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Search Results for " janus "

105

抑制剂 & 化合物

7

天然产物

1

化合物库

10

重组蛋白

3

同位素标记化合物

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Cat. No.	Product Name
L3700	JAK-STAT 化合物库		252 compounds
	252 个 JAK/STAT 靶点相关的小分子化合物的独特集合，用于高通量、高内涵筛选；

化合物库

JAK-STAT 化合物库

Cat.No: L3700

Compounds: 252

Cat. No.	Product Name	Target	Signaling Pathways
T32264	Janus green C.I. 11045,EINECS 225-029-8,Janus Green G
	Janus green is a basic dye.
T20027	Janus green B NSC13986,NSC 13986,Janus Green V,NSC-13986
	Janus green B is an agent of basic dye.
T32265	Janus red NSC-9609,NSC9609,Janus Red B,NSC 9609,C.I. 26115
	Janus red is a basic dye.
T32263	Janus blue C.I. 12210,Indoine Blue R,EINECS 224-951-8,C.I. Basic Blue 16,Indazol Blue R
	Janus blue is a basic dye.
T3080	Pyridone 6 Janus-Associated Kinase Inhibitor I,JAK Inhibitor,CMP 6,吡啶酮6,JAK Inhibitor I	Tyrosine Kinases; JAK	Angiogenesis; Chromatin/Epigenetic; JAK/STAT signaling; Stem Cells; Tyrosine Kinase/Adaptors
	Pyridone 6 (JAK Inhibitor) 是一种泛JAK 抑制剂，有效抑制 JAK 激酶家族，对JAK2、TYK2、JAK3和JAK1的IC50分别为 1、1、5 和 15 nM。
T38624	Fosifidancitinib	JAK	Angiogenesis; Chromatin/Epigenetic; JAK/STAT signaling; Stem Cells
	Fosifidancitinib 是有效的JAK 激酶 1/3 选择性抑制剂。它在过敏、哮喘和自身免疫性疾病中有研究价值。
T11710	JAK-IN-5	JAK	Angiogenesis; Chromatin/Epigenetic; JAK/STAT signaling; Stem Cells
	JAK-IN-5 是一种 JAK 抑制剂。
T5492	JAK3-IN-6	JAK	Angiogenesis; Chromatin/Epigenetic; JAK/STAT signaling; Stem Cells
	JAK3-IN-6 是JAK3的选择性不可逆抑制剂，IC50值为 0.15 nM。
T3069	AZD-1480	JAK	Angiogenesis; Chromatin/Epigenetic; JAK/STAT signaling; Stem Cells
	AZD1480 是 ATP 竞争型JAK1和JAK2抑制剂，IC50分别为 1.3 和 0.4 nM。
T4210	SAR-20347 SAR20347	Tyrosine Kinases; JAK	Angiogenesis; Chromatin/Epigenetic; JAK/STAT signaling; Stem Cells; Tyrosine Kinase/Adaptors
	SAR-20347 是 TYK2、JAK1、JAK2和JAK3的抑制剂，IC50值分别为 0.6、23、26 和 41 nM。
T5091	FM-381 FM381	JAK	Angiogenesis; Chromatin/Epigenetic; JAK/STAT signaling; Stem Cells
	FM-381 是一种可逆的JAK3共价抑制剂，靶向 Cys909 位点，对 JAK3 的IC50值为127 pM，选择性分别比 JAK1、JAK2 和 TYK2 高 410、2700 和 3600 倍。
T6790	BMS-911543 BMS911543	Tyrosine Kinases; Histone Methyltransferase; JAK	Angiogenesis; Chromatin/Epigenetic; JAK/STAT signaling; Stem Cells; Tyrosine Kinase/Adaptors
	BMS-911543 是一种选择性 JAK2抑制剂，IC50值为 1.1 nM，对 JAK1、JAK3 和 TYK2 的选择性相对较弱，IC50值分别为 75、360 和 66 nM。
T6122	CEP-33779 CEP33779	JAK	Angiogenesis; Chromatin/Epigenetic; JAK/STAT signaling; Stem Cells
	CEP-33779是一种新型，选择性，有口服活性的JAK2抑制剂，IC50值为1.8±0.6 nM。
T2156	WP1066	Apoptosis; JAK; STAT	Angiogenesis; Apoptosis; Chromatin/Epigenetic; JAK/STAT signaling; Stem Cells
	WP1066 是一种新型JAK2和STAT3抑制剂，对 STAT5 和 ERK1/2 也起作用。它用于研究黑色素瘤、脑癌、实体瘤和中枢神经系统肿瘤治疗。
T6838	FLLL32	Apoptosis; JAK; STAT	Angiogenesis; Apoptosis; Chromatin/Epigenetic; JAK/STAT signaling; Stem Cells
	FLLL32是一种姜黄素的合成类似物，是JAK2/STAT3的双重抑制剂，具有抗肿瘤癌活性。它作用于乳腺癌细胞，可抑制 IFNα 和 IL-6 诱导的 STAT3 磷酸化。
