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Search Results for " k -atpase "

Targets Recommended: Others

89

抑制剂 & 化合物

27

天然产物

6

重组蛋白

6

同位素标记化合物

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Cat. No.	Product Name	Target	Signaling Pathways
T9553	K-transporting ATPase α chain 1 Inhibitor 1	Others	Others
	8-[(2,6-dimethylbenzyl)amino]-2,3-dimethylimidazo[1,2-a]pyridine-6-car 是一种 H+/K+ ATPase 抑制剂，IC50=0.38μM。
T0712	Suloctidil	ATPase; Platelet aggregation	Membrane transporter/Ion channel; Others
	Suloctidil 是一种外周血管扩张剂，作用于大鼠脑突触, 影响Na+/ K+ ATP 酶活性和膜流动性，可治疗痴呆和血栓形成病症。
T6443	Chloroprocaine hydrochloride 盐酸氯普鲁卡因,Chloroprocaine HCl	ATPase; Others	Membrane transporter/Ion channel; Others
	Chloroprocaine hydrochloride (Chloroprocaine HCl) 是一种 Na/K-ATPase 活性抑制剂，IC50为 13 mM，可阻断外周神经。
T20626	Esomeprazole	Proton pump; Cysteine Protease	Membrane transporter/Ion channel; Proteases/Proteasome
	Esomeprazole 是奥美拉唑(omeprazole) 的S-异构体，抑制溶酶体半胱氨酸蛋白酶legumain，防止癌症转移。它是一种质子泵抑制剂（PPI）。
T0490	Chlorpropamide Diabinese,氯磺丙脲	ATPase; ABC	Membrane transporter/Ion channel
	Chlorpropamide (Diabinese) 是口服降糖剂，可用于研究非胰岛素依赖型糖尿病。
T6953	Prilocaine Citanest,丙胺卡因,Propitocaine,NSC 40027	ATPase; Sodium Channel	Membrane transporter/Ion channel
	Prilocaine (NSC-40027) 是一种氨基酰胺类局部麻醉剂，作用于神经元膜上的钠通道并限制癫痫发作的扩散。它是Na/K-ATPase 抑制剂，具有神经毒性作用。
T0796	Prilocaine hydrochloride Prilocaine HCl,Propitocaine hydrochloride,Xylonest,盐酸丙胺卡因	ATPase; Sodium Channel	Membrane transporter/Ion channel
	Prilocaine hydrochloride (Prilocaine HCl) 是一种氨基酰胺类局部麻醉剂，作用于神经元膜上的钠通道并限制癫痫发作的扩散。它是Na/K-ATPase 抑制剂，具有神经毒性作用。
T2176	2,3-Butanedione 2-Monoxime Diacetyl monoxime,2,3-Butanedione-2-monoxime	Akt	Cytoskeletal Signaling; PI3K/Akt/mTOR signaling
	2,3-Butanedione 2-Monoxime (Diacetyl monoxime) 是一种肌球蛋白 ATP 酶(myosin ATPase) 抑制剂。它诱导肌质网 Ca2+释放，能够有效抑制骨骼肌和心肌收缩。
T2621	Rostafuroxin PST 2238	ATPase; RSV	Membrane transporter/Ion channel; Microbiology/Virology
	Rostafuroxin (PST 2238) 是洋地黄毒苷衍生物，是一种口服有效的 Na+,K+-ATPase 抑制剂，具有抗高血压和抗 RSV 活性，用于研究治疗原发性高血压的试验。
T2686L	Esomeprazole Sodium 埃索美拉唑钠,(S)-Omeprazole sodium	ATPase; Proton pump	Membrane transporter/Ion channel
	Esomeprazole Sodium ((S)-Omeprazole sodium) 是一种口服有效的活性质子泵抑制剂。Esomeprazole sodium 通过抑制胃壁细胞中的 H+, K+-ATPase 来降低酸分泌，在胃食管反流疾病中有研究价值。Esomeprazole 是一种外泌体抑制剂，通过抑制 V-H+-ATPases 来阻断外泌体的释放。
T2686	Esomeprazole Magnesium (S)-Omeprazole magnesium,NEXIUM,埃索美拉唑镁,(-)-Omeprazole magnesium	ATPase; Proton pump	Membrane transporter/Ion channel
	Esomeprazole Magnesium (NEXIUM) 是一种口服有效的 H+, K+-ATPase 抑制剂，在上消化道疾病和胃食管反流疾病中具有研究价值。Esomeprazole magnesium 是一种外泌体抑制剂，通过抑制 V-H+-ATPases 来阻断外泌体的释放。
T6928	Pantoprazole SKF96022,泮托拉唑,BY1023	Apoptosis; Proton pump; Autophagy	Apoptosis; Autophagy; Membrane transporter/Ion channel
	Pantoprazole (BY1023) 是一种质子泵抑制剂，用于短期治疗由胃食管反流病引起的食管糜烂和溃疡。它联合阿霉素可显著增加肿瘤生长延迟。它是一种取代的苯并咪唑，是H+/K+-ATPase 抑制剂，可改善 pH 值稳定性，具有抗分泌和抗溃疡的作用。
T8386	Esomeprazole Magnesium trihydrate 埃索美拉唑镁三水合物,埃索美拉唑镁(三水),(S)-Omeprazole magnesium trihydrate	Proton pump	Membrane transporter/Ion channel
	Esomeprazole Magnesium trihydrate ((S)-Omeprazole magnesium trihydrate) 是一种口服有效的H+, K+-ATPase 抑制剂，在上消化道疾病和胃食管反流疾病的研究中具有价值。它是一种外泌体抑制剂，通过抑制 V-H+-ATPases 来阻断外泌体的释放。
T0161	Pantoprazole Sodium Hydrate SKF96022 sodium hydrate,泮托拉唑钠水合物,BY1023 (sodium hydrate),SKF96022 (sodium hydrate)	Apoptosis; Potassium Channel; Proton pump; Autophagy	Apoptosis; Autophagy; Membrane transporter/Ion channel
	Pantoprazole Sodium Hydrate (BY1023 (sodium hydrate)) 是一种具有口服活性的质子泵抑制剂。它是取代的苯并咪唑，是H+/K+-ATPase 抑制剂。它可改善 pH 值稳定性，具有抗分泌和抗溃疡的作用。它联合阿霉素可显著增加肿瘤生长延迟。
