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Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T2591 |
Veliparib
ABT-888,NSC 737664,维利帕尼 |
PARP; Autophagy | Autophagy; Chromatin/Epigenetic; DNA Damage/DNA Repair |
Veliparib (ABT-888) 是一种可口服的 PARP 抑制剂,抑制PARP1和PARP2的Ki 分别为 5.2 和 2.9 nM。它增强细胞凋亡和自噬。 | |||
T2105 |
Veliparib dihydrochloride
维利帕尼二盐酸盐,ABT-888 dihydrochloride |
PARP; Autophagy | Autophagy; Chromatin/Epigenetic; DNA Damage/DNA Repair |
Veliparib dihydrochloride (ABT-888 dihydrochloride) 是一种PARP1和PARP2抑制剂,Ki 分别为5.2 nM 和2.9 nM。 | |||
T11199 |
Endothelial lipase inhibitor-1
|
Lipase | Metabolism |
Endothelial lipase inhibitor-1是有效,选择性的内皮脂肪酶抑制剂,IC50为 49 nM。 | |||
T67991 |
Iliparcil
|
Others | Others |
Iliparcil 是一种具有口服活性的抗血栓化合物。 | |||
T65529 |
Lipase, triacylglycerol
|
Others | Others |
Lipase, triacylglycerol 是一种有用的有机化合物,可用于生命科学领域的相关研究。其产品编号为 T65529,CAS号为 9001-62-1。 | |||
T69004 |
Falipamil hydrochloride
|
Others | Others |
Falipamil hydrochloride is a calcium channel antagonist potentially for the treatment of ischaemic heart disorder and sinus. | |||
T76120 |
Phospholipase D
|
Others | Others |
PhospholipaseD (PLD) ,即磷脂酶 D,是磷脂酶超家族的一种酶,广泛存在于细菌、酵母、植物、动物和病毒中,常用于生化研究。PhospholipaseD 可以催化甘油磷脂的磷酸二酯键水解,产生磷脂酸和可溶性胆碱。PhospholipaseD 参与了多种疾病相关过程,包括糖尿病、动脉粥样硬化形成、肥胖、肿瘤发生、免疫反应和神经内分泌功能。 | |||
T76182 |
Phospholipase A2
|
||
PhospholipaseA2 (PLA2) 催化膜磷脂质在 sn-2 位置的水解作用,释放出花生四烯酸 (AA)。该酶为钙依赖型且热稳定,广泛应用于生化实验中。 | |||
T27302 |
Falipamil
AQ-A 39,AQ-A-39,AQ-A39 |
Others | Others |
Falipamil is a verapamil derivative and a calcium channel antagonist. Falipamil exerts antitachycardic effects by a direct action on the sinus node. Falipamil decreases HR at exercise in normal subjects and may exert antianginal effects in patients with m | |||
T63015 |
Pancreatic lipase/Carboxylesterase 1-IN-1
|
Others | Others |
Pancreatic lipase/Carboxylesterase 1-IN-1 (Compound 39) 是一种有效的、双重的胰脂酶 (PL) 和人羧酸酯酶 1A (hCES1A) 抑制剂,作用于 PL (IC50: 2.13 μM) 和 hCES1A (IC50: 0.055 μM)。 | |||
T61294 |
Monoacylglycerol lipase inhibitor 1
|
Others | Others |
Monoacylglycerol lipase inhibitor 1 是一种有效的单酰基甘油脂肪酶 (MGL) 抑制剂 (化合物 13)。 | |||
T29865 |
Alipamide
CI-546,D-1721,CN 38474,Alipamidum,CN-38,474 |
Others | Others |
Alipamide is a bio-active chemical. | |||
TP2467 |
Plipastatin B 1
|
||
Plipastatin B 1 is a lipopeptide. | |||
T39383 |
Lipase Substrate
|
Others | Others |
Lipase Substrate is a substrate of lipase to detect activity. | |||
T125927 |
Folipastatin
|
Others | Others |
Folipastatin 是一种有用的有机化合物,可用于生命科学领域的相关研究。其产品编号为 T125927,CAS号为 139959-71-0。 | |||
T73610 |
Lipoprotein lipase
|
Others | Others |
Lipoprotein lipase 是来自于脂肪组织、心肌和骨骼肌、胰岛和巨噬细胞的多功能酶。Lipoprotein lipase 促进正常脂蛋白代谢、组织特异性底物的输送和利用。Lipoprotein lipase 催化脂质在血液循环的限速步骤。 | |||
T126497 |
Plipastatin A2
|
Others | Others |
Plipastatin A2 是一种有用的有机化合物,可用于生命科学领域的相关研究。其产品编号为 T126497,CAS号为 103955-72-2。 | |||
T126496 |
Plipastatin B2
|
Others | Others |
Plipastatin B2 是一种有用的有机化合物,可用于生命科学领域的相关研究。其产品编号为 T126496,CAS号为 103955-74-4。 | |||
T78528 |
ERX-41
|
Others | Others |
ERX-41是一种口服活性的立体特异性小分子,靶向溶酶体酸性脂肪酶A (LIPA)。该化合物通过诱导内质网(ER)应激从而导致细胞死亡,这一作用表明ERX-41功能独立于LIPA,但依赖于其在内质网的定位。ERX-41主要用于实体瘤靶向研究。 |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T5320 |
Tulipalin A
α-methylene-γ-butyrolactone,2-Methylenebutyrolactone,2-甲烯基丁内酯 |
Others; Drug Metabolite | Metabolism; Others |
Tulipalin A (α-methylene-γ-butyrolactone) 是来源于郁金香鳞茎的有毒糖苷。Tulipalin A 是引起过敏性接触皮炎的致敏性致敏物 (causative allergen),在低剂量影响免疫细胞的功能,例如 Jurkat T 细胞。 | |||
T83864 |
Plipastatin A1
SNA-60-367-3,Fengycin IX |
Others | Others |
