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39
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Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T6641 |
Rilmenidine Phosphate
|
Apoptosis; Adrenergic Receptor; Autophagy; Imidazoline Receptor | Apoptosis; Autophagy; GPCR/G Protein; Neuroscience |
Rilmenidine phosphate 是一种新型的抗高血压药物和口服活性选择性 I1 咪唑啉受体激动剂。它可调节白血病细胞增殖,刺激促凋亡蛋白 Bax,从而诱导人白血病 K562 细胞线粒体通路的紊乱和凋亡。它可通过减少交感神经过度活跃而发挥中枢作用,并通过抑制 Na+/H+反向转运而在肾脏中发挥作用。 | |||
T13224 |
Tubulin inhibitor 6
iHAP1 |
Microtubule Associated | Cytoskeletal Signaling |
Tubulin inhibitor 6 (iHAP1) 是一种微管蛋白抑制剂,抑制微管蛋白聚合,IC50为 0.87 μM。它抑制多种癌细胞系,抑制 K562 细胞生长,IC50为 840 nM。 | |||
T1448 |
Dasatinib
BMS-354825,达沙替尼 |
Apoptosis; Bcr-Abl; Src; c-Kit; Autophagy | Angiogenesis; Apoptosis; Autophagy; Cytoskeletal Signaling; Tyrosine Kinase/Adaptors |
Dasatinib (BMS-354825) 是一种酪氨酸激酶抑制剂,抑制 Src 和 Bcr-Abl (Ki=16/30 pM),具有口服活性和 ATP 竞争性。Dasatinib 具有抗肿瘤活性,用于治疗白血病和淋巴瘤等。 | |||
T16545 |
Pivanex
Pivalyloxymethyl butyrate,AN-9 |
Apoptosis; HDAC; Bcr-Abl | Angiogenesis; Apoptosis; Chromatin/Epigenetic; Cytoskeletal Signaling; DNA Damage/DNA Repair; Tyrosine Kinase/Adaptors |
Pivanex (Pivalyloxymethyl butyrate) 是丁酸的一种衍生物,是具有口服活性的 HDAC 抑制剂。Pivanex 通过下调 bcr-abl 蛋白增强凋亡。Pivanex 显示出抗转移和抗血管生成的活性。 | |||
T1448L |
Dasatinib monohydrate
达沙替尼,BMS-354825 Monohydrate |
Apoptosis; Bcr-Abl; Src; c-Kit; Ephrin Receptor; Autophagy | Angiogenesis; Apoptosis; Autophagy; Cytoskeletal Signaling; Tyrosine Kinase/Adaptors |
Dasatinib monohydrate (BMS-354825 Monohydrate) 是一种具有口服活性的,ATP 竞争性的双重Src/Bcr-Abl 抑制剂,有抗肿瘤活性,还诱导凋亡和自噬。它抑制Src 和Bcr-Abl 的IC50分别为 0.5 nM 和 <1.0 nM,Ki 值分别为 16 pM 和 30 pM。 | |||
T5858 |
Sertindole
Lu 23-174,舍吲哚 |
Dopamine Receptor; 5-HT Receptor; Adrenergic Receptor; Autophagy | Autophagy; GPCR/G Protein; Neuroscience |
Sertindole (Lu 23-174) 是一种非典型抗精神病药,可与多巴胺 D2 受体和血清素受体亚型 5-HT1D、5-HT2A 和 5-HT2C 结合,Kd 值分别为 2.7、20、0.14 和 6 nM。 | |||
T2394 |
Pixantrone dimaleate
匹克生琼来酸盐,BBR-2778,Pixantrone Maleate,BBR 2778 dimaleate,马来酸匹衫琼 |
Topoisomerase | DNA Damage/DNA Repair |
Pixantrone dimaleate (Pixantrone Maleate) 是一种拓扑异构酶 II 的抑制剂和 DNA 嵌入剂,是一种实验性抗肿瘤药物。 | |||
T24838 |
Stafib-1
Stafib 1,Stafib1 |
STAT | JAK/STAT signaling; Stem Cells |
Stafib-1 是一种特异性的 STAT5β 抑制剂,靶向 SH2 结构域,IC50 为 154 nM,Ki 为 44 nM。 | |||
T6018 |
Zosuquidar trihydrochloride
唑喹达三盐酸盐,Zosuquidar (LY335979) 3HCl,RS 33295-198 trihydrochloride,RS 33295-198 (D06387) 3HCl,Zosuquidar 3HCl,LY-335979 trihydrochloride |
P-gp | Membrane transporter/Ion channel; Neuroscience |
Zosuquidar trihydrochloride (LY-335979 trihydrochloride) 是一种P-糖蛋白抑制剂,Ki 值为 59 nM。 | |||
T16940 |
STAT5-IN-2
|
Apoptosis; STAT | Apoptosis; JAK/STAT signaling; Stem Cells |
STAT5-IN-2 是一种具有抗白血病作用的 STAT5 抑制剂(EC50:在 K562 和 KU812 细胞中分别为 9 μM 和 5 μM)。 | |||
T13226 |
Tubulin inhibitor 8
|
Microtubule Associated | Cytoskeletal Signaling |
Tubulin inhibitor 8是管蛋白和多种癌症细胞系的抑制剂,对管蛋白聚合和K562细胞生长具有抑制作用 ,IC50分别为0.73μM 和14nM。 | |||
T2539 |
Fingolimod hydrochloride
Fingolimod (FTY720) HCl,FTY720,盐酸芬戈莫德 |
TRP/TRPV Channel; S1P Receptor; PAK; LPL Receptor | Cytoskeletal Signaling; GPCR/G Protein; Membrane transporter/Ion channel |