T6929	Pantoprazole sodium Pantecta,泮托拉唑钠盐,SKF96022 sodium,SKF96022 (sodium),BY1023 (sodium),泮托拉唑钠,BY-1023 sodium,Pantoloc	Apoptosis; Others; Proton pump; HIF; Autophagy	Angiogenesis; Apoptosis; Autophagy; Chromatin/Epigenetic; Membrane transporter/Ion channel; Others
	Pantoprazole sodium (Pantecta) 是一种具有口服活性的质子泵抑制剂，是一种取代的苯并咪唑，是H+/K+-ATPase 抑制剂，IC50为 6.8 μM。它可以改善 pH 值稳定性，具有抗分泌和抗溃疡的作用。它联合阿霉素可显著增加肿瘤生长延迟。
T27812	Leminoprazole	ATPase	Membrane transporter/Ion channel
	Leminoprazole 是一种可口服的 H+，K（+）-ATPase 抑制剂，可保护胃黏膜细胞免受各种细胞损伤，可用于治疗胃溃疡。
T2404	Vonoprazan fumarate 富马酸沃诺拉赞,TAK-438	ATPase	Membrane transporter/Ion channel
	Vonoprazan fumarate (TAK-438) 是一种新型 P-CAB（钾竞争性酸阻滞剂），可可逆地抑制 H+/K+、ATP 酶。
T17030	Tegoprazan	ATPase; Proton pump	Membrane transporter/Ion channel
	Tegoprazan 是一种口服有效的、高选择性胃 H+/K+-ATP 酶 (H+/K+-ATPase) 抑制剂，能够控制胃酸分泌和运动，在体外检测的对猪、犬、人的 H+/K+-ATP 酶的 IC50为0.29-0.52 μM。
T21254	Vonoprazan Fumarate TAK-438,TAK 438,Vonoprazan Fumurate,TAK438,富马酸沃诺拉赞	Proton pump	Membrane transporter/Ion channel
	Vonoprazan Fumarate (TAK438) 是质子泵的有效抑制剂，是口服有效的高效钾竞争性酸阻断剂，具有抗分泌活性。在 pH 为 6.5 时，它抑制猪胃微粒体中的 H+,K+-ATPase 酶活性，IC50为 19 nM。它被开发用于研究酸相关疾病，如消化性溃疡和胃食管反流病。
T16865	SCH28080	ATPase; Proton pump	Membrane transporter/Ion channel
	SCH28080 是一种可逆且具有 K+ 竞争性的胃 H+/K+-ATP 酶 (H+/K+-ATPase) 抑制剂，IC50 值为 20 nM (家兔微粒体膜)。SCH28080 在体内是有效的酸分泌抑制剂，具有抗溃疡活性、抗分泌和细胞保护活性。
T2189	Sodium orthovanadate Sodium vanadate,钒酸钠,Trisodium vanadate,Sodium pervanadate	ATPase; Phosphatase	Membrane transporter/Ion channel; Metabolism
	Sodium orthovanadate 是一种蛋白酪氨酸磷酸酶，碱性磷酸酶和一些ATP 酶的抑制剂，有可能充当磷酸盐类似物。它具有胰岛素样作用、对心室肌的正性肌力作用和其他代谢作用。
T10435	Linaprazan 利那拉生,AZD0865	Potassium Channel	Membrane transporter/Ion channel
	Linaprazan (AZD0865) 通过K+竞争抑制胃中的H+,K+ -ATPase. (IC 50: 1.0 ± 0.2 μM)。Linaprazan 对酸有很强的抑制作用。
T28136	NC-1300-B NC1300B,NC 1300 B	ATPase	Membrane transporter/Ion channel
	NC-1300-B 抑制 H（+）-K（+）-ATP 酶，可用于研究胃溃疡。
T19826	Rabeprazole LY307640	Potassium Channel; STAT	JAK/STAT signaling; Membrane transporter/Ion channel; Stem Cells
	Rabeprazole (LY307640) 是一种 H+/K+-ATPase 抑制剂，通过靶向 STAT3 介导的糖酵解来抑制胃上皮细胞中的细胞增殖，可用于研究胃溃疡。
T1651	Rabeprazole sodium Dexrabeprazole Sodium,LY307640 sodium,Habeprazole Sodium,雷贝拉唑钠,Rebeprazole sodium,Aciphex Sodium	Apoptosis; Proton pump	Apoptosis; Membrane transporter/Ion channel
	Rabeprazole sodium (Habeprazole Sodium) 是一种质子泵抑制剂，不可逆地抑制胃 H+/K+-ATPase，可研究胃溃疡和胃食管反流。它诱导细胞凋亡，也抑制尿苷核苷核糖水解酶，IC50为 0.3 μM。
T20714	Levolansoprazole 左旋兰索拉唑,(S)-Lansoprazole,(-)-Lansoprazole	Proton pump	Membrane transporter/Ion channel
	Levolansoprazole ((S)-Lansoprazole) 是一种质子泵抑制剂，不可逆地抑制壁细胞中 H+/K+ 刺激的 ATPase 泵 (IC50: 5.2 µM)。它还抑制分离的犬壁细胞中的酸形成(IC50：82 µM)。 (R)-和 (S)-兰索拉唑均具有药理活性，具有相似的效力。
TP1033L	Transdermal Peptide Disulfide Acetate TD 1 (peptide) acetate,Transdermal Peptide Disulfide Acetate (888486-23-5 free base)	ATPase	Membrane transporter/Ion channel
	Transdermal Peptide acetate(888486-23-5 free base) (TD 1 (peptide) acetate) 是一种 11 个氨基酸的肽，与 Na+/K+-ATPase β 亚基 (ATP1B1) 结合，主要与 ATP1B1 的 C 端相互作用。透皮肽可以增强许多大分子的透皮传递。透皮肽 TD 1 酰胺是一种新型肽，旨在增强透皮药物传递。
T14052	5-IAF 5-Iodoacetamidofluorescein
	5-IAF 是吲哚乙酰胺的一种荧光素衍生物，是一种荧光探针，可用来标记蛋白质和其他含有游离硫醇（半胱氨酸侧链）。5-IAF 可标记狗肾脏Na,K-ATP 酶的催化（α）亚单位。
T0674	Lansoprazole 兰索拉唑,A-65006,AG-1749	Proton pump; Phospholipase; Antibacterial	Membrane transporter/Ion channel; Metabolism; Microbiology/Virology
	Lansoprazole (A-65006) 是一种可抑制胃酸生成的质子泵抑制剂。它是中性鞘磷脂酶的外泌体抑制剂。
T10221	Abeprazan hydrochloride DWP14012 hydrochloride,Fexuprazan hydrochloride	Proton pump	Membrane transporter/Ion channel
