. globulus, serves in the synthesis of diverse macrocyclic lactones. [Matreya, LLC. Catalog No. 1760] | |||
T85271 |
17-methyl Stearic Acid methyl ester
Methyl 17-methyl Octadecanoate Acid,SFE 20:0 |
Others | Others |
17-Methyl stearic acid methyl ester is a methylated derivative of fatty acid methyl ester, identified in mutton tallow and as a volatile constituent in roasted tigernut (C. esculentus) oil [Matreya, LLC. Catalog No. 1603]. | |||
T85170 |
3-hydroxy Undecanoic Acid methyl ester
Methyl 3-hydroxyundecanoate |
Others | Others |
3-Hydroxy Undecanoic Acid Methyl Ester, a hydroxylated fatty acid methyl ester, is present in methyl-branched poly(3-hydroxyalkanoate) (PHA) polymers synthesized by P. oleovorans, P. putida, and D. tsuruhatensis [Matreya, LLC. Catalog No. 1730]. | |||
T85265 |
3-hydroxy Lauric Acid methyl ester
Methyl β-Hydroxydodecanoate,Methyl 3-Hydroxydodecanoate |
Others | Others |
3-Hydroxy lauric acid methyl ester, a hydroxylated fatty acid methyl ester, is identified in methyl-branched poly(3-hydroxyalkanoate) (PHA) polymers produced by P. putida and D. tsuruhatensis [Matreya, LLC. Catalog No. 1732]. | |||
T85277 |
2-fluoro Palmitic Acid methyl ester
Methyl 2-fluoro Palmitate,Methyl 2-fluoro Hexadecanoate |
Others | Others |
2-Fluoro palmitic acid methyl ester, a monofluorinated derivative of palmitic acid methyl ester, serves as an intermediate in the synthesis of 2-iodoaldehydes, monofluorinated fatty acids, and polyfluoro ketones [Matreya, LLC. Catalog No. 1718]. | |||
T85272 |
cis-9,10-Methyleneoctadecanoic Acid methyl ester
Dihydrosterculic Acid methyl ester,Methyl cis-9,10-Methyleneoctadecanoate |
Others | Others |
Cis-9,10-Methyleneoctadecanoic acid methyl ester, a cyclopropane fatty acid methyl ester, stimulates DNA synthesis in rat hepatocytes and serves as a standard for quantifying cis-9,10-methyleneoctadecanoic acid in bacterial membranes through co-chromatography. [Matreya, LLC. Catalog No. 1823] | |||
T85274 |
2-hydroxy Myristic Acid methyl ester
|
Others | Others |
2-Hydroxy Myristic Acid Methyl Ester, a rare hydroxylated fatty acid methyl ester isolated from aquatic microbial sources, experiences a decrease in levels to <1% within these communities following Atradex pesticide exposure at 245 mg/L concentration. [Matreya, LLC. Catalog No. 1704] | |||
T85164 |
2-hydroxy Arachidic Acid
α-hydroxy Eicosanoic Acid,α-hydroxy Arachic Acid,2-Hydroxy C20:0 |
Others | Others |
2-Hydroxy arachidic acid is a hydroxylated fatty acid identified in various sources, including pasture grass (S. sphacelata), soil from abandoned pastures in Ecuador, wool wax, and as the N-acyl chain of galactosylceramides in mouse brain. [Matreya, LLC. Catalog No. 1709] | |||
T38281 |
C22 Galactosylceramide (d18:1/22:0)
|
Others | Others |
C22 Galactosylceramide is a sphingolipid that has been found in the central nervous system.1,2C22 Galactosylceramide levels are increased in the spinal cord, but not the brain or liver, of mice fed a methionine-restricted diet.1C22 Galactosylceramide has been found in postmortem hippocampus from patients with Alzheimer's disease.2[Matreya, LLC.] | |||
T85263 |
13-methyl Pentadecanoic Acid methyl ester
Methyl 13-methyl Pentadecanoate Acid |
