Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T69646 |
JS25
|
Others | Others |
JS25 是一种选择性的 BTK 共价抑制剂 (IC50=5.8 nM),通过螯合Tyr551而使BTK 失活。JS25 抑制癌细胞增殖,诱导细胞死亡,对鼠中的 Burkitt 淋巴瘤异种移植模型具有改善效果。JS25 能够透过血脑屏障。 | |||
T69645 |
BRD20322
|
Others | Others |
BRD20322 is a novel potent inhibitor of spCas9, disrupting spCas9-DNA binding and exerting dose and temporal control of spCas9 in human cell lines. | |||
T36629 |
Givinostat
|
Others | Others |
Givinostat (ITF-2357) is a HDAC inhibitor with an IC50 of 198 and 157 nM for HDAC1 and HDAC3, respectively. Givinostat (ITF2357) suppresses total LPS-induced IL-1β production robustly compared with the reduction by ITF3056. At 25, 50, and 100 nM, Givinostat reduced IL-1β secretion more than 70%. Givinostat (ITF-2357) suppresses the production of IL-6 in PBMCs stimulated with TLR agonists as well as the combination of IL-12 plus IL-18. IL-6 secretion decreases to 50% at 50 nM Givinostat, but at 1... |