27
5
8
44
Cat. No. | Product Name | ||
---|---|---|---|
L2200 | 酪氨酸激酶分子库 | 1016 compounds | |
1016 种酪氨酸激酶抑制剂的独特集合,可用于高通量筛选和高内涵筛选; | |||
L1610 | FDA 上市激酶抑制剂库 | 263 compounds | |
263种靶向激酶的上市药物集合,用于特定靶向激酶,可用于高通量筛选和高内涵筛选; | |||
L1600 | 激酶抑制剂库 | 2720 compounds | |
2720 种激酶抑制剂/调节剂的独特集合,用于特定靶向激酶,可用于高通量筛选和高内涵筛选; | |||
L9410 | 共价抑制剂库 | 1920 compounds | |
1920 种小分子的独特集合,包含已发现的共价抑制剂以及包含某些共价反应基团常见弹头的分子,如氯乙酰基,2-氯丙酰基,丙烯酰基,1-丙-2-炔基,1-丁-2-炔基,酮羰基,二硫键等,可以用于共价抑制剂药物研发; | |||
L1120 | AMPK靶向分子库 | 80 compounds | |
80 个靶向AMPK 的分子集合,可用于高通量和高内涵筛选; | |||
L1300 | PI3K/Akt/mTOR 化合物库 | 420 compounds | |
420 种与PI3K/Akt/mTOR 相关的生物活性小分子化合物的特有集合,用于PI3K/Akt/mTOR 相关研究以及高通量、高内涵筛选; | |||
L1400 | MAPK 抑制剂库 | 365 compounds | |
365 种与MAPK 信号通路相关的生物活性小分子化合物的特有集合,可用于高通量筛选和高内涵筛选; | |||
L7700 | 神经再生化合物库 | 524 compounds | |
524 种神经再生相关化合物的独特集合,可用于高通量筛选和高内涵筛选; |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T7764 |
CCG-222740
|
ROCK; Rho; Ras | Cell Cycle/Checkpoint; Cytoskeletal Signaling; GPCR/G Protein; MAPK; Stem Cells |
CCG-222740 是一种口服有效的选择性Rho/MRTF 途径抑制剂。它也是 α-平滑肌的肌动蛋白表达抑制剂,可减少皮肤纤维化并阻止黑色素瘤转移。 | |||
T4496 |
LM22B-10
LM22B10 |
ERK; Trk receptor; Akt | Cytoskeletal Signaling; MAPK; PI3K/Akt/mTOR signaling; Tyrosine Kinase/Adaptors |
LM22B-10 是TrkB/TrkC 神经营养因子受体激活剂,诱导体内外TrkB、TrkC、AKT 和ERK 的活化。 | |||
T7122 |
AZD-7648
|
DNA-PK | DNA Damage/DNA Repair; PI3K/Akt/mTOR signaling |
AZD-7648 是一种 DNA 依赖性蛋白激酶 (DNA-PK) 抑制剂,在酶试验中 IC50 为 0.63 nM,具有抗肿瘤活性。 | |||
T8586 |
cicloprofen
|
Others | Others |
cicloprofen 是细胞分裂周期 7 相关蛋白激酶(人)抑制剂。 | |||
T3623 |
Cobimetinib
可美替尼,考比替尼,RG7420,XL518,GDC-0973 |
Apoptosis; MEK | Apoptosis; MAPK |
Cobimetinib (GDC-0973) 是一种可口服的 MEK1选择性抑制剂,抑制MEK1的IC50为4.2 nM。 | |||
T10572L |
BMT-124110 Formate
BMT-124110 Formate(1679371-59-5 Free base) |
Serine/threonin kinase; TGF-beta/Smad; AAK1 (AP2 associated kinase 1) | Cell Cycle/Checkpoint; Metabolism; Neuroscience; Stem Cells |
BMT-124110 Formate 是一种具有选择性的AAK1抑制剂(IC50: 0.9 nM),具有抗伤害感受活性。BMT-124110 Formate 抑制BMP -2诱导蛋白激酶BIKE,其IC50为 17 nM。BMT-124110 Formate 抑制细胞周期蛋白 G 相关激酶GAK,其IC50:为99 nM。 | |||
T10406 |
Tuvusertib
M1774,ATR inhibitor 1 |
Apoptosis; ATM/ATR; Others; Chk | Apoptosis; Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Others; PI3K/Akt/mTOR signaling |
Tuvusertib (M1774) 是一种可口服的共济失调毛细血管扩张和 Rad3相关(ATR)激酶抑制剂(Ki< 1 µΜ),具有选择性和潜在的抗肿瘤活性。Tuvusertib 选择性抑制 ATR 活性,阻断丝氨酸/苏氨酸蛋白激酶检查点激酶1 (CHK1)的下游磷酸化,从而抑制 DNA 损伤检查点激活,破坏 DNA 损伤修复,诱导肿瘤细胞凋亡。 | |||
T28975 |
Tigilanol tiglate
EBC-46,EBC 46,EBC46 |
Others | Others |
Tigilanol tiglate is a phorbol ester and acts as a protein kinase C regulator along with other related compounds. | |||
T39718 |
Tinengotinib
|
Others | Others |
Tinengotinib, a novel compound, acts as a potent modulator of protein kinases including Aurora kinase and VEGFR kinase. With its unique properties, Tinengotinib holds promise for investigating diseases marked by abnormalities in these kinases, particularly cancer-related conditions (WO2018108079A1). | |||
T40077 |
ATR-IN-9
|
Others | Others |
ATR-IN-9 is a highly effective inhibitor of Ataxia-telangiectasia and RAD-3-related protein kinase (ATR). With an IC50 value as low as 10 nM, ATR-IN-9 demonstrates exceptional potency. | |||
T26981 |
Ceralasertib formate
Ceralasertib,AZD-6738,AZD 6738,AZD6738 |
Others | Others |
Ceralasertib is an orally available inhibitor of ataxia telangiectasia and rad3 related (ATR) kinase. Ceralasertib selectively inhibits ATR activity by blocking the downstream phosphorylation of the serine/threonine protein kinase CHK1. This prevents ATR- | |||
T61246 |
TRK-IN-15
|
Others | Others |
TRK-IN-15 (WO2012034091A1, compound X-55) is a highly effective inhibitor of TRK, a protein kinase with crucial involvement in the regulation of cellular growth, differentiation, and signal transduction. Offering significant potential for studying TRK-related diseases, TRK-IN-15 holds promise for advancing research in this field [1]. | |||
T83753 |
RAD17-derived Peptide TFA
|
||
RAD17衍生肽是一种针对共济失调-毛细血管扩张及RAD3相关蛋白/激酶(ATR)的肽类底物。它已被用于识别ATR的抑制剂。 | |||
T63670 |
HPK1-IN-9
|
Others | Others |
HPK1-IN-9 是一种有效的 HPK1 抑制剂。其中 HPK1 是一种丝氨酸/苏氨酸蛋白激酶,由造血祖细胞克隆得到,是哺乳动物Ste-20相关蛋白激酶MAP4K 家族成员之一。HPK1-IN-10 对HPK1 相关疾病具有研究潜力。 | |||
T73380 |
CK2-IN-6
|
Others | Others |
CK2-IN-6是一种高效的蛋白激酶CK2抑制剂,适用于癌症及其他激酶相关疾病(如炎症、疼痛和特定免疫疾病)的研究。 | |||
T61941 |
BMT-090605 hydrochloride
|
Others | Others |
BMT-090605 hydrochloride 是有效的,选择性的连接蛋白-2 相关激酶 1(AAK1)抑制剂,(IC50=0.6 nM)。BMT-090605 hydrochloride 抑制 BMP-2 诱导蛋白激酶 (BIKE) (IC50=45 nM)和细胞周期蛋白 G 相关激酶 GAK(IC50=60 nM)。BMT-090605 hydrochloride 显示抗伤害活性。BMT-090605 hydrochloride 在神经性疼痛中具有研究价值。 | |||