	Abeprazan hydrochloride (Fexuprazan hydrochloride) 是一种有效的、可逆的、具有口服活性的potassium-competitive acid 阻滞剂，通过竞争性的与钾离子结合抑制 H+，K+- ATPase，而无需酸激活。Abeprazan hydrochloride 是一种质子泵抑制剂(PPI)，通过减少胃酸的产生而起作用，可用于治疗胃酸相关疾病，如胃食管反流病(GERD)和消化性溃疡。
T8388	Vonoprazan TAK-438 (free base),沃诺拉赞	Proton pump	Membrane transporter/Ion channel
	Vonoprazan (TAK-438 (free base)) 是一种质子泵抑制剂，是口服活性钾竞争性酸阻断剂，有抗分泌作用。在 pH 为 6.5 时，它抑制猪胃微粒体中的 H+,K+-ATPase 酶活性，IC50值为 19 nM。它可用于研究胃酸相关疾病。
T1756L	Ilaprazole IY81149,艾普拉唑,IY 81149,IY-81149	Proton pump; TOPK	MAPK; Membrane transporter/Ion channel
	Ilaprazole (IY-81149) 是一种具有口服活性质子泵抑制剂，以剂量依赖性方式不可逆地抑制H+/K+-ATPase，在兔壁细胞制剂中的IC50为 6 μM。它也是一种有效的T 细胞起源蛋白激酶(TOPK)抑制剂，用于胃溃疡的研究。
T1756	Ilaprazole sodium IY-81149 sodium,艾普拉唑钠	Proton pump; TOPK	MAPK; Membrane transporter/Ion channel
	Ilaprazole sodium (IY-81149 sodium) 是一种具有口服活性质子泵抑制剂，以剂量依赖性方式不可逆地抑制 H+/K+-ATPase，在兔壁细胞制剂中的 IC50为 6 μM。它也是一种有效的 T 细胞起源蛋白激酶(TOPK)抑制剂，用于胃溃疡的研究。
T0825	Ebselen SPI-1005,PZ-51,依布硒,CCG-39161	Phosphatase; Virus Protease; Calcium Channel; COX; HIV Protease	Immunology/Inflammation; Membrane transporter/Ion channel; Metabolism; Microbiology/Virology; Neuroscience; Proteases/Proteasome
	Ebselen (CCG-39161) 是一种谷胱甘肽过氧化物酶模拟物，是电压依赖性钙通道阻断剂。它抑制Mpro 和COVID-19病毒，是HIV-1衣壳 CTD 二聚化的抑制剂，具有抗炎、抗癌和抗氧化活性。
T1734	Rabeprazole Sulfide 雷贝拉唑相关物质E,Rabeprazole Related Compound E	Proton pump; Antibacterial	Membrane transporter/Ion channel; Microbiology/Virology
	Rabeprazole Sulfide (Rabeprazole Related Compound E) 是 Rabeprazole 的活性代谢产物。Rabeprazole 是一种质子泵抑制剂类的抗溃疡药物，有效抑制幽门螺旋杆菌的活性，可通过与胃壁细胞中的(H+/K+)-ATPase 相互作用来抑制胃酸分泌，可研究各种消化系统疾病。
T2093	PF 03716556 PF-3716556	ATPase	Membrane transporter/Ion channel
	PF 03716556 (PF-3716556) 是一种有效且特异性的 P-CAB（钾竞争性酸阻滞剂），用于治疗胃食管反流病。
T15599	Istaroxime hydrochloride PST2744 hydrochloride	Others	Others
	Istaroxime hydrochloride is an inhibitor of Na+/K+-ATPase (IC50: 0.11 μM). It also is a sarcoplasmic/endoplasmic reticulum calcium ATPase 2 (SERCA 2) activator.
T15600	Istaroxime PST2744	Others	Others
	Istaroxime is an effective inhibitor of Na+, K+-ATPase (IC50: 0.11 μM).
T12471	Picoprazole	Others	Others
	Picoprazole is a specific H+/K+-ATPase inhibitor (IC50 of 3.1±0.4 μM).
T12822	S3337	Others	Others
	S3337 is an inhibitor of H+, K+-ATPase
T16894	SKF96067	Others	Others
	SKF96067 is a reversible gastric H+/K+-ATPase inhibitor.
T12977	Soraprazan BYK61359	Others	Others
	Soraprazan is a reversible, and fast-acting gastric H+/K+ ATPase inhibitor.
T35923	Caloxin 2A1 TFA
	Caloxin 2A1 TFA is a peptide inhibitor specifically targeting the extracellular plasma membrane Ca2+-ATPase (PMCA), without influencing the basal activities of Mg2+-ATPase or Na+-K+-ATPase[1].
T23685	AHR-9294	Others	Others
	AHR-9294 is a novel inhibitor of H, K-ATPase. It also antagonizes gastric HCl secretion in vivo.
T76374	SPAI-1
	SPAI-1，特异性单价阳离子ATP酶抑制剂，源自猪十二指肠。能体外抑制Na+，K+-ATP酶和H+，K+-ATP酶，同时刺激Mg2+-ATP酶。
T30250	AZD0865 AZD-0865,AZD 0865	Others	Others
	AZD0865 is an effective drug that inhibits gastric H(+), K(+) -ATPase activity and acid formation in vitro, with rapid onset.
T68916	ASI-254	Others	Others
	ASI-254 is an aminosugar cardiac glycoside and an inhibitor of Na+,K+ -ATPase.
T78564	Depramine GP 31406	Others	Others
	Depramine (GP 31406) 是三环抗抑郁剂，具药理活性。该化合物可抑制乙酰胆碱酯酶、Mg2+-ATPase 与 Na+/K+ ATPase 活性。
T69801	AU-461	Others	Others
	AU-461 is a gastric H(+)/K(+) ATPase inhibitor which acts as an anti-ulcer agent.
T36060	Digoxigenin Monodigitoxoside	Others	Others
	Digoxigenin monodigitoxoside是地高辛的一种Na+/K+ ATPase 抑制剂和强心苷代谢物。

