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Cat. No. | Product Name | ||
---|---|---|---|
L3700 | JAK-STAT 化合物库 | 252 compounds | |
252 个 JAK/STAT 靶点相关的小分子化合物的独特集合,用于高通量、高内涵筛选; |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T40443 |
JAK2-IN-6
JAK2-IN-6 |
JAK | Angiogenesis; Chromatin/Epigenetic; JAK/STAT signaling; Stem Cells |
JAK2-IN-6是一种有效的、有选择性的 JAK2抑制剂(ic50为22.86 μg/mL),是一种多取代氨基噻唑衍生物。JAK2-IN-6抑制 JAK2酶的活性 ,通过干扰与 JAK2相关的信号通路,从而对 JAK2失调的特定疾病产生治疗作用, 对 JAK1和JAK3不显示出活性。JAK2是一种参与调节细胞生长和分裂的信号通路的蛋白质。JAK2的异常激活与多种疾病有关,包括某些类型的癌症和炎症性疾病。JAK2-IN-6对癌细胞具有抗增殖活性。 | |||
T35900 |
JAK2-IN-7
JAK2-IN-7 |
JAK | Angiogenesis; Chromatin/Epigenetic; JAK/STAT signaling; Stem Cells |
JAK2-IN-7 是一种选择性 JAK2抑制剂,对 JAK2,SET-2 和 Ba/F3V617F 细胞的IC50为 3、11.7 和 41 nM。 JAK2-IN-7 的选择性是 JAK1, JAK3,FLT3 的 14 倍以上。JAK2-IN-7 刺激细胞周期停滞在 G0/G1 期,并诱导肿瘤细胞凋亡 (apoptosis),具有抗肿瘤活性。 | |||
T3042 |
JAK2 Inhibitor V
JAK2 Inhibitor V Z3,Z3,NSC42834 |
JAK | Angiogenesis; Chromatin/Epigenetic; JAK/STAT signaling; Stem Cells |
JAK2 Inhibitor V (JAK2 Inhibitor V Z3) 是一种新型的 Jak2 特异性抑制剂,以剂量依赖性方式抑制 Jak2-V617F 和 Jak2-WT 自磷酸化。 | |||
T72754L |
(R)-JAK2/STAT3-IN-10a
|
Antiviral | Immunology/Inflammation |
(R)-JAK2/STAT3-IN-10a 是 JAK2/STAT3-IN-1 的R型异构体。JAK2/STAT3-IN-1 是一种 GP130 D1 结构域抑制剂,具有抗肿瘤活性,抑制 JAK2 和 STAT3 磷酸化。(R)-JAK2/STAT3-IN-1 对 GP130 蛋白的 KD 值为3.8μM。 | |||
T8742 |
G5-7
JAK2 inhibitor G5-7 |
Apoptosis; JAK | Angiogenesis; Apoptosis; Chromatin/Epigenetic; JAK/STAT signaling; Stem Cells |
JAK2 inhibitor G5-7 (JAK2 inhibitor G5-7) 是具有口服活性的JAK2变构抑制剂,可通过结合到 JAK2,选择性的抑制JAK2介导的 EGFR 和 STAT3 的磷酸化和激活。它诱导细胞周阻滞和诱导凋亡、具有抗血管生成活性。它有用于胶质瘤研究的潜能。 | |||
T72754 |
JAK2/STAT3-IN-1
|
Interleukin | Immunology/Inflammation |
JAK2/STAT3-IN-1 是一种 GP130 抑制剂,具有抗肿瘤作用,可用研究炎症,自身免疫和癌症。 | |||
T11708 |
JAK2-IN-4
|
JAK | Angiogenesis; Chromatin/Epigenetic; JAK/STAT signaling; Stem Cells |
JAK2-IN-4 is a selective JAK2/JAK3 inhibitor, with IC50 values of 0.7 nM and 23.2 nM for JAK2 and JAK3, respectively. | |||
T19017 |
JAK2 JH2 Tracer
|
Others | Others |
JAK2 JH2 Tracer is a fluorescent probe for the JAK2 JH2 domain (Kd: 0.2 μM). | |||
T11707 |
JAK2/FLT3-IN-1
|
JNK | MAPK |
JAK2/FLT3-IN-1 has anti-cancer activity. JAK2/FLT3-IN-1 is a potent and orally effective dual JAK2/FLT3 (Janus kinase 2/ FMS-like tyrosine kinase 3) inhibitor with IC50 values of 0.7 nM, 4 nM, 26 nM and 39 nM for JAK2, FLT3, JAK1 and JAK3, respectively. | |||
T71193 |
Jak2-IN-7j
|
Others | Others |
Jak2-IN-7j is a selective Jak2 inhibitor which demonstrates a time-dependent knock-down of pSTAT5, which is a downstream target of Jak2. | |||
T63146 |
JAK2/TYK2-IN-1
|
||
JAK2/TYK2-IN-2 是一种有效的、选择性的 TYK2 (IC50: 9 nM) 和 JAK2 (IC50: 157 nM) 抑制剂,具有抗炎作用。 | |||
T64104 |
JAK2/FLT3-IN-1 TFA
|
Others | Others |
JAK2/FLT3-IN-1 (TFA) 是一种口服具有活力的 JAK2/FLT3 双重抑制剂,表现出抗癌效果,能够作用于 JAK2 (IC50: 0.7 nM),FLT3 (IC50: 4 nM),JAK1 (IC50: 26 nM) 和 JAK3 (IC50: 39 nM)。 | |||
T64227 |
JAK2 JH2 binder-1
|
Others | Others |
JAK2 JH2 binder-1 是一种有效的、选择性的 JAK2 JH2 结合剂 (Ki: 37.1 nM)。JAK2 JH2 binder-1 具有用于研究各种骨髓增生性肿瘤的潜力。 | |||
T79581 |
JAK2-IN-9
|
JAK | Angiogenesis; Chromatin/Epigenetic; JAK/STAT signaling; Stem Cells |
JAK2-IN-9(Compound A8)是一款选择性JAK2抑制剂(IC50:5 nM),能够抑制JAK2、STAT3和STAT5的磷酸化,并显示出代谢稳定性。此外,JAK2-IN-9能够诱导细胞凋亡(apoptosis),适用于骨髓增生性肿瘤(MPN)的研究。 | |||
TP1269 |
Tyrosine Protein Kinase JAK 2 (Phospho-Tyr8, 9)
Tyrosine Protein Kinase JAK2 Phospho-Tyr8, 9 |
||
Tyrosine Protein Kinase JAK 2 (Phospho-Tyr8, 9) is a peptide derived from mouse JAK2, specifically composed of amino acids 475 to 491. | |||
T80921 |
Tubulin/JAK2-IN-1
|
Others | Others |
Tubulin/JAK2-IN-1是一种针对Janus激酶2 (JAK2)和微管的双重抑制剂,在抑制癌细胞增殖方面展现出有效活性。 | |||