T63659 |
HPK1-IN-10
|
Others | Others |
HPK1-IN-10 是 HPK1 的有效抑制剂。HPK1 是一种丝氨酸/苏氨酸蛋白激酶,由造血祖细胞克隆得到,是哺乳动物Ste-20相关蛋白激酶MAP4K 家族成员之一。HPK1-IN-10 对HPK1 相关疾病具有研究潜力。 | |||
T74373 |
ERK1/2 inhibitor 3
|
Others | Others |
ERK1/2 inhibitor 3 是一种有效的 ERK1/2抑制剂。丝裂原活化蛋白激酶 (MAPK) 在信号转导通路中起着极其重要的作用,而细胞外信号调节激酶 (ERK) 是 MAPK 家族的成员。ERK1/2 inhibitor 3 具有研究或预防癌症、炎症或其他增殖性疾病的潜力。 | |||
T69895 |
Lonaprisan
|
Others | Others |
Lonaprisan is an orally bioavailable pentafluoroethyl derivative of a mifepristone-related steroid with antiprogestagenic activity. Lonaprisan is a pure, highly receptor-selective progesterone receptor (PR) antagonist; binding of this agent to PRs inhibits PR activation and the associated proliferative effects. Unlike many other antiprogestins such as mifepristone, this agent does not appear to convert to an agonist in the presence of protein kinase A (PKA) activators and shows high antiprogesta... | |||
T80210 |
TAT-GluN2BCTM
|
DAPK | Apoptosis |
TAT-GluN2BCTM 是一种靶向DAPK1的膜透性肽,能够促使活性DAPK1定向降解于溶酶体。该化合物通过降低DAPK1的表达,有助于防护神经元免遭氧化应激和NMDAR-介导的兴奋毒性。TAT-GluN2BCTM常用于神经保护性研究领域。 | |||
T71223 |
SR-33805
|
Others | Others |
SR-33805 is a calcium channel antagonist potentially for the treatment of atherosclerosis and heart failure. SR-33805 restored the MI-altered cell shortening without affecting the Ca(2+) transient amplitude, suggesting an increase of myofilament Ca(2+) sensitivity in MI myocytes. A SR33805-induced sensitization of myofilament activation was found to be associated with a slight increase in myosin light chain-2 phosphorylation and a more significant decrease on troponin I (TnI) phosphorylation. D... | |||
T60953 |
BSc5367
|
Others | Others |
BSc5367 是Nek1激酶结构域的有效抑制剂,IC50值为 11.5 nM。Nek1 是一种NIMA 相关的蛋白激酶,在细胞周期调节、DNA 修复和微管调节中起着关键作用。Nek1 功能障碍在肌萎缩侧索硬化症 (ALS)、多囊肾病 (PKD) 和几种类型的放疗耐药性癌症中发挥关键作用。BSc5367 为更好的理解上述疾病提供了有用工具。 | |||
T63991 |
BRD4/CK2-IN-1
|
Others | Others |
BRD4/CK2-IN-1 是高效的、口服具有活力的 BRD4/CK2 (含溴结构域蛋白 4/酪蛋白激酶 2) 双靶点抑制剂,能够作用于 BRD4 (IC50: 180 nM) 和 CK2 (IC50: 230 nM)。在三阴性乳腺癌 (TNBC) 中,BRD4/CK2-IN-1 能够诱导细胞凋亡和自噬相关的细胞死亡。BRD4/CK2-IN-1 表现出显著的抗癌效果,且没有明显毒性。 | |||
T69618 |
XR3054
|
Others | Others |
XR3054 is a novel inhibitor of farnesyl protein transferase (FPTase). XR3054 inhibited the proliferation of the prostatic cancer cell lines LnCAP and PC3 and the colon carcinoma SW480 and HT1080 (IC50 values of 12.4, 12.2, 21.4 and 8.8 microM, respectively) but was relatively inactive when tested against a panel of breast carcinoma cell lines. The activity did not relate to the presence of mutant or wild-type ras in the cell lines tested. In conclusion XR3054 inhibits ras farnesylation, MAP kina... | |||
T62651 |
ATR-IN-11
|
Others | Others |
ATR-IN-11 (Compound Hit01) 是一种共济失调毛细血管扩张症和 Rad3 相关 (ATR) 激酶的有效抑制剂。ATR 激酶是 DNA 损伤反应 (DDR) 中的一个关键调节蛋白,负责感知复制压力 (RS)。ATR-IN-11 是一种有希望的先导化合物,能够用于发现后续针对 ATR 激酶的药物。 ATR-IN-11具有潜力进行癌症疾病的研究。 | |||
T36578 |
Boc-Lys(Ac)-AMC
|
Others | Others |
Commendamide (N-acyl-3-hydroxypalmitoyl-glycine) is a newly discovered GPCR G2A/GPR132 agonist (EC50=11.8 μM) that isolated from Bacteroides vulgatus. [1] G2A/GPR132 belongs to the guanine nucleotide-binding protein (G protein)-coupled receptor (GPCR) superfamily. GPR132/G2A is first reported to be a transcriptional target for BCR-ABL tyrosine kinase attenuating B-cell expansion in vitro and arresting cells at G2 during mitosis. It has been involved in autoimmune disease and atherosclerosis. [1]... | |||
T36679 |
Rp-cAMPS sodium salt
|
Others | Others |
Rp-cAMPS sodium salt, a cAMP analog, is a potent, competitive cAMP-induced activation of cAMP-dependent PKA I and II (Kis of 12.5 μM and 4.5 μM, respectively) antagonist. Rp-cAMPS sodium salt is resistant to hydrolysis by phosphodiesterases[1][2][3][4][5][6]. A membrane-permeable competitive cAMP antagonist (Rp-cAMPS) that blocks PKA activation by binding to the regulatory subunits without dissociating the kinase holoenzyme also inhibits synaptic plasticity but has no effect on normal synaptic t... |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
TN1410 |
Asperulosidic acid
ASPA,车叶草苷酸 |
ERK; NF-κB | MAPK; NF-κB |
Asperulosidic acid (ASPA) 是从白花蛇舌草药中提取的一种环烯醚萜苷,具有抗肿瘤、抗氧化和抗炎作用。它通过抑制 NF-κB 和丝裂原活化蛋白激酶信号通路抑制炎性细胞因子释放发挥抗炎作用。 | |||
T5S0581 |
Sec-O-Glucosylhamaudol
亥茅酚苷,Hamaudol 3-glucoside |
Others; Opioid Receptor | Endocrinology/Hormones; GPCR/G Protein; Neuroscience; Others |