化合物

K-transporting ATPase α chain 1 Inhibitor 1

Cat.No: T9553

Target: Others

Cat.No: T0712

Target: ATPase, Platelet aggregation

Chloroprocaine hydrochloride

Cat.No: T6443

Synonym: 盐酸氯普鲁卡因,Chloroprocaine HCl

Target: ATPase, Others

Cat.No: T20626

Target: Proton pump, Cysteine Protease

Cat.No: T0490

Synonym: Diabinese,氯磺丙脲

Target: ATPase, ABC

Cat.No: T6953

Synonym: Citanest,丙胺卡因,Propitocaine,NSC 40027

Target: ATPase, Sodium Channel

Prilocaine hydrochloride

Cat.No: T0796

Synonym: Prilocaine HCl,Propitocaine hydrochloride,Xylonest,盐酸丙胺卡因

Target: ATPase, Sodium Channel

2,3-Butanedione 2-Monoxime

Cat.No: T2176

Synonym: Diacetyl monoxime,2,3-Butanedione-2-monoxime

Target: Akt

Cat.No: T2621

Synonym: PST 2238

Target: ATPase, RSV

Esomeprazole Sodium

Cat.No: T2686L

Synonym: 埃索美拉唑钠,(S)-Omeprazole sodium

Target: ATPase, Proton pump

Esomeprazole Magnesium

Cat.No: T2686

Synonym: (S)-Omeprazole magnesium,NEXIUM,埃索美拉唑镁,(-)-Omeprazole magnesium

Target: ATPase, Proton pump

Cat.No: T6928

Synonym: SKF96022,泮托拉唑,BY1023

Target: Apoptosis, Proton pump, Autophagy

Esomeprazole Magnesium trihydrate

Cat.No: T8386

Synonym: 埃索美拉唑镁三水合物,埃索美拉唑镁(三水),(S)-Omeprazole magnesium trihydrate

Target: Proton pump

Pantoprazole Sodium Hydrate

Cat.No: T0161

Synonym: SKF96022 sodium hydrate,泮托拉唑钠水合物,BY1023 (sodium hydrate),SKF96022 (sodium hydrate)

Target: Apoptosis, Potassium Channel, Proton pump, Autophagy

Pantoprazole sodium

Cat.No: T6929

Synonym: Pantecta,泮托拉唑钠盐,SKF96022 sodium,SKF96022 (sodium),BY1023 (sodium),泮托拉唑钠,BY-1023 sodium,Pantoloc

Target: Apoptosis, Others, Proton pump, HIF, Autophagy

Cat.No: T27812

Target: ATPase

Vonoprazan fumarate

Cat.No: T2404

Synonym: 富马酸沃诺拉赞,TAK-438

Target: ATPase

Cat.No: T17030

Target: ATPase, Proton pump

Vonoprazan Fumarate

Cat.No: T21254

Synonym: TAK-438,TAK 438,Vonoprazan Fumurate,TAK438,富马酸沃诺拉赞

Target: Proton pump

Cat.No: T16865

Target: ATPase, Proton pump

Sodium orthovanadate

Cat.No: T2189

Synonym: Sodium vanadate,钒酸钠,Trisodium vanadate,Sodium pervanadate

Target: ATPase, Phosphatase

Cat.No: T10435

Synonym: 利那拉生,AZD0865

Target: Potassium Channel

Cat.No: T28136

Synonym: NC1300B,NC 1300 B

Target: ATPase

Cat.No: T19826

Synonym: LY307640

Target: Potassium Channel, STAT

Rabeprazole sodium

Cat.No: T1651

Synonym: Dexrabeprazole Sodium,LY307640 sodium,Habeprazole Sodium,雷贝拉唑钠,Rebeprazole sodium,Aciphex Sodium

Target: Apoptosis, Proton pump

Levolansoprazole

Cat.No: T20714

Synonym: 左旋兰索拉唑,(S)-Lansoprazole,(-)-Lansoprazole

Target: Proton pump

Transdermal Peptide Disulfide Acetate

Cat.No: TP1033L

Synonym: TD 1 (peptide) acetate,Transdermal Peptide Disulfide Acetate (888486-23-5 free base)