Others | Others |
13-Methylpentadecanoic acid methyl ester is a methylated version of fatty acid methyl ester detected in the bioactive fragment of A. malabarica extract, C. variabilis microalgae, and baboon liver. [Matreya, LLC. Catalog No. 1613] | |||
T78975 |
IDO1-IN-22
|
Indoleamine 2,3-Dioxygenase (IDO) | Metabolism |
IDO1-IN-22(Compound 3)是一种效能显著的IDO1抑制剂,具备低纳摩尔级生化活性(hIDO1 IC50:67.4 nM)以及显著的细胞内抑制效果(HeLa细胞中hIDO1 IC50:17.6 nM)。在小鼠LLC异种移植模型中表现出卓越的抗肿瘤效果,并表现出有利的药代动力学(PK)特性。 | |||
T85143 |
β-L-Gulopyranosyl-caldarchaetidyl-glycerol
GuCGp,Gulopyranosyl-(β1-1)-caldarchaetidylglycerol |
Others | Others |
β-L-Gulopyranosyl-caldarchaetidyl-glycerol is the principal polar lipid in the archaeon T. acidophilum. Its cellular levels in T. acidophilum HO-62 show a positive correlation with culture pH and a negative correlation with temperature. This compound also serves as a standard for polar lipid quantification from T. acidophilum HO-62. [Matreya, LLC. Catalog No. 1303] | |||
T85262 |
3-hydroxy Stearic Acid methyl ester
Methyl 3-hydroxyoctadecanoate,β-hydroxy Octadecanoic Acid methyl ester,β-hydroxy Stearic Acid methyl ester |
Others | Others |
3-Hydroxy Stearic acid methyl ester, a hydroxylated fatty acid methyl ester, occurs in methyl-branched poly(3-hydroxyalkanoate) (PHA) polymers synthesized by Streptomyces sp. JM3 and is present in trace amounts in M. bijuga fruit. Additionally, it is identified as a chemical scent constituent in the feces of adult wild Iberian wolves (C. lupus signatus). [Matreya, LLC. Catalog No. 1744] | |||
T85167 |
9(Z),11(E)-Conjugated Linoleic Acid methyl ester
Methyl 9(Z),11(E)-Octadecadienoate,9Z,11E-CLA |
Others | Others |
9(Z),11(E)-Conjugated Linoleic Acid Methyl Ester, identified in lemon grass (C. flexuosus), serves as a standard for quantifying conjugated linoleic acids in thermally stressed olive oil and trans fats in bakery products. [Matreya, LLC. Catalog No. 1255] | |||
T85169 |
3-hydroxy Nonanoic Acid
β-hydroxy Nonanoic Acid |
Others | Others |
3-Hydroxy Nonanoic Acid, a hydroxylated fatty acid, is present in the young peridioles of Pisolithus fungi, LPS of P. aeruginosa, bovine milk, and the methyl-branched poly(3-hydroxyalkanoate) (PHA) polymers synthesized by P. oleovorans [Matreya, LLC. Catalog No. 1725]. | |||
T85145 |
10(Z)-Pentadecenoic Acid methyl ester
SFE 16:1,C15:1 (cis-10) methyl ester,cis-10-Pentadecenoic Acid methyl ester |
Others | Others |
10(Z)-Pentadecenoic acid methyl ester is the methyl ester derivative of the fatty acid known as 10(Z)-pentadecenoic acid. This compound serves as a standard for quantifying pentadecenoic acid in vernix caseosa, as indicated by Matreya, LLC. Catalog No. 1210. | |||
T85160 |
9(Z),11(E),13(Z)-Octadecatrienoic Acid methyl ester
SFE 19:3,Methyl Punicate,Punicic Acid methyl ester |
Others | Others |
9(Z),11(E),13(Z)-Octadecatrienoic acid methyl ester, an isomer of 9(Z),11(E),13(E)-octadecatrienoic acid methyl ester and the methyl ester derivative of 9(Z),11(E),13(Z)-octadecatrienoic acid, serves as a standard for quantifying 9(Z),11(E),13(Z)-octadecatrienoic acid in wild growing pomegranate (P. granatum) seed oil [Matreya, LLC. Catalog No. 1240]. | |||
T85174 |
3-keto Sphinganine (d12:0) hydrochloride