TQ0037	Abrocitinib PF-04965842	JAK	Angiogenesis; Chromatin/Epigenetic; JAK/STAT signaling; Stem Cells
	Abrocitinib (PF-04965842) 是可口服、选择性的JAK1抑制剂，可用于自身免疫症的研究，对 JAK1 和 JAK2 的IC50值分别为 29 和 803 nM。它可抑制 TYK2 的活性，IC50为1.253 μM，也可抑制刺激后 STAT1、STAT3 和 STAT5 的磷酸化水平。
T5382	Ritlecitinib PF-06651600	JAK	Angiogenesis; Chromatin/Epigenetic; JAK/STAT signaling; Stem Cells
	Ritlecitinib (PF-06651600) 是一种口服有效的选择性JAK3抑制剂，IC50值为 33.1 nM。
T8546	BD750	JAK; STAT	Angiogenesis; Chromatin/Epigenetic; JAK/STAT signaling; Stem Cells
	BD750 是免疫抑制剂和JAK3/STAT5的抑制剂，可抑制 IL-2 诱导的、JAK3/STAT5 依赖的 T 细胞增殖，对小鼠和人 T 细胞增殖的IC50值分别为 1.5 和 1.1 μM。
T39113L	Povorcitinib phosphate	JAK	Angiogenesis; Chromatin/Epigenetic; JAK/STAT signaling; Stem Cells
	Povorcitinib phosphate 是一种选择性 JAK1 抑制剂，可用于治疗皮肤红斑狼疮和扁平苔藓的研究。
T1929	Filgotinib GLPG0634	Tyrosine Kinases; JAK	Angiogenesis; Chromatin/Epigenetic; JAK/STAT signaling; Stem Cells; Tyrosine Kinase/Adaptors
	Filgotinib (GLPG0634) 是一种选择性的JAK 抑制剂，对 JAK1、JAK2、JAK3 和 TYK2 的活性，IC50值分别为 10、28、810 和 116 nM。
T10431	Golidocitinib AZD4205	JAK	Angiogenesis; Chromatin/Epigenetic; JAK/STAT signaling; Stem Cells
	Golidocitinib (AZD4205) 是一种选择性 JAK1抑制剂，IC50值为 73 nM。
TQ0010	Brepocitinib PF-06700841	Tyrosine Kinases; JAK	Angiogenesis; Chromatin/Epigenetic; JAK/STAT signaling; Stem Cells; Tyrosine Kinase/Adaptors
	Brepocitinib (PF-06700841) 是JAK1和TYK2双重抑制剂，IC50分别为 17 nM 和 23 nM。它抑制JAK2和JAK3的效果较弱，IC50分别为 77 nM 和 6.49 μM 。
T6309	AZ960 AZ 960	Apoptosis; Virus Protease; JAK; Parasite	Angiogenesis; Apoptosis; Chromatin/Epigenetic; JAK/STAT signaling; Microbiology/Virology; Stem Cells
	AZ960 是一种高效选择性的 JAK2激酶抑制剂，Ki 值为0.45 nM。
T6217	LFM-A13	PLK; JAK; BTK	Angiogenesis; Cell Cycle/Checkpoint; Chromatin/Epigenetic; JAK/STAT signaling; Stem Cells; Tyrosine Kinase/Adaptors
	LFM-A13 是一种 BTK，JAK2，PLK 有效抑制剂，可抑制 BTK、Plx1 和 PLK3 的活性，IC50分别为 2.5、10 和 61 μM。
T14331	Gusacitinib ASN-002	JAK; Syk	Angiogenesis; Chromatin/Epigenetic; JAK/STAT signaling; Stem Cells; Tyrosine Kinase/Adaptors
	Gusacitinib (ASN-002) 是一种有效的 SYK 激酶和JAK 激酶的双抑制剂，IC50值为 5 到 46 nM 之间，具有抗癌活性。
T22416	RO495 CS-2667	Tyrosine Kinases; JAK	Angiogenesis; Chromatin/Epigenetic; JAK/STAT signaling; Stem Cells; Tyrosine Kinase/Adaptors
	RO495 (CS-2667) 是一种有效的非受体酪氨酸蛋白激酶2抑制剂。
T3072	XL019	Apoptosis; FLT; JAK; PDGFR	Angiogenesis; Apoptosis; Chromatin/Epigenetic; JAK/STAT signaling; Stem Cells; Tyrosine Kinase/Adaptors
	XL019 是一种具有口服活性的选择性JAK2抑制剂。它对JAK2的选择性是 100 多种丝氨酸/苏氨酸和酪氨酸激酶的 50 倍以上。它对 JAK2 V617F 和野生型 JAK2 细胞中 STAT3 和 STAT5 磷酸化有抑制作用。
T12266	Ilginatinib NS-018	Tyrosine Kinases; JAK	Angiogenesis; Chromatin/Epigenetic; JAK/STAT signaling; Stem Cells; Tyrosine Kinase/Adaptors
	Ilginatinib (NS-018) 是一种可口服的JAK2强效抑制剂，IC50值为 0.72 nM，对其选择性是对 JAK1、JAK3和 Tyk2 的 46、54 和 22 倍，IC50分别为 33、39 和 22 nM。
T7503	Upadacitinib 乌帕替尼,ABT-494	JAK	Angiogenesis; Chromatin/Epigenetic; JAK/STAT signaling; Stem Cells
