126
14
1
4
3
Cat. No. | Product Name | ||
---|---|---|---|
L7300 | 钾通道分子库 | 152 compounds | |
152 种钾通道相关化合物的独特集合,可用于高通量筛选和高内涵筛选; |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T15385 |
Glibornuride
|
Potassium Channel | Membrane transporter/Ion channel |
Glibornuride 是对 ATP 敏感的 K+通道 (KATP 通道) 阻滞剂,pKi 为 5.75。Glibornuride 显示抗糖尿病活性。 | |||
TQ0144 |
(S)-(-)-Bay-K-8644
(S)-(-)-Bay K 8644 |
Calcium Channel | Membrane transporter/Ion channel; Metabolism |
(S)-(-)-Bay-K-8644 ((S)-(-)-Bay K 8644) 是 L 型 Ca2+ 通道的激动剂,可激活 Ba2+ 电流,其EC50 为 32 nM。 | |||
T0163 |
Nisoldipine
尼索地平,BAY-k 5552 |
Calcium Channel; Reactive Oxygen Species | Immunology/Inflammation; Membrane transporter/Ion channel; Metabolism; NF-κB |
Nisoldipine (BAY-k 5552) 是一种高效特异的L 型Cav1.2通道阻断剂,IC50=10 nM。 | |||
T6777 |
Bay K 8644
(±)-BAY-K-8644,SQ 28,873 |
Calcium Channel | Membrane transporter/Ion channel; Metabolism |
Bay K 8644 (SQ 28,873)是一种二氢吡啶化合物,是一种选择性的 L 型 Ca2+ 通道激活剂,IC50 为 17.3 nM。它通过增加通道的开放时间来增加通过肌膜 Ca2+通道的 Ca2+流入。 | |||
T1603 |
Glipizide
CP 28720,K 4024,格列吡嗪 |
Potassium Channel; PPAR; ABC | DNA Damage/DNA Repair; Membrane transporter/Ion channel; Metabolism |
Glipizide (CP 28720) 是一种有效的、具有口服活性的磺酰脲类抗糖尿病试剂 (anti-diabetic agent),在 2 型糖尿病的研究中具有价值,但不适用于1 型糖尿病。Glipizide 是通过部分阻断郎格汉斯胰岛细胞中 ATP 敏感钾通道 (KATP)发挥活性 。 | |||
T8581 |
Flecainide hydrochloride
|
Others | Others |
Flecainide hydrochloride 是一种用于预防和治疗异常快速心率的药物。这包括室性和室上性心动过速。 | |||
T0386L |
Ropivacaine
LEA-103 HCl,罗哌卡因 |
Potassium Channel; Sodium Channel | Membrane transporter/Ion channel |
Ropivacaine (LEA-103 HCl) 是有效的钠通道阻断剂,通过可逆地抑制钠离子内流从而引起神经纤维脉冲传导阻滞。Ropivacaine 也是一种 K2P(双孔钾通道)TREK-1的抑制剂,在 COS-7 细胞膜上的 IC50值为 402.7 μM。Ropivacaine 可以用于神经性疼痛的缓解的相关研究。 | |||
T0386 |
Ropivacaine hydrochloride
盐酸罗哌卡因,Ropivacaine monohydrochloride |
Potassium Channel; Sodium Channel | Membrane transporter/Ion channel |
Ropivacaine hydrochloride (Ropivacaine monohydrochloride) 是钠通道阻断剂,通过可逆地抑制钠离子内流从而引起神经纤维脉冲传导阻滞。Ropivacaine hydrochloride 也是 K2P(双孔钾通道)TREK-1的抑制剂。在动物实验模型中,Ropivacaine hydrochloride 可用于神经性疼痛的缓解。 | |||
T8135 |
Minoxidil sulfate
Minoxidil sulphate,U-58838,米诺地尔硫酸盐 |
Potassium Channel | Membrane transporter/Ion channel |
Minoxidil sulfate (U-58838) 是米诺地尔的硫酸代谢物,是ATP 敏感的 K+通道激动剂。它被认为是血管扩张试剂,在动物实验模型中,促进头发生长。 | |||
T1278 |
Astemizole
Laridal,Histaminos,Paralergin,阿司咪唑 |
Potassium Channel; Histamine Receptor | GPCR/G Protein; Immunology/Inflammation; Membrane transporter/Ion channel; Neuroscience |
Astemizole (Laridal) 是一种长效、非镇静抗组胺药,用于治疗季节性过敏性鼻炎、哮喘、过敏性结膜炎和慢性特发性荨麻疹。它是组胺 H1 受体的拮抗剂,IC50值为 4 nM,还阻断 hERG K+通道,IC50值为 0.9 nM,具有抗胆碱能和止痒作用。 | |||