3-keto Sphinganine (d12:0),3-keto Dihydrosphingosine (d12:0) |
Others | Others |
3-Keto Sphinganine (d12:0) is a short-chain analog of 3-keto sphinganine (d18:0), which typically possesses a C18 chain length. The latter is a lyso-sphingolipid synthesized through the condensation of L-serine and palmitoyl-CoA mediated by the enzyme serine palmitoyl transferase (SPT). A deficiency in Vitamin K deactivates SPT, leading to a reduced synthesis of 3-keto sphinganine among other sphingolipids. [Matreya, LLC. Catalog No. 1893] | |||
T85264 |
3-hydroxy Hexanoic Acid
3-hydroxy Caproic Acid |
Others | Others |
3-Hydroxy hexanoic acid, a hydroxylated fatty acid, is present in methyl-branched poly(3-hydroxyalkanoate) (PHA) polymers synthesized by P. oleovorans, P. putida, and D. tsuruhatensis. Additionally, it appears in the urine and serum of diabetic patients experiencing ketoacidosis, unlike in healthy individuals or diabetics without ketoacidosis. [Matreya, LLC. Catalog No. 1747] | |||
T85146 |
11-Hexadecenoic Acid
C16:1 (cis-11/trans-11) Fatty Acid |
Others | Others |
11-Hexadecenoic acid, a monounsaturated fatty acid, comprises both 11-cis-hexadecenoic acid and 11-trans-hexadecenoic acid. These isoforms are present in ewe milk fat and their concentrations increase when the diet is supplemented with lipids from linseed, sunflower, olive, or fish oils. Additionally, 11-trans-hexadecenoic acid is found in intramuscular fat of both male and female foals. The product is a blend of the 11-cis and 11-trans forms. [Matreya, LLC. Catalog No. 1208] | |||
T85176 |
2-hydroxy Arachidic Acid methyl ester
methyl 2-hydroxy Eicosanoate |
Others | Others |
2-Hydroxy arachidic acid methyl ester, a hydroxylated fatty acid methyl ester identified in sediment samples from the Harney River and in petroleum ether extracts of I. eriocarpa, serves as a volatile flavoring compound in anhydrous milk fat (AMF). Its presence is diminished upon treatment with lipases lipozyme-435 and TL-IM in a time-dependent fashion. [Matreya, LLC. Catalog No. 1710] | |||
T85260 |
14-methyl Palmitic Acid methyl ester
Methyl 14-methylhexadecanoate |
Others | Others |
14-Methyl palmitic acid methyl ester is a methylated fatty acid methyl ester identified in A. indica leaf extract, S. alboflavus TD-1, and as a less prominent constituent in biodiesel from C. sorokiniana microalgae. It acts as a volatile agent emanating from maize, impeding the growth of F. verticillioides in a dose-responsive manner. Additionally, this compound is utilized as a reference standard for quantifying 14-methyl palmitic acid in diverse foods via GC-MS. [Matreya, LLC. Catalog No. 1614... | |||
T84632 |
9(E),11(E)-Conjugated Linoleic Acid
9E,11E-CLA |
Others | Others |
9(E),11(E)-Conjugated Linoleic Acid (9(E),11(E)-CLA) belongs to a group of eight geometric isomers of linoleic acid, characterized by adjacent double bonds. This specific isomer, 9,11 all-trans linoleic acid, was first discovered in ground beef and is found in various dairy products as well. Notably, it has been shown to decrease mammary tumors in rats with dietary inclusion as minimal as 0.1%. [Matreya, LLC. Catalog No. 1181] | |||
T38286 |
C26 Sphingomyelin (d18:1/26:0)
C26 Sphingomyelin (d18:1/26:0) |