	Upadacitinib (ABT-494) 是高效选择性的，具有口服活性的 JAK1抑制剂，IC50为43 nM，可用于多种自身免疫性疾病的研究。它对 JAK1 的选择性约为 JAK2 的 74 倍。
T6321	Tofacitinib 托法替尼,Tasocitinib,CP-690550	ROCK; Apoptosis; JAK; Src	Angiogenesis; Apoptosis; Cell Cycle/Checkpoint; Chromatin/Epigenetic; Cytoskeletal Signaling; JAK/STAT signaling; Stem Cells; Tyrosine Kinase/Adaptors
	Tofacitinib (Tasocitinib) 是口服小分子 Janus 激酶抑制剂，用于治疗中度至重度类风湿性关节炎。
T15096	Delgocitinib JTE-052,迪高替尼,Corectim（Delgocitinib）	Tyrosine Kinases; JAK	Angiogenesis; Chromatin/Epigenetic; JAK/STAT signaling; Stem Cells; Tyrosine Kinase/Adaptors
	Delgocitinib（JTE-052）是一种特异性的JAK（Janus激酶）抑制剂，其对JAK1、JAK2、JAK3 和 Tyk2 的 IC50 值分别为 2.8、2.6、13 和 58 nM。Delgocitinib 通过JAK-依赖性细胞因子参与多种炎症和自身免疫性疾病，能有效地遏制多种细胞因子信号传递，同时抑制了因细胞因子而引发的瘙痒。它可广泛用于治疗各种炎症性疾病，包括自身免疫性疾病和超敏反应。
T3042	JAK2 Inhibitor V JAK2 Inhibitor V Z3,Z3,NSC42834	JAK	Angiogenesis; Chromatin/Epigenetic; JAK/STAT signaling; Stem Cells
	JAK2 Inhibitor V (JAK2 Inhibitor V Z3) 是一种新型的 Jak2 特异性抑制剂，以剂量依赖性方式抑制 Jak2-V617F 和 Jak2-WT 自磷酸化。
T3998	Itacitinib 伊他替尼,INCB39110,INCB039110	JAK	Angiogenesis; Chromatin/Epigenetic; JAK/STAT signaling; Stem Cells
	Itacitinib (INCB039110) 是一种选择性 JAK1抑制剂，对人JAK1的IC50值为 2 nM。它对JAK1选择性是 JAK2 的 20 倍多，是 JAK3 和 TYK2 的 100 倍多。
T12427	Brepocitinib P-Tosylate PF-06700841 P-Tosylate	JAK	Angiogenesis; Chromatin/Epigenetic; JAK/STAT signaling; Stem Cells
	Brepocitinib P-Tosylate (PF-06700841 P-Tosylate) 是一种有效的 JAK1和TYK2双重抑制剂，IC50值分别为 17 和 23 nM。它还抑制JAK2和JAK3，IC50值分别为 77 和 6.49 μM。
T2636	Decernotinib VX-509,VRT-831509	Tyrosine Kinases; JAK	Angiogenesis; Chromatin/Epigenetic; JAK/STAT signaling; Stem Cells; Tyrosine Kinase/Adaptors
	Decernotinib (VRT-831509) 是一种可口服的JAK3抑制剂，对JAK3、JAK1、JAK2 和 TYK2 的Ki 值分别为 2.5、11、13 和 11 nM。
T3076	GLPG0634 analog GLPG0634 analogue	Tyrosine Kinases; JAK	Angiogenesis; Chromatin/Epigenetic; JAK/STAT signaling; Stem Cells; Tyrosine Kinase/Adaptors
	GLPG0634 analog (GLPG0634 analogue) 是一种 JAK 广谱性抑制剂，对 JAK1/JAK2/JAK3 的 IC50值为 50 到 200 nM 之间。
T6020	Pacritinib SB1518	FLT; Tyrosine Kinases; JAK	Angiogenesis; Chromatin/Epigenetic; JAK/STAT signaling; Stem Cells; Tyrosine Kinase/Adaptors
	Pacritinib (SB1518) 是一种野生型 JAK2和 JAK2V617F 突变型抑制剂，IC50分别为 23 和 19 nM。它也抑制 FLT3及其突变型 FLT3D835Y，IC50分别为 22 和 6 nM。
T3065	TG101209	Apoptosis; FLT; c-RET; JAK; Autophagy	Angiogenesis; Apoptosis; Autophagy; Chromatin/Epigenetic; JAK/STAT signaling; Stem Cells; Tyrosine Kinase/Adaptors
	TG101209 是一种选择性有效的 JAK2抑制剂，IC50值为 6 nM。它能抑制 Flt3和RET 的活性，IC50值分别为 25 nM 和 17 nM。
T7123	AMG-47a	VEGFR; p38 MAPK; JAK; Src	Angiogenesis; Chromatin/Epigenetic; JAK/STAT signaling; MAPK; Stem Cells; Tyrosine Kinase/Adaptors
	AMG-47a 是具有口服活性的 Lck 抑制剂，IC50值为 0.2 nM。它具有抗炎作用，对 VEGF2、p38α、p38α、Jak3、MLR 和 IL-2的 IC50值分别为 1、3、72、30 和 21 nM。