Fingolimod hydrochloride (FTY720) 是一种新型免疫调节剂,是一种 1-磷酸鞘氨醇(S1P) 拮抗剂,作用于 K562 和 NK 细胞,IC50为 0.033 nM。它诱导 S1P1 的内化,从而抑制 S1P 活性。它被鞘氨醇激酶磷酸化,尤其是被 SK2 磷酸化,从而可与 S1PR1、3、4 和 5 结合 | |||
T12341 |
P-gp inhibitor 1
|
Others; P-gp | Membrane transporter/Ion channel; Neuroscience; Others |
P-gp inhibitor 1 抑制逆转 P-糖蛋白介导的多药耐药性,EC50 为 57.9 nM(K562/A02 细胞)。 | |||
T1937 |
Spautin-1
Spautin 1 |
Apoptosis; DUB; Autophagy | Apoptosis; Autophagy; Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Ubiquitination |
Spautin-1是一种特异性自噬抑制剂,可抑制泛素特异性肽酶 USP10和 USP13,IC50s 约为0.6到0.7 μM。 | |||
T74186 |
PROTAC-O4I2
|
Apoptosis; PROTACs | Apoptosis; PROTAC |
PROTAC-O4I2 是一种靶向剪接因子 3B1 (SF3B1) 的 PROTAC连接体, 在 K562 细胞中促使 FLAG-SF3B1 降解,IC50 值为 0.244 μM。PROTAC-O4I2 促使 K562 WT 细胞凋亡 (apoptosis)。 | |||
T84810 |
Cu(II)-Elesclomol
|
Others | Others |
Cu(II)-Elesclomol为Elesclomol的Cu2+络合物。该化合物可诱导K562细胞凋亡并引起G1期细胞周期阻滞,同时诱发DNA双链断裂。此外,Cu(II)-Elesclomol对DNA拓扑异构酶I有轻微的抑制作用。因其上述作用,Cu(II)-Elesclomol展现出抗癌活性。 | |||
T28475 |
Pyrazoloacridine
PD-115934,NSC 366140,NSC-366140,PD 115,934,PD 115934 |
Apoptosis; Topoisomerase | Apoptosis; DNA Damage/DNA Repair |
Pyrazoloacridine (PD 115934) 是一种核酸结合剂,在 K562 细胞中抑制 topo I 和 II 的活性,IC50 为 1.25 μM。 Pyrazoloacridine 具有抗癌活性。 | |||
T4595 |
YHO-13177
YHO 13177,YHO13177 |
BCRP | Membrane transporter/Ion channel |
YHO-13177 是高活性乳腺癌耐药蛋白多药转运通道(BCRP)抑制剂,可增强SN-38活性。 | |||
T62745 |
AMPK-IN-3
|
VEGFR; AMPK | Angiogenesis; Chromatin/Epigenetic; PI3K/Akt/mTOR signaling; Tyrosine Kinase/Adaptors |
AMPK-IN-3 是一种新型且选择性和强效性的 AMPK 抑制剂,其对AMPK (α2)、AMPK (α1) 和 KDR 具有抑制作用, IC50 值分别为 60.7、107 和 3820 nM。AMPK-IN-3 在 K562 细胞中显示出抗癌活性。 | |||
T77728 |
Tubulin polymerization-IN-55
|
Microtubule Associated | Cytoskeletal Signaling |
Tubulin polymerization-IN-55 是一种高效的 Tubulin Polymerization 抑制剂,具有潜在的抗血管生成和抗肿瘤活性,对 A549、K562、HepG2、MDA-MB-231 和 HFL-1 显示出抗增殖作用。 | |||
T12926 |
SJB3-019A
|
Others; DUB | Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Others; Ubiquitination |
SJB3-019A 是一种有效的、有效的和新型的泛素特异性蛋白酶1(USP1)抑制剂,在 K562细胞中促进 ID1降解和细胞毒性的作用是 SJB2-043的5倍,IC50为0.0781 μM。SJB3-019A 抑制细胞增殖,使细胞凋亡。 | |||
T21911 |
Rilmenidine hemifumarate
Rilmenidine (hemifumarate),S-3341 hemifumarate |
Apoptosis; Imidazoline Receptor | Apoptosis; Neuroscience |
Rilmenidine hemifumarate (S-3341 hemifumarate) 是一种新型且具有口服活性和选择性 的 I1咪唑啉受体 (I1 imidazoline receptor) 和α2肾上腺素受体激动剂,可诱导自噬 ,调节白血病细胞增殖,刺激促凋亡蛋白 Bax,诱导人白血病 K562 细胞线粒体通路的紊乱和凋亡。 | |||
T6691 |
TAI-1
|
Apoptosis; Microtubule Associated | Apoptosis; Cytoskeletal Signaling |
TAI1 是一种具有口服活性的特异性 Hec1 抑制剂,有抗肿瘤活性,在 K562 细胞中的 GI50值为 13.48 nM。 | |||
T24912 |
Tyrphostin AG 568
Tyrphostin AG-568,Tyrphostin AG568 |
Others | Others |
Tyrphostin AG 568 promotes Tyrphostin-induced inhibition of p210bcr-abl tyrosine kinase activity. It also induces K562 to differentiate. | |||
T24911 |
Tyrphostin AG 1112
Tyrphostin AG-1112,Tyrphostin AG1112 |
Others | Others |
Tyrphostin AG 1112 is a Bcr-Abl kinase blocker. It can activate the terminal differentiation of K562 cells and the purging of Ph+ cells. | |||
T82715 |
Cisplatin-resistant cells-IN-1
|
Others | Others |
Cisplatin-resistant cells-IN-1(化合物8)对顽固的铂类药物抗性细胞具有较高的细胞毒性。在低纳摩尔浓度范围内(IC50:0.14–1.79 μM in A549/A549-R, K562/K562-R, and MCF-7/MCF-7TamR cells),该化合物能有效降低代谢活性。 | |||