Others | Others |
C26 Sphingomyelin is a sphingolipid that has been found in serum and cell or brain extracts.1,2,3C26 sphingomyelin levels are increased in the serum of patients with hemophagocytic lymphohistiocytosis, an inflammatory condition characterized by excessive immune activation.3C26 sphingomyelin has been used a component of monolayers to study the influence of sphingomyelin acyl chain length on sphingomyelin-sterol interactions.4[Matreya, LLC.] 1.Wang, J.-R., Zhang, H., Yau, L.D., et al.Improved sphi... | |||
T85008 |
Phosphatidylinositol (plant, wheat germ) sodium
|
Others | Others |
Phosphatidylinositols, comprising about 10% of total cellular phospholipids, are glycerophospholipids featuring a glycerol backbone, two non-polar fatty acid tails (primarily C16:0 and C18:0), and a polar inositol head group. Synthesized from cytidine diphosphate diacylglycerol (CPD-DAG) and myoinositol via phosphoinositol synthase, these compounds play pivotal roles in cellular processes, including calcium regulation, vesicle trafficking, mitogenesis, cell survival, and actin rearrangement. Pho... | |||
T85269 |
Sphingomyelin (chicken egg)
SMs (egg) |
Others | Others |
Sphingomyelins (SMs) are bioactive sphingolipids present in the cell membranes of mammals, constituting 2-15% of the total cellular phospholipid content, with higher concentrations in the brain and myelin sheaths of peripheral nerves. These compounds play a crucial role in modulating cholesterol distribution and maintaining cellular cholesterol balance. SMs are hydrolyzed by sphingomyelinase into ceramides, key sphingolipid signaling molecules. The product contains SM species predominantly with ... | |||
T85147 |
Sterculic Acid methyl ester
SFE 20:2,Methyl Sterculate |
Others | Others |
Sterculic acid methyl ester, an ester derivative of sterculic acid known for inhibiting Δ9 desaturase, has been found to adversely affect and exhibit toxicity towards R. opacus bacteria at a concentration of 0.75 mM. It not only hampers bacterial growth but also modifies fatty acid composition by reducing stearate and oleate levels, increasing the palmitate ratio, and decreasing overall fatty acid content at 0.25 or 0.5 mM concentrations. Additionally, at 50 ppm, Sterculic acid methyl ester enha... | |||
T36695 |
TAS-103
|
Others | Others |
TAS-103 is a dual inhibitor of DNA topoisomerase I/II, used for cancer research. TAS-103 is a dual inhibitor of DNA topoisomerase I/II. TAS-103 (0.1-10 μM) is active on CCRF-CEM cells, with an IC50 value of 5 nM. TAS-103 (0.1 μM) significantly increases levels of topo IIα FITC immunofluorescence in individual CCRF-CEM cells[1]. TAS-103 (0.01-1 μM) is highly cytotoxic to Lewis lung carcinoma (LLC) cells, and Liposomal TAS-103 is almost as active as free TAS-103[2]. TAS-103 inhibits the viability ... | |||
T37455 |
C18 D-threo Ceramide (d18:1/18:0)
C18 D-threo Ceramide (d18:1/18:0) |
Others | Others |
C18 D-threoCeramide (d18:1/18:0) is a synthetic ceramide and stereoisomer of C18 ceramide .1It inhibits rat brain mitochondrial ceramidase (mt-CDase) with an IC50value of 16.6 μM.2[Matreya, LLC. Catalog No. 1855] 1.Koolath, S., Murai, Y., Suga, Y., et al.Chiral combinatorial preparation and biological evaluation of unique ceramides for inhibition of sphingomyelin synthaseChirality32(3)308-313(2019) 2.Usta, J., El Bawab, S., Roddy, P., et al.Structural requirements of ceramide and sphingosine bas... | |||