T7606 |
Guanosine 5'-diphosphate disodium salt
5'-二磷酸鸟苷二钠,5'-GDP-Na2,鸟苷-5'-二磷酸二钠盐 |
Endogenous Metabolite | Metabolism |
Guanosine 5'-diphosphate disodium salt (5'-GDP-Na2) 是一种核苷二磷酸。它是一种潜在的铁动员剂,能够阻断铁调素-铁转运蛋白相互作用,也可以调节白 IL-6/stat-3 途径。 | |||
T6541 |
Ibutilide Fumarate
Corvert Fumarate,U70226E,富马酸伊布利特 |
Calcium Channel; Sodium Channel | Membrane transporter/Ion channel; Metabolism |
Ibutilide Fumarate (U70226E) 是一种 III 类抗心律失常药物,可作用于急性心梗阻塞。 | |||
T6645 |
Ropivacaine hydrochloride monohydrate
Ropivacaine HCl,Ropivacaine HCl monohydrate,LEA 103,盐酸罗哌卡因,盐酸罗哌卡因一水合物,LEA-103 HCl |
Potassium Channel; Sodium Channel | Membrane transporter/Ion channel |
Ropivacaine hydrochloride monohydrate (LEA-103 HCl) 是钠通道阻断剂,通过可逆地抑制钠离子内流从而引起神经纤维脉冲传导阻滞。Ropivacaine HCl monohydrate 也是 K2P(双孔钾通道)TREK-1的抑制剂。在动物实验模型中,Ropivacaine HCl monohydrate 可用于神经性疼痛的缓解。 | |||
T11990 |
Meclofenamic acid
甲氯芬那酸,Meclofenamate |
Others; Gap Junction Protein | Cytoskeletal Signaling; Others |
Meclofenamic acid (Meclofenamate) 是一种非特异性 gap-junction 阻滞剂和特异性脂肪量和肥胖相关 (FTO) 酶抑制剂。 Meclofenamic acid 具有抗炎活性。 | |||
T29457L |
5-Hydroxydecanoate sodium
|
Potassium Channel | Membrane transporter/Ion channel |
5-Hydroxydecanoate sodium 是一种选择性 ATP 敏感的 K+ (KATP) 通道阻滞剂,IC50 约为 30 μM。 它是线粒体外膜酰基辅酶A 合成酶的底物,具有抗氧化性。 | |||
T29050 |
UK 66914
UK66914,UK-66914 |
Potassium Channel | Membrane transporter/Ion channel |
UK 66914 是一种 K(+)通道阻断剂,可用于研究心律失常。 | |||
TQ0150 |
Levcromakalim
(-)-Cromakalim,左色满卡林,BRL 38227 |
Potassium Channel | Membrane transporter/Ion channel |
Levcromakalim (BRL 38227) 是 一种 ATP 敏感性的 K+通道 (KATP) 激活剂。 | |||
T90604 |
PCO 400
|
Others | Others |
PCO 400 是一种 comakalim 类似物,可作为一种选择性强的 ATP 敏感型 K+ 通道开放剂。 | |||
T3543 |
NS-638
NS 638 |
Calcium Channel | Membrane transporter/Ion channel; Metabolism |
NS-638 是一种 Ca2+ 通道阻滞剂,可阻断 K+ 刺激的细胞内 Ca2+ 升高,IC50值为3.4 μM。 | |||
T24786 |
SG-209
|
Others | Others |
SG 209是nicorandil的类似物,可作为K+通道开放剂和无硝酸盐的冠状血管扩张剂。 | |||
T17227 |
Vernakalant Hydrochloride
RSD1235 hydrochloride |
Potassium Channel; Sodium Channel | Membrane transporter/Ion channel |
Vernakalant Hydrochloride (RSD1235 hydrochloride) 是一种混合电压和频率依赖性的 Na+ 和 K+ 通道阻断剂。Vernakalant 抑制 Kv1.5 channelwt,Kv1.5 channelI508F,Kv1.5 channelT479A,IC50 分别为 13.35±0.93 μM。 | |||
T21478 |
Cromakalim
BRL34915,(±)-Cromakalim,BRL 34915,BRL-34915 |
Potassium Channel | Membrane transporter/Ion channel |
Cromakalim (BRL 34915) 是一种 ATP 依赖性 K(+) 通道开启剂,是一种平滑肌松弛剂。Cromakalim 具有抗癫痫和抗惊厥活性,可用于研究哮喘和与血管扩张相关的疾病。 | |||
T6978 |
Almitrine mesylate