Sec-O-Glucosylhamaudol (Hamaudol 3-glucoside) 是从滨海前胡中分离得到的一种天然产物,能够降低 μ 阿片受体的蛋白水平,可用于缓解疼痛的研究。它通过调节脂多糖刺激的 RAW264.7 细胞系中的 p38 丝裂原活化蛋白激酶具有抗炎作用。 | |||
T5S0754 |
Isoquercetin
3-Glucosylquercetin,Hirsutrin,Isoquercitrin,异槲皮苷,Quercetin 3-o-glucopyranoside,槲皮素-3-葡萄糖苷 |
NF-κB; Wnt/beta-catenin; NO Synthase | Cytoskeletal Signaling; Immunology/Inflammation; NF-κB; Stem Cells |
Isoquercetin (3-Glucosylquercetin) 是天然存在的多酚,具有抗氧化,抗增殖和抗炎特性。它通过调节核因子-κB 转录调节系统调节一氧化氮合酶 2 的表达。它通过 Nrf2/ARE 抗氧化剂信号传导途径减轻乙醇诱导的肝毒性,氧化应激和炎症反应。它具有高生物利用度和低毒性,是预防糖尿病妊娠出生缺陷的有希望的候选药物。 | |||
T81484 |
Phorbol 12-tiglate
|
||
Phorbol12-tiglate为Phorbol衍生物,后者乃巴豆油水解产物,可激活蛋白激酶C,进而促进肿瘤发展。Phorbol及其衍生物在生物医学领域,广泛用于建立致癌模型研究。 | |||
TN2534 |
1-Hydroxy-2,3,5-trimethoxyxanthone
|
IκB/IKK; Calcium Channel; NOS; 5-HT Receptor; COX | GPCR/G Protein; Immunology/Inflammation; Membrane transporter/Ion channel; Metabolism; Neuroscience; NF-κB |
1-Hydroxy-2,3,5-trimethoxyxanthone (HM-1) has vasodilator action ,which involves both an endothelium-dependent mechanism involving NO and an endothelium-independent mechanism by inhibiting Ca(2+) influx through L-type voltage-operated Ca(2+) channels; a minor contribution to the effects of HM-1 may be related to inhibition of the protein kinase C-mediated release of intracellular Ca(2+) stores. HM-1,at the concentration of 1 ug/mL, can effectively inhibit the osteoclast differentiation in a co-c... |
Cat. No. | Product Name | Species | Expression System |
---|---|---|---|
TMPH-02899 |
VRK1 Protein, Mouse, Recombinant (His & Myc)
Vaccinia-related kinase 1,Serine/threonine... |
Mouse | E. coli |
VRK1 Protein, Mouse, Recombinant (His & Myc) is expressed in E. coli expression system with N-6xHis and C-Myc tag. The predicted molecular weight is 55.2 kDa and the accession number is Q80X41. | |||
TMPH-02087 |
STK38L Protein, Human, Recombinant (His)
Serine/threonine-protein kinase 38-like,Nu... |
Human | E. coli |
Involved in the regulation of structural processes in differentiating and mature neuronal cells. STK38L Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 33.5 kDa and the accession number is Q9Y2H1. | |||
TMPH-00340 |
ATG1 Protein, Candida glabrata, Recombinant (His)
Autophagy-related protein 1,Serine/threoni... |
Candida glabrata | E. coli |
ATG1 Protein, Candida glabrata, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 38.4 kDa and the accession number is Q6FL58. | |||
TMPH-03753 |
MYLK Protein, Human, Recombinant (His)
MYLK,Myosin light chain kinase, smooth muscle,Telok... |
Human | E. coli |
Calcium/calmodulin-dependent myosin light chain kinase implicated in smooth muscle contraction via phosphorylation of myosin light chains (MLC). Also regulates actin-myosin interaction through a non-kinase activity. Phosphorylates PTK2B/PYK2 and myosin light-chains. Involved in the inflammatory response (e.g. apoptosis, vascular permeability, leukocyte diapedesis), cell motility and morphology, airway hyperreactivity and other activities relevant to asthma. Required for tonic airway smooth muscl... | |||
TMPH-02090 |
PKN1 Protein, Human, Recombinant (His)
Protein kinase C-like 1,Protease-activated... |
Human | E. coli |
PKN1 Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 34.5 kDa and the accession number is Q16512. | |||
TMPJ-00088 |
EFNA1 Protein, Mouse, Recombinant (hFc & His)
Epgl1,Epl1,Immediate early response protein B61,Ler... |
Mouse | HEK293 Cells |
Ephrin-A1 is a cell membrane protein and contains 1 ephrin RBD (ephrin receptor-binding) domain. EFNA1 belongs to the ephrin (EPH) family. The ephrins and EPH-related receptors comprise the largest subfamily of receptor protein-tyrosine kinases and have been implicated in mediating developmental events, especially in the nervous system and in erythropoiesis. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membran... | |||
TMPH-02962 |
Lyn Protein, Mouse, Recombinant (His & Myc)
Tyrosine-protein kinase Lyn,p53Lyn,p56Lyn,... |
Mouse | E. coli |
Lyn Protein, Mouse, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 63.7 kDa and the accession number is P25911. | |||
TMPJ-00403 |
EphB1 Protein, Human, Recombinant (hFc)
EPHT2,EPH Tyrosine Kinase 2,EK6,Tyrosine-Protei... |
Human | HEK293 Cells |
Ephrin Type-B Receptor 1 (EPHB1) is a single-pass type I membrane protein that belongs to the Ephrin-B family of receptor tyrosine kinases that is involved in embryonic nervous and vascular system development. EPHB1/EPHT2 contains two fibronectin type-III domains, one protein kinase domain and one SAM (sterile α motif) domain. EPHB1 could stimulate fibroblast motility on extracellular matrix in a kinase-dependent manner, which also correlated with its association with Grb7, an adaptor molecule i... | |||