T12266 |
Ilginatinib
NS-018 |
Tyrosine Kinases; JAK | Angiogenesis; Chromatin/Epigenetic; JAK/STAT signaling; Stem Cells; Tyrosine Kinase/Adaptors |
Ilginatinib (NS-018) 是一种可口服的JAK2强效抑制剂,IC50值为 0.72 nM,对其选择性是对 JAK1、JAK3和 Tyk2 的 46、54 和 22 倍,IC50分别为 33、39 和 22 nM。 | |||
T3133 |
YM-90709
YM90709,YM 90709 |
IL Receptor; Interleukin | Immunology/Inflammation |
YM-90709是新型的能够抑制IL-5与IL-5受体结合的拮抗剂, 。 | |||
T62317 |
α7 nAchR-JAK2-STAT3 agonist 1
|
Others | Others |
α7 nAchR-JAK2-STAT3 agonist 1 是一种 α7 nAchR-JAK2-STAT3 通路的有效抑制剂,能够作用于一氧化氮 (NO) (IC50: 0.32 μM)。α7 nAchR-JAK2-STAT3 agonist 1 在小鼠巨噬细胞 RAW264.7 中对 iNOS、IL-1β 和 IL-6 的表达具有有效的抑制作用。α7 nAchR-JAK2-STAT3 agonist 1 对 LPS 诱导的 NO 释放、NF-κB 激活和细胞因子产生具有抑制作用。α7 nAchR-JAK2-STAT3 agonist 1 能够用于研究败血症。 | |||
T12266L |
Ilginatinib maleate
NS-018 maleate |
Tyrosine Kinases; JAK | Angiogenesis; Chromatin/Epigenetic; JAK/STAT signaling; Stem Cells; Tyrosine Kinase/Adaptors |
Ilginatinib maleate (NS-018 maleate) 是一种可口服的 JAK2强效抑制剂,IC50值为 0.72 nM,对其选择性是对 JAK1、JAK3和 Tyk2 的 46、54 和 22 倍,IC50分别为 33、39 和 22 nM。 | |||
T71191 |
Covidcil-19
|
Others | Others |
Covidcil-19 binds to the revised attenuator hairpin structure of the SARS-CoV-2 frameshifting element (FSE) with high affinity (Kd = 11 nM). It stabilizes the hairpin's folded state and reduces frameshifting efficiency in cells. Covidcil-19 inhibits viral propagation and reduces viral infectivity by > 3.5 orders of magnitude. | |||
T12266L2 |
Ilginatinib hydrochloride
NS-018 hydrochloride |
Tyrosine Kinases; JAK | Angiogenesis; Chromatin/Epigenetic; JAK/STAT signaling; Stem Cells; Tyrosine Kinase/Adaptors |
Ilginatinib hydrochloride (NS-018 hydrochloride) 是一种可口服的 JAK2强效抑制剂,IC50值为 0.72 nM,对其选择性是对 JAK1、JAK3和 Tyk2 的 46、54 和 22 倍,IC50分别为 33、39 和 22 nM。 | |||
T22338 |
2,6-Dichloro-N-(2-(cyclopropanecarboxamido)pyridin-4-yl)benzamide
GDC046 |
Others; JAK | Angiogenesis; Chromatin/Epigenetic; JAK/STAT signaling; Others; Stem Cells |
2,6-Dichloro-N-(2-(cyclopropanecarboxamido)pyridin-4-yl)benzamide (GDC046) 是一种具有口服活性的选择性TYK2抑制剂,对 TYK2、JAK1、JAK2 和 JAK3 的Ki 分别为 4.8、0.7、0.7 和 0.4 nM。 | |||
T1995 |
Fedratinib
TG-101348,SAR 302503 |
Apoptosis; FLT; c-RET; JAK | Angiogenesis; Apoptosis; Chromatin/Epigenetic; JAK/STAT signaling; Stem Cells; Tyrosine Kinase/Adaptors |
Fedratinib (TG-101348) 是一种 JAK2 抑制剂,具有选择性、ATP 竞争性和具有口服活性,抑制 JAK2 和 JAK2V617F 激酶 (IC50=3 nM)。Fedratinib 可诱导肿瘤细胞凋亡,并可用于骨髓增生性疾病的研究。 | |||
T38436 |
JAK-2/3-IN-1
|
Others | Others |
JAK-2/3-IN-1 is a highly effective inhibitor targeting both JAK-2 and JAK-3 isoforms. It exhibits remarkable potency, with Ki values below 250 nM for both isoforms. | |||
T9251 |
Fedratinib hydrochloride hydrate
TG-101348 hydrochloride hydrate,SAR 302503 hydrochloride hydrate |
Apoptosis; JAK | Angiogenesis; Apoptosis; Chromatin/Epigenetic; JAK/STAT signaling; Stem Cells |
Fedratinib hydrochloride hydrate (SAR 302503 hydrochloride hydrate) 是一种选择性的,ATP 竞争性和具有口服活性的JAK2抑制剂,对于JAK2和JAK2V617F 激酶的IC50均为 3 nM。它可诱导癌细胞凋亡,可研究骨髓增生性疾病。 | |||
T21503 |
(E/Z)-Zotiraciclib
(E/Z)-TG02,(E/Z)-SB1317 |
FLT; JAK; CDK | Angiogenesis; Cell Cycle/Checkpoint; Chromatin/Epigenetic; JAK/STAT signaling; Stem Cells; Tyrosine Kinase/Adaptors |
(E/Z)-Zotiraciclib ((E/Z)-TG02) 是一种 CDK2、JAK2和FLT3的抑制剂,IC50分别为 13、73 和 56 nM。 | |||
T5049 |
NVP-BSK805
NVP-BSK805 2HCl,8-[3,5-二氟-4-(4-吗啉基甲基)苯基]-2-[1-(4-哌啶基)-1H-吡唑-4-基]喹喔啉,BSK 805 |
Tyrosine Kinases; JAK | Angiogenesis; Chromatin/Epigenetic; JAK/STAT signaling; Stem Cells; Tyrosine Kinase/Adaptors |
NVP-BSK805 (BSK 805) 是 ATP 竞争性的 JAK2抑制剂,对 JAK1 JH1、 JAK2 JH1 (JAK 同源 1)、JAK3 JH1和 TYK2 JH1 的 IC50值分别为 31.63、0.48、8.68 和 10.76 nM。 | |||
T3072 |
XL019
|