T23617 |
Aclacinomycin
Aclacinomycins,Siwenmycin |
Others | Others |
Aclacinomycin A is an anthracycline drug. It sensitizes K562 chronic myeloid leukemia cells to imatinib through p38MAPK-mediated erythroid differentiation. It is used in the treatment of cancer. | |||
T82774 |
Caspase-3 activator 3
|
Caspase | Apoptosis; Proteases/Proteasome |
Caspase-3 activator 3 (compound 2h) 通过激活caspase 3诱导HL-60和K562细胞apoptosis,表现出抗白血病活性。其对HL-60细胞的IC50值为42.89 μM,对K562细胞的IC50值为33.61 μM。 | |||
T77974 |
PROTAC BCR-ABL Degrader-1
|
PROTACs | PROTAC |
PROTACBCR-ABLDegrader-1(化合物PROTAC1)是一种含有2-oxoethyl linker的PROTAC。该化合物能通过泛素蛋白酶体(ubiquitinproteasom)系统诱导Bcr-Abl的降解,并对K562细胞表现出抗增殖效果,显示出其在癌症研究中的应用潜力。 | |||
T63932 |
BCR-ABL-IN-4
|
Others | Others |
BCR-ABL-IN-4 是 BCR-ABLL 抑制剂,表现出抗癌活性。BCR-ABL-IN-4 对癌细胞生长具有抑制作用,能够作用于 K562 细胞 (IC50: 0.67 nM) 和 BCR-ABL T315I 转染的 Ba/F3 细胞 (IC50: 16 nM)。 | |||
T37544 |
Anhydroophiobolin A
|
Others | Others |
Anhydroophiobolin A is an ophiobolin fungal metabolite that has been found in C. heterostrophus fermentation broths. It is cytotoxic to HepG2 and K562 cancer cells (IC50s = 55.7 and 39.5 μM, respectively). | |||
T13225 | Tubulin inhibitor 7 | Microtubule Associated | Cytoskeletal Signaling |
Tubulin inhibitor 7 is an inhibitor of tubulin and a potent inhibitor of multiple cancer cell lines (tubulin polymerization (IC50: 0.52 μM), K562 cell growth (IC50: 11 nM)). | |||
T37804 |
8MDP
|
Others | Others |
Potent equilibrative nucleoside transporter 1 (ENT1) inhibitor (IC50 = 0.43 nM). Inhibits hENT1 and hENT2 uptake of [H3]uridine in K562 cells and K15NTD cells respectively. Lin et al (2011) Design, synthesis, and evaluation of 2-diethanolamino-4,8-diheptamethyleneimino-2-(N-aminoethyl-N-ethanolamino)-6-(N,N-diethanolamino)pyrimido[5,4-d]pyrimidine-fluorescein conjugate (8MDP-fluor), as a novel equilibrativ Bioconjug.Chem. 22 1221 PMID:21539390 |Lin et al (2007) Synthesis, flow cytometric evaluat... | |||
T63159 |
Anticancer agent 28
|
Others | Others |
Anticancer agent 28 在体内 H22 同种异体移植小鼠中具有良好的抗肿瘤作用。Anticancer agent 28 对 K562 细胞的作用是 Oridonin 的50倍,其 IC50 值为 0.09 μM。 | |||
T78815 |
MOZ-IN-3
|
Histone Acetyltransferase | Chromatin/Epigenetic |
MOZ-IN-3 (Compound 6j) 是KAT6A (MOZ) 乙酰转移酶的抑制剂,IC50值为30 nM。该化合物在四种髓系白血病细胞系(HL-60、U937、SKNO-1、K562)上展现了抗肿瘤活性,并且显示出良好的代谢稳定性及药代动力学特性。 | |||
T28092 |
MPT0B206
|
Others | Others |
MPT0B206 is a novel tubulin polymerization inhibitor. MPT0B206 induced G2/M cell cycle arrest and the appearance of the mitotic marker MPM-2 in K562 and K562R cells, which is associated with the upregulation of cyclin B1 and the dephosphorylation of Cdc2. | |||
T63665 |
EIF2α activator 1
|
Others | Others |
EIF2α activator 1(Compound 40)为真核生物起始因子2α(eIF2α)磷酸化的激活剂,能够提高EIF2α下游蛋白ATF和CHOP的表达水平。该化合物对K562细胞和PBMC细胞展现出抗增殖活性,其IC50值分别为4.00 μM和19.3 μM。 | |||
T62217 |
Tubulin polymerization-IN-9
|
Others | Others |
Tubulin polymerization-IN-9 是一种微管蛋白 (tubulin) 的有效抑制剂 (IC50: 1.82 μM)。Tubulin polymerization-IN-9 能够将 K562 细胞的细胞周期停滞在 G2/M 期,并诱导其凋亡 (apoptosis) 及线粒体去极化。Tubulin polymerization-IN-9 表现出强大的抗血管和抗肿瘤作用。 | |||
T73451 |
