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Search Results for " kinesin "

Targets Recommended: Kinesin Kinesin

40

抑制剂 & 化合物

1

化合物库

4

重组蛋白

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Cat. No.	Product Name
L1310	细胞骨架化合物库		759 compounds
	759 种细胞骨架相关的化合物，可以用于高通量和高内涵筛选；

化合物库

细胞骨架化合物库

Cat.No: L1310

Compounds: 759

Cat. No.	Product Name	Target	Signaling Pathways
T3118	Dimethylenastron	Kinesin	Cytoskeletal Signaling
	Dimethylenastron 是一种驱动蛋白Eg5抑制剂，IC50值为 200 nM。它可阻止具有单极纺锤体的细胞，所有染色体都以单极纺锤体方式附着在该纺锤体上。
T4048	Monastrol (±)-Monastrol	Apoptosis; Kinesin	Apoptosis; Cytoskeletal Signaling
	Monastrol ((±)-Monastrol) 是一种具有高效性和细胞渗透性的有丝分裂驱动蛋白Eg5的抑制剂，IC50值为 14 μM。
T6209	CW-069 CW069	Kinesin; Microtubule Associated	Cytoskeletal Signaling
	CW-069 是一种微管运动蛋白 HSET 的变构选择性抑制剂，IC50值为 75 μM，对 KSP 具有显着的特异性。
T36816	S-trityl-L-Cysteine STLC	Kinesin	Cytoskeletal Signaling
	S-Trityl-L-cysteine 是别构驱动蛋白Eg5的选择性抑制剂。rityl-L-cysteine 抑制基础 ATPase 活性的IC50为 1 μM，抑制微管激活的 ATPase 活性的IC50为 140 nM。S-Trityl-L-cysteine 显示出抗肿瘤活性。
T2039	GSK-923295	Apoptosis; Kinesin	Apoptosis; Cytoskeletal Signaling
	GSK923295 是一种特异性的变构着丝粒相关蛋白-E 驱动蛋白 ATPase 活性抑制剂，作用于人类和犬类此酶，Ki 分别为 3.2±0.2 nM 和 1.6±0.1 nM。
T12359	Paprotrain (alphaZ)-alpha-(3-Pyridinylmethylene)-1H-indole-3-acetonitrile	Kinesin	Cytoskeletal Signaling
	Paprotrain ((alphaZ)-alpha-(3-Pyridinylmethylene)-1H-indole-3-acetonitrile) 是可渗透细胞的 kinesin MKLP-2的抑制剂，抑制 MKLP-2 的 ATPase 活性，IC50值为 1.35 μM，Ki 值为 3.36 μM。它对 DYRK1A 有中等的抑制作用，IC50值为 5.5 μM。
T6393	ARQ 621	Kinesin	Cytoskeletal Signaling
	ARQ 621 是一种变构和选择性 Eg5 有丝分裂运动蛋白抑制剂，具有抗肿瘤活性。
T3120	K858 (Racemic) K858 Racemic,K858	Apoptosis; Kinesin	Apoptosis; Cytoskeletal Signaling
	K858 Racemic (K858) 是一种选择性有丝分裂驱动蛋白 Eg5 抑制剂，以 ATP 非竞争性方式起作用，IC50值为 1.3 μM。
T2255	SB-743921 hydrochloride SB743921 HCl,SB743921	Kinesin; KSP	Cell Cycle/Checkpoint; Cytoskeletal Signaling
	SB-743921 hydrochloride (SB743921 HCl) 是一种有效的驱动蛋白纺锤体蛋白 KSP 抑制剂，Ki 值为 0.1 nM。
T2103	Ispinesib 伊匹尼塞,伊斯平斯,CK0238273,SB-715992	Apoptosis; Kinesin; KSP	Apoptosis; Cell Cycle/Checkpoint; Cytoskeletal Signaling
	Ispinesib (SB-715992) 是一种选择性可逆的驱动蛋白纺锤体蛋白抑制剂，具有抗肿瘤特性。
T8342	BRD9876 6-叔丁基-2,3-二氰基萘	Others; Kinesin; Microtubule Associated	Cytoskeletal Signaling; Others
	BRD9876 是一种 MM1S 生长的选择性抑制剂，可将驱动蛋白 5 锁定在增强微管结合的状态，从而导致 MT 的捆绑和稳定。它特异性靶向微管结合的 Eg5，选择性抑制 CD34 细胞的骨髓瘤，有用于多发性骨髓瘤的研究潜力。
T9207	GW406108X GW108X	Kinesin; Autophagy	Autophagy; Cytoskeletal Signaling