Apoptosis; FLT; JAK; PDGFR | Angiogenesis; Apoptosis; Chromatin/Epigenetic; JAK/STAT signaling; Stem Cells; Tyrosine Kinase/Adaptors |
XL019 是一种具有口服活性的选择性JAK2抑制剂。它对JAK2的选择性是 100 多种丝氨酸/苏氨酸和酪氨酸激酶的 50 倍以上。它对 JAK2 V617F 和野生型 JAK2 细胞中 STAT3 和 STAT5 磷酸化有抑制作用。 | |||
T6309 |
AZ960
AZ 960 |
Apoptosis; Virus Protease; JAK; Parasite | Angiogenesis; Apoptosis; Chromatin/Epigenetic; JAK/STAT signaling; Microbiology/Virology; Stem Cells |
AZ960 是一种高效选择性的 JAK2激酶抑制剂,Ki 值为0.45 nM。 | |||
T2360 |
Baricitinib phosphate
Baricitinib Phosphate,LY3009104,磷酸巴瑞克替尼,INCB-028050 phosphate,LY-3009104 phosphate,INCB028050 |
Tyrosine Kinases; JAK | Angiogenesis; Chromatin/Epigenetic; JAK/STAT signaling; Stem Cells; Tyrosine Kinase/Adaptors |
Baricitinib phosphate (INCB028050) 是一种选择性的,可口服的 JAK1/JAK2抑制剂,IC50值分别为 5.9 和 5.7 nM。 | |||
T20742 |
TG-89
|
FLT; c-RET; JAK | Angiogenesis; Apoptosis; Chromatin/Epigenetic; JAK/STAT signaling; Stem Cells; Tyrosine Kinase/Adaptors |
TG-89是 JAK2、JAK3、RET 和 FLT3的抑制剂,对 JAK2的 IC50值为11.2 μM,在卵巢癌和宫颈癌的治疗中显示出抗癌活性。 | |||
T3065 |
TG101209
|
Apoptosis; FLT; c-RET; JAK; Autophagy | Angiogenesis; Apoptosis; Autophagy; Chromatin/Epigenetic; JAK/STAT signaling; Stem Cells; Tyrosine Kinase/Adaptors |
TG101209 是一种选择性有效的 JAK2抑制剂,IC50值为 6 nM。它能抑制 Flt3和RET 的活性,IC50值分别为 25 nM 和 17 nM。 | |||
T6122 |
CEP-33779
CEP33779 |
JAK | Angiogenesis; Chromatin/Epigenetic; JAK/STAT signaling; Stem Cells |
CEP-33779是一种新型,选择性,有口服活性的JAK2抑制剂,IC50值为1.8±0.6 nM。 | |||
T6294 |
NVP-BSK805 2HCl (1092499-93-8(free base))
NVP-BSK805 dihydrochloride,BSK 805,NVP-BSK805 (dihydrochloride) |
Tyrosine Kinases; JAK | Angiogenesis; Chromatin/Epigenetic; JAK/STAT signaling; Stem Cells; Tyrosine Kinase/Adaptors |
NVP-BSK805 2HCl (1092499-93-8(free base)) (BSK 805) 是一种特异性有效的 ATP 竞争性 JAK2 抑制剂,其特异性是 JAK1、JAK3 和 TYK2 的 20 倍以上。 | |||
T2638 |
Gandotinib
LY2784544 |
VEGFR; FGFR; FLT; JAK | Angiogenesis; Chromatin/Epigenetic; JAK/STAT signaling; Stem Cells; Tyrosine Kinase/Adaptors |
Gandotinib (LY2784544) 是一种JAK2抑制剂,IC50为 3 nM。它也抑制FLT3、FLT4、FGFR2、TYK2 和 TRKB,IC50分别为 4、25、32、44 和 95 nM。 | |||
T6838 |
FLLL32
|
Apoptosis; JAK; STAT | Angiogenesis; Apoptosis; Chromatin/Epigenetic; JAK/STAT signaling; Stem Cells |
FLLL32是一种姜黄素的合成类似物,是JAK2/STAT3的双重抑制剂,具有抗肿瘤癌活性。它作用于乳腺癌细胞,可抑制 IFNα 和 IL-6 诱导的 STAT3 磷酸化。 | |||
T4227 |
SB1317 hydrochloride (1204918-72-8(free base))
TG-02 hydrochloride,14-甲基-20-氧杂-5,7,14,27-四氮杂四环[19.3.1.1(2,6).1(8,12)]二十七碳-1(25),2,4,6(27),8,10,12(26),16,21,23-十烯 |
FLT; JAK; CDK | Angiogenesis; Cell Cycle/Checkpoint; Chromatin/Epigenetic; JAK/STAT signaling; Stem Cells; Tyrosine Kinase/Adaptors |
SB1317 hydrochloride (1204918-72-8(free base)) (TG-02 hydrochloride) 是一种有效的 CDK2/JAK2/FLT3 抑制剂(IC50:13/73/56 nM)。 | |||
T61494 |
JAK-IN-21
|
Tyrosine Kinases; JAK | Angiogenesis; Chromatin/Epigenetic; JAK/STAT signaling; Stem Cells; Tyrosine Kinase/Adaptors |
JAK-IN-21 是一种具有选择性和高效性的 JAK 抑制剂,对 JAK1、JAK2、J2V617F 和 TYK2 具有抑制作用,IC50 值分别为 1.73、2.04、109 和 62.9 nM。 | |||
T3068 |
AT9283
J-504568 |
Apoptosis; FLT; JAK; Bcr-Abl; Aurora Kinase; Autophagy | Angiogenesis; Apoptosis; Autophagy; Cell Cycle/Checkpoint; Chromatin/Epigenetic; Cytoskeletal Signaling; JAK/STAT signaling; Stem Cells; Tyrosine Kinase/Adaptors |
AT9283 (J-504568) 是一种多靶点激酶抑制剂,抑制多种实体瘤在体内外的生长和存活,有效抑制Aurora A/B,JAK2/3,Abl (T315I),和Flt3,IC50值范围为 1-30 nM。 | |||
T3069 |
AZD-1480
|
JAK | Angiogenesis; Chromatin/Epigenetic; JAK/STAT signaling; Stem Cells |
AZD1480 是 ATP 竞争型JAK1和JAK2抑制剂,IC50分别为 1.3 和 0.4 nM。 | |||
T2156 |
WP1066
|
Apoptosis; JAK; STAT | Angiogenesis; Apoptosis; Chromatin/Epigenetic; JAK/STAT signaling; Stem Cells |
WP1066 是一种新型JAK2和STAT3抑制剂,对 STAT5 和 ERK1/2 也起作用。它用于研究黑色素瘤、脑癌、实体瘤和中枢神经系统肿瘤治疗。 | |||