T2485	Baricitinib INCB028050,LY3009104,巴瑞克替尼	Tyrosine Kinases; JAK; Chk	Angiogenesis; Cell Cycle/Checkpoint; Chromatin/Epigenetic; JAK/STAT signaling; Stem Cells; Tyrosine Kinase/Adaptors
	Baricitinib (INCB028050) 是一种选择性，可口服的JAK1和JAK2抑制剂，IC50分别为5.9 nM 和 5.7 nM，具有潜在的抗炎、免疫调节和抗肿瘤活性。
T22338	2,6-Dichloro-N-(2-(cyclopropanecarboxamido)pyridin-4-yl)benzamide GDC046	Others; JAK	Angiogenesis; Chromatin/Epigenetic; JAK/STAT signaling; Others; Stem Cells
	2,6-Dichloro-N-(2-(cyclopropanecarboxamido)pyridin-4-yl)benzamide (GDC046) 是一种具有口服活性的选择性TYK2抑制剂，对 TYK2、JAK1、JAK2 和 JAK3 的Ki 分别为 4.8、0.7、0.7 和 0.4 nM。
T12266L	Ilginatinib maleate NS-018 maleate	Tyrosine Kinases; JAK	Angiogenesis; Chromatin/Epigenetic; JAK/STAT signaling; Stem Cells; Tyrosine Kinase/Adaptors
	Ilginatinib maleate (NS-018 maleate) 是一种可口服的 JAK2强效抑制剂，IC50值为 0.72 nM，对其选择性是对 JAK1、JAK3和 Tyk2 的 46、54 和 22 倍，IC50分别为 33、39 和 22 nM。
T3620	Solcitinib 索西替尼,GLPG-0778,GSK-2586184	JAK	Angiogenesis; Chromatin/Epigenetic; JAK/STAT signaling; Stem Cells
	Solcitinib (GLPG-0778) 是一种可口服的，选择性的竞争性JAK1抑制剂，IC50值为 9.8 nM，可用于银屑病的研究。它对其选择性是对 JAK2、JAK3 和 TYK2 的 11、55 和 23 倍。
T1849	Momelotinib CYT11387,CYT387,LM-1149	Apoptosis; JAK; Autophagy	Angiogenesis; Apoptosis; Autophagy; Chromatin/Epigenetic; JAK/STAT signaling; Stem Cells
	Momelotinib (LM-1149) 是一种 ATP 竞争性的 JAK1/JAK2抑制剂，IC50值分别为 11 nM/18 nM。
T12266L2	Ilginatinib hydrochloride NS-018 hydrochloride	Tyrosine Kinases; JAK	Angiogenesis; Chromatin/Epigenetic; JAK/STAT signaling; Stem Cells; Tyrosine Kinase/Adaptors
	Ilginatinib hydrochloride (NS-018 hydrochloride) 是一种可口服的 JAK2强效抑制剂，IC50值为 0.72 nM，对其选择性是对 JAK1、JAK3和 Tyk2 的 46、54 和 22 倍，IC50分别为 33、39 和 22 nM。
T2045	JANEX-1 Jak3 inhibitor I,WHI-P131	JAK	Angiogenesis; Chromatin/Epigenetic; JAK/STAT signaling; Stem Cells
	JANEX-1 (Jak3 inhibitor I) 是一种特异性JAK3抑制剂，Ki 和IC50分别为 2.3 和 78 μM。
T8742	G5-7 JAK2 inhibitor G5-7	Apoptosis; JAK	Angiogenesis; Apoptosis; Chromatin/Epigenetic; JAK/STAT signaling; Stem Cells
	JAK2 inhibitor G5-7 (JAK2 inhibitor G5-7) 是具有口服活性的JAK2变构抑制剂，可通过结合到 JAK2，选择性的抑制JAK2介导的 EGFR 和 STAT3 的磷酸化和激活。它诱导细胞周阻滞和诱导凋亡、具有抗血管生成活性。它有用于胶质瘤研究的潜能。
T1829	Ruxolitinib 芦可替尼,INCB018424,鲁索替尼,(R)-Ruxolitinib	Apoptosis; Mitophagy; Tyrosine Kinases; JAK; Autophagy	Angiogenesis; Apoptosis; Autophagy; Chromatin/Epigenetic; JAK/STAT signaling; Stem Cells; Tyrosine Kinase/Adaptors
	Ruxolitinib (INCB018424) 是一种 JAK1/2 抑制剂 (IC50=3.3/2.8 nM)，具有有效性和选择性。Ruxolitinib 具有抗肿瘤活性，可以诱导细胞自噬和凋亡。
T8719	SC99	Apoptosis; JAK; STAT	Angiogenesis; Apoptosis; Chromatin/Epigenetic; JAK/STAT signaling; Stem Cells
	SC99 是一种口服有效选择性STAT3抑制剂，靶向 JAK2-STAT3 途径，抑制血小板活化和聚集，有抗骨髓瘤和抗血栓活性。它结合在 JAK2 的 ATP 结合袋中，抑制 JAK2 和 STAT3 的磷酸化。
T2487	Cerdulatinib PRT2070,赛度替尼,PRT062070	Tyrosine Kinases; JAK; Syk	Angiogenesis; Chromatin/Epigenetic; JAK/STAT signaling; Stem Cells; Tyrosine Kinase/Adaptors
	Cerdulatinib (PRT2070) 是一种选择性 Tyk2抑制剂，IC50为 0.5 nM。它是 JAK 和 SYK 的双抑制剂，抑制JAK1、2、3 和SYK 的IC50分别为12、6、8 和 32。

