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Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T8936 |
Proteinase K
proteinase K for tritirachium album,Protease K,蛋白酶 K |
Others | Others |
Proteinase K (proteinase K for tritirachium album) 是一种非特异性丝氨酸蛋白酶,可用于蛋白消化。它在有 SDS 或尿素存在的情况下,在很大 pH 值 (4-12)、盐浓度和温度单位内均有活性。 | |||
T21254 |
Vonoprazan Fumarate
TAK-438,TAK 438,Vonoprazan Fumurate,TAK438,富马酸沃诺拉赞 |
Proton pump | Membrane transporter/Ion channel |
Vonoprazan Fumarate (TAK438) 是质子泵的有效抑制剂,是口服有效的高效钾竞争性酸阻断剂,具有抗分泌活性。在 pH 为 6.5 时,它抑制猪胃微粒体中的 H+,K+-ATPase 酶活性,IC50为 19 nM。它被开发用于研究酸相关疾病,如消化性溃疡和胃食管反流病。 | |||
T14366 |
AZ10606120 dihydrochloride
|
P2X Receptor | Membrane transporter/Ion channel; Neuroscience |
AZ10606120 dihydrochloride 是一种可选择的、有效的、高亲和力的受体拮抗剂,在人和大鼠 P2X 7 受体上的 K D 值分别为 1.4 和 19 nM。AZ10606120 dihydrochloride 抑制肿瘤生长,具有抗血管生成活性 。AZ 10606120在与 ATP 结合位点偶联的位点结合时充当负变构调节剂。 | |||
T8388 |
Vonoprazan
TAK-438 (free base),沃诺拉赞 |
Proton pump | Membrane transporter/Ion channel |
Vonoprazan (TAK-438 (free base)) 是一种质子泵抑制剂,是口服活性钾竞争性酸阻断剂,有抗分泌作用。在 pH 为 6.5 时,它抑制猪胃微粒体中的 H+,K+-ATPase 酶活性,IC50值为 19 nM。它可用于研究胃酸相关疾病。 | |||
T2404 |
Vonoprazan fumarate
富马酸沃诺拉赞,TAK-438 |
ATPase | Membrane transporter/Ion channel |
Vonoprazan fumarate (TAK-438) 是一种新型 P-CAB(钾竞争性酸阻滞剂),可可逆地抑制 H+/K+、ATP 酶。 | |||
T0825 |
Ebselen
SPI-1005,PZ-51,依布硒,CCG-39161 |
Phosphatase; Virus Protease; Calcium Channel; COX; HIV Protease | Immunology/Inflammation; Membrane transporter/Ion channel; Metabolism; Microbiology/Virology; Neuroscience; Proteases/Proteasome |
Ebselen (CCG-39161) 是一种谷胱甘肽过氧化物酶模拟物,是电压依赖性钙通道阻断剂。它抑制Mpro 和COVID-19病毒,是HIV-1衣壳 CTD 二聚化的抑制剂,具有抗炎、抗癌和抗氧化活性。 | |||
T72330 |
Antibacterial agent 19
|
Others | Others |
Antibacterial agent 19 是一种有效的抗菌剂。Antibacterial agent 19 对K. pneumoniae,(M-R)S. aureus 和 (M-R,V-R)S. aureus 具有抗菌活性, 其 MIC 值为 0.022, 0.022 和 0.045 mg/mL。 | |||
T61491 |
(R)-ND-336
|
Others | Others |
(R)-ND-336 is a highly potent and selective MMP-9 inhibitor, displaying a K i value of 19 nM. It also exhibits inhibitory activity against MMP-2 (K i = 127 nM) and MMP-14 (K i =119 nM). With its significant potential, (R)-ND-336 is being investigated in the field of diabetic foot ulcers (DFUs) research [1]. | |||
T40893 |
Estrogen receptor modulator 6
|
Others | Others |
Estrogen receptor modulator 6 (compound 3a) is a highly specific and potent agonist of the estrogen receptor (ER) β with a remarkable affinity (K i = 0.44 nM). This compound exhibits an impressive 19-fold selectivity for ERβ over ERα, as evidenced by its affinity (K i = 8.4 nM). | |||
T79648 |
CDK2-IN-19
|
CDK | Cell Cycle/Checkpoint |