T20743 |
TG-46
TG46,TG 46 |
FLT; JAK | Angiogenesis; Chromatin/Epigenetic; JAK/STAT signaling; Stem Cells; Tyrosine Kinase/Adaptors |
TG-46 (TG46) 对 JAK2, FLT3, RET, JAK3 具有抑制作用,可用于研究青光眼。 | |||
T1929 |
Filgotinib
GLPG0634 |
Tyrosine Kinases; JAK | Angiogenesis; Chromatin/Epigenetic; JAK/STAT signaling; Stem Cells; Tyrosine Kinase/Adaptors |
Filgotinib (GLPG0634) 是一种选择性的JAK 抑制剂,对 JAK1、JAK2、JAK3 和 TYK2 的活性,IC50值分别为 10、28、810 和 116 nM。 | |||
TQ0010 |
Brepocitinib
PF-06700841 |
Tyrosine Kinases; JAK | Angiogenesis; Chromatin/Epigenetic; JAK/STAT signaling; Stem Cells; Tyrosine Kinase/Adaptors |
Brepocitinib (PF-06700841) 是JAK1和TYK2双重抑制剂,IC50分别为 17 nM 和 23 nM。它抑制JAK2和JAK3的效果较弱,IC50分别为 77 nM 和 6.49 μM 。 | |||
T17019 |
TCS 21311
NIBR3049 |
GSK-3; JAK; PKC | Angiogenesis; Chromatin/Epigenetic; Cytoskeletal Signaling; JAK/STAT signaling; PI3K/Akt/mTOR signaling; Stem Cells |
TCS 21311 (NIBR3049) 是一种高选择性JAK3抑制剂,IC50为 8 nM,它的选择性是 JAK1、JAK2 和 TYK2 的100倍以上,还抑制PKCα、PKCθ和GSK3β,IC50值分别为 13、68 和 3 nM。 | |||
T3080 |
Pyridone 6
Janus-Associated Kinase Inhibitor I,JAK Inhibitor,CMP 6,吡啶酮6,JAK Inhibitor I |
Tyrosine Kinases; JAK | Angiogenesis; Chromatin/Epigenetic; JAK/STAT signaling; Stem Cells; Tyrosine Kinase/Adaptors |
Pyridone 6 (JAK Inhibitor) 是一种泛JAK 抑制剂,有效抑制 JAK 激酶家族,对JAK2、TYK2、JAK3和JAK1的IC50分别为 1、1、5 和 15 nM。 | |||
T6217 |
LFM-A13
|
PLK; JAK; BTK | Angiogenesis; Cell Cycle/Checkpoint; Chromatin/Epigenetic; JAK/STAT signaling; Stem Cells; Tyrosine Kinase/Adaptors |
LFM-A13 是一种 BTK,JAK2,PLK 有效抑制剂,可抑制 BTK、Plx1 和 PLK3 的活性,IC50分别为 2.5、10 和 61 μM。 | |||
T6266 |
PP2
AGL 1879,AG 1879,AGL 1879 |
EGFR; Tyrosine Kinases; JAK; Src | Angiogenesis; Chromatin/Epigenetic; JAK/STAT signaling; Stem Cells; Tyrosine Kinase/Adaptors |
PP2 (AG 1879,AGL 1879) 是 Lck/Fyn 抑制剂 (IC50:4/5 nM),对 EGFR 的效力降低约 100 倍,对 ZAP-70、PKA 和 JAK2 无活性。 | |||
T8719 |
SC99
|
Apoptosis; JAK; STAT | Angiogenesis; Apoptosis; Chromatin/Epigenetic; JAK/STAT signaling; Stem Cells |
SC99 是一种口服有效选择性STAT3抑制剂,靶向 JAK2-STAT3 途径,抑制血小板活化和聚集,有抗骨髓瘤和抗血栓活性。它结合在 JAK2 的 ATP 结合袋中,抑制 JAK2 和 STAT3 的磷酸化。 |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T2S1975 |
Ponicidin
冬凌草乙素,Rubescensine B |
Apoptosis; JAK; STAT | Angiogenesis; Apoptosis; Chromatin/Epigenetic; JAK/STAT signaling; Stem Cells |
Ponicidin (Rubescensine B) 是来源于冬凌草的一种二萜,具有免疫调节、抗炎、抗病毒和抗癌作用。它可诱导胃癌细胞凋亡,降低 JAK2 和 STAT3 的磷酸化水平。 | |||
TQ0196 |
Cucurbitacin I
NSC-521777,JSI-124,Elatericin B,葫芦素 I |
JAK; STAT | Angiogenesis; Chromatin/Epigenetic; JAK/STAT signaling; Stem Cells |
Cucurbitacin I (JSI-124) 是从曲莲中提取的一种天然产物,是 JAK2/STAT3选择性抑制剂,有抗肿瘤活性。 | |||
TJS1779 |
Protosappanin A
原苏木素A,PTA |
NADPH-oxidase; IL Receptor; IκB/IKK; TNF; NF-κB; TLR; ROS; COX; HIV Protease; JAK; NO Synthase; STAT | Angiogenesis; Apoptosis; Chromatin/Epigenetic; Immunology/Inflammation; JAK/STAT signaling; Microbiology/Virology; Neuroscience; NF-κB; Proteases/Proteasome; Stem Cells |
Protosappanin A (PTA) 是从苏木中分离得到的免疫抑制成分和主要联苯化合物,通过下调 JAK2和 STAT3的磷酸化,抑制 JAK2/STAT3依赖的炎症通路。 | |||
T5S0734 |
Desmethoxyyangonin
Desmethoxy yangonin,去甲氧基醉椒素,Demethoxyyangonin,5,6-Dehydrokavain |
Others; Monoamine Oxidase | Neuroscience; Others |
Desmethoxyyangonin (5,6-Dehydrokavain) 是一种MAO-B 可逆性抑制剂。 | |||
T3398 |
Icaritin
Anhydroicaritin,去水淫羊藿黄素,Cycloicaritin |
Apoptosis; JAK; STAT; Autophagy | Angiogenesis; Apoptosis; Autophagy; Chromatin/Epigenetic; JAK/STAT signaling; Stem Cells |
Icaritin (Anhydroicaritin) 是Epimedium Genusis 的异戊二烯类黄酮衍生物,有效抑制 K562 细胞和原代 CML 细胞的增殖。它可以调节MAPK/ERK/JNK 和JAK2/STAT3/AKT 信号传导,并具有增强成骨的作用。 | |||
T3S1471 |
Cucurbitacin IIA
葫芦素Iia,Dihydrocucurbitacin Q1,Hemslecin A,Curcurbitacin IIA |
