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抑制剂 & 化合物

同位素标记化合物

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Cat. No.	Product Name	Target	Signaling Pathways
T39313	KALA
	KALA, an amphiphilic peptide, adopts an α-helical conformation under physiological pH conditions. It functions as a fusogenic peptide, modifying the liposomal membrane that encapsulates plasmid DNA, thereby facilitating liver targeting and DNA transfection through galactose receptors.
T2712	Nifekalant hydrochloride	Potassium Channel	Membrane transporter/Ion channel
	Nifekalant hydrochloride 是一种 IKr 钾通道阻滞剂，IC50为10 µM，属于 III 类抗心律不齐化合物，可用于快速室上性心律失常的研究。
T17227	Vernakalant Hydrochloride RSD1235 hydrochloride	Potassium Channel; Sodium Channel	Membrane transporter/Ion channel
	Vernakalant Hydrochloride (RSD1235 hydrochloride) 是一种混合电压和频率依赖性的 Na+ 和 K+ 通道阻断剂。Vernakalant 抑制 Kv1.5 channelwt，Kv1.5 channelI508F，Kv1.5 channelT479A，IC50 分别为 13.35±0.93 μM。
T70540	Pinokalant LOE-908	SARS-CoV; TRP/TRPV Channel	Membrane transporter/Ion channel; Microbiology/Virology
	Pinokalant (LOE-908) 是一种新型非选性阳离子通道抑制剂。Pinokalant 在体内实验中可显著减少皮质梗死体积，可改善缺血半影区的代谢和电生理状态，可减少大鼠大脑中动脉闭塞后急性期磁共振图像上的病变大小。Pinokalant是一种潜在的SARS-CoV-2蛋白酶抑制剂，可用于研究脑卒中。
T63736	Bafrekalant	Others	Others
	Bafrekalant 是一种二氮杂双环取代的咪唑并[1,2-a]嘧啶衍生物。Bafrekalant 可用于研究阻塞性和中枢性睡眠呼吸暂停和打鼾等与睡眠相关的呼吸障碍类疾病。
T71446	Kalafungin	Others	Others
	Kalafungin antimicrobial agent that is inhibitory in vitro against a variety of pathogenic fungi, yeasts, protozoa, gram-positive bacteria, and, to a lesser extent, gram-negative bacteria.
T63330	Clamikalant sodium	Others	Others
	Clamikalant sodium 是非选择性的、 ATP 敏感性的钾 (KATP) 通道阻滞剂，能够用于研究心律不齐。
T14189	Almokalant H 234/09	Potassium Channel	Membrane transporter/Ion channel
	Almokalant is a class III antiarrhythmic drug, acts as a potassium channel blocker. And it inhibits a specific component (Ikr) of the time-dependent delayed rectifier K+ current.
TQ0307	Vernakalant RSD1235,维那卡兰	Potassium Channel	Membrane transporter/Ion channel
	Vernakalant (RSD-1235) is a mixed ion channel blocker.
T71929	Clamikalant	Others	Others
	Clamikalant inhibits ATP-sensitive potassium channel.