	GW406108X (GW108X) 是一种 Kif15 抑制剂，在 ATPase 测定中的 IC50 为 0.82 uM。它也是一种 ULK1 激酶抑制剂，pIC50 值为 6.37(427 nM)，可阻断自噬通量。
T9207L	GW406108X(Z/E)	Kinesin; Autophagy	Autophagy; Cytoskeletal Signaling
	GW406108X(Z/E) 是不同配置的 GW406108X 的混合物，它是 Kinesin-12 和 ULK1 的抑制剂。
T11759	Kif15-IN-2	Others	Others
	Kif15-IN-2 is used for the research of cellular proliferative diseases. Kif15-IN-2 is an inhibitor of the mitotic kinesin Kif15.
T10428	AZ82	Microtubule Associated	Cytoskeletal Signaling
	AZ82 is a selective kinesin-like protein KIFC1 (HSET/KIFC1) inhibitor (Ki: 43 nM; IC50: 300 nM for KIFC1).
T39994	Sovilnesib AMG650	Microtubule Associated	Cytoskeletal Signaling
	Sovilnesib 是一种有效kinesin-like protein KIF18A 抑制剂。它可用于癌症的研究。
T77586	Eg5-IN-1	Kinesin	Cytoskeletal Signaling
	Eg5-IN-1 是一种有效的驱动蛋白家族运动蛋白 (Eg5) 抑制剂，对 Eg5 的 IC50 值为 1.97 µM。Eg5-IN-1 可用于研究癌症。
T23543	YIL 781	GHSR	GPCR/G Protein
	YIL 781是一种选择性ghrelin 受体拮抗剂(GHS-R1a) (Ki = 17 nM))，对运动素受体显示出较弱的亲和力(K = 6 μ M)。YIL 781通过阻断胃饥饿素分泌对体内和体外胰岛素分泌改善体内葡萄糖稳态。
TQ0318	Filanesib ARRY-520,ARRY 520	KSP	Cell Cycle/Checkpoint
	Filanesib (ARRY 520) 是一种选择性的驱动蛋白纺锤体蛋白(KSP)的抑制剂(IC50 = 6 nM)，具有强大的抗增殖活性。
T60026	KIF18A-IN-2	Microtubule Associated	Cytoskeletal Signaling
	KIF18A-IN-2 是有丝分裂驱动蛋白 Kif18A 的抑制剂，IC50 为 28 nM，可用于染色体不稳定性相关漏洞的研究。
TQ0318L	ARRY 520 hydrochloride	KSP	Cell Cycle/Checkpoint
	ARRY 520 hydrochloride 是一种驱动蛋白纺锤体蛋白 (KSP) 抑制剂。它通过凋亡诱导细胞死亡，并具有有效的抗增殖活性。
T9682	AZD-4877 AZD4877	Apoptosis; Kinesin	Apoptosis; Cytoskeletal Signaling
	AZD-4877 是一种高效的纺锤体驱动蛋白 (Eg5) 抑制剂，对其 IC50 值为 2 nM。 AZD-4877 是 Ispinesib 的另一种构型，能够抑制细胞有丝分裂，诱导形成单极纺锤体表型，介导细胞凋亡(Apoptosis)。 AZD-4877 具有抗肿瘤活性，对循环外周血单核细胞 (PBMC)有抑制作用。
TQ0314	EMD534085	Kinesin	Cytoskeletal Signaling
	EMD534085 is an effective and selective mitotic kinesin-5 inhibitor (IC50: 8 nM).
T4649	(S)-Monastrol	Kinesin	Cytoskeletal Signaling
	(S)-Monastroll is a potent and cell-permeable inhibitor of the mitotic kinesin Eg5.
T25409	FCPT	Others	Others
	FCPT is an ATP competitive kinesin-5 inhibitor.
T24150	HR22C16 HR-22-C-16,HR 22 C 16	Others	Others
	HR22C16 is an effective, selective, and cell-permeable mitotic kinesin Eg5 inhibitor.
T28694	SB-743921 free base SB743921,SB-921,SB921,SB-743921,GSK-743921,GSK-921	Others	Others
	SB-743921, a kinesin spindle protein (KSP) inhibitor, is used potentially for the treatment of non-Hodgkin's lymphoma (NHL).
T25418	Filanesib TFA Filanesib trifluoroacetic acid,ARRY-520 TFA,ARRY 520 TFA,ARRY520 TFA	Others	Others