Almitrine dimesylate,甲磺酸阿米三嗪,Almitrine bismethanesulfonate,Almitrine bismesylate |
Potassium Channel | Membrane transporter/Ion channel |
Almitrine mesylate (Almitrine dimesylate) 是外周化学感受器激动剂,对Ca2+依赖性的K+通道具有选择性抑制作用。 | |||
T12255 |
NS19504
|
Potassium Channel | Membrane transporter/Ion channel |
NS19504 是 Ca2+激活的 K+通道激活剂 (EC50=11.0 µM),对膀胱平滑肌自发性相位收缩具有松弛作用。 | |||
T60061 |
RU-TRAAK-2
|
Potassium Channel | Membrane transporter/Ion channel |
RU-TRAAK-2 是 TWIK 相关的花生四烯酸刺激的 K+ 通道的可逆抑制剂,对包括 Kv1.2、GIRK2 和 Slo1 在内的非 K2P 通道没有活性。 | |||
T6186 |
TRAM-34
Triarylmethane-34,TRAM 34 |
Potassium Channel; IκB/IKK | Membrane transporter/Ion channel; NF-κB |
TRAM-34 (Triarylmethane-34) 是一种高选择性的钙激活 K+通道 (IKCa1)阻断剂,Kd 值为 20 nM。 | |||
T15286 |
Flindokalner
BMS-204352 |
Potassium Channel | Membrane transporter/Ion channel |
Flindokalner (BMS-204352) 是一种钾离子通道调节剂。它是大电导钙激活 K 通道正向调节剂。它是在 HEK293 细胞中表达的所有神经元 Kv7通道亚型的正调节剂。它在 Kv7.1 通道 (Ki=3.7 μM) 处显示负调节活性,并充当 GABAA 受体的负调节剂。它在体内显示出抗焦虑功效。 | |||
T26086L |
(Iso)-Rilmakalim
|
Others | Others |
1-((3R,4S)-3-hydroxy-2,2-dimethyl-6-(phenylsulfonyl)chroman-4-yl)pyrrolidin-2-one 是 Rilmakalim 的异构体,Rilmakalim 是一种钾通道打开剂 (PCO),可以激活心脏或其它组织中 ATP-敏感 K+ 通道 | |||
TQ0145 |
(R)-(+)-Bay-K-8644
(R)-(+)-Bay K 8644 |
Calcium Channel; PPAR | DNA Damage/DNA Repair; Membrane transporter/Ion channel; Metabolism |
(R)-(+)-Bay-K-8644 是一种 Ca2+ 通道抑制剂,也能抑制 Ba2+电流 (IBa),诱导猫的中枢性呼吸抑制,通过竞争性拮抗血栓素 A2-前列腺素 H2 受体抑制血小板活化。 | |||
T22826 |
GW 542573X
|
Potassium Channel | Membrane transporter/Ion channel |
GW 542573X 是一种有效且具有选择性的 Ca2+ 激活 K+ 2 (SK2) 通道激活剂。GW 542573X 诱导 hSK1 的 Ca2+ 反应曲线从 EC50 (Ca2+) 值 410 nM 左移至 240 nM,可用于研究关于神经元相关的疾病。 | |||
T7774 |
A2793
2-[(5-氯-8-喹啉基)氧基]乙酸乙酯 |
Potassium Channel | Membrane transporter/Ion channel |
A2793 是 TWIK 相关酸敏感 K+通道 1(TASK-1)/TRESK 的双重抑制剂,对 mTRESK 的 IC50为 6.8 μM。它对 TRESK 选择性更好, 对 TREK-1 和 TALK-1 相对弱一些。 | |||
T3574 |
Sematilide hydrochloride
司美利特,CK-1752A,CK-1752,Sematilide HCl |
Potassium Channel | Membrane transporter/Ion channel |
Sematilide hydrochloride (CK-1752) 是一种选择性的 IKr 通道阻滞剂。Sematilide 以浓度依赖性抑制延迟整流钾通道 (K+current),IC50为 25 μM。Sematilide 是一种 III 类抗心律不齐剂。 | |||
T10977 |
DCEBIO
|
Potassium Channel | Membrane transporter/Ion channel |
DCEBIO 是1-EBIO 的衍生物,是 T84 结肠细胞中Cl-分泌的极有效的激活剂。DCEBIO 通过激活 hIK1 K+通道和顶端膜的 Cl-传导促进 Cl-的分泌。 | |||
T0860L |
Mefloquine
Ro215998,WR 142490,Ro-215998,氟甲喹羟哌啶,Lariam,Ro 215998 |
Others | Others |
Mefloquine (Ro 215998) 是一种喹啉抗疟药,是一种抗 SARS-CoV-2 进入抑制剂。 Mefloquine 也是一种 K+ 通道 (KvQT1/minK) 拮抗剂,IC50 为 ~1 μM。它可用于疟疾、系统性红斑狼疮和癌症研究。 | |||
T27624 |
Iptakalim Hydrochloride
|