TMPJ-00791 |
HER2/ERBB2 Protein, Rat, Recombinant (E. coli, His)
p185erbB2,Epidermal growth factor receptor-related ... |
Rat | E. coli |
ERBB2 belongs to the protein kinase superfamily, Tyr protein kinase family and EGF receptor subfamily. It contains a protein kinase domain. ERBB2 is widely expressed in epithelial cells, and amplification and/or overexpression of ErbB2 has been reported associated with malignancy and a poor prognosis in numerous carcinomas, including breast, prostate and ovarian cancers. Rat ERBB2 is an essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. ErbB... | |||
TMPJ-00546 |
EFNA1 Protein, Human, Recombinant (hFc)
TNFAIP4,LERK1,Tumor Necrosis Factor α-Induced Protein |
Human | HEK293 Cells |
Ephrin-A1 is a member of the A-type ephrin family of cell surface proteins that function as ligands for the A-type Eph receptor tyrosine kinase family. Ephrin-A1 can be induced by TNF and IL1B. Its expression levels can be down-regulated in primary glioma tissues compared to the normal tissues. The soluble monomeric form is expressed in the glioblastoma multiforme (GBM) and breast cancer cells. Soluble Ephrin-A1 is necessary for the transformation of HeLa and SK-BR3 cells and participates in the... | |||
TMPY-02028 |
RON/CD136 Protein, Human, Recombinant (His)
CD136,macrophage stimulating 1 receptor,CDw136,PTK8,RON |
Human | HEK293 Cells |
The tyrosine kinase receptor, macrophage-stimulating 1 receptor (MST1R), a c-met-related tyrosine kinase, also known as the Ron receptor or CD136, controls cell survival and motility programs related to invasive growth. As the tyrosine kinase receptor is comprised of an extracellular domain, MST1R protein contains the ligand-binding pocket and an intracellular region where the kinase domain is located. MST1R signaling may be involved in the regulation of macrophage and T-lymphocyte activation in... | |||
TMPY-05004 |
FGF-4 Protein, Human, Recombinant
HST-1,KFGF,fibroblast growth factor 4,HSTF1,K-FGF,HST,HBGF-4 |
Human | E. coli |
FGF (fibroblast growth factor) signalling is known to be required for many aspects of mesoderm formation and patterning during Xenopus development and has been implicated in regulating genes required for the specification of both blood and skeletal muscle lineages. Fibroblast growth factor 4 (FGF4) signaling induces differentiation from embryonic stem cells (ESCs) via the phosphorylation of downstream molecules such as mitogen-activated protein kinase/extracellular signal-related kinase (MEK) a... | |||
TMPY-02953 |
TEM8/ANTXR1 Protein, Human, Recombinant (hFc)
ATR,TEM8,anthrax toxin receptor 1,GAPO |
Human | HEK293 Cells |
ANTXR1 contains 1 VWFA domain and belongs to the ATR family. ATR (Ataxia telangiectasia and Rad3 related) and ATM (Ataxia telangiectasia mutated) are closely related kinases that are activated by DNA damage. They are serine-threonine protein kinases and belongs to the phosphatidylinositol 3' kinase-like kinase (PIKK) family. Upon recruitment by the DNA damage binding proteins/complexes (ATRIP for ATR; MRN for ATM), ATM/ATR initiate the DNA damage checkpoint by phosphorylating a number of key pro... | |||
TMPY-04396 |
C-ABL/ABL1 Protein, Human, Recombinant (GST)
v-abl,ABL,JTK7,ABL proto-oncogene 1, non-receptor tyrosine <... |
Human | Baculovirus Insect Cells |
c-Abl belongs to the class of tyrosine kinases and is the prototype of a subfamily which includes two members, c-Abl and Arg (Abl-related gene). Both proteins are localized at the cell membrane, actin cytoskeleton and cytosol, and c-Abl is present in the nucleus as well. c-Abl is a non-receptor tyrosine kinase that participates in multiple signaling pathways linking the cell surface, cytoskeleton, and the nucleus. Recent in vitro studies have also linked c-Abl to amyloid-beta-induced toxicity an... | |||
TMPY-04559 |
CDC42BPB Protein, Human, Recombinant (His & GST)
CDC42 binding protein kinase beta (DMPK-li... |
Human | Baculovirus Insect Cells |
CDC42BPB is a member of the serine / threonine protein kinase family that contains a Cdc42 / Rsc-binding p21 binding domain similar to that of PAK kinase. The kinase domain of this protein is related to the myotonic dystrophy kinase related ROK and this kinase may have functions in downstream regulating of Cdc42 in cytoskeletal recognization. It has been reported that the CDC42BPB protein take part in regulating numerous cellular functions by binding to members of a serine / threonine protein ki... | |||