Target: ATPase

Cat.No: T14052

Synonym: 5-Iodoacetamidofluorescein

Cat.No: T0674

Synonym: 兰索拉唑,A-65006,AG-1749

Target: Proton pump, Phospholipase, Antibacterial

Abeprazan hydrochloride

Cat.No: T10221

Synonym: DWP14012 hydrochloride,Fexuprazan hydrochloride

Target: Proton pump

Cat.No: T8388

Synonym: TAK-438 (free base),沃诺拉赞

Target: Proton pump

Cat.No: T1756L

Synonym: IY81149,艾普拉唑,IY 81149,IY-81149

Target: Proton pump, TOPK

Ilaprazole sodium

Cat.No: T1756

Synonym: IY-81149 sodium,艾普拉唑钠

Target: Proton pump, TOPK

Cat.No: T0825

Synonym: SPI-1005,PZ-51,依布硒,CCG-39161

Target: Phosphatase, Virus Protease, Calcium Channel, COX, HIV Protease

Rabeprazole Sulfide

Cat.No: T1734

Synonym: 雷贝拉唑相关物质E,Rabeprazole Related Compound E

Target: Proton pump, Antibacterial

Cat.No: T2093

Synonym: PF-3716556

Target: ATPase

Istaroxime hydrochloride

Cat.No: T15599

Synonym: PST2744 hydrochloride

Target: Others

Cat.No: T15600

Synonym: PST2744

Target: Others

Cat.No: T12471

Target: Others

Cat.No: T12822

Target: Others

Cat.No: T16894

Target: Others

Cat.No: T12977

Synonym: BYK61359

Target: Others

Caloxin 2A1 TFA

Cat.No: T35923

Cat.No: T23685

Target: Others

Cat.No: T76374

Cat.No: T30250

Synonym: AZD-0865,AZD 0865

Target: Others

Cat.No: T68916

Target: Others

Cat.No: T78564

Synonym: GP 31406

Target: Others

Cat.No: T69801

Target: Others

Digoxigenin Monodigitoxoside

Cat.No: T36060

Target: Others

Cat. No.	Product Name	Target	Signaling Pathways
T1719	Bufalin	ATPase	Membrane transporter/Ion channel
	Bufalin 是蟾酥中的一种成分，是Na+/K+-ATPase 抑制剂，具有抗肿瘤活性，可与其基 α1、α2 和 α3 结合，Kd 值分别为 42.5、45 和 40 nM。
TJP2872	Acevaltrate Acevaltratum,乙酰缬草三酯,Acetoxyvaltrate	ATPase; Others	Membrane transporter/Ion channel; Others
	Acevaltrate (Acevaltratum) 对人小细胞肺癌细胞系 GLC(4) 和人结肠直肠癌细胞系 COLO 320 具有高细胞毒性，IC50 值为 1-6 uM。它抑制大鼠肾和脑半球中 Na+/K+-ATP 酶活性，IC50分别为 22.8 和 42.3 μM。
T5S0890	Oleandrin Neriostene,Folinerin,Foliandrin,欧夹竹桃苷	Apoptosis; ATPase; Potassium Channel; Sodium Channel	Apoptosis; Membrane transporter/Ion channel
	Oleandrin (Folinerin) 是夹竹桃属中的一种类固醇，可抑制Na+/K+-ATPase 活性，IC50为 620 nM。
TN5073	Strophanthidin 毒毛旋花子甙元,Strophanthidine,葡萄球菌素	ATPase; Calcium Channel	Membrane transporter/Ion channel; Metabolism
	Strophanthidin (Strophanthidine) 是黄花夹竹桃中的一种类固醇，可增加舒张期和收缩期胞内 Ca2+浓度。它在 0.1 和 1 nmol/L 增加Na+/K+-ATPase 活性，1到100 μ mol/L 抑制Na+/K+-ATPase 活性，10 和 100 nmol/L 对Na+/K+-ATPase 活性无影响。
T0295	Digitoxin Digitoxoside,洋地黄毒苷,Unidigin,洋地黄毒甙,Digitoxinum,洋地黄	ATPase; Others	Membrane transporter/Ion channel; Others
	Digitoxin (Digitoxinum) 是Na+/K+-ATPase 有效抑制剂, EC50 值为0.78 μM。
T8183	Deslanoside 洋地黄,去乙酰西地兰,Desacetyllanatoside C,Deacetyllanatoside C	ATPase; Drug Metabolite	Membrane transporter/Ion channel; Metabolism
	Deslanoside (Desacetyllanatoside C) 是一种快速作用的强心苷，可抑制Na-K-ATPase 膜泵，导致细胞内钠和钙浓度增加。它用于研究充血性心力衰竭和因折返机制引起的室上性心律失常，并在研究慢性心房颤动时控制心室率。
T2922	Phlorizin Floridzin,根皮甙,根皮苷,NSC 2833,Phloridzin	ATPase; SGLT	GPCR/G Protein; Membrane transporter/Ion channel
	Phlorizin (Phloridzin) 是非选择性的SGLT 抑制剂，也是Na+/K+-ATPase 抑制剂，对于hSGLT1和hSGLT2的Ki 值分别为 300 和 39 nM。
T2O2668	Oleic acid Elaidoic acid,9Z-Octadecenoic acid,Oleate,9-Octadecenoic Acid,Glycon Wo,9-cis-Octadecenoic acid,油酸	Apoptosis; ATPase; Others; Endogenous Metabolite	Apoptosis; Membrane transporter/Ion channel; Metabolism; Others
	Oleic acid (Glycon Wo) 属于天然产物，是一种常见的不饱和脂肪酸，在存在于多种动物、植物的脂肪和油脂中。Oleic acid 是一种 Na+/K+ATP 酶激活剂。
T2822	Ginsenoside Rb1 Gypenoside Ⅲ,人参皂苷Rb1,人参皂苷 Rb1,Gypenoside III	ATPase; Mitophagy; IRAK; NF-κB; Autophagy; HSV	Autophagy; Immunology/Inflammation; Membrane transporter/Ion channel; Microbiology/Virology; NF-κB
	Ginsenoside Rb1 (Gypenoside Ⅲ) 是中药人参的成分，可能具有抑制或阻止肿瘤生长的特性。
T3432	Cinobufagin 华蟾蜍精,华蟾酥毒基,Cinobufagine	Apoptosis; ATPase; Autophagy	Apoptosis; Autophagy; Membrane transporter/Ion channel
	Cinobufagin (Cinobufagine) 是一种具有抗肿瘤功效的天然产物。
TQ0184	Chebulinic acid	ATPase; Proton pump; DNA/RNA Synthesis; Antibacterial; TGF-beta/Smad	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Membrane transporter/Ion channel; Microbiology/Virology; Stem Cells
	Chebulinic acid 是从诃子果中提取的一种天然产物，结核分枝杆菌 DNA 促旋酶的有效抑制剂。它也能抑制 SMAD-3 phosphorylation 和 H+ K+-ATPase 的活性。
T36390	Sodium oleate Oleic acid sodium salt,Sodium oleate,cis-9-Octadecenoic acid sodium salt	ATPase	Membrane transporter/Ion channel
	Sodium oleate (cis-9-Octadecenoic acid sodium salt) (Oleic acid sodium) 是人脂肪细胞和其他组织中最常见的单不饱和脂肪酸钠盐。Sodium oleate 是一种 Na+/K+ ATP 酶激活剂。