Apoptosis; Survivin | Apoptosis |
Cucurbitacin IIA (Dihydrocucurbitacin Q1) 是从园果雪胆中分离得到的一种三萜烯,可诱导细胞凋亡和增强自噬,有助于葫芦素IIA 对炎症相关疾病的抗炎活性。它可降低癌细胞中生存素的表达,降低磷酸化组蛋白 H3 的水平,增加裂解的 PARP 的水平。 | |||
T3805 |
Prim-O-glucosylcimifugin
升麻苷,Cimifugin beta-D-glucopyranoside,Cimifugin 7-glucoside |
TNF; COX; JAK; NO Synthase | Angiogenesis; Apoptosis; Chromatin/Epigenetic; Immunology/Inflammation; JAK/STAT signaling; Neuroscience; Stem Cells |
Prim-O-glucosylcimifugin (Cimifugin 7-glucoside) 具有强效的抗炎作用。通过调节 JAK2/STAT3 信号传导可抑制iNOS 和COX-2表达。 | |||
T3673 |
Mollugin
大叶茜草素,Rubimaillin |
HER; JAK | Angiogenesis; Chromatin/Epigenetic; JAK/STAT signaling; Stem Cells; Tyrosine Kinase/Adaptors |
Mollugin (Rubimaillin) 是Rubia cordifolia L.中主要的生物活性成分。它能通过 p38-Smad 信号通路增强 BMP-2 的成骨作用。它通过抑制 TNF-α 诱导的 NF-κB 激活起抗癌疗效。 | |||
T5S0167 |
Atractylenolide I
白术内酯 I,白术内酯I;苍术内酯I |
IL Receptor; TNF; TLR; JAK; STAT | Angiogenesis; Apoptosis; Chromatin/Epigenetic; Immunology/Inflammation; JAK/STAT signaling; Stem Cells |
Atractylenolide I 是从白术根中得到的一种倍半萜烯,具有神经保护、抗过敏、抗炎和抗癌等多种生物活性。它是一种TLR4拮抗剂,在 A375 细胞中,能够降低JAK2和STAT3的磷酸化水平。 | |||
T19557 |
Sanshool
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Others | Others |
Sanshool is a natural product isolated from Zanthoxylum bungeanum. Sanshool improves UVB-induced skin photodamage by targeting JAK2/STAT3-dependent autophagy. | |||
TN3541 |
Broussonin E
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ERK; p38 MAPK; TNF; JAK; STAT | Angiogenesis; Apoptosis; Chromatin/Epigenetic; JAK/STAT signaling; MAPK; Stem Cells |
Broussonin E could suppress inflammation by modulating macrophages activation state via inhibiting the ERK and p38 MAPK and enhancing JAK2-STAT3 signaling pathway, and can be further developed as a promising drug for the treatment of inflammation-related | |||
T4S1499 |
Ginsenoside Rk1
人参皂苷RK1,人参皂苷 |
Apoptosis; Others; NF-κB; PI3K; JAK | Angiogenesis; Apoptosis; Chromatin/Epigenetic; JAK/STAT signaling; NF-κB; Others; PI3K/Akt/mTOR signaling; Stem Cells |
Ginsenoside Rk1 是人参的高温加工提取物,抑制Jak2/Stat3信号通路和NF-κB 的激活。它具有抗肿瘤、抗血小板聚集活性、抗炎、抗胰岛素抵抗、肾保护和抗菌作用,可使认知功能增强,脂质积聚减少和预防骨质疏松症,还诱导细胞凋亡。 |
Cat. No. | Product Name | Species | Expression System |
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TMPH-02274 |
JAK2 Protein, Human, Recombinant (His)
JAK2,Janus kinase 2,Tyrosine-prot... |
Human | E. coli |
Non-receptor tyrosine kinase involved in various processes such as cell growth, development, differentiation or histone modifications. Mediates essential signaling events in both innate and adaptive immunity. In the cytoplasm, plays a pivotal role in signal transduction via its association with type I receptors such as growth hormone (GHR), prolactin (PRLR), leptin (LEPR), erythropoietin (EPOR), thrombopoietin (THPO); or type II receptors including IFN-alpha, IFN-beta, IFN-gamma and multiple int... | |||
TMPY-04125 |
PTP1B Protein, Human, Recombinant (His)
protein tyrosine phosphatase, non-receptor type 1,PTP1B,PTPN... |
Human | E. coli |
PTP1B, also known as PTPN1, belongs to the protein-tyrosine phosphatase (PTP) family. PTPs catalyze the hydrolysis of the phosphate monoesters specifically on tyrosine residues. Members of the PTP family share a highly conserved catalytic motif, which is essential for the catalytic activity. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. PTP1B contains 1 tyrosine-protein p... | |||
TMPK-00136 |
ULBP-2 Protein, Human, Recombinant (His & Avi)
ALCAN-α,RAET1L,NKG2D ligand 2,ALCAN-alpha,... |
Human | HEK293 Cells |