Potassium Channel; AChR | Membrane transporter/Ion channel; Neuroscience |
Iptakalim hydrochloride 是一种亲脂性的对氨基化合物,是 ATP 敏感的钾通道的开放剂,也是含α4β2的烟碱乙酰胆碱受体拮抗剂。它也是一种 K(ir) 6.1/SUR2B 激活剂,可通过保护内皮功能减轻大鼠缺氧引起的肺动脉高压。 | |||
T6953 |
Prilocaine
Citanest,丙胺卡因,Propitocaine,NSC 40027 |
ATPase; Sodium Channel | Membrane transporter/Ion channel |
Prilocaine (NSC-40027) 是一种氨基酰胺类局部麻醉剂,作用于神经元膜上的钠通道并限制癫痫发作的扩散。它是Na/K-ATPase 抑制剂,具有神经毒性作用。 | |||
T7512 |
BMS-191011
BMS-A |
Potassium Channel | Membrane transporter/Ion channel |
BMS-191011 (BMS-A) 是一种大电导 Ca2+激活的钾通道 (Ca2+-activated potassium (maxi-K) channel) 激活剂,在中风模型中有研究价值。 | |||
T4341 |
Betrixaban
贝曲西班,PRT054021 |
Factor Xa | Metabolism |
Betrixaban (PRT054021) 是一种口服具有活力的选择性factor Xa(fXa) 抑制剂,IC50=1.5 nM。 | |||
T68113 |
Naluzotan hydrochloride
PRX 00023 hydrochloride |
EGFR; 5-HT Receptor | Angiogenesis; GPCR/G Protein; JAK/STAT signaling; Neuroscience; Tyrosine Kinase/Adaptors |
Naluzotan hydrochloride (PRX 00023 hydrochloride) 是一种小分子、非氮杂吡酮、5-羟色胺(5-HT)1A 受体激动剂和sigma-1受体拮抗剂。在之前的临床试验中,该化合物在400多名患者中被证明安全且耐受性良好。 | |||
T1527 |
Gliclazide
格列齐特,S1702,SE1702 |
Potassium Channel | Membrane transporter/Ion channel |
Gliclazide (SE1702) 是一种有效的全细胞的 β 细胞 ATP 敏感型钾流阻断剂,IC50为 184 nM,用作降糖药。 | |||
T0860 |
Mefloquine hydrochloride
Mefloquin hydrochloride,Mefloquine HCl,盐酸甲氟喹 |
Potassium Channel; SARS-CoV; Reactive Oxygen Species; Parasite; Autophagy | Autophagy; Immunology/Inflammation; Membrane transporter/Ion channel; Metabolism; Microbiology/Virology; NF-κB |
Mefloquine hydrochloride (Mefloquin hydrochloride) 是喹啉抗疟药,是抗 SARS-CoV-2进入抑制剂,可研究疟疾、系统性红斑狼疮和癌症。它也是 K+通道(KvQT1/minK) 拮抗剂,IC50约为 1 μM。 | |||
T0371 |
Gliquidone
AR-DF 26,格列喹酮,Glurenorm |
Potassium Channel | Membrane transporter/Ion channel |
Gliquidone (AR-DF 26) 是一种磺酰脲类的抗糖尿病药物,可用于2型糖尿病的研究。 | |||
T4980 |
Betrixaban maleate
|
Factor Xa | Metabolism |
Betrixaban maleate 是一种非维生素 K 口服抗凝剂,其作用是由 Xa 因子的竞争性和可逆抑制作用驱动的。 | |||
T7195 |
GSK369796 Dihydrochloride
N-tert-butylisoquine |
Potassium Channel; Parasite | Membrane transporter/Ion channel; Microbiology/Virology |
GSK369796 Dihydrochloride (N-tert-butylisoquine) 是一种抗疟药,可抑制 hERG 钾离子通道复极化,IC50值为 7.5 μM。 | |||
T3303 |
ML277
ML-277,CID-53347902 |
Potassium Channel | Membrane transporter/Ion channel |
ML277 (CID-53347902) 是一种有效的,选择性K(v)7.1 钾离子通道激动剂,EC50为270nM。 | |||
T1496 |
Amiodarone hydrochloride
盐酸胺碘酮,Amiodar,Amiodarone HCl,Nexterone |
Potassium Channel; Adrenergic Receptor; Autophagy | Autophagy; GPCR/G Protein; Membrane transporter/Ion channel; Neuroscience |