	Filanesib (ARRY-520) targets the kinesin spindle protein (KSP) with potential antineoplastic activity. ARRY-520 specifically inhibits KSP (kinesin-5 or Eg5), resulting in activation of the spindle assembly checkpoint, induction of cell cycle arrest during
T11859	Litronesib Racemate LY-2523355 Racemate,KF-89617 Racemate	Others	Others
	Litronesib is a selective, allosteric inhibitor of kinesin Eg5.Litronesib (Racemate) is the racemate of litronesib.
T21321	MK-0731	Others	Others
	MK-0731, a synthetic small molecule with potential antineoplastic activity, selectively inhibits kinesin spindle protein (KSP), leading to the inhibition of mitotic spindle assembly, induction of cell cycle arrest during the mitotic phase and apoptosis in
T11859L	Litronesib KF-89617,LY-2523355	Kinesin	Cytoskeletal Signaling
	Litronesib is a selective inhibitor of mitosis-specific kinesin Eg5. It also has antitumor activity.
T15661	Kif15-IN-1	Others	Others
	Kif15-IN-1, a mitotic Kinesin family member 15 (Kif15) inhibitor, is utilized in the study of cellular proliferative diseases.
T24490	MMV666693 MMV-666693,MMV 666693	Others	Others
	MMV666693 is a selective allosteric Plasmodium Kinesin-5 inhibitor.
T40232	KIF18A-IN-1 KIF18A-IN-1	Others	Others
	KIF18A-IN-1 is a potent inhibitor of the mitotic kinesin KIF18A. This compound demonstrates significant anti-tumor properties.
T30573	BQS-481	Others	Others
	BQS-481 inhibits Kinesin-like protein KIF11.
T30308	BDPSB	Others	Others
	BDPSB is a highly efficient photocontroller of mitotic kinesin Eg5 ATPase activity.
T68743	AZD4877 HCl	Others	Others
	AZD4877 is a synthetic kinesin spindle protein (KSP) inhibitor with potential antineoplastic activity. KSP inhibitor AZD4877 selectively inhibits microtubule motor protein KSP (also called kinesin-5 or Eg5), which may result in the inhibition of mitotic spindle assembly; activation of the spindle assembly checkpoint; induction of cell cycle arrest during the mitotic phase; and cell death in tumor cells that are actively dividing. Because KSP is not involved in postmitotic processes, such as neur...
T63726	AM-5308	Others	Others
	AM-5308 是驱动蛋白 KIF18A 的有效抑制剂。
T10373	(R)-Filanesib (R)-ARRY-520	Others	Others
	(R)-Filanesib is the R-enantiomer of ARRY-520. (R)-Filanesib is a synthetic kinesin spindle protein (KSP) inhibitor (IC50: 6 nM).
T78125	PVZB1194	Kinesin	Cytoskeletal Signaling
	PVZB1194是一种联苯型激酶Eg5（亦称KIF11）抑制剂，与细胞周期相关，可以通过抑制Eg5的ATP酶活性导致细胞周期阻滞和细胞凋亡，从而显现抗癌潜力。该化合物与α4/α6变抗袋结合，展现ATP竞争性活性。