T36974 |
D-threo-PPMP hydrochloride
|
Others | Others |
D-threo-PPMP is a glucosylceramide (GlyCer) synthetase inhibitor.1,2It is the active enanantiomer and enzymatic inhibitory component of the racemic DL-threo-PPMP . In MDCK kidney epithelial cells, D-threo-PPMP induces a 70% reduction in cell growthin vitroat 20 μM and significantly inhibits DNA synthesis at 3 μM.3[Matreya, LLC. Catalog No. 1865] 1.Shen, W., Henry, A.G., Paumier, K.L., et al.Inhibition of glucosylceramide synthase stimulates autophagy flux in neuronsJ. Neurochem.129(5)884-894(201... | |||
T37953 |
Sphingomyelins (buttermilk)
|
Others | Others |
Sphingomyelins (SMs) are bioactive sphingolipids found in mammalian cell membranes.1SMs make up 2-15% of the total organ phospholipid population but are found at higher concentrations in the brain and myelin sheaths surrounding peripheral nerves. They interact with cholesterol to control its distribution within cellular membranes and maintain cholesterol homeostasis in cells. SMs undergo hydrolysis by sphingomyelinase to form ceramides, which are sphingolipid mediators of intracellular signaling... | |||
T35854 |
9(Z),11(E)-Conjugated Linoleic Acid (sodium salt)
|
Others | Others |
9(Z),11(E)-Conjugated linoleic acid is an isomer of linoleic acid that has been found in beef and milk fat.1It binds to peroxisome proliferator-activated receptor α (PPARα; IC50= 140 nM) and activates the receptor in a reporter assay using COS-1 cells expressing mouse PPARα when used at a concentration of 100 μM.29(Z),11(E)-Conjugated linoleic acid inhibits TNF-α-inducedGLUT4expression and increases insulin-stimulated glucose transport in 3T3-L1 adipocytes.3Dietary administration of 9(Z)11(E)-co... | |||
T37187 |
D-erythro/L-threo Lysosphingomyelin (d18:1)
D-erythro/L-threo Lysosphingomyelin (d18:1) |
Others | Others |
Lysosphingomyelin is an endogenous bioactive sphingolipid and a constituent of lipoproteins.1,2It is produced by the removal of the acyl group from sphingomyelin by a deacylase and acts as a precursor in the biosynthesis of sphingosine-1-phosphate . D-erythroLysosphingomyelin is an agonist of the S1P receptors S1P1, S1P2, and S1P3(EC50s = 167.7, 368.1, and 482.6 nM, respectively, for the human receptors).3It is also an agonist of the orphan receptor ovarian cancer G protein-coupled receptor 1 (O... | |||
T37582 |
Ganglioside GM1 Mixture (ovine) (ammonium salt)
|
Others | Others |
Ganglioside GM1is a monosialylated ganglioside and the prototypic ganglioside for those containing one sialic acid residue.1,2It is found in a large variety of cells, including immune cells and neurons, and is enriched in lipid rafts in the cell membrane.3It associates with growth factor receptors, including TrkA, TrkB, and the GDNF receptor complex containing Ret and GFRα, and is required for TrkA expression on the cell surface. Ganglioside GM1interacts with other proteins to increase calcium i... |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T5S0106 |
Peimisine
贝母辛,Ebeiensine |
RAAS; AChR | Endocrinology/Hormones; Neuroscience |