Plipastatin A1是一种在B. cereus中发现的脂肽类化合物,具有酶抑制活性和免疫抑制活性。它能抑制磷脂酶A2(PLA2)、PLC和PLD(IC50分别为2.9、1.3和1.4 µM)。Plipastatin A1(100 µg/ml)能抑制LPS诱导的B细胞爆发生成和Concanavalin A诱导的T细胞爆发生成。在体内,Plipastatin A1(0.1 mg/动物)能抑制小鼠的迟发型超敏反应。 |
Cat. No. | Product Name | Species | Expression System |
---|---|---|---|
TMPH-03323 |
LIPA Protein, Rat, Recombinant (His)
Lysosomal acid lipase/cholesteryl ester hydrolase,<... |
Rat | E. coli |
Catalyzes the deacylation of triacylglyceryl and cholesteryl ester core lipids of endocytosed low density lipoproteins to generate free fatty acids and cholesterol. LIPA Protein, Rat, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 48.6 kDa and the accession number is Q64194. | |||
TMPH-01626 |
LIPA Protein, Human, Recombinant (GST)
Lysosomal acid lipase/cholesteryl ester hydrolase,<... |
Human | E. coli |
Catalyzes the deacylation of triacylglyceryl and cholesteryl ester core lipids of endocytosed low density lipoproteins to generate free fatty acids and cholesterol. LIPA Protein, Human, Recombinant (GST) is expressed in E. coli expression system with N-GST tag. The predicted molecular weight is 70.0 kDa and the accession number is P38571. | |||
TMPH-01625 |
LIPA Protein, Human, Recombinant (His)
Cholesteryl esterase,Lysosomal acid lipase/choleste... |
Human | P. pastoris (Yeast) |
Catalyzes the deacylation of triacylglyceryl and cholesteryl ester core lipids of endocytosed low density lipoproteins to generate free fatty acids and cholesterol. LIPA Protein, Human, Recombinant (His) is expressed in yeast with N-6xHis tag. The predicted molecular weight is 45.0 kDa and the accession number is P38571. | |||
TMPH-00066 |
Phospholipase A2 Protein, Apis mellifera, Recombinant (His)
Allergen Api m I,Phospholipase A2,Phosphatidylcholi... |
Apis mellifera | E. coli |
PLA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides. | |||
TMPH-00449 |
Phospholipase A2 Protein, Crotalus atrox, Recombinant (His & Myc)
Phospholipase A2,Phosphatidylcholine 2-acylhydrolas... |
Crotalus atrox | Baculovirus Insect Cells |
Phospholipase A2 Protein, Crotalus atrox, Recombinant (His & Myc) is expressed in Baculovirus. | |||
TMPH-02829 |
Phospholipase D3/PLD3 Protein, Mouse, Recombinant (His)
Phosphatidylcholine-hydrolyzing phospholipase D3,Pl... |
Mouse | E. coli |
5'->3' DNA exonuclease which digests single-stranded DNA (ssDNA). Regulates inflammatory cytokine responses via the degradation of nucleic acids, by reducing the concentration of ssDNA able to stimulate TLR9, a nucleotide-sensing receptor in collaboration with PLD4. May be important in myotube formation. Plays a role in lysosomal homeostasis. Involved in the regulation of endosomal protein sorting. | |||
TMPH-00421 |
Phospholipase C Protein, Clostridium perfringens, Recombinant (His)
Phospholipase C,plc,Alpha-toxin,Hemolysin,Phosphati... |
C.perfringens | E. coli |
Phospholipase C Protein, Clostridium perfringens, Recombinant (His) is expressed in E. coli. | |||
TMPH-03568 |
Phospholipase C Protein, S. aureus, Recombinant (His)
hlb,Beta-hemolysin,Phospholipase C,Beta-toxin,Sphin... |
Staphylococcus aureus | P. pastoris (Yeast) |
Bacterial hemolysins are exotoxins that attack blood cell membranes and cause cell rupture. Beta-hemolysin is a phospholipase C with specific activity toward sphingomyelins. Has a high specificity for sphingomyelin, hydrolyzes lysophosphatidylcholine at a much lower rate, but has no activity towards phosphatidylcholine, phosphatidylethanolamine, or phosphatidylserine. Phospholipase C Protein, S. aureus, Recombinant (His) is expressed in yeast with N-6xHis tag. The predicted molecular weight is 3... |