TMPY-04558 |
NEK7 Protein, Human, Recombinant (His & GST)
NIMA-related kinase 7 |
Human | Baculovirus Insect Cells |
NIMA (never in mitosis gene a)-related kinase 7, NEK7 belongs to the NIMA subfamily, NEK Ser/Thr protein kinase family, protein kinase superfamily. NEKs (NIMA-related kinases) are mammalian serine/threonine (Ser/Thr) protein kinases structurally related to Aspergillus NIMA (Never in Mitosis, gene A), which plays essential roles in mitotic signaling. NEKs share an amino-terminal catalytic domain related to NIMA, an Aspergillus kinase involved in the control of several aspects of mitosis, and dive... | |||
TMPY-04411 |
YES1 Protein, Human, Recombinant (His & GST)
HsT441,c-yes,YES proto-oncogene 1, Src family tyrosine k... |
Human | Baculovirus Insect Cells |
Proto-oncogene tyrosine-protein kinase Yes, also known as Proto-oncogene c-Yes, p61-Yes and YES1, is a cytoplasm protein that belongs to the protein kinase superfamily, Tyr protein kinase family and SRC subfamily. YES1 / c-Yes contains one protein kinase domain, one SH2 domain and one SH3 domain. It is thought that the subcellular distribution of Src-family tyrosine kinases, including c-Yes binding to the cellular membrane, is membranous and/or cytoplasmic. YES1 / c-Yes protein tyrosine kinase i... | |||
TMPY-04547 |
PBK/TOPK Protein, Human, Recombinant (His)
HEL164,Nori-3,CT84,TOPK,PDZ binding kinase,SPK |
Human | Baculovirus Insect Cells |
PDZ binding kinase (PBK), also known as TOPK (T-LAK cell-originated protein kinase), is a serine/threonine kinase related to the dual specific mitogen-activated protein kinase kinase (MAPKK) family, and has all the characteristic protein kinase subdomains and a C-terminal PDZ-binding T/SXV motif. PBK is expressed in the testis restrictedly expressed in outer cell layer of seminiferous tubules, as well as placenta. PBK may be enrolled in the activation of lymphoid cells and support testicular fun... | |||
TMPK-00634 |
MSPR/Ron Protein, Human, Recombinant (His)
MST1R,RON,MSP R,CD136,PTK8,p185-Ron,MSPR,CDw136,MSP receptor |
Human | HEK293 Cells |
Macrophage-stimulating protein (MSP) is a serum protein belonging to the plasminogen-related growth factor family. The specific receptor for MSP is the RON (recepteur d'origine nantais) receptor tyrosine kinase - a member of the MET proto-oncogene family. Activation of RON by MSP exerts dual functions on macrophages. | |||
TMPY-04562 |
GRK2 Protein, Human, Recombinant (His & GST)
β,adrenergic, beta, receptor kinase 1 |
Human | Baculovirus Insect Cells |
G-protein coupled receptor kinase 2 (GRK2), also referred as Adrenergic, beta, receptor kinase 1 (ADRBK1), is a ubiquitous member of the G protein-coupled receptor kinase (GRK) family that appears to play a central, integrative role in signal transduction cascades. GRK2 can phosphorylate a growing number of non-GPCR substrates and associate with a variety of proteins related to signal transduction, thus suggesting that this kinase could also have diverse 'effector' functions. GRK2 has been repor... | |||
TMPY-04463 |
CDKL2 Protein, Human, Recombinant (His)
KKIAMRE,P56,cyclin-dependent kinase-like 2 (CDC2- |
Human | Baculovirus Insect Cells |
Cyclin-dependent kinase-like 2 (Cdkl2) is a member of cdc2-related serine / threonine protein kinase family and it is found expressed in various brain regions, including the cerebral cortex, entorinal cortex, hippocampus, amygdala, and dorsal thalamus. The high expression in these brain regions suggests that Cdkl2 may have functions in congnition and emotion processes. Cdkl2 accumulates primarily in the cytoplasm, with lower levels in the nucleus. | |||
TMPJ-00886 |
ATF1 Protein, Human, Recombinant (His)
Cyclic AMP-dependent transcription factor ATF-1,Activating t... |
Human | E. coli |
Cyclic AMP-dependent transcription factor ATF-1(ATF1) which contains 1 bZIP (basic-leucine zipper) domain and 1 KID (kinase-inducible) domain, belongs to the bZIP family. It influences cellular physiologic processes by regulating the expression of downstream target genes, which are related to growth, survival, and other cellular activities. ATF1 binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters. It also binds to the ... | |||
TMPK-00391 |
FGFR3 beta (IIIb) Protein, Human, Recombinant (His & Avi), Biotinylated