Peimisine (Ebeiensine) 非竞争性拮抗气管平滑肌 M 受体,抑制 Ach 引起的平滑肌收缩。它兴奋 β 受体和拮抗内钙释放,促进一氧化氮释放,可舒张气管平滑肌,有平喘作用。 | |||
TN1040 |
Skullcapflavone II
|
COX; Antibacterial; TGF-beta/Smad | Immunology/Inflammation; Microbiology/Virology; Neuroscience; Stem Cells |
Skullcapflavone II 是从黄芩中提取的黄酮,具有抗炎作用。它对 M. aurum 和 M. bovisBCG 具有较强的抗菌活性。它还调节破骨细胞的分化、存活和功能。 | |||
TN5033 |
Skullcapflavone I
|
IL Receptor; Caspase; Prostaglandin Receptor | Apoptosis; GPCR/G Protein; Immunology/Inflammation; Proteases/Proteasome |
Skullcapflavone I has anti-inflammatory and anti-allergic potential, it can significantly inhibit LPS stimulated NO and PGE(2) release in J774A.1 macrophages and inhibit LPS induced IL-6 production in a concentration dependent manner. Skullcapflavone I se | |||
T3S1967 |
(S)-Indoximod
N-ME-Tryptophan,Abrine,相思豆碱,L-Abrine |
Others; Indoleamine 2,3-Dioxygenase (IDO) | Metabolism; Others |
(S)-Indoximod (L-Abrine) 是一种吲哚胺-2,3-双加氧酶 (IDO) 抑制剂,可用于研究癌症。 | |||
TN4457 | Lucidal | Others | Others |
Lucialdehyde C (Lucidal) exhibits potent cytotoxicity against LLC, T-47D, Sarcoma 180, and Meth-A tumor cells with ED(50) values of 10.7, 4.7, 7.1, and 3.8 microg/ml, respectively. | |||
TN4455 |
Lucialdehyde B
|
Integrase; HSV | Microbiology/Virology |
Lucialdehyde B exhibits potent inhibitory activity against herpes simplex virus. It shows cytotoxic effects on Lewis lung carcinoma (LLC), T-47D, Sarcoma 180, and Meth-A tumor cell lines. | |||
T35483 |
19,20-Epoxycytochalasin D
|
Others | Others |
19,20-Epoxycytochalasin D is a fungal metabolite that has been found in the endophytic fungus Nemania sp. UM10M. It is active against the chloroquine-sensitive and -resistant strains of P. falciparum (MIC = 0.4 ng/ml for both) without inducing cytotoxicity in Vero cells. It is cytotoxic to BT-549, LLC-PK11, and P388 cells (IC50s = 7.84, 8.4, and 0.16 µM, respectively) but not SK-MEL, KB, or SKOV3 cells up to a concentration of 10 µM. | |||
TN4108 |
Ganoderic acid Z
|
Antifection | Microbiology/Virology |
The binding affinities of ganoderic acid DM and ganoderic acid Z (ÎGbind, -16.83 and-10.99 kcal mol-1) are comparable to that of current commercial drug oseltamivir (-23.62 kcal mol-1);Ganoderic acid DM is a potential source of anti-influenza ingredient, with novel binding pattern and advantage over oseltamivir, it has steric hindrance on the 150 cavity of N1 protein, and exerts activities across the H274Y and N294S mutations, is the attractive candidates of novel neuraminidase (NA) inhibitors.... |
Cat. No. | Product Name | Species | Expression System |
---|---|---|---|
TMPY-03397 |
TPPP3 Protein, Human, Recombinant (His)
CGI-38,TPPP3,p25gamma,tubulin polymerization-promoting prote... |
Human | E. coli |
TPPP3, a member of the Tubulin polymerization-promoting protein family, is an intrinsically unstructured protein that induces tubulin polymerization. TPPP3 is a marker in the developing musculoskeletal system. In tendons, Tppp3 is expressed in cells at the circumference of the developing tendons, likely the progenitors of connective tissues that surround tendons: the tendon sheath, epitenon, and paratenon. Tppp3 is also expressed in forming synovial joints. The onset of Tppp3 expression in joint... |