Amiodarone hydrochloride (Amiodarone HCl) 是一种抗心绞痛和 III 类抗心律失常药物,通过抑制钾通道和电压门控钠通道来增加心室和心房肌肉作用的持续时间,可导致心率和血管阻力降低。它通过成纤维细胞中的 ERK1/2和 p38 MAPK 信号传导诱导细胞增殖和肌成纤维细胞分化,可研究室上性和室性心律失常。 | |||
T1066L |
Ketanserin tartrate
KJK 945 tartrate,KJK-945 tartrate,KJK945 tartrate |
5-HT Receptor; Serotonin Transporter; Adrenergic Receptor | GPCR/G Protein; Neuroscience |
Ketanserin tartrate (KJK-945 tartrate) 是 5-HT2A 受体和α1-肾上腺素能受体拮抗剂,具有抗高血压活性,抑制血清素诱导的血管收缩和血小板活化,可用于研究系统性硬化症。 | |||
T34616 |
Seridopidine
ACR-343,ACR 343,ACR343 |
Dopamine Receptor | GPCR/G Protein; Neuroscience |
Seridopidine (ACR343) 是一种多巴胺能活性调节剂,可作为精神分裂症、帕金森病和抽动秽语综合征的口服疗法。 | |||
T3528 |
Senicapoc
塞尼卡泊,ICA-17043 |
Potassium Channel | Membrane transporter/Ion channel |
Senicapoc (ICA-17043) 是有效的,选择性的Gardos 通道 (Ca2+激活的 K+通道;KCa3.1) 阻断剂,IC50为 11 nM。Senicapoc 阻断人红细胞的 Ca2+诱导的铷通量,IC50为 11 nM, 抑制红细胞脱水的IC50为 30 nM。 | |||
T23563 |
ZM 226600
|
Potassium Channel | Membrane transporter/Ion channel |
ZM 226600是一种 ATP 敏感的钾通道开启剂 ,EC50值是500 nM。ZM226600 对膀胱自发活动有抑制作用。 |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T37709 |
2,2,2-Trichloroethanol
|
Potassium Channel; Endogenous Metabolite | Membrane transporter/Ion channel; Metabolism |
2,2,2-Trichloroethanol 是非经典的 K2P 通道 TREK-1和 TRAAK 的激动剂。 | |||
T7210 |
Guanosine 5'-diphosphate
GDP,鸟苷-5ˊ-二磷酸 |
Endogenous Metabolite | Metabolism |
Guanosine 5'-diphosphate (GDP) 是核苷二磷酸,是潜在的铁动员剂,能够阻断铁调素-铁转运蛋白相互作用并调节白细胞介素-6 (IL-6)/stat-3 途径。 | |||
T6631 |
Quinine hydrochloride dihydrate
奎宁单盐酸盐二水合物,Quinine HCl Dihydrate,奎宁盐酸盐二水合物 |
Potassium Channel; Parasite | Membrane transporter/Ion channel; Microbiology/Virology |
Quinine hydrochloride dihydrate (Quinine HCl Dihydrate) 是一种白色结晶 K+ 通道阻滞剂,用于治疗疟疾,具有退热,抗疟,止痛,抗炎等特性。 | |||
T0266 |
Quinidine hydrochloride monohydrate
奎宁树,奎尼丁盐酸盐一水合物,奎尼丁盐酸盐,Quinidine hydrochloride |
Potassium Channel; Sodium Channel; Parasite | Membrane transporter/Ion channel; Microbiology/Virology |
Quinidine hydrochloride monohydrate 是一种抗心律失常剂,也是 K+通道 (K+channel) 的有效阻断剂,其IC50值为 19.9 μM。它是一种有效且选择性的细胞色素 P450db (cytochrome P450db) 抑制剂,也可用作疟疾的研究。 | |||
Fr14207 |
(-)-Isopulegol
|
Others | Others |
(-)-Isopulegol 具有抗氧化和神经活性特性。它还具有由异胡薄荷醇诱导的胃保护作用,似乎至少部分由内源性前列腺素介导,K+ATP 通道开放和与 GSH 相关的抗氧化特性增加。 | |||
T3S0870 |
Paederosidic acid methyl ester
鸡屎藤苷酸甲酯,紫草酸甲酯 |
ATPase; Potassium Channel; NO Synthase | Immunology/Inflammation; Membrane transporter/Ion channel |
Paederosidic acid methyl ester 是 ATP 敏感的 K+channel 通道激活剂,分离自 P. scandens。它通过激活脑中和脊髓水平中 ATP 敏感型 K+通道提高了痛觉阈值,表现出显著的中枢缓解疼痛活性。 | |||
T0690 |
Quinine
奎宁树 |
Potassium Channel; Platelet aggregation; Parasite | Membrane transporter/Ion channel; Microbiology/Virology; Others |