HSFGFR3EX,FGFR3,FGF R3,ACH,CD333,FGFR3 β (IIIb),EC 2.7.10,CE... |
Human | HEK293 Cells |
Four distinct genes encoding closely related FGF receptors, FGF R1-4, are known. All four genes for FGF Rs encode proteins with an N-terminal signal peptide, three immunoglobulin (Ig)-like domains, an acid‑box region containing a run of acidic residues between the IgI and IgII domains, a transmembrane domain and the split tyrosine-kinase domain.FGFR3 is tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell p... | |||
TMPJ-00123 |
FLT3LG Protein, Mouse, Recombinant (His)
Fms-related tyrosine kinase 3 ligand (Flt3... |
Mouse | HEK293 Cells |
Fms-related tyrosine kinase 3 ligand(Flt3L) is a single-pass type I membrane protein and consists of 232 amino acids. Flt3L is a hematopoietic four helical bundle cytokine, structurally homologous to stem cell factor and colony stimulating factor. Flt3L synergizes well with a number of other colony stimulating factors and interleukins. Flt3L stimulates the proliferation and differentiation of various blood cell progentiors by activating FLT3. | |||
TMPK-00980 |
EPhA2 Protein, Cynomolgus, Recombinant (hFc)
EC:2.7.10.1,Ephrin type-A receptor 2,EPHA2 |
Cynomolgus | HEK293 Cells |
Ephrin type-A receptor 2 (EPHA2) is a receptor tyrosine kinase (RTK), whose over-expression has been observed in a variety of cancers, including breast cancer. EPHA2 expression may be causally related to tumorigenesis; therefore, it is important to understand how EPHA2 gene (EPHA2) expression is regulated. EPhA2 Protein, Cynomolgus, Recombinant (hFc) is expressed in HEK293 mammalian cells with C-hFc tag. The predicted molecular weight is 83.1 kDa and the accession number is Q1KL86. | |||
TMPK-00979 |
EPhA2 Protein, Cynomolgus, Recombinant (His & Avi)
EPHA2,EC:2.7.10.1,Ephrin type-A receptor 2 |
Cynomolgus | HEK293 Cells |
Ephrin type-A receptor 2 (EPHA2) is a receptor tyrosine kinase (RTK), whose over-expression has been observed in a variety of cancers, including breast cancer. EPHA2 expression may be causally related to tumorigenesis; therefore, it is important to understand how EPHA2 gene (EPHA2) expression is regulated. EPhA2 Protein, Cynomolgus, Recombinant (His & Avi) is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 59.2 kDa and the accession number is Q1KL86. | |||
TMPY-04374 |
MST4 Protein, Human, Recombinant (GST)
serine/threonine protein kinase 26,MST4,MA... |
Human | Baculovirus Insect Cells |
MST4, also known as mammalian STE2-like protein kinase 4, is a novel member of the germinal center kinase subfamily of human Ste2-like kinases and is closely related to MST3. The 416 amino acid full-length MST4 contains a C-terminal regulatory domain and an N-terminal kinase domain, both of which are required for full activation of the kinase. MST4 is highly expressed in the placenta, thymus, and peripheral blood leukocytes. MST4 specifically activates ERK but not JNK or p38 MAPK in transiently ... | |||
TMPK-00387 |
FGFR3 beta (IIIc) Protein, Human, Recombinant (His & Avi), Biotinylated
HSFGFR3EX,FGF R3,EC 2.7.10,CD333,FGFR3 β (IIIc),CEK2,FGFR3,J... |
Human | HEK293 Cells |
Four distinct genes encoding closely related FGF receptors, FGF R1-4, are known. All four genes for FGF Rs encode proteins with an N-terminal signal peptide, three immunoglobulin (Ig)-like domains, an acid‑box region containing a run of acidic residues between the IgI and IgII domains, a transmembrane domain and the split tyrosine-kinase domain.FGFR3 is tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell p... | |||
TMPJ-01126 |
RheB Protein, Human, Recombinant (GST)
RHEB,Ras Homolog Enriched in Brain,GTP-Binding Protein |
Human | E. coli |
GTP-Binding Protein Rheb (RHEB) is a member of the small GTPase superfamily and encodes a lipid-anchored, cell membrane protein with five repeats of the RAS-related GTP-binding region. Highest levels of RHEB can be found in the skeletal and cardiac muscle, and it is vital in the regulation of growth and cell cycle progression due to its role in the Insulin/TOR/S6K signaling pathway. RHEB stimulates the phosphorylation of S6K1 and EIF4EBP1 through activation of mTORC1 signaling, and it activates... | |||
TMPY-04443 |
NEK3 Protein, Mouse, Recombinant (His & GST)
NIMA-related kinase 3 |
Mouse | Baculovirus Insect Cells |