BAY-364
BAY-299N |
Others | Others |
BAY-364 (BAY-299N) 为TAF1第二溴结构域抑制剂。对于Kasumi-1细胞、CD34+细胞及K562细胞中的TAF1显示出抑制作用,其IC50值分别为1.0 µM、10.4 µM与10.0 µM。 | |||
T82775 |
Caspase-3 activator 2
|
Caspase | Apoptosis; Proteases/Proteasome |
Caspase-3 activator 2 (Compound 2f) 是诱导细胞凋亡的caspase 3激活剂,适用于癌症研究。该化合物对 HL-60 细胞和 K562 细胞展示出细胞毒性,IC50 值分别为 33.52 μM 和 76.90 μM。 | |||
T62637 |
EIF2α activator 2
|
Others | Others |
EIF2α activator 2(Compound 1)是一种真核生物起始因子2α(eIF2α)磷酸化的激活剂。EIF2α 激活剂 2 在 SRB 细胞增殖试验中表现出高效力 (IC50: 0.46 μM)。EIF2α activator 2 对 K562 (IC50: 4.79 μM)和 PBMC (IC50: 10.52 μM) 细胞表现出抗增殖活性。 | |||
T33510 |
MS-073
CP162398,CP-162398,CP 162398,MS 073 |
Others | Others |
MS-073 (CP-162398) is a P-glycoprotein inhibitor (P-gp). The in vitro resistance to vincristine (VCR) was almost completely reversed in VCR-resistant P388 cells, and the resistance of VCR, adriamycin (ADM), etoposide, and actinomycin D in ADM-resistant hu | |||
T38044 |
Reveromycin B
|
Others | Others |
Reveromycin B is a spiroketal bacterial metabolite originally isolated from Streptomyces. It inhibits EGF-induced mitogenic activity in Balb/MK cells (IC50 = 6 μg/ml) and exhibits pH-dependent antifungal activity against C. albicans (MICs = 15.6 and >500 μg/ml at pH 3.0 and 7.4, respectively). Unlike reveromycin A and reveromycin C , reveromycin B does not inhibit proliferation of KB and K562 cells. | |||
T1817 |
GNF-2
GNF2 |
SARS-CoV; Bcr-Abl | Angiogenesis; Cytoskeletal Signaling; Microbiology/Virology; Tyrosine Kinase/Adaptors |
GNF-2 是一种高选择性的非 ATP 竞争性 Bcr-Abl 抑制剂。 它抑制 Ba/F3.p210 增殖,IC50为 138 nM。 | |||
T37423 |
Reveromycin D
|
Others | Others |
Reveromycin D is a bacterial metabolite originally isolated from Streptomyces. It inhibits EGF-induced mitogenic activity in Balb/MK cells and has pH-dependent antifungal activity against C. albicans (MICs = 2 and >500 μg/ml at pH 3 and 7.4, respectively). Reveromycin D also inhibits proliferation of KB and K562 cells (IC50s = 1.6 and 1.3 μg/ml, respectively). | |||
T79683 |
HDAC/CD13-IN-1
|
Others | Others |
HDAC/CD13-IN-1 (Compound 12) 作为HDAC/CD13抑制剂, 对hCD13的IC50为0.34 μM, 猪CD13为0.53 μM, 对HDAC1/2/3的IC50分别为0.03、0.06、0.02 μM。此化合物有效抑制MV4-11、K562、Jeko-1 和 HL60细胞增殖, IC50范围为0.25-2.04 μM,并诱导癌细胞凋亡。同时表现出抗转移和抗侵袭的特性。 | |||
T78843 |
MET/PDGFRA-IN-1
|
c-Met/HGFR | Tyrosine Kinase/Adaptors |
MET/PDGFRA-IN-1 (compound 8c) 作为MET和PDGFRA蛋白的抑制剂,以36 μM对MET的IC50值显示活性。该化合物能够抑制MET磷酸化并触发细胞凋亡(apoptosis)。此外,MET/PDGFRA-IN-1有效抑止了多种MET阳性细胞系的增殖,包括AsPc-1、EBC-1、MKN-45、Mia-Paca-2、HT-29和K562,其IC50s分别为15.3、19.0、22.0、25.6、21.0、31.5 μM。 | |||
T79754 |
JNK-IN-14
|
JNK | MAPK |
JNK-IN-14是一种激酶(JNK1/2/3)抑制剂,IC50值为1.81、12.7和10.5 nM。它能诱导早期apoptosis,并在G2/M阶段引起细胞周期阻滞。与SP600125相比,在K562白血病细胞中,JNK-IN-14更强有效地抑制了Beclin-1的表达。 | |||
T79322 |
Antiproliferative agent-30
|
Others | Others |
Antiproliferative agent-30 (Compound 8g) 抑制微管蛋白组装且可抑制FLT3及Abl1。该化合物展现出对血管的破坏活性,并对多种癌细胞系表现出强效的抗增殖能力,包括HCT-116、K562及MV-4-11细胞(IC50值分别为0.054 nM、0.008 nM、0.144 nM)。此外,Antiproliferative agent-30 亦对携带FLT3-ITD-TKD突变的AML显示出抗癌效果。 | |||
T78844 |
MET/PDGFRA-IN-2
|
c-Met/HGFR | Tyrosine Kinase/Adaptors |