化合物

Cat.No: T32264

Synonym: C.I. 11045,EINECS 225-029-8,Janus Green G

Janus green B

Cat.No: T20027

Synonym: NSC13986,NSC 13986,Janus Green V,NSC-13986

Cat.No: T32265

Synonym: NSC-9609,NSC9609,Janus Red B,NSC 9609,C.I. 26115

Cat.No: T32263

Synonym: C.I. 12210,Indoine Blue R,EINECS 224-951-8,C.I. Basic Blue 16,Indazol Blue R

Cat.No: T3080

Synonym: Janus-Associated Kinase Inhibitor I,JAK Inhibitor,CMP 6,吡啶酮6,JAK Inhibitor I

Target: Tyrosine Kinases, JAK

Fosifidancitinib

Cat.No: T38624

Target: JAK

Cat.No: T11710

Target: JAK

Cat.No: T5492

Target: JAK

Cat.No: T3069

Target: JAK

Cat.No: T4210

Synonym: SAR20347

Target: Tyrosine Kinases, JAK

Cat.No: T5091

Synonym: FM381

Target: JAK

Cat.No: T6790

Synonym: BMS911543

Target: Tyrosine Kinases, Histone Methyltransferase, JAK

Cat.No: T6122

Synonym: CEP33779

Target: JAK

Cat.No: T2156

Target: Apoptosis, JAK, STAT

Cat.No: T6838

Target: Apoptosis, JAK, STAT

Cat.No: TQ0037

Synonym: PF-04965842

Target: JAK

Cat.No: T5382

Synonym: PF-06651600

Target: JAK

Cat.No: T8546

Target: JAK, STAT

Povorcitinib phosphate

Cat.No: T39113L

Target: JAK

Cat.No: T1929

Synonym: GLPG0634

Target: Tyrosine Kinases, JAK

Cat.No: T10431

Synonym: AZD4205

Target: JAK

Cat.No: TQ0010

Synonym: PF-06700841

Target: Tyrosine Kinases, JAK

Cat.No: T6309

Synonym: AZ 960

Target: Apoptosis, Virus Protease, JAK, Parasite

Cat.No: T6217

Target: PLK, JAK, BTK

Cat.No: T14331

Synonym: ASN-002

Target: JAK, Syk

Cat.No: T22416

Synonym: CS-2667

Target: Tyrosine Kinases, JAK

Cat.No: T3072

Target: Apoptosis, FLT, JAK, PDGFR

Cat.No: T12266

Synonym: NS-018

Target: Tyrosine Kinases, JAK

Cat.No: T7503

Synonym: 乌帕替尼,ABT-494

Target: JAK

Cat.No: T6321

Synonym: 托法替尼,Tasocitinib,CP-690550

Target: ROCK, Apoptosis, JAK, Src

Cat.No: T15096

Synonym: JTE-052,迪高替尼,Corectim（Delgocitinib）

Target: Tyrosine Kinases, JAK

JAK2 Inhibitor V

Cat.No: T3042

Synonym: JAK2 Inhibitor V Z3,Z3,NSC42834

Target: JAK

Cat.No: T3998

Synonym: 伊他替尼,INCB39110,INCB039110

Target: JAK

Brepocitinib P-Tosylate

Cat.No: T12427

Synonym: PF-06700841 P-Tosylate

Target: JAK

Cat.No: T2636

Synonym: VX-509,VRT-831509

Target: Tyrosine Kinases, JAK

GLPG0634 analog

Cat.No: T3076

Synonym: GLPG0634 analogue

Target: Tyrosine Kinases, JAK

Cat.No: T6020

Synonym: SB1518

Target: FLT, Tyrosine Kinases, JAK

Cat.No: T3065

Target: Apoptosis, FLT, c-RET, JAK, Autophagy

Cat.No: T7123

Target: VEGFR, p38 MAPK, JAK, Src

Cat.No: T2485

Synonym: INCB028050,LY3009104,巴瑞克替尼

Target: Tyrosine Kinases, JAK, Chk

2,6-Dichloro-N-(2-(cyclopropanecarboxamido)pyridin-4-yl)benzamide

Cat.No: T22338

Synonym: GDC046

Target: Others, JAK

Ilginatinib maleate

Cat.No: T12266L

Synonym: NS-018 maleate

Target: Tyrosine Kinases, JAK

Cat.No: T3620

Synonym: 索西替尼,GLPG-0778,GSK-2586184

Target: JAK