CDK2-IN-19 (Compound 32)为一种口服活性的选择性CDK2抑制剂(Ki:0.18 nM),在带OVCAR3肿瘤的小鼠模型中表现出显著的抗癌效果。 | |||
T79325 |
5-HT6 agonist 1
|
5-HT Receptor | GPCR/G Protein; Neuroscience |
5-HT6 agonist 1 (Compound 19)为一种5-HT6激动剂 (Ki: 5 nM),展现出抗抑郁样特性并能改善认知缺陷,同时能抑制血小板聚集,具备高代谢稳定性。 | |||
T73372 |
GNE-2256
|
Others | Others |
GNE-2256 (molecule 19) 是一种具有口服活性的IRAK4(白介素 1 受体关联激酶 4) 抑制剂 (IRAK4Ki=1.4 nM ; IL-6IC50=190 nM)。 | |||
T79373 |
A3AR agonist 2
|
Adenosine Receptor | GPCR/G Protein; Neuroscience |
A3AR agonist 2 (Compound 19) 是高选择性A3AR激动剂,Ki为22.1 nM。本化合物有效促进β-arrestin2募集,展现出EC50为4.36 nM。A3AR agonist 2 主要用于研究炎症性疾病、缺血、癌症、神经性疼痛、肝脏病以及其他慢性病态。 | |||
T7492 |
Ripasudil free base
K-115 (free base) |
ROCK; Antibacterial | Cell Cycle/Checkpoint; Cytoskeletal Signaling; Microbiology/Virology; Stem Cells |
Ripasudil free base (K-115 (free base)) 是一种ROCK 特异性抑制剂,能够抑制ROCK1和ROCK2的活性,IC50值分别为 51 和 19 nM。 | |||
T61643 |
Vonoprazan hydrochloride
|
Others | Others |
Vonoprazan hydrochloride 是一种高效且具口服活性的质子泵抑制剂 (PPI) 和钾竞争性酸阻断剂 (potassium-competitive acid blocker, P-CAB),展示出优秀的抗分泌活性。在 pH 为 6.5 的条件下,该化合物可抑制猪胃微粒体内 H+,K+-ATPase 的酶活性,呈现出 19 nM 的 IC50 值。Vonoprazan hydrochloride 主要应用于胃酸相关疾病的研究,包括胃食管反流病和消化性溃疡,并可用于根除幽门螺杆菌。 | |||
T9686 |
YH-53
|
Others | Others |
YH-53 是一种有效的3CLpro 抑制剂,对 SARS-CoV-1 3CLpro 和 SARS-CoV-2 3CLpro 的Ki 值分别为 6.3 nM、34.7 nM。YH-53 能够有效阻断 SARS-CoV-2 复制。YH-53 是一种具有独特苯并噻唑基酮的拟肽化合物。YH-53 具有用于研究新冠病毒的潜力。 | |||
T37285 |
1-thio-β-D-Glucose Tetraacetate
|
Others | Others |
1-thio-β-D-Glucose tetraacetate is a building block.1,2It has been used in the synthesis of aromatic glucosinolates with anti-inflammatory activity, as well as glucosylated poly(pentafluorostyrene) derivatives for coating magnetic iron oxide nanoparticles. 1.Vo, Q.V., Trenerry, C., Rochfort, S., et al.Synthesis and anti-inflammatory activity of aromatic glucosinolatesBioorg. Med. Chem.21(19)5945-5954(2013) 2.Babiuch, K., Wyrwa, R., Wagner, K., et al.Functionalized, biocompatible coating for supe... | |||
T38385 |
IT-143B
|
Others | Others |
IT-143B is a bacterial metabolite that has been found in S. iakyrus.1 It inhibits the proliferation of OS-RC-2 and ACHN cancer cells (IC50s = 22 and 98 μM, respectively). |1. Li, K., Liang, Z., Chen, W., et al. Iakyricidins A-D, antiproliferative piericidin analogues bearing a carbonyl group or cyclic skeleton from Streptomyces iakyrus SCSIO NS104. J. Org. Chem. 84(19), 12626-12631 (2019). | |||
T36999 |
7(S),17(S)-dihydroxy-8(E),10(Z),13(Z),15(E),19(Z)-Docosapentaenoic Acid
|
Others | Others |