MET/PDGFRA-IN-2(化合物8h)是一种针对MET和PDGFRA蛋白的抑制剂,具有诱导细胞凋亡(apoptosis)的功能。该化合物能有效抑制多种MET表达细胞系的增殖,包括AsPc-1、EBC-1、MKN-45、Mia-Paca-2、HT-29和K562细胞,其IC50分别为9.7、6.1、12.0、11.5、8.6和34.4μM。 |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T0974 |
Novobiocin Sodium
Albamycinsodium,新生霉素钠,Cathomycin,Albamycin |
Potassium Channel; DNA gyrase; Topoisomerase; Antibacterial; Antibiotic; ABC; Autophagy | Autophagy; DNA Damage/DNA Repair; Membrane transporter/Ion channel; Microbiology/Virology |
Novobiocin Sodium (Albamycinsodium) 是源自 Streptomyces niveus 的抗生素。 它的化学结构类似于香豆素。Novobiocin 与 DNA 促旋酶结合并阻断三磷酸腺苷活性。 | |||
T3138 |
Astaxanthin
β-Carotene-4,4'-dione,Ovoester,AstaXin,AstaREAL,trans-Astaxanthin,虾青素 |
Reactive Oxygen Species; PPAR | DNA Damage/DNA Repair; Immunology/Inflammation; Metabolism; NF-κB |
Astaxanthin (trans-Astaxanthin) 是可从雨生红球藻等多种海洋生物中提取得到的红色类胡萝卜素,是过氧化物酶体增殖物活化受体γ 的调节剂,具有抗增殖、神经保护作用和抗炎活性。它是一种抗氧化剂,有用于癌症和心血管疾病的研究潜力,作为颜色添加剂用于动物食品中。 | |||
T1511 |
Daunorubicin hydrochloride
Daunomycin HCl,盐酸佐柔比星,盐酸柔红霉素,RP-13057 Hydrochloride,Rubidomycin hydrochloride,Daunorubicin HCl,Daunomycin |
Apoptosis; DNA/RNA Synthesis; Topoisomerase; Antibacterial; Antibiotic; Autophagy; ADC Cytotoxin | Antibody-drug Conjugate/ADC Related; Apoptosis; Autophagy; Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Microbiology/Virology |
Daunorubicin hydrochloride (Rubidomycin hydrochloride) 是一种蒽环类氨基糖苷类化合物,一种拓扑异构酶 II (Topo II) 抑制剂。Daunorubicin hydrochloride 可以抑制 DNA 和 RNA 的合成,具有抗肿瘤活性。 | |||
T7939 |
Fingolimod
2-氨基-2-[2-(4-辛基苯基)乙基]-1,3-丙二醇,FTY-720A,FTY-720,芬戈莫德 |
S1P Receptor; PAK; LPL Receptor | Cytoskeletal Signaling; GPCR/G Protein |
Fingolimod (FTY-720A) 是一种 1-磷酸鞘氨醇 (S1P) 拮抗剂,作用于 K562 和 NK 细胞,IC50为 0.033 nM。它还是pak1激活剂和免疫抑制剂。 | |||
T6S1843 |
Tenacissoside I
通关藤苷I,Tenacissimoside B |
Others | Others |
Tenacissoside I (Tenacissimoside B) 是一种 C21 甾体,来自于Marsdenia tenacissima 中,在M. tenacissima 含量较高。 | |||
TN2755 |
2-Desoxy-4-epi-pulchellin
|
Anti-infection | Microbiology/Virology |
2-Desoxy-4-epi-pulchellin 是分离自 Polygonum hydropiper 的二氯甲烷可溶部分的一种化合物。 | |||
T4S1943 |
Kirenol
奇壬醇,奇任醇,Kirel |
Wnt/beta-catenin | Cytoskeletal Signaling; Stem Cells |
Kirenol (Kirel) 是分离自 Siegesbeckia orientalis 中的,具有抗氧化、抗炎、抗过敏、抗关节炎活性,可用于缓解疼痛的研究。 | |||
TN2211 |
Silybin B
Silibinin B |
Apoptosis; Beta Amyloid; Bcr-Abl | Angiogenesis; Apoptosis; Cytoskeletal Signaling; Neuroscience; Tyrosine Kinase/Adaptors |
Silybin B (Silibinin B) 是雷洛昔芬4′-和6-葡萄糖醛酸化的有效抑制剂,是水飞蓟素有效的抗纤维原性和抗低聚物成分,具有清除1,1-二苯基-2-吡啶酰肼(DPPH)自由基的活性 ,可通过减轻 DNA 损伤和细胞凋亡对顺铂诱导的神经毒性具有保护作用。Silybin B 对人慢性髓系白血病 K562细胞的生长抑制和诱导凋亡有较强的作用。 | |||
T4085 |
Paris saponin VII
重楼皂苷 VII,Chonglou Saponin VII,Polyphyllin-VII,Dioscinin,Paris saponin-VII |
Apoptosis; BCL; Others; PARP; p38 MAPK; Akt; Caspase; P-gp; Autophagy | Apoptosis; Autophagy; Chromatin/Epigenetic; Cytoskeletal Signaling; DNA Damage/DNA Repair; MAPK; Membrane transporter/Ion channel; Neuroscience; Others; PI3K/Akt/mTOR signaling; Proteases/Proteasome |
Paris saponin VII (Dioscini) 是从延龄草的根和根茎中分离的一种甾体皂苷。它减弱线粒体膜电位,增加凋亡相关蛋白的表达,并降低Bcl-2、caspase-9、caspase-3、PARP-1和p-Akt 的蛋白表达水平。它在 K562/ADR 细胞中诱导强烈的自噬,可研究白血病。 | |||
T3398 |
Icaritin
Anhydroicaritin,去水淫羊藿黄素,Cycloicaritin |
Apoptosis; JAK; STAT; Autophagy | Angiogenesis; Apoptosis; Autophagy; Chromatin/Epigenetic; JAK/STAT signaling; Stem Cells |