T4973	Paraxanthine 1,7-二甲基黄嘌呤,1,7-DIMETHYLXANTHINE	Endogenous Metabolite	Metabolism
	Paraxanthine (1,7-dimethylxanthine) 是一种 caffeine 的代谢物，能够刺激Ryanodine 受体通道来抑制多巴胺能细胞的死亡。
T6S1049	Wilforine	ATPase	Membrane transporter/Ion channel
	Wilforine 是一倍半萜吡啶化合物，T. wilfordii 植物中的重要生物活性化合物，可有效治疗特发性肺纤维化。它具有抗炎和杀虫活性。
T7190	Actein	Apoptosis; Akt; JNK; Autophagy	Apoptosis; Autophagy; Cytoskeletal Signaling; MAPK; PI3K/Akt/mTOR signaling
	Actein 是从升麻的根茎中分离的一种三萜糖苷，通过促进ROS/JNK 活化和钝化人膀胱癌中的AKT 途径来抑制细胞增殖，诱导自噬和凋亡。
T5S1982	Periplocin Periplocoside,杠柳毒苷	Apoptosis; Others	Apoptosis; Others
	Periplocin (Periplocoside) 是从黑龙骨中分离出的一种强心类固醇。它可促进肿瘤细胞凋亡并抑制肿瘤生长。它通过激活 Na/K-ATPase 介导的 Src/ERK 和 PI3K/Akt 途径，具有促进伤口愈合的潜力。
T13618	Citreoviridin	Others	Others
	Citreoviridin, a toxin from Penicillium citreoviride NRRL 2579, inhibits brain synaptosomal Na+/K+-ATPase whereas, in microsomes, both Na+/K+-ATPase and Mg2+-ATPase activities are significantly stimulated in a dose-dependent manner.
TN6631	Chamigrenol
	Chamigrenol is a promising candidate for the development of potent Na+/K+ ATPase inhibitors and antimicrobial agents. It inhibited the activities of Na+/K+-ATPase, with the IC50 value of 15.9 ± 0.54 μg/mL.
TN5141	Thevetin B	ATPase; Potassium Channel; Sodium Channel	Membrane transporter/Ion channel
	Thevetin B 是一种强心苷，是Na+-, K+-依赖性腺苷三磷酸酶 (Na+,K+-ATPase) 的抑制剂，来自 Thevetia peruviana。
TN4697	Odoroside H	ATPase; Potassium Channel; Sodium Channel	Membrane transporter/Ion channel
	Odoroside H has anticancer activities, the cytotoxic effects are induced by the inhibition of the plasma membrane bound Na(+)/K(+)-ATPase.
T10455	Bafilomycin B1 巴佛洛霉素 B1	Others	Others
	Bafilomycin B1, a macrolide antibiotic isolated from Streptomyces sp, acts as an inhibitor of K+-dependent ATPase of E. coli. It also inhibits Gram-positive bacteria and fungi.
TN2306	Wilfordine	ATPase; Potassium Channel; Sodium Channel	Membrane transporter/Ion channel
	Wilfordine is an insecticidally active alkaloid, Na+-K+-ATPase may be an acting target of wilfordine against some larvae of insect.
TN5060	Stauntosaponin A	ATPase; Potassium Channel; Sodium Channel	Membrane transporter/Ion channel
	Stauntosaponin A and stauntosaponin B show moderate inhibitory activities against Na+/K+-ATPase with IC50 values of 21 and 29 uM, respectively.
T38069	Aquastatin A	Others	Others
	Aquastatin A is a fungal metabolite originally isolated fromF. aquaeductuumthat has diverse biological activities.1It is active againstS. aureus(MIC = 32 μg/ml) and inhibits enoyl-acyl carrier protein reductase (Fabl; IC50= 3.2 μM) andS. aureusfatty acid synthesis (IC50= 3.5 μM).2Aquastatin A also inhibits the Na+/K+-ATPase and H+/K+-ATPase (IC50s = 7.1 and 6.2 μM, respectively), as well as protein tyrosine phosphatase 1B (PTP1B; IC50= 0.19 μM).1,3 1.Hamano, K., Kinoshita-Okami, M., Minagawa, K....
TN7524	Bassianin	Others	Others
	Bassianin, a fungal metabolite identified in Beauveria, demonstrates inhibition of Mg2+-, Ca2+-, and Na+/K+-ATPase activities in equine erythrocyte ghosts, with inhibition rates of 81%, 58%, and 23%, respectively, at a concentration of 200 µg/ml. Additionally, bassianin exhibits cytotoxic properties against Sf9 and Sf21 insect cells, with 50% cytotoxic concentration (CC50) values of 4.91 µM and 12.12 µM, respectively.
TN7505	Thujopsene NSC 44707	Others	Others
	Thujopsene, a sesquiterpene found in T. dolabrata, exhibits a wide range of biological activities. It inhibits Na+/K+-ATPase and cytochrome P450 (CYP) isoform CYP2B6 with IC50 values of 25.9 µg/ml and Ki of 0.8 µM, respectively. Additionally, thujopsene demonstrates antimicrobial efficacy against both Gram-positive and Gram-negative bacteria, such as S. aureus, M. luteus, and S. typhimurium, with MICs ranging from 25-50 µg/ml. It also suppresses antigen-induced β-hexosaminidase release in IgE-se...
T35779	Oosporein	Others	Others
	Oosporein is a mycotoxin that has been found inBeauveriaand has diverse biological activities.1,2It is cytotoxic to Sf9 and Sf21 insect cells with 50% cytotoxic concentration (CC50) values of 4.23 and 10.43 μM, respectively.3Oosporin induces lethality in day-old cockerels (LD50= 6.12 mg/kg).4It inhibits Na+/K+-, Ca2+-, and Mg2+-ATPase activities by 27, 52, and 100%, respectively, in equine erythrocyte ghosts when used at a concentration of 200 μg/ml.2Oosporein inhibits herpes simplex 1 (HSV-1), ...