NEK3 (NIMA (never in mitosis gene a)-related expressed kinase 3), contains 1 protein kinase domain and is a member of the NimA (never in mitosis A) family of serine/threonine protein kinases. Members of the NEK family of protein kinases share high amino acid homology with NIMA (never in mitosis gene a). NEK3 differs from other NimA family members in that it is not the cell cycle-regulated and is found primarily in the cytoplasm. It is activated by prolactin stimulation, leading to phosphorylatio... | |||
TMPY-03977 |
DAP10 Protein, Human, Recombinant (mFc)
PIK3AP,DAP10,hematopoietic cell signal transducer,KAP10 |
Human | HEK293 Cells |
HCST (Hematopoietic Cell Signal Transducer, also known as DAP1) is a Protein Coding gene. HCST belongs to the DAP10 family. It is a transmembrane signaling adaptor that contains a YxxM motif in its cytoplasmic domain. The encoded protein may form part of the immune recognition receptor complex with the C-type lectin-like receptor NKG2D. HCST may be part of the immune recognition receptor complex. This receptor plays a major role in triggering cytotoxicity against target cells expressing cell sur... | |||
TMPJ-00972 |
CDKN1B Protein, Human, Recombinant (His)
KIP1,CDKN1B,Cyclin-Dependent Kinase Inhibitor p27,C... |
Human | E. coli |
Cyclin-Dependent Kinase Inhibitor 1B (CDKN1B) is a Kinesin-related motor protein necessary for mitotic spindle assembly and chromosome segregation. CDKN1B is expressed in all tissues with highest levels observed in skeletal muscle. CDKN1B is a potent inhibitor of Cyclin E- and Cyclin A-CDK2 complexes. CDKN1B forms a complex with Cyclin Type D-CDK4 complexes and is involved in the assembly, stability, and modulation of CCND1-CDK4 complex activation. In addition, CDKN1B acts as an inhibitor or an ... | |||
TMPY-04260 |
p38 Protein, Human, Recombinant (His)
mitogen-activated protein kinase 14,CSPB1,... |
Human | Baculovirus Insect Cells |
MAPK14 contains 1 protein kinase domain and belongs to the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation, and development. MAPK14 can be detected in the brain, heart, placenta, pancreas, and skeletal muscle and it is expressed to a lesser extent in the lung, liver, and kidney. MAPK14 is activated by various environmental stresses ... | |||
TMPH-01532 |
IKBKB Protein, Human, Recombinant (E. coli, His)
Nuclear factor NF-kappa-B inhibitor kinase beta,Ser... |
Human | E. coli |
Serine kinase that plays an essential role in the NF-kappa-B signaling pathway which is activated by multiple stimuli such as inflammatory cytokines, bacterial or viral products, DNA damages or other cellular stresses. Acts as part of the canonical IKK complex in the conventional pathway of NF-kappa-B activation. Phosphorylates inhibitors of NF-kappa-B on 2 critical serine residues. These modifications allow polyubiquitination of the inhibitors and subsequent degradation by the proteasome. In tu... | |||
TMPH-01531 |
IKBKB Protein, Human, Recombinant (His)
Serine/threonine protein kinase IKBKB,Nucl... |
Human | Baculovirus Insect Cells |
Serine kinase that plays an essential role in the NF-kappa-B signaling pathway which is activated by multiple stimuli such as inflammatory cytokines, bacterial or viral products, DNA damages or other cellular stresses. Acts as part of the canonical IKK complex in the conventional pathway of NF-kappa-B activation. Phosphorylates inhibitors of NF-kappa-B on 2 critical serine residues. These modifications allow polyubiquitination of the inhibitors and subsequent degradation by the proteasome. In tu... | |||
TMPJ-00194 |
IL-20RB Protein, Human, Recombinant (hFc)
DIRS1,IL-20R-β,Interleukin-20 receptor subunit β,IL-20 recep... |
Human | HEK293 Cells |
Interleukin-20 receptor subunit beta(IL20RB) is a single-pass type I membrane protein and belongs to the type II cytokine receptor family. It contains 2 fibronectin type-III domains. There are two kinds of type II cytokine receptors : cytokine receptors that bind type I and type II interferons; cytokine receptors that bind members of the interleukin-10 family (interleukin-10, interleukin-20 and interleukin-22). Type II cytokine receptors are similar to type I cytokine receptors except they do no... | |||
TMPJ-01081 |
Dtk Protein, Human, Recombinant (His)
RSE,SKY,DTK,Tyrosine-protein kinase DTK,Ty... |
Human | HEK293 Cells |
Axl (Ufo, Ark), Dtk (Sky, Tyro3, Rse, Brt) and Mer (human and mouse homologues of chicken cEyk)constitute a new receptor tyrosine kinase subfamily. The extracellular domain of these proteins contain two Ig-like motifs and two fibronectin type III motifs. This characteristic topology is also found in neural cell adhesion molecules and in receptor tyrosine phosphatases. All three receptors bind the vitamin K-dependent protein growth-arrest specific gene 6 (Gas6) which is structurally related to th... | |||