ULBPs activate multiple signaling pathways in primary NK cells, resulting in the production of cytokines and chemokines. Binding of ULBPs ligands to NKG2D induces calcium mobilization and activation of the JAK2, STAT5, ERK and PI3K kinase/Akt signal transduction pathway, mediating natural killer cell cytotoxicity. | |||
TMPH-03110 |
Erythropoietin Protein, Pig, Recombinant (His)
EPO,Erythropoietin |
Sus scrofa (Pig) | P. pastoris (Yeast) |
Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3. Erythropoietin Protein, Pig, Recombinant (His) is expressed in yeast with N-6xHis tag. The predicted molecular weight is 20.6 kDa and the accession number is P49157. | |||
TMPH-01558 |
IL12RB2 Protein, Human, Recombinant (His)
Interleukin-12 receptor subunit beta-2,IL1... |
Human | P. pastoris (Yeast) |
Receptor for interleukin-12. This subunit is the signaling component coupling to the JAK2/STAT4 pathway. Promotes the proliferation of T-cells as well as NK cells. Induces the promotion of T-cells towards the Th1 phenotype by strongly enhancing IFN-gamma production. IL12RB2 Protein, Human, Recombinant (His) is expressed in yeast with N-6xHis tag. The predicted molecular weight is 69.7 kDa and the accession number is Q99665. | |||
TMPH-03111 |
Erythropoietin Protein, Pig, Recombinant (B2M & His)
EPO,Erythropoietin |
Sus scrofa (Pig) | E. coli |
Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3. Erythropoietin Protein, Pig, Recombinant (B2M & His) is expressed in E. coli expression system with N-6xHis-B2M tag. The predicted molecular weight is 32.6 kDa and the accession number is P49157. | |||
TMPH-02426 |
Erythropoietin Protein, Cynomolgus, Recombinant (His & Myc)
EPO,Erythropoietin |
Cynomolgus | HEK293 Cells |
Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3. Erythropoietin Protein, Cynomolgus, Recombinant (His & Myc) is expressed in HEK293 mammalian cells with N-6xHis-Myc tag. The predicted molecular weight is 22.2 kDa and the accession number is P07865... | |||
TMPY-04817 |
Syntenin Protein, Human, Recombinant (His)
MDA-9,SYCL,TACIP18,syndecan binding protein (syntenin),ST1,M... |
Human | E. coli |
Syntenin1/SDCBP (syndecan binding protein), also known as melanoma differentiation associated gene-9 (MDA-9), is a PDZ domain-containing molecule, which was initially identified as a key oncogene in melanoma. IL-6 promotes glioma cell proliferation and invasion by inducing SDCBP expression, which is mediated by JAK2/STAT3 signaling. SDCBP might be an important marker for identifying Triple negative breast cancer (TNBC) cases that are suitable for dasatinib therapy. | |||
TMPH-00828 |
Erythropoietin Protein, Horse, Recombinant (His & SUMO)
EPO,Erythropoietin |
Horse | E. coli |
Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3. Erythropoietin Protein, Horse, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 34.3 kDa and the accession number is Q867B1... | |||
TMPH-00827 |
Erythropoietin Protein, Horse, Recombinant (hFc)
Erythropoietin,EPO |
Horse | HEK293 Cells |
Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3. Erythropoietin Protein, Horse, Recombinant (hFc) is expressed in HEK293 mammalian cells with C-hFC tag. The predicted molecular weight is 47.3 kDa and the accession number is Q867B1. | |||
TMPH-02427 |
Erythropoietin Protein, Cynomolgus, Recombinant (His & SUMO)
Erythropoietin,EPO |
Cynomolgus | E. coli |
Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3. Erythropoietin Protein, Cynomolgus, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 34.2 kDa and the accession number is P... | |||
TMPH-03287 |
EPOR Protein, Rat, Recombinant (His & SUMO)
Epor,Erythropoietin receptor |
Rat | E. coli |