天然产物

Cat.No: T1719

Target: ATPase

Cat.No: TJP2872

Synonym: Acevaltratum,乙酰缬草三酯,Acetoxyvaltrate

Target: ATPase, Others

Cat.No: T5S0890

Synonym: Neriostene,Folinerin,Foliandrin,欧夹竹桃苷

Target: Apoptosis, ATPase, Potassium Channel, Sodium Channel

Cat.No: TN5073

Synonym: 毒毛旋花子甙元,Strophanthidine,葡萄球菌素

Target: ATPase, Calcium Channel

Cat.No: T0295

Synonym: Digitoxoside,洋地黄毒苷,Unidigin,洋地黄毒甙,Digitoxinum,洋地黄

Target: ATPase, Others

Cat.No: T8183

Synonym: 洋地黄,去乙酰西地兰,Desacetyllanatoside C,Deacetyllanatoside C

Target: ATPase, Drug Metabolite

Cat.No: T2922

Synonym: Floridzin,根皮甙,根皮苷,NSC 2833,Phloridzin

Target: ATPase, SGLT

Cat.No: T2O2668

Synonym: Elaidoic acid,9Z-Octadecenoic acid,Oleate,9-Octadecenoic Acid,Glycon Wo,9-cis-Octadecenoic acid,油酸

Target: Apoptosis, ATPase, Others, Endogenous Metabolite

Ginsenoside Rb1

Cat.No: T2822

Synonym: Gypenoside Ⅲ,人参皂苷Rb1,人参皂苷 Rb1,Gypenoside III

Target: ATPase, Mitophagy, IRAK, NF-κB, Autophagy, HSV

Cat.No: T3432

Synonym: 华蟾蜍精,华蟾酥毒基,Cinobufagine

Target: Apoptosis, ATPase, Autophagy

Chebulinic acid

Cat.No: TQ0184

Target: ATPase, Proton pump, DNA/RNA Synthesis, Antibacterial, TGF-beta/Smad

Cat.No: T36390

Synonym: Oleic acid sodium salt,Sodium oleate,cis-9-Octadecenoic acid sodium salt