Icaritin (Anhydroicaritin) 是Epimedium Genusis 的异戊二烯类黄酮衍生物,有效抑制 K562 细胞和原代 CML 细胞的增殖。它可以调节MAPK/ERK/JNK 和JAK2/STAT3/AKT 信号传导,并具有增强成骨的作用。 | |||
T6S1315 |
Oroxylin A
千层纸素A,6-Methoxybaicalein,Baicalein 6-methyl ether |
Virus Protease; HIF/HIF Prolyl-Hydroxylase; Autophagy | Autophagy; Chromatin/Epigenetic; Metabolism; Microbiology/Virology |
Oroxylin A (Baicalein 6-methyl ether) 是一种有活性的黄酮,具有较强的抗癌作用。 | |||
T2S2215 |
Crebanine
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Apoptosis; Others; Akt | Apoptosis; Cytoskeletal Signaling; Others; PI3K/Akt/mTOR signaling |
Crebanine 是来自于韦诺萨千金藤的一种生物碱,通过抑制 MAPKs 和 Akt 信号通路表现出抗炎活性,还具有抗心律失常的作用。它可诱导人类癌细胞的 G1阻滞和凋亡。 | |||
TN4284 |
Isodonal
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Others | Others |
Isodonal shows abilities to inhibit K562 cells camparable to that of cisplatin. | |||
T81318 |
R-30-Hydroxygambogic acid
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R-30-Hydroxygambogic acid是从藤黄提取的一种聚戊烯酰黄酮外聚体,对K562/R和K562/S两种人白血病细胞系的IC50分别为2.89 μM和1.27 μM。该化合物适用于癌症研究领域。 | |||
T80995 |
Theasaponin E2
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Theasaponin E2, 一种从茶树分离得到的化合物,对K562和HL60细胞表现出显著的细胞毒性,其半抑制浓度(IC50)为14.7 μg/mL。 | |||
TN5358 |
Eupahualin C
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Eupahualin C shows significant activities against cell lines of human chronic myelogenous leukemia (K562) and human bone cancer (U2OS). | |||
TN6054 |
Norglaucine hydrochloride
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(+)-Norglaucine shows cytotoxic activity toward the tumor cell lines B16-F10 (mouse melanoma), HepG2 (human hepatocellular carcinoma), K562 (human chronic myelocytic leukemia) and HL-60 (human promyelocytic leukemia) and non-tumor peripheral blood mononuc | |||
T81232 |
S-30-Hydroxygambogic acid
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S-30-Hydroxygambogic acid,一聚戊烯酰黄酮外聚体,源自藤黄。针对人白血病细胞系K562/R及K562/S,其IC50值别为4.49 μM与3.61 μM。S-30-Hydroxygambogic acid主用于癌症研究领域。 | |||
TN4011 |
Erythrodiol 3-palmitate
|
Others | Others |
Erythrodiol 3-palmitate has antitumor activity, it inhibited the proliferation of K562 cells with the inhibition rate of 47% at 100 ug/mL. | |||
TN5274 |
Yunnancoronarin A
|
Others | Others |
Yunnancoronarin A shows cytotoxicity against the lung adenocarcinoma cells A549 and leukemia cells K562, with the IC(50) value of 2.20 microM. | |||
TN5934 |
2-Hydroxydiplopterol
2,22-Hopanediol |
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2-Hydroxydiplopterol exhibits cytotoxicity against K562 cells with an IC50 value of 22 microM. | |||
TN3528 |
Bonducellpin D
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Antifection | Microbiology/Virology |
Bonducellpin D may show inhibitory activities on the Para3 virus. It also exhibits moderate activity against four tested human cancer cell lines, HepG-2, K562, HeLa, and Du145. | |||
TN3760 |
Danshenol A
|
Reductase | Endocrinology/Hormones; Metabolism |