化合物

Dimethylenastron

Cat.No: T3118

Target: Kinesin

Cat.No: T4048

Synonym: (±)-Monastrol

Target: Apoptosis, Kinesin

Cat.No: T6209

Synonym: CW069

Target: Kinesin, Microtubule Associated

S-trityl-L-Cysteine

Cat.No: T36816

Synonym: STLC

Target: Kinesin

Cat.No: T2039

Target: Apoptosis, Kinesin

Cat.No: T12359

Synonym: (alphaZ)-alpha-(3-Pyridinylmethylene)-1H-indole-3-acetonitrile

Target: Kinesin

Cat.No: T6393

Target: Kinesin

Cat.No: T3120

Synonym: K858 Racemic,K858

Target: Apoptosis, Kinesin

SB-743921 hydrochloride

Cat.No: T2255

Synonym: SB743921 HCl,SB743921

Target: Kinesin, KSP

Cat.No: T2103

Synonym: 伊匹尼塞,伊斯平斯,CK0238273,SB-715992

Target: Apoptosis, Kinesin, KSP

Cat.No: T8342

Synonym: 6-叔丁基-2,3-二氰基萘

Target: Others, Kinesin, Microtubule Associated

Cat.No: T9207

Synonym: GW108X

Target: Kinesin, Autophagy

Cat.No: T9207L

Target: Kinesin, Autophagy

Cat.No: T11759

Target: Others

Cat.No: T10428

Target: Microtubule Associated

Cat.No: T39994

Synonym: AMG650

Target: Microtubule Associated

Cat.No: T77586

Target: Kinesin

Cat.No: T23543

Target: GHSR

Cat.No: TQ0318

Synonym: ARRY-520,ARRY 520

Target: KSP

Cat.No: T60026

Target: Microtubule Associated

ARRY 520 hydrochloride

Cat.No: TQ0318L

Target: KSP

Cat.No: T9682

Synonym: AZD4877

Target: Apoptosis, Kinesin

Cat.No: TQ0314

Target: Kinesin

Cat.No: T4649

Target: Kinesin

Cat.No: T25409

Target: Others

Cat.No: T24150

Synonym: HR-22-C-16,HR 22 C 16

Target: Others

SB-743921 free base

Cat.No: T28694

Synonym: SB743921,SB-921,SB921,SB-743921,GSK-743921,GSK-921

Target: Others

Cat.No: T25418

Synonym: Filanesib trifluoroacetic acid,ARRY-520 TFA,ARRY 520 TFA,ARRY520 TFA

Target: Others

Litronesib Racemate

Cat.No: T11859

Synonym: LY-2523355 Racemate,KF-89617 Racemate

Target: Others

Cat.No: T21321

Target: Others

Cat.No: T11859L

Synonym: KF-89617,LY-2523355

Target: Kinesin

Cat.No: T15661

Target: Others

Cat.No: T24490

Synonym: MMV-666693,MMV 666693

Target: Others

Cat.No: T40232

Synonym: KIF18A-IN-1

Target: Others

Cat.No: T30573

Target: Others

Cat.No: T30308

Target: Others

Cat.No: T68743

Target: Others

Cat.No: T63726

Target: Others

Cat.No: T10373

Synonym: (R)-ARRY-520

Target: Others

Cat.No: T78125

Target: Kinesin

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-00522	KLC2 Protein, Human, Recombinant (His & GST) kinesin light chain 2	Human	Baculovirus Insect Cells
	KLC2 Protein, Human, Recombinant (His & GST) is expressed in Baculovirus insect cells with His and GST tag. The predicted molecular weight is 96.8 kDa and the accession number is Q9H0B6-1.
TMPH-01592	KIF18B Protein, Human, Recombinant (His & Myc) Kinesin-like protein KIF18B,KIF18B	Human	E. coli
	In complex with KIF2C, constitutes the major microtubule plus-end depolymerizing activity in mitotic cells. Its major role may be to transport KIF2C and/or MAPRE1 along microtubules.
TMPJ-00972	CDKN1B Protein, Human, Recombinant (His) KIP1,CDKN1B,Cyclin-Dependent Kinase Inhibitor p27,Cyclin-Dep...	Human	E. coli
	Cyclin-Dependent Kinase Inhibitor 1B (CDKN1B) is a Kinesin-related motor protein necessary for mitotic spindle assembly and chromosome segregation. CDKN1B is expressed in all tissues with highest levels observed in skeletal muscle. CDKN1B is a potent inhibitor of Cyclin E- and Cyclin A-CDK2 complexes. CDKN1B forms a complex with Cyclin Type D-CDK4 complexes and is involved in the assembly, stability, and modulation of CCND1-CDK4 complex activation. In addition, CDKN1B acts as an inhibitor or an ...
TMPH-02846	BICD2 Protein, Mouse, Recombinant (GST) Bicd2,Kiaa0699,Bic-D 2,Protein bicaudal D homolog 2	Mouse	E. coli
	Acts as an adapter protein linking the dynein motor complex to various cargos and converts dynein from a non-processive to a highly processive motor in the presence of dynactin. Facilitates and stabilizes the interaction between dynein and dynactin and activates dynein processivity (the ability to move along a microtubule for a long distance without falling off the track). Facilitates the binding of RAB6A to the Golgi by stabilizing its GTP-bound form. Regulates coat complex coatomer protein I (...

重组蛋白

KLC2 Protein, Human, Recombinant (His & GST)

Cat.No: TMPY-00522

Species: Human

Expression System: Baculovirus Insect Cells

KIF18B Protein, Human, Recombinant (His & Myc)

Cat.No: TMPH-01592

Species: Human

Expression System: E. coli

CDKN1B Protein, Human, Recombinant (His)

Cat.No: TMPJ-00972

Species: Human

Expression System: E. coli

BICD2 Protein, Mouse, Recombinant (GST)

Cat.No: TMPH-02846

Species: Mouse

Expression System: E. coli

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