Quinine 是一种从金鸡纳树皮中提取的生物碱,用于预防和治疗疟疾。它也用于特发性肌肉痉挛,可抑制电压脉冲引起的 MT mSlo3 (KCa5.1) 通道 +100 mV 电流, 其IC50值为 169 μM,是一种钾离子通道抑制剂。 | |||
TN3636 |
Chlorahololide C
|
Potassium Channel | Membrane transporter/Ion channel |
Chlorahololide C is a potent and selective potassium channel blocker, it exerts potent and selective inhibition on the delayed rectifier (I(K)) K(+) current with the IC(50) value of 3.6 +/- 10.1 mu M. | |||
TN6051 |
Songoramine
|
||
Songoramine(10 uM) demonstrates significant hERG K+ channel inhibition. | |||
TN4638 |
Neolinine
|
EGFR; Potassium Channel | Angiogenesis; JAK/STAT signaling; Membrane transporter/Ion channel; Tyrosine Kinase/Adaptors |
Neolinine(at 10uM) shows significant hERG K+ channel inhibition activity. | |||
T21266 |
Quinine sulfate
|
Others | Others |
Quinidine sulfate 是一种抗心律失常剂。Quinidine sulfate 是一种口服有效的、选择性的细胞色素 P450db (cytochrome P450db) 抑制剂。Quinidine sulfate 是 K+通道 (K+channel) 的有效阻断剂,IC50值为 19.9 μM。Quinidine sulfate 同时具有抗疟疾的研究潜力。 | |||
T75333 |
Quinine hemisulfate hydrate
|
Others | Others |
Quinine hemisulfate hydrate,一种从金鸡纳树皮提取的生物碱,具有抗疟疾效果。作为钾离子通道 (potassium channel) 抑制剂,它能够抑制由电压脉冲触发的MT mSlo3 (KCa5.1) 通道在+100 mV下的电流活动,其IC50值达169 μM。 | |||
T73764 |
L-Palmitoylcarnitine TFA
|
Others | Others |
L-Palmitoylcarnitine TFA 是一种长链酰基肉碱和脂肪酸代谢产物,在缺血期间积聚于肌膜并扰乱膜脂环境。L-Palmitoylcarnitine TFA 通过与Kir6.2的相互作用抑制KATP 通道活性,而不影响单通道电导。 | |||
TN4322 |
Isopulegol
|
ATPase; Potassium Channel; GABA Receptor | Membrane transporter/Ion channel; Neuroscience |
Isopulegol presents depressant- and anxiolytic-like effects, it also has anticonvulsant and bioprotective effects against PTZ-induced convulsions are possibly related to positive modulation of benzodiazepine-sensitive GABAA receptors and to antioxidant properties.Isopulegol presents significant gastroprotective effects in both ethanol- and indomethacin-induced ulcer models, which appear to be mediated, at least in part, by endogenous prostaglandins, K(ATP) channel opening, and antioxidant proper... |
Cat. No. | Product Name | Species | Expression System |
---|---|---|---|
TMPH-01889 |
KCNK3 Protein, Human, Recombinant (His & Myc)
Potassium channel subfamily K member 3,TWI... |
Human | E. coli |
pH-dependent, voltage-insensitive, background potassium channel protein. Rectification direction results from potassium ion concentration on either side of the membrane. Acts as an outward rectifier when external potassium concentration is low. When external potassium concentration is high, current is inward. KCNK3 Protein, Human, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 50.5 kDa and the accession number is O... | |||