Target: ATPase

Cat.No: T4973

Synonym: 1,7-二甲基黄嘌呤,1,7-DIMETHYLXANTHINE

Target: Endogenous Metabolite

Cat.No: T6S1049

Target: ATPase

Cat.No: T7190

Target: Apoptosis, Akt, JNK, Autophagy

Cat.No: T5S1982

Synonym: Periplocoside,杠柳毒苷

Target: Apoptosis, Others

Cat.No: T13618

Target: Others

Cat.No: TN6631

Cat.No: TN5141

Target: ATPase, Potassium Channel, Sodium Channel

Cat.No: TN4697

Target: ATPase, Potassium Channel, Sodium Channel

Cat.No: T10455

Synonym: 巴佛洛霉素 B1

Target: Others

Cat.No: TN2306

Target: ATPase, Potassium Channel, Sodium Channel

Stauntosaponin A

Cat.No: TN5060

Target: ATPase, Potassium Channel, Sodium Channel

Cat.No: T38069

Target: Others

Cat.No: TN7524

Target: Others

Cat.No: TN7505

Synonym: NSC 44707

Target: Others

Cat.No: T35779

Target: Others

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-06599	ATP1B4 Protein, Human, Recombinant (His) ATPase, Na+/K+ transporting, β 4 polypepti...	Human	E. coli
	ATP1B4 is a member of the X(+)/potassium ATPases subunit beta family. It is highly expressed in skeletal muscle and at a lower level in heart. ATP1B4 gene can be found in all vertebrate genomes sequenced to date. However, this gene has undergone a change in function in placental mammals compared to other species. Specifically, in fish, avian, and amphibian species, this gene encodes plasma membrane-bound beta-subunits of Na, K-ATPase. In placental mammals, the encoded protein interacts with the ...
TMPY-03788	ATP1B1 Protein, Human, Recombinant (His) ATPase, Na+/K+ transporting, β 1 polypepti...	Human	HEK293 Cells
	ATP1B1 belongs to the family of Na+/K+and H+/K+-ATPases beta chain proteins, and to the subfamily of Na+/K+ -ATPases. ATP1B1 is a subunit of Na+/K+-ATPase. Na+/K+-ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. Na+/K+-ATPase is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). ATP1B1 regulates, through assembly of alpha/beta heterodim...
TMPY-04927	ATP1B2 Protein, Human, Recombinant (His) ATPase, Na+/K+ transporting, β 2 polypepti...	Human	HEK293 Cells
	ATP1B2 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 27.7 kDa and the accession number is P14415.
TMPH-01893	ATP4B Protein, Human, Recombinant (GST) Proton pump beta chain,Gastric H(+)/K(+) ATPase...	Human	E. coli
	ATP4B Protein, Human, Recombinant (GST) is expressed in E. coli expression system with N-GST tag. The predicted molecular weight is 53.6 kDa and the accession number is P51164.
TMPH-01894	ATP4B Protein, Human, Recombinant Proton pump beta chain,Potassium-transporting ATPase	Human	E. coli
	ATP4B Protein, Human, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 26.6 kDa and the accession number is P51164.
TMPH-01892	ATP4A Protein, Human, Recombinant (His & Myc) ATP4A,Gastric H(+)/K(+) ATPase subunit alp...	Human	E. coli
	ATP4A Protein, Human, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 54.6 kDa and the accession number is P20648.

重组蛋白

ATP1B4 Protein, Human, Recombinant (His)

Cat.No: TMPY-06599

Species: Human

Expression System: E. coli

ATP1B1 Protein, Human, Recombinant (His)

Cat.No: TMPY-03788

Species: Human

Expression System: HEK293 Cells

ATP1B2 Protein, Human, Recombinant (His)

Cat.No: TMPY-04927

Species: Human

Expression System: HEK293 Cells

ATP4B Protein, Human, Recombinant (GST)

Cat.No: TMPH-01893

Species: Human

Expression System: E. coli

ATP4B Protein, Human, Recombinant

Cat.No: TMPH-01894

Species: Human

Expression System: E. coli

ATP4A Protein, Human, Recombinant (His & Myc)

Cat.No: TMPH-01892

Species: Human

Expression System: E. coli

Cat. No.	Product Name	Target	Signaling Pathways
TMIH-0301	Levolansoprazole-d4
	Levolansoprazole-d4 是 Levolansoprazole 的氘代化合物。Levolansoprazole 的 CAS 号为 138530-95-7。Levolansoprazole 是一种质子泵抑制剂，不可逆地抑制壁细胞中 H+/K+ 刺激的 ATPase 泵 (IC50: 5.2 µM)。它还抑制分离的犬壁细胞中的酸形成（IC50：82 µM）。 (R)-和 (S)-兰索拉唑均具有药理活性，具有相似的效力。
TMIJ-0503	Digoxin-d3
	Digoxin-d3 是 Digoxin 的氘代化合物。Digoxin 的 CAS 号为 20830-75-5。Digoxin是Na+/K+-ATPase有效抑制剂，用于治疗各种心脏疾病。
TMIH-0601	Vonoprazan-d3
	Vonoprazan-d3 是 Vonoprazan 的氘代化合物。Vonoprazan 的 CAS 号为 881681-00-1。Vonoprazan 是一种质子泵抑制剂，是口服活性钾竞争性酸阻断剂，有抗分泌作用。在 pH 为 6.5 时，它抑制猪胃微粒体中的 H+,K+-ATPase 酶活性，IC50值为 19 nM。它可用于研究胃酸相关疾病。
TMIH-0602	Vonoprazan-d4
	Vonoprazan-d4 是 Vonoprazan 的氘代化合物。Vonoprazan 的 CAS 号为 881681-00-1。Vonoprazan 是一种质子泵抑制剂，是口服活性钾竞争性酸阻断剂，有抗分泌作用。在 pH 为 6.5 时，它抑制猪胃微粒体中的 H+,K+-ATPase 酶活性，IC50值为 19 nM。它可用于研究胃酸相关疾病。
TMIJ-0192	Pantoprazole-d6
	Pantoprazole-d6 是 Pantoprazole 的氘代化合物。Pantoprazole 的 CAS 号为 102625-70-7。Pantoprazole 是一种质子泵抑制剂，用于短期治疗由胃食管反流病引起的食管糜烂和溃疡。它联合阿霉素可显著增加肿瘤生长延迟。它是一种取代的苯并咪唑，是H+/K+-ATPase抑制剂，可改善 pH 值稳定性，具有抗分泌和抗溃疡的作用。
TMIH-0222	Esomeprazole sodium-d6
	Esomeprazole sodium-d6 是 Esomeprazole sodium 的氘代化合物。Esomeprazole sodium 的 CAS 号为 161796-78-7。Esomeprazole sodium 是一种口服有效的活性质子泵抑制剂。Esomeprazole sodium通过抑制胃壁细胞中的H+, K+-ATPase来降低酸分泌，在胃食管反流疾病中有研究价值。Esomeprazole 是一种外泌体抑制剂，通过抑制 V-H+-ATPases 来阻断外泌体的释放。

同位素标记化合物

Levolansoprazole-d4

Cat.No: TMIH-0301

Cat.No: TMIJ-0503

Cat.No: TMIH-0601

Cat.No: TMIH-0602

Pantoprazole-d6

Cat.No: TMIJ-0192

Esomeprazole sodium-d6

Cat.No: TMIH-0222

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