Danshenol A has strong aldose reductase (AR) inhibitory activity, has IC50 of 0.10 microM which is comparable to that of epalrestat in clinical use. Danshenol A also has antitumor activity in T-24, QGY, K562, Me180 and BIU87 cell lines, shows inhibited growth of K562 (IC50 = 0.53 μg/mL), T-24 (IC50 = 7.94 μg/mL), QGY (IC50 = 4.65 μg/mL) and Me180 (IC50 = 6.89 μg/mL) cell lines. | |||
TN4976 | Scutebata E | Others | Others |
Scutebata E shows weak cytotoxicity with IC50 values ranging from 35.11 to 42.73 μM against K562 cell lines. | |||
TN2128 |
Quercetin 3-O-robinobioside
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Others | Others |
Quercetin-3-O-robinobioside is a quercetin-derived flavonol, exhibits antioxidant activities. It exhibits in-vitro inhibitory activities against leukemia K562 cells. | |||
T80996 |
Theasaponin E1
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Theasaponin E1,一种可从茶籽分离的茶皂苷,对人肿瘤细胞系K562和HL60展示了抗肿瘤潜能。此外,Theasaponin E1具备醌还原酶(QR)诱导活性,有助于作为抗癌预防药物的研究。 | |||
TN4215 |
Hispidanin B
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Others | Others |
Hispidanin B shows significant cytotoxicities against tumor cell lines SGC7901, SMMC7721, and K562, with IC50 values of 10.7, 9.8, and 13.7 uM, respectively. | |||
TN2192 | Scutebarbatine B | Others | Others |
Scutebarbatine B shows weak cytotoxicity with IC50 values ranging from 35.11 to 42.73 μM against K562 cell lines and HL60 cell lines. | |||
T75677 |
Protoneogracillin
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Others | Others |
Protoneogracillin 是一种呋甾醇糖苷,具有抑制植物病原真菌 P.oryzae 的活性 (MMDC=94.0 μM),对 K562 癌细胞的细胞毒活性 (IC50=6.6 μM)。 | |||
T37543 |
Anhydroepiophiobolin A
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Others | Others |
Anhydroepiophiobolin A is a sesterterpenoid fungal metabolite that has been found in B. oryzae. It is cytotoxic to HepG2 and K562 cells (IC50s = 47.1 and 35.6 μM, respectively) as well as A549, SKOV3, SK-MEL-2, XF498, and HCT15 cells (IC50s = 1.6-1.9 μg/ml). Anhydroepiophiobolin A is phytotoxic to S. viridis and D. erucoides in a leaf puncture assay. | |||
TN3417 |
Angophorol
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Apoptosis | Apoptosis |
Angophorol 是一种来自蹄盖蕨科植物禾秆蹄盖蕨的黄酮化合物。Angophorol 通过 K562 细胞的生长抑制和凋亡 (apoptosis) 发挥潜在的抗癌活性。 | |||
TN1144 |
Enmein
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Antifection; Immunology/Inflammation related | Immunology/Inflammation; Microbiology/Virology |
Enmein 是分离自 I. serra 中,拥有免疫抑制活性。 | |||
T0194 |
Chloroquine phosphate
Chloroquine diphosphate,Aralen phosphate,磷酸氯喹,Chingamin phosphate |
SARS-CoV; TLR; HIV Protease; Antibiotic; Parasite; Autophagy | Autophagy; Immunology/Inflammation; Microbiology/Virology; Proteases/Proteasome |
Chloroquine phosphate (Aralen phosphate) 是广泛用于疟疾和类风湿性关节炎的抗疟疾和抗炎剂。它是autophagy 和toll-like receptors 抑制剂,有效抑制SARS-CoV-2(COVID-19) 感染 (EC50=1.13 μM)。 | |||
TN4404 |
Ladanein
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HCV Protease | Microbiology/Virology; Proteases/Proteasome |
Ladanein is a phytochemicals inhibitor that is known to disrupt the interactions of core and other hepatitis C virus (HCV) proteins.Ladanein possesses free radicals DPPH and ABTS +.scavenging activity, it also displays moderate (20-40 microM) activities against K562, K562R (imatinib-resistant), and 697 human leukemia cell lines. | |||
