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Search Results for " lats1 "

Targets Recommended: Others

4

抑制剂 & 化合物

9

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T9032	MGH-CP1	Others	Others
	MGH-CP1 是 TEAD2 (IC50:710 nM) 及 TEAD4 (IC50:672 nM) 自棕榈酰化抑制剂，口服有活性，可降低细胞内源性或异位表达的 TEAD 蛋白棕榈酰化水平。MGH-CP1 与 Lats1/2 缺失，是 Myc 的表达受到抑制，阻碍上皮细胞过度增殖，诱导细胞凋亡。
T9053	Lats-IN-1	Others; YAP	Others; Stem Cells
	Lats-IN-1 是一种 ATP 竞争性的、高效的Lats1和Lats2激酶抑制剂，能促进有丝分裂后哺乳动物组织的 Yap 依赖性增殖。
T60013	GA-017	Others	Others
	GA-017是一种有效的选择性 LATS1和 LATS2(大型肿瘤抑制激酶 1/2) 抑制剂，其 IC50值分别为 4.10 和 3.92 nM。GA-017 是细胞增殖的激活剂。GA-017 促进 YAP/TAZ 激活和核转位。GA-017 在 3D 培养条件下促进细胞生长。GA-017 增强小鼠肠道类器官的离体形成。
T73429	VT02956	Others	Others
	VT02956 是一种LATS 抑制剂 (IC50: LATS1 为 0.76 nM，LATS2 为 0.52 nM)。VT02956 靶向Hippo 信号通路。VT02956 抑制 ER+ 乳腺癌细胞系和患者来源的肿瘤类器官的生长和 ESR1 表达。

化合物

Cat.No: T9032

Target: Others

Cat.No: T9053

Target: Others, YAP

Cat.No: T60013

Target: Others

Cat.No: T73429

Target: Others

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPH-02088	LATS1 Protein, Human, Recombinant (His & Myc) Serine/threonine-protein kinase LATS1,WART...	Human	E. coli
	LATS1 Protein, Human, Recombinant (His & Myc) is expressed in E. coli.
TMPH-03764	YAP1 Protein, Human, Recombinant (His) YAP1-2gamma,YAP2L,YAP65	Human	P. pastoris (Yeast)
	Transcriptional regulator which can act both as a coactivator and a corepressor and is the critical downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1,...
TMPJ-01335	MOB1A Protein, Human, Recombinant (His) C2orf6,MOB4B,Mob1A,MOBK1B,Mps One Binder K...	Human	E. coli
	MOB Kinase Activator 1A (MOB1A) belongs to the MOB1/phocein family, which acts as an activator of LATS1/2 in the Hippo signaling pathway, plays a key role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. MOBKL1B stimulates the kinase activity of STK38 and STK38L. MOBKL1B binds to and regulate downstream targets such as the NDR-family protein kinases and LATS1 kinase.
TMPY-03416	TNFAIP8 Protein, Human, Recombinant (His) GG2-1,tumor necrosis factor, alpha-induced protein ...	Human	E. coli
	Tumor necrosis factor (TNF)-alpha-induced protein 8 (TNFAIP8) family is a newly identified protein with vital roles in maintaining immune homeostasis. Tumor necrosis factor-alpha-inducible protein 8 (TNFAIP8) is a TNF-alpha inducible anti-apoptotic protein with multiple roles in tumor growth and survival. by the creation of cellular autophagy events, TNFAIP8 promotes cell survival and drug resistance in prostate cancer cells. TNFAIP8 regulates Hippo pathway through interacting with LATS1 to prom...
TMPH-01662	Merlin Protein, Human, Recombinant (His) Merlin,Moesin-ezrin-radixin-like protein,Schwannomin,Neurofi...	Human	E. coli
	Probable regulator of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway, a signaling pathway that plays a pivotal role in tumor suppression by restricting proliferation and promoting apoptosis. Along with WWC1 can synergistically induce the phosphorylation of LATS1 and LATS2 and can probably function in the regulation of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway. May act as a membrane stabilizing protein. May inhibit PI3 kinase by binding to AGAP2 and impairing its stimulating activity. Suppress...
TMPH-02226	TEAD3 Protein, Human, Recombinant (His & SUMO) DTEF-1,TEA domain family member 3,Transcriptional e...	Human	E. coli
	Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expr...
TMPY-03442	MOB4A/MOB1B Protein, Human, Recombinant (GST) MOB kinase activator 1B,MOBKL1A,MATS2,MOB4...	Human	E. coli
	MST1 and MST2 are the mammalian Ste2-related protein kinases most closely related to Drosophila Hippo, a major regulator of cell proliferation and survival during development. Overexpression of MST1 or MST2 in mammalian cells is proapoptotic. MST1 and MST2 activity increase during mitosis, especially in nocodazole-arrested mitotic cells, where these kinases exhibit an increase in both abundance and activation. MST1 and MST2 also can be activated nonphysiologically by okadaic acid or H2O2. The MO...
TMPH-02225	TEAD2 Protein, Human, Recombinant (His & Myc) TEA domain family member 2,Transcriptional enhancer factor T...	Human	E. coli
	Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expr...
TMPH-02222	TEAD1 Protein, Human, Recombinant (His) TEAD1,Transcriptional enhancer factor TEF-1	Human	E. coli
	Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expr...

重组蛋白

LATS1 Protein, Human, Recombinant (His & Myc)

Cat.No: TMPH-02088

Species: Human

Expression System: E. coli

YAP1 Protein, Human, Recombinant (His)

Cat.No: TMPH-03764

Species: Human

Expression System: P. pastoris (Yeast)

MOB1A Protein, Human, Recombinant (His)

Cat.No: TMPJ-01335

Species: Human

Expression System: E. coli

TNFAIP8 Protein, Human, Recombinant (His)

Cat.No: TMPY-03416

Species: Human

Expression System: E. coli

Merlin Protein, Human, Recombinant (His)

Cat.No: TMPH-01662

Species: Human

Expression System: E. coli

TEAD3 Protein, Human, Recombinant (His & SUMO)

Cat.No: TMPH-02226

Species: Human

Expression System: E. coli

MOB4A/MOB1B Protein, Human, Recombinant (GST)

Cat.No: TMPY-03442

Species: Human

Expression System: E. coli

TEAD2 Protein, Human, Recombinant (His & Myc)

Cat.No: TMPH-02225

Species: Human

Expression System: E. coli

TEAD1 Protein, Human, Recombinant (His)

Cat.No: TMPH-02222

Species: Human

Expression System: E. coli

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