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Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T62198 |
AR524
|
Others | Others |
AR524 是一种转基因抑制剂,抑制活性高于已知的转基因抑制剂 kifunensine。AR524 能够抑制低浓度 (10 μM) 的人类恶性细胞球状体的形成。 |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T20628 | Kifunensine | ||
Kifunensine, a potent and selective inhibitor of class I α-mannosidases, may serve as a key inhibitor of glycoprotein biosynthesis. Its inhibitory effect may lead to high mannose glycoproteins in cell culture. |
Cat. No. | Product Name | Species | Expression System |
---|---|---|---|
TMPJ-01384 |
MAN1B1 Protein, Human, Recombinant (His)
ER Alpha-1,Man9GlcNAc2-Specific-Processing Alpha-Mannosidase... |
Human | HEK293 Cells |
Endoplasmic Reticulum Mannosyl-Oligosaccharide 1,2-α-Mannosidase (MAN1B1) belongs to the glycosyl hydrolase 47 family. MAB1B1 is a single-pass type II membrane protein and widely expressed in many tissues. MAB1B1 is involved in glycoprotein quality control targeting of misfolded glycoproteins for degradation. MAB1B1 can be inhibited by both 1-deoxymannojirimycin (dMNJ) and kifunensine. Defects in MAN1B1 are the cause of mental retardation autosomal recessive type 15 (MRT15). Mental retardation i... |