Receptor for erythropoietin. Mediates erythropoietin-induced erythroblast proliferation and differentiation. Upon EPO stimulation, EPOR dimerizes triggering the JAK2/STAT5 signaling cascade. In some cell types, can also activate STAT1 and STAT3. May also activate LYN tyrosine kinase. EPOR Protein, Rat, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO and C-6xHis tag. The predicted molecular weight is 39.1 kDa and the accession number is Q07303. | |||
TMPH-03204 |
GHR Protein, Rabbit, Recombinant (His & Myc)
GHR,Somatotropin receptor,Growth hormone receptor |
Rabbit | E. coli |
Receptor for pituitary gland growth hormone involved in regulating postnatal body growth. On ligand binding, couples to, and activates the JAK2/STAT5 pathway.; The soluble form (GHBP) acts as a reservoir of growth hormone in plasma and may be a modulator/inhibitor of GH signaling. GHR Protein, Rabbit, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 34.6 kDa and the accession number is P19941. | |||
TMPJ-00398 |
IL-12RB2 Protein, Mouse, Recombinant (hFc)
interleukin-12 receptor β-2 chain,IL-1... |
Mouse | HEK293 Cells |
The IL12 receptor complex, formed by IL12RB1 and IL12RB2, mediates the type I immune responses of various types of lymphocytes. Its ligand, IL12, is a heterodimeric cytokine composed of IL-12p35 and IL-12p40 subunits that are linked via disulfide bonds. Ligation of IL-12 to its receptor involves the binding of IL-12p35 to IL12RB1 and IL-12p40 to IL12RB2. This will result in the activation of tyrosine kinase 2 (TYK2), which is associated with the IL12RB1 chain and Janus kinase 2 (JAK2), which is ... | |||
TMPH-03112 |
GHR Protein, Pig, Recombinant (His)
Growth hormone receptor,GHR,Somatotropin receptor |
Sus scrofa (Pig) | E. coli |
Receptor for pituitary gland growth hormone involved in regulating postnatal body growth. On ligand binding, couples to, and activates the JAK2/STAT5 pathway.; The soluble form (GHBP) acts as a reservoir of growth hormone in plasma and may be a modulator/inhibitor of GH signaling. GHR Protein, Pig, Recombinant (His) is expressed in E. coli expression system with C-6xHis tag. The predicted molecular weight is 30.3 kDa and the accession number is P19756. | |||
TMPH-02440 |
GHR Protein, Rhesus macaque, Recombinant (His)
GHR,Somatotropin receptor,Growth hormone receptor |
Rhesus | E. coli |
Receptor for pituitary gland growth hormone involved in regulating postnatal body growth. On ligand binding, couples to, and activates the JAK2/STAT5 pathway.; The soluble form (GHBP) acts as a reservoir of growth hormone in plasma and may be a modulator/inhibitor of GH signaling. GHR Protein, Rhesus macaque, Recombinant (His) is expressed in E. coli expression system with C-6xHis tag. The predicted molecular weight is 30.2 kDa and the accession number is P79194. | |||
TMPY-02194 |
SOCS3 Protein, Human, Recombinant (His & Trx)
SOCS-3,SSI-3,ATOD4,Cish3,SSI3,suppressor of cytokine signali... |
Human | E. coli |
Suppressor of cytokine signaling 3, also known as SOCS-3, Cytokine-inducible SH2 protein 3, CIS-3, STAT-induced STAT inhibitor 3, SOCS3 and CIS3, is a protein which is widely expressed with high expression in heart, placenta, skeletal muscle, peripheral blood leukocytes, fetal and adult lung, and fetal liver and kidney. SOCS3 / CIS3 contains one SH2 domain and one SOCS box domain. SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. ... | |||
TMPY-03125 |
SHP-2 Protein, Mouse, Recombinant (His)
SAP-2,Syp,PTP1D,SH-PTP2,SH-PTP3,SHP-2<... |
Mouse | HEK293 Cells |