Cat.No: T1849

Synonym: CYT11387,CYT387,LM-1149

Target: Apoptosis, JAK, Autophagy

Ilginatinib hydrochloride

Cat.No: T12266L2

Synonym: NS-018 hydrochloride

Target: Tyrosine Kinases, JAK

Cat.No: T2045

Synonym: Jak3 inhibitor I,WHI-P131

Target: JAK

Cat.No: T8742

Synonym: JAK2 inhibitor G5-7

Target: Apoptosis, JAK

Cat.No: T1829

Synonym: 芦可替尼,INCB018424,鲁索替尼,(R)-Ruxolitinib

Target: Apoptosis, Mitophagy, Tyrosine Kinases, JAK, Autophagy

Cat.No: T8719

Target: Apoptosis, JAK, STAT

Cat.No: T2487

Synonym: PRT2070,赛度替尼,PRT062070

Target: Tyrosine Kinases, JAK, Syk

Cat. No.	Product Name	Target	Signaling Pathways
T4672	Brevilin A	Apoptosis; Anti-infection; JAK; STAT; Autophagy	Angiogenesis; Apoptosis; Autophagy; Chromatin/Epigenetic; JAK/STAT signaling; Microbiology/Virology; Stem Cells
	Brevilin A 是从Centipeda minima 中分离的倍半萜内酯，具有抗癌活性。它通过线粒体途径和 PI3K/AKT/mTOR 失活诱导结肠腺癌细胞 CT26 的凋亡和自噬。它是一种选择性JAK-STAT 信号通路抑制剂，通过减弱 JAK 信号和阻塞 STAT3 信号起作用。
TJS1779	Protosappanin A 原苏木素A,PTA	NADPH-oxidase; IL Receptor; IκB/IKK; TNF; NF-κB; TLR; ROS; COX; HIV Protease; JAK; NO Synthase; STAT	Angiogenesis; Apoptosis; Chromatin/Epigenetic; Immunology/Inflammation; JAK/STAT signaling; Microbiology/Virology; Neuroscience; NF-κB; Proteases/Proteasome; Stem Cells
	Protosappanin A (PTA) 是从苏木中分离得到的免疫抑制成分和主要联苯化合物，通过下调 JAK2和 STAT3的磷酸化，抑制 JAK2/STAT3依赖的炎症通路。
TN2269	Tetramethylcurcumin	Apoptosis; STAT	Apoptosis; JAK/STAT signaling; Stem Cells
	Tetramethylcurcumin 是一种新型姜黄素类似物，是一种有效的 STAT3 磷酸化、DNA 结合活性和体外反式激活抑制剂。它具有抗炎和抗癌作用。
T6S1966	Curculigoside Curculigoside A,仙茅苷	Antioxidant; NF-κB; JAK; STAT	Angiogenesis; Chromatin/Epigenetic; JAK/STAT signaling; NF-κB; oxidation-reduction; Stem Cells
	Curculigoside (Curculigoside A) 是仙茅中的主要皂苷，具有显著的抗氧化、抗骨质疏松、抗抑郁和神经保护作用。它通过调节JAK/STAT/NF-κB 信号传导途径，具有抗关节炎作用。
T5S0167	Atractylenolide I 白术内酯 I,白术内酯I；苍术内酯I	IL Receptor; TNF; TLR; JAK; STAT	Angiogenesis; Apoptosis; Chromatin/Epigenetic; Immunology/Inflammation; JAK/STAT signaling; Stem Cells
	Atractylenolide I 是从白术根中得到的一种倍半萜烯，具有神经保护、抗过敏、抗炎和抗癌等多种生物活性。它是一种TLR4拮抗剂，在 A375 细胞中，能够降低JAK2和STAT3的磷酸化水平。
TQ0196	Cucurbitacin I NSC-521777,JSI-124,Elatericin B,葫芦素 I	JAK; STAT	Angiogenesis; Chromatin/Epigenetic; JAK/STAT signaling; Stem Cells
	Cucurbitacin I (JSI-124) 是从曲莲中提取的一种天然产物，是 JAK2/STAT3选择性抑制剂，有抗肿瘤活性。
T4S1499	Ginsenoside Rk1 人参皂苷RK1,人参皂苷	Apoptosis; Others; NF-κB; PI3K; JAK	Angiogenesis; Apoptosis; Chromatin/Epigenetic; JAK/STAT signaling; NF-κB; Others; PI3K/Akt/mTOR signaling; Stem Cells
	Ginsenoside Rk1 是人参的高温加工提取物，抑制Jak2/Stat3信号通路和NF-κB 的激活。它具有抗肿瘤、抗血小板聚集活性、抗炎、抗胰岛素抵抗、肾保护和抗菌作用，可使认知功能增强，脂质积聚减少和预防骨质疏松症，还诱导细胞凋亡。

天然产物

Cat.No: T4672

Target: Apoptosis, Anti-infection, JAK, STAT, Autophagy

Protosappanin A

Cat.No: TJS1779

Synonym: 原苏木素A,PTA

Target: NADPH-oxidase, IL Receptor, IκB/IKK, TNF, NF-κB, TLR, ROS, COX, HIV Protease, JAK, NO Synthase, STAT