TMPY-03442 |
MOB4A/MOB1B Protein, Human, Recombinant (GST)
MOB kinase activator 1B,MOBKL1A,MATS2,MOB4A |
Human | E. coli |
MST1 and MST2 are the mammalian Ste2-related protein kinases most closely related to Drosophila Hippo, a major regulator of cell proliferation and survival during development. Overexpression of MST1 or MST2 in mammalian cells is proapoptotic. MST1 and MST2 activity increase during mitosis, especially in nocodazole-arrested mitotic cells, where these kinases exhibit an increase in both abundance and activation. MST1 and MST2 also can be activated nonphysiologically by okadaic acid or H2O2. The MO... | |||
TMPJ-00224 |
EFNB2 Protein, Mouse, Recombinant (hFc & His)
Ephrin-B2,Htkl,Lerk5.,ELF-2,Epl5,Eplg5,EPH-related ... |
Mouse | HEK293 Cells |
Ephrin-B2 is a single-pass type I membrane protein and it contains 1 ephrin RBD (ephrin receptor-binding) domain. Ephrin-B2 belongs to the ephrin (EPH) family and it is cell surface transmembrane ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. The ephrins and EPH-related receptors contain the largest subfamily of receptor protein-tyrosine kinases and have been associated ... | |||
TMPY-02708 |
NRG4 Protein, Human, Recombinant
HRG4,neuregulin 4 |
Human | E. coli |
NRG4 (neuregulin 4) is a member of the neuregulin protein family. The neuregulins consist of four structurally-related proteins that are part of the EGF family of proteins. It has been shown that these proteins have diverse functions in the development of the nervous system and play multiple essential roles in vertebrate embryogenesis including cardiac development, Schwann cell, and oligodendrocyte differentiation, some aspects of neuronal development, as well as the formation of neuromuscular s... | |||
TMPY-00564 |
MCP-4 Protein, Human, Recombinant (His)
MCP-4,CCL13,SCYL1,NCC-1,MCP4,NCC1,CKb10,SCYA13,chemokine (C-... |
Human | P. pastoris (Yeast) |
Monocyte Chemoattractant Proteins 4 (MCP-4/CCL13) is a member of a distinct, structurally-related subclass of CC chemokines mainly involved in recruitment of eosinphils to inflammatory sites. CCL13/MCP-4, is a CC family chemokine that is chemoattractant for eosinophils, basophils, monocytes, macrophages, immature dendritic cells, and T cells, and its capable of inducing crucial immuno-modulatory responses through its effects on epithelial, muscular and endothelial cells. Similar to other CC chem... | |||
TMPY-01958 |
RhoA Protein, Human, Recombinant (His)
ras homolog family member A,ARHA,RHO12,RHOH12,ARH12 |
Human | Baculovirus Insect Cells |
Transforming protein RhoA, also known as Rho cDNA clone 12, Ras homolog gene family member A, RHOA and ARH12, is a cell membrane and cytoplasm protein that belongs to the small GTPase superfamily and Rho family. The Rho family of small GTPases plays a key role in the dynamic regulation of the actin cytoskeleton that underlies various important cellular functions such as shape changes, migration, and polarity. RHOA / ARH12 is part of a larger family of related proteins known as the Ras superfamil... | |||
TMPY-02516 |
Interferon alpha 10/IFNA10 Protein, Human, Recombinant (hFc)
interferon, α10,interferon, alpha 10,IFN-alphaC,MGC119879,干扰... |
Human | HEK293 Cells |
Interferon alpha-10 (IFNA10) is a member of the interferon family. Interferons belong to the group of the regulatory glycoproteins, of low molecular mass. They are the products of infected cell-genome, but not virus, as a consequence of the cause answer by different inductors. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase. They allow communication between cells to trigger the protective defenses of the immune system that eradicate pathogen... | |||
TMPH-01692 |
MAPK3 Protein, Human, Recombinant (His)
MAP kinase isoform p44,p44-ERK1,MAPK3,Extracellular... |
Human | E. coli |
Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK1/ERK2 and MAPK3/ERK1 are the 2 MAPKs which play an important role in the MAPK/ERK cascade. They participate also in a signaling cascade initiated by activated KIT and KITLG/SCF. Depending on the cellular context, the MAPK/ERK cascade mediates diverse biological functions such as cell growth, adhesion, survival and differentiation through the regulation of transcription, translation, c... |