TMPH-01028 |
KCNMA1 Protein, Human, Recombinant
K(VCA)alpha,Calcium-activated potassium channel... |
Human | E. coli |
KCNMA1 Protein, Human, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 17.2 kDa and the accession number is Q12791. | |||
TMPH-02309 |
KCNAB2 Protein, Human, Recombinant (His & SUMO)
Kv-beta-2,K(+) channel subunit be... |
Human | E. coli |
KCNAB2 Protein, Human, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 57.0 kDa and the accession number is Q13303. | |||
TMPH-01890 |
KCNA1 Protein, Human, Recombinant (His)
Voltage-gated potassium channel subunit Kv... |
Human | E. coli |
KCNA1 Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 22.2 kDa and the accession number is Q09470. |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T37847 |
Zonisamide-13C2,15N
Zonisamide-13C2,15N |
||
Zonisamide-13C2,15N is intended for use as an internal standard for the quantification of zonisamide by GC- or LC-MS. Zonisamide is an antiepileptic agent.1 It selectively inhibits the repeated firing of sodium channels (IC50 = 2 μg/ml) in mouse embryo spinal cord neurons and inhibits spontaneous channel firing when used at concentrations greater than 10 μg/ml.2 In rat cerebral cortex neurons, zonisamide (1-1,000 μM) inhibits T-type calcium channels with a maximum reduction of 60% of the calcium... | |||
T35789 |
Palmitic acid-1-13C
|
||
Palmitic acid-13C is intended for use as an internal standard for the quantification of palmitic acid by GC- or LC-MS. Palmitic acid is a 16-carbon saturated fatty acid. It comprises approximately 25% of human total plasma lipids.1 It increases protein levels of COX-2 in RAW 264.7 cells when used at a concentration of 75 μM.2 Palmitic acid is involved in the acylation of proteins to anchor membrane-bound proteins to the lipid bilayer.2,3,4,5,6 |1. Santos, M.J., López-Jurado, M., Llopis, J., et a... | |||
T35791 |
Palmitic acid-13C
|
||
Palmitic acid-13C is intended for use as an internal standard for the quantification of palmitic acid by GC- or LC-MS. Palmitic acid-13C contains 13C at the C2 position and has been used in the study of free fatty acid incorporation into phospholipid fatty acids in soil microbes.1 Palmitic acid is a 16-carbon saturated fatty acid. It comprises approximately 25% of human total plasma lipids.2 It increases protein levels of COX-2 in RAW 264.7 cells when used at a concentration of 75 μM.3 Palmitic ... |