T37451 |
Stachybotrysin B
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Others | Others |
Stachybotrysin B is a fungal metabolite originally isolated from S. chartarum and has antiviral and anticancer activities.1,2 It has antiviral activity against HIV in SupT1 cells (IC50 = 19.2 μM).1 Stachybotrysin B is cytotoxic to K562, HeLa, and HL-60 cells (IC50s = 21.72, 39.63, and 18.5 μM, respectively).2 |1. Zhao, J., Feng, J., Tan, Z., et al. Stachybotrysins A-G, phenylspirodrimane derivatives from the fungus Stachybotrys chartarum. J. Nat. Prod. 80(6), 1819-1826 (2017).|2. Ma, X.-h., Zhen... | |||
T38243 |
Hygrolidin
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Others; ADC Cytotoxin | Antibody-drug Conjugate/ADC Related; Others |
Hygrolidin is a macrocyclic lactone originally isolated from S. hygroscopicus. It inhibits proliferation of a variety of cancer cell lines, including DLD-1 colon cancer, LNCaP prostate cancer, and K562 leukemia cells (IC50s = 2.9, 5.2, and 33 ng/ml, respectively). Hygrolidin induces the expression and levels of p21 in DLD-1 cells, but not WI-38 fibroblasts, and leads to cell accumulation in the G1 and S phases without inducing apoptosis. It has antiparasitic activity against T. cruzi, L. donovan... | |||
T37008 |
Reveromycin A
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Others | Others |
Reveromycin A is the major component of a complex of spiroketal antibiotics isolated from Streptomyces sp. It inhibits the mitogenic activity of epidermal growth factor in Balb/MK cells (IC50 = 0.7 μg/ml), displays antiproliferative activity against human KB and K562 tumor cell lines (IC50s = 1.9 and 1.6 μg/ml, respectively), and demonstrates antifungal activity against C. albicans (MIC = 2 μg/ml at pH 3). Reveromycin A also has been shown to inhibit bone resorption by inducing apoptosis in oste... | |||
T1507 |
Streptozocin
STZ,Streptozotocin,链脲佐菌素,NSC-85998,链脲菌素,U 9889 |
DNA Alkylator/Crosslinker; DNA Alkylation; DNA/RNA Synthesis; Antibacterial; Antibiotic; Autophagy | Autophagy; Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Microbiology/Virology |
Streptozocin (NSC-85998) 是一种抗生素,可诱导 DNA 甲基化。Streptozocin 对产生胰岛素的胰岛 B 细胞具有毒性,常用于构建 1 型糖尿病的动物模型。该产品在溶液中不稳定,建议现配现用。 | |||
TN2646 |
16-Hydroxycleroda-3,13-dien-15,16-olide
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Autophagy | Autophagy |
16-Hydroxycleroda-3,13-dien-15,16-olide, and prodigiosin are presented as candidates for autophagy inducers that can trigger cell death in a supplement or alternative medicine for cancer therapy. 16-Hydroxycleroda-3,13-dien-15,16-olide regulates the expre |
Cat. No. | Product Name | Target | Signaling Pathways |
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TMIH-0236 |
Fingolimod-d4 HCl
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Fingolimod-d4 HCl 是 Fingolimod HCl 的氘代化合物。Fingolimod HCl 的 CAS 号为 162359-56-0。Fingolimod hydrochloride 是一种新型免疫调节剂,是一种 1-磷酸鞘氨醇 (S1P) 拮抗剂,作用于 K562 和 NK 细胞,IC50为 0.033 nM。它诱导 S1P1 的内化,从而抑制 S1P 活性。它被鞘氨醇激酶磷酸化,尤其是被 SK2 磷酸化,从而可与 S1PR1、3、4 和 5 结合 |