Novel oxylipins, referred to as docosanoids, have been derived from C22polyunsaturated fatty acids 7(S),17(S)-dihydroxy-8(E),10(Z),13(Z),15(E),19(Z)-Docosapentaenoic acid (7(S),17(S)-hydroxy DPA) is a DPA-derived analog of the 17(S)-dihydroxy series of docosanoids known as protectins. Protectin D1, a DHA-derived dihydroxy fatty acid, exhibits potent anti-inflammatory activities.1,2,3Potentially, 7(S),17(S)-hydroxy DPA demonstrates similar properties; however, its biological activity has yet to b... | |||
T35533 |
6-Hydroxypyridin-3-ylboronic Acid
|
Others | Others |
6-Hydroxypyridin-3-ylboronic acid is a heterocyclic building block.1,2It has been used in the synthesis of non-nucleoside inhibitors of hepatitis C virus (HCV) RNA-dependent RNA polymerase nonstructural protein 5B (NS5B).16-Hydroxypyridin-3-ylboronic acid has also been used in the synthesis of mammalian target of rapamycin (mTOR) inhibitors.2 1.Hendricks, R.T., Spencer, S.R., Blake, J.F., et al.3-Hydroxyisoquinolines as inhibitors of HCV NS5b RNA-dependent RNA polymeraseBioorg. Med. Chem. Lett.1... | |||
T37065 |
6-Chloro-2-fluoropurine
|
Others | Others |
6-Chloro-2-fluoropurine is a heterocyclic building block.1,2It has been used in the synthesis of purine nucleosides that inhibit cyclin-dependent kinases (CDKs)in vitro.16-Chloro-2-fluoropurine has also been used in the synthesis of purine nucleosides that are active against HIV-1 and hepatitis B virus (HBV)in vitro.2 1.Wilson, S.C., Atrash, B., Barlow, C., et al.Design, synthesis and biological evaluation of 6-pyridylmethylaminopurines as CDK inhibitorsBioorg. Med. Chem.19(22)6949-6965(2011) 2.... | |||
T36722 |
Deltorphin II (trifluoroacetate salt)
|
Others | Others |
Deltorphin II is a peptide agonist of δ2-opioid receptors.1,2It is selective for δ-opioid receptors over μ- and κ-opioid receptors in radioligand bindings assays (Kis = 0.0033, >1, and >1 μM, respectively) and induces [35S]GTPγS binding in mouse brain membrane preparations (EC50= 0.034 μM). Deltorphin II (0.12 mg/kg) decreases the infarction zone:risk zone ratio in a rat model of myocardial ischemia-reperfusion injury induced by coronary occlusion, an effect that can be reversed by the δ2-opioid... |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T35609 |
19-O-Acetylchaetoglobosin A
|
Others | Others |
19-O-Acetylchaetoglobosin A is a fungal metabolite originally isolated fromC. globosumthat has actin polymerization inhibitory and cytotoxic activities.1,2It inhibits actin polymerization in a cell-free assay when used at a concentration of 2 μM.219-O-Acetylchaetoglobosin A (3.2, 10, and 32 μg/ml) is cytotoxic to HeLa cervical cancer cells.1 1.Umeda, M., Ohtsubo, K., Saito, M., et al.Cytotoxicity of new cytochalasans from Chaetomium globosumExperientia31(4)435-438(1975) 2.Sekita, S., Yoshihira, ... | |||
