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Targets Recommended: Others

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Cat. No. Product Name Target Signaling Pathways
T69646 JS25

Others Others
JS25 是一种选择性的 BTK 共价抑制剂 (IC50=5.8 nM),通过螯合Tyr551而使BTK 失活。JS25 抑制癌细胞增殖,诱导细胞死亡,对鼠中的 Burkitt 淋巴瘤异种移植模型具有改善效果。JS25 能够透过血脑屏障。
T69645 BRD20322

Others Others
BRD20322 is a novel potent inhibitor of spCas9, disrupting spCas9-DNA binding and exerting dose and temporal control of spCas9 in human cell lines.
T36629 Givinostat

Others Others
Givinostat (ITF-2357) is a HDAC inhibitor with an IC50 of 198 and 157 nM for HDAC1 and HDAC3, respectively. Givinostat (ITF2357) suppresses total LPS-induced IL-1β production robustly compared with the reduction by ITF3056. At 25, 50, and 100 nM, Givinostat reduced IL-1β secretion more than 70%. Givinostat (ITF-2357) suppresses the production of IL-6 in PBMCs stimulated with TLR agonists as well as the combination of IL-12 plus IL-18. IL-6 secretion decreases to 50% at 50 nM Givinostat, but at 1...

化合物

JS25
Cat.No: T69646
Synonym:
Target: Others
BRD20322
Cat.No: T69645
Synonym:
Target: Others
Givinostat
Cat.No: T36629
Synonym:
Target: Others
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