SHP2, also known as PTPN11, belongs to the protein-tyrosine phosphatase(PTP) family, non-receptor class 2 subfamily. PTPs catalyze the removal of phosphate groups from tyrosine residues by the hydrolysis of phosphoric acid monoesters. They dephosphorylate EGFR, JAK2 and TYK2 kinases, promoting oncogenic transformation. SHP2 is widely expressed, with highest levels in heart, brain, and skeletal muscle. SHP2 acts downstream of various receptor and cytoplasmic protein tyrosine kinases to participat... | |||
TMPH-02156 |
SOCS1 Protein, Human, Recombinant (His)
SOCS1,STAT-induced STAT inhibitor 1,JAK-binding pro... |
Human | P. pastoris (Yeast) |
SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS1 is involved in negative regulation of cytokines that signal through the JAK/STAT pathway. Through binding to JAKs and IFNGR1, inhibits their kinase activity. In vitro, also suppresses Tec protein-tyrosine activity. Appears to be a major regulator of signaling by interleukin 6 (IL6) and leukemia inhibitory factor (LIF). Regulates interferon-gamma mediated sensory neuron surviv... | |||
TMPY-02122 |
IFNGR2 Protein, Mouse, Recombinant (His)
interferon γ receptor 2 (interferon γ transducer 1)... |
Mouse | HEK293 Cells |
Interferon-gamma receptor beta chain (IFNgammaR2), also known as IFNGR2, belongs to the type II cytokine receptor family, whose deficiency is a cause of autosomal recessive mendelian susceptibility to mycobacterial disease (MSMD), also known as familial disseminated atypical mycobacterial infection. This accessory factor is an integral part of the IFN-gamma signal transduction pathway and is likely to interact with GAF, JAK1, and/or JAK2. IFNGR2 is a component of the IFNgamma receptor complex al... | |||
TMPH-00775 |
IFN gamma Protein, Goat, Recombinant (His & Myc)
Interferon gamma,IFNG |
Goat | E. coli |
Type II interferon produced by immune cells such as T-cells and NK cells that plays crucial roles in antimicrobial, antiviral, and antitumor responses by activating effector immune cells and enhancing antigen presentation. Primarily signals through the JAK-STAT pathway after interaction with its receptor IFNGR1 to affect gene regulation. Upon IFNG binding, IFNGR1 intracellular domain opens out to allow association of downstream signaling components JAK2, JAK1 and STAT1, leading to STAT1 activati... | |||
TMPJ-00047 |
IL-31 Protein, Human, Recombinant
IL-31,Interleukin-31,白介素,白细胞介素,IL31 |
Human | E. coli |
Human Interleukin 31 (IL-31) is a cytokine containing a four-helix bundle structure. It shares several structural and functional characteristics with IL-6, Oncostatin M, LIF, and Cardiotrophin-1. Human IL-31 cDNA encodes a 164 amino acid precursor that contains a 23 amino acid signal peptide and a 141 amino acid mature protein. Human and mouse IL-31 share 24% sequence identity in the mature region. IL-31 is mainly associated with activated T cells and is preferentially expressed by type 2 helper... |
Cat. No. | Product Name | Target | Signaling Pathways |
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TMID-0049 |
Pacritinib-d8
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Pacritinib-d8 是 Pacritinib 的氘代化合物。Pacritinib 的 CAS 号为 937272-79-2。Pacritinib 是一种野生型JAK2和JAK2V617F突变型抑制剂,IC50分别为 23 和 19 nM。它也抑制FLT3及其突变型FLT3D835Y,IC50分别为 22 和 6 nM。 | |||
TMIJ-0261 |
Baricitinib-d5
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Baricitinib-d5 是 Baricitinib 的氘代化合物。Baricitinib 的 CAS 号为 1187594-09-7。Baricitinib 是一种选择性,可口服的JAK1和JAK2抑制剂,IC50分别为5.9 nM 和 5.7 nM,具有潜在的抗炎、免疫调节和抗肿瘤活性。 | |||
TMIJ-0267 |
Upadacitinib-15N-d2
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Upadacitinib-15N-d2 是 Upadacitinib 的 15N 和氘代化合物。Upadacitinib 的 CAS 号为 1310726-60-3。Upadacitinib 是高效选择性的,具有口服活性的JAK1抑制剂,IC50为43 nM,可用于多种自身免疫性疾病的研究。它对 JAK1 的选择性约为 JAK2 的 74 倍。 |