T38069 |
Aquastatin A
|
Others | Others |
Aquastatin A is a fungal metabolite originally isolated fromF. aquaeductuumthat has diverse biological activities.1It is active againstS. aureus(MIC = 32 μg/ml) and inhibits enoyl-acyl carrier protein reductase (Fabl; IC50= 3.2 μM) andS. aureusfatty acid synthesis (IC50= 3.5 μM).2Aquastatin A also inhibits the Na+/K+-ATPase and H+/K+-ATPase (IC50s = 7.1 and 6.2 μM, respectively), as well as protein tyrosine phosphatase 1B (PTP1B; IC50= 0.19 μM).1,3 1.Hamano, K., Kinoshita-Okami, M., Minagawa, K.... |
Cat. No. | Product Name | Species | Expression System |
---|---|---|---|
TMPK-00687 |
keratin, type I cytoskeletal 19 (310-399) Protein, Canine, Recombinant (His)
KRT19,CK-19,K |
Canine | E. coli |
Keratin 19 (K19) belongs to the keratin family of proteins, which maintains structural integrity of epithelia. In cancer, K19 is highly expressed in several types where it serves as a diagnostic marker. |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
TMIH-0601 |
Vonoprazan-d3
|
||
Vonoprazan-d3 是 Vonoprazan 的氘代化合物。Vonoprazan 的 CAS 号为 881681-00-1。Vonoprazan 是一种质子泵抑制剂,是口服活性钾竞争性酸阻断剂,有抗分泌作用。在 pH 为 6.5 时,它抑制猪胃微粒体中的 H+,K+-ATPase 酶活性,IC50值为 19 nM。它可用于研究胃酸相关疾病。 | |||
TMIH-0602 |
Vonoprazan-d4
|
||
Vonoprazan-d4 是 Vonoprazan 的氘代化合物。Vonoprazan 的 CAS 号为 881681-00-1。Vonoprazan 是一种质子泵抑制剂,是口服活性钾竞争性酸阻断剂,有抗分泌作用。在 pH 为 6.5 时,它抑制猪胃微粒体中的 H+,K+-ATPase 酶活性,IC50值为 19 nM。它可用于研究胃酸相关疾病。 | |||
T35591 |
Guanfacine-13C,15N3
Guanfacine-13C,15N3 |
||
Guanfacine-13C,15N3is intended for us as an internal standard for the quantification of guanfacine by GC- or LC-MS. Guanfacine is an α2-adrenergic receptor (α2-AR) agonist with Kivalues of 93, 1,380, and 3,890 nM for α2A-, α2B-, and α2C-ARs, respectively, in a radioligand binding assay.1It has EC50values of 52, 288, and 602 nM for α2A-, α2B-, and α2C-ARs, respectively, for stimulated [35S]GTPγS binding. It also binds to imidazoline receptor 1 (Ki= 19 nM in a radioligand binding assay).2Guanfacin... | |||
T36055 |
Nitisinone-13C6
Nitisinone-13C6 |
||
Nitisinone-13C6is intended for use as an internal standard for the quantification of nitisinone by GC- or LC-MS. Nitisinone is an inhibitor of 4-hydroxyphenylpyruvate dioxygenase (HPPD), which converts 4-hydroxyphenylpyruvate (HPPA) to homogentisate in the tyrosine catabolic pathway.1Nitisinone increases urinary levels of HPPA and 4-hydroxyphenyllactate (HPLA) in rats when administered at a dose of 10 mg/kg. Nitisinone (3 mg/kg) prevents the neonatal lethality of fumarylacetoacetate hydrolase (F... |