Tetramethylcurcumin

Cat.No: TN2269

Target: Apoptosis, STAT

Cat.No: T6S1966

Synonym: Curculigoside A,仙茅苷

Target: Antioxidant, NF-κB, JAK, STAT

Atractylenolide I

Cat.No: T5S0167

Synonym: 白术内酯 I,白术内酯I；苍术内酯I

Target: IL Receptor, TNF, TLR, JAK, STAT

Cat.No: TQ0196

Synonym: NSC-521777,JSI-124,Elatericin B,葫芦素 I

Target: JAK, STAT

Ginsenoside Rk1

Cat.No: T4S1499

Synonym: 人参皂苷RK1,人参皂苷

Target: Apoptosis, Others, NF-κB, PI3K, JAK

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPH-02272	JAK1 Protein, Human, Recombinant (E. coli, His) Tyrosine-protein kinase JAK1,JAK1,Janus kinase 1	Human	E. coli
	Tyrosine kinase of the non-receptor type, involved in the IFN-alpha/beta/gamma signal pathway. Kinase partner for the interleukin (IL)-2 receptor as well as interleukin (IL)-10 receptor. Directly phosphorylates STAT but also activates STAT signaling through the transactivation of other JAK kinases associated with signaling receptors.
TMPH-02961	JAK1 Protein, Mouse, Recombinant (His) Janus kinase 1,Jak1,Tyrosine-protein kinase JAK1	Mouse	E. coli
	Tyrosine kinase of the non-receptor type, involved in the IFN-alpha/beta/gamma signal pathway. Kinase partner for the interleukin (IL)-2 receptor as well as interleukin (IL)-10 receptor. Directly phosphorylates STAT but also activates STAT signaling through the transactivation of other JAK kinases associated with signaling receptors. JAK1 Protein, Mouse, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 39.1 kDa and the accession numb...
TMPH-02274	JAK2 Protein, Human, Recombinant (His) JAK2,Janus kinase 2,Tyrosine-protein kinase JAK2	Human	E. coli
	Non-receptor tyrosine kinase involved in various processes such as cell growth, development, differentiation or histone modifications. Mediates essential signaling events in both innate and adaptive immunity. In the cytoplasm, plays a pivotal role in signal transduction via its association with type I receptors such as growth hormone (GHR), prolactin (PRLR), leptin (LEPR), erythropoietin (EPOR), thrombopoietin (THPO); or type II receptors including IFN-alpha, IFN-beta, IFN-gamma and multiple int...
TMPH-02273	JAK1 Protein, Human, Recombinant (His) JAK1,Janus kinase 1,Tyrosine-protein kinase JAK1	Human	P. pastoris (Yeast)
	Tyrosine kinase of the non-receptor type, involved in the IFN-alpha/beta/gamma signal pathway. Kinase partner for the interleukin (IL)-2 receptor as well as interleukin (IL)-10 receptor. Directly phosphorylates STAT but also activates STAT signaling through the transactivation of other JAK kinases associated with signaling receptors.
TMPY-02002	PHPT1 Protein, Human, Recombinant (His) phosphohistidine phosphatase 1,CGI-202,HSPC141,HEL-S-132P,PH...	Human	E. coli
	PHPT1, also known as 14 kDa phosphohistidine phosphatase, phosphohistidine phosphatase 1, protein janus-A homolog, PHP14, is a cytoplasm protein which belongs to the janus family. PHPT1 / PHP14 is expressed abundantly in heart and skeletal muscle. Phosphatases are a diverse group of enzymes that regulate numerous cellular processes. Much of what is known relates to the tyrosine, threonine, and serine phosphatases, whereas the histidine phosphatases have not been studied as much. Protein histidin...
TMPK-01105	IL-22RA1 Protein, Human, Recombinant (hFc) IL-22R-alpha-1,CRF2-9,IL-TIF-R1,IL-22R-α-1,IL22R1,zcytoR11,I...	Human	HEK293 Cells
	Interleukin (IL)-22 is a member of the IL-10 family of cytokines and represents an important effector molecule of activated Th22, Th1, and Th17 cells, as well as Tc-cell subsets, gammadelta T cells, natural killer (NK), and NKT cells. IL-22 mediates its effects via a heterodimeric transmembrane receptor complex consisting of IL-22R1 and IL-10R2 and subsequent Janus kinase-signal transducers and activators of transcription (JAK-STAT) signaling pathways including Jak1, Tyk2, and STAT3. IL-22RA1 Pr...
TMPK-01071	IL-22RA1 Protein, Mouse, Recombinant (hFc) IL-22R α1,IL22R,zcytoR11,IL-TIF-R1,CRF2-9,IL-22R-alpha-1,IL-...	Mouse	HEK293 Cells
	Interleukin (IL)-22 is a member of the IL-10 family of cytokines and represents an important effector molecule of activated Th22, Th1, and Th17 cells, as well as Tc-cell subsets, gammadelta T cells, natural killer (NK), and NKT cells. IL-22 mediates its effects via a heterodimeric transmembrane receptor complex consisting of IL-22R1 and IL-10R2 and subsequent Janus kinase-signal transducers and activators of transcription (JAK-STAT) signaling pathways including Jak1, Tyk2, and STAT3. IL-22RA1 Pr...
TMPJ-00356	GHR/Growth Hormone R Protein, Mouse, Recombinant (hFc) GHBP,GHR,Somatotropin receptor,growth hormone receptor,growt...	Mouse	HEK293 Cells
	Growth hormone receptor is a transmembrane receptor for growth hormone (GH). GH is a single-chain polypeptide that is mainly synthesized and released from the anterior pituitary gland and plays essential roles in growth, development and metabolism. GH exerts its physiological actions via GH binding to its receptor in its extracellular domain. Binding of growth hormone to the receptor leads to receptor dimerization and the activation of an intra- and intercellular signal transduction pathway lead...
TMPJ-00194	IL-20RB Protein, Human, Recombinant (hFc) DIRS1,IL-20R-β,Interleukin-20 receptor subunit β,IL-20 recep...	Human	HEK293 Cells
	Interleukin-20 receptor subunit beta（IL20RB） is a single-pass type I membrane protein and belongs to the type II cytokine receptor family. It contains 2 fibronectin type-III domains. There are two kinds of type II cytokine receptors : cytokine receptors that bind type I and type II interferons; cytokine receptors that bind members of the interleukin-10 family (interleukin-10, interleukin-20 and interleukin-22). Type II cytokine receptors are similar to type I cytokine receptors except they do no...
TMPJ-00398	IL-12RB2 Protein, Mouse, Recombinant (hFc) interleukin-12 receptor β-2 chain,IL-12RB2,interleukin-12 re...	Mouse	HEK293 Cells
	The IL12 receptor complex, formed by IL12RB1 and IL12RB2, mediates the type I immune responses of various types of lymphocytes. Its ligand, IL12, is a heterodimeric cytokine composed of IL-12p35 and IL-12p40 subunits that are linked via disulfide bonds. Ligation of IL-12 to its receptor involves the binding of IL-12p35 to IL12RB1 and IL-12p40 to IL12RB2. This will result in the activation of tyrosine kinase 2 (TYK2), which is associated with the IL12RB1 chain and Janus kinase 2 (JAK2), which is ...

重组蛋白

JAK1 Protein, Human, Recombinant (E. coli, His)

Cat.No: TMPH-02272

Species: Human

Expression System: E. coli

JAK1 Protein, Mouse, Recombinant (His)

Cat.No: TMPH-02961

Species: Mouse

Expression System: E. coli

JAK2 Protein, Human, Recombinant (His)

Cat.No: TMPH-02274

Species: Human

Expression System: E. coli

JAK1 Protein, Human, Recombinant (His)

Cat.No: TMPH-02273

Species: Human

Expression System: P. pastoris (Yeast)

PHPT1 Protein, Human, Recombinant (His)

Cat.No: TMPY-02002

Species: Human

Expression System: E. coli

IL-22RA1 Protein, Human, Recombinant (hFc)

Cat.No: TMPK-01105

Species: Human

Expression System: HEK293 Cells

IL-22RA1 Protein, Mouse, Recombinant (hFc)

Cat.No: TMPK-01071

Species: Mouse

Expression System: HEK293 Cells

GHR/Growth Hormone R Protein, Mouse, Recombinant (hFc)

Cat.No: TMPJ-00356

Species: Mouse

Expression System: HEK293 Cells

IL-20RB Protein, Human, Recombinant (hFc)

Cat.No: TMPJ-00194

Species: Human

Expression System: HEK293 Cells

IL-12RB2 Protein, Mouse, Recombinant (hFc)

Cat.No: TMPJ-00398

Species: Mouse

Expression System: HEK293 Cells

Cat. No.	Product Name	Target	Signaling Pathways
T14687	Deucravacitinib BMS-986165	Tyrosine Kinases; JAK; IFNAR; Interleukin	Angiogenesis; Chromatin/Epigenetic; Immunology/Inflammation; JAK/STAT signaling; Stem Cells; Tyrosine Kinase/Adaptors
	Deucravacitinib (BMS-986165) 是一种高选择性、口服生物可利用的变构 TYK2 抑制剂，用于治疗自身免疫性疾病。它通过稳定调节 JH2 结构域来阻断受体介导的 Tyk2 激活，可抑制IL-12/23和 I 型IFN 途径。它选择性结合 TYK2 假激酶 (JH2) 结构域，IC50为1.0 nM。
TMIJ-0261	Baricitinib-d5
	Baricitinib-d5 是 Baricitinib 的氘代化合物。Baricitinib 的 CAS 号为 1187594-09-7。Baricitinib 是一种选择性，可口服的JAK1和JAK2抑制剂，IC50分别为5.9 nM 和 5.7 nM，具有潜在的抗炎、免疫调节和抗肿瘤活性。
TMIJ-0267	Upadacitinib-15N-d2
	Upadacitinib-15N-d2 是 Upadacitinib 的 15N 和氘代化合物。Upadacitinib 的 CAS 号为 1310726-60-3。Upadacitinib 是高效选择性的，具有口服活性的JAK1抑制剂，IC50为43 nM，可用于多种自身免疫性疾病的研究。它对 JAK1 的选择性约为 JAK2 的 74 倍。

同位素标记化合物

Deucravacitinib

Cat.No: T14687

Synonym: BMS-986165

Target: Tyrosine Kinases, JAK, IFNAR, Interleukin

Cat.No: TMIJ-0261

Upadacitinib-15N-d2

Cat.No: TMIJ-0267

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