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Search Results for " jak "

Targets Recommended: JAK JAK

188

抑制剂 & 化合物

15

天然产物

6

化合物库

23

重组蛋白

2

同位素标记化合物

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Cat. No.	Product Name
L3700	JAK-STAT 化合物库		252 compounds
	252 个 JAK/STAT 靶点相关的小分子化合物的独特集合，用于高通量、高内涵筛选；
L3400	临床期小分子药物库		3404 compounds
	3404 个临床期化合物集合，可用于高通量筛选和高内涵筛选；
L2192	抗胰腺癌化合物库		2238 compounds
	2238 种与胰腺癌相关的化合物，可以用于高通量和高内涵筛选；
L3600	细胞因子抑制剂库		604 compounds
	604 个与细胞因子紧密相关的化合物集合，是高通量、高内涵筛选的良好载体；
L1610	FDA 上市激酶抑制剂库		263 compounds
	263种靶向激酶的上市药物集合，用于特定靶向激酶，可用于高通量筛选和高内涵筛选；
L1600	激酶抑制剂库		2720 compounds
	2720 种激酶抑制剂/调节剂的独特集合，用于特定靶向激酶，可用于高通量筛选和高内涵筛选；

化合物库

JAK-STAT 化合物库

Cat.No: L3700

Compounds: 252

临床期小分子药物库

Cat.No: L3400

Compounds: 3404

抗胰腺癌化合物库

Cat.No: L2192

Compounds: 2238

细胞因子抑制剂库

Cat.No: L3600

Compounds: 604

FDA 上市激酶抑制剂库

Cat.No: L1610

Compounds: 263

激酶抑制剂库

Cat.No: L1600

Compounds: 2720

Cat. No.	Product Name	Target	Signaling Pathways
T27650	JAK3i JAK-3i,JAK 3i	JAK	Angiogenesis; Chromatin/Epigenetic; JAK/STAT signaling; Stem Cells
	JAK3i 是JAK3激酶的选择性共价抑制剂。JAK3i 揭示了STAT5磷酸化的两个不同的时间波，并且更有效地靶向第二波，这是细胞周期进程和T 细胞增殖所必需的。
T13571	JAK-IN-10	JAK	Angiogenesis; Chromatin/Epigenetic; JAK/STAT signaling; Stem Cells
	JAK-IN-10 是一种 JAK 抑制剂，可用于干眼症的研究。
T11710	JAK-IN-5	JAK	Angiogenesis; Chromatin/Epigenetic; JAK/STAT signaling; Stem Cells
	JAK-IN-5 是一种 JAK 抑制剂。
T12549	JAK-IN-11 R-348	JAK	Angiogenesis; Chromatin/Epigenetic; JAK/STAT signaling; Stem Cells
	JAK-IN-11 (R-348)是 JAK 的强效选择性抑制剂，具有治疗皮肤疾病的潜力。
T61494	JAK-IN-21	Tyrosine Kinases; JAK	Angiogenesis; Chromatin/Epigenetic; JAK/STAT signaling; Stem Cells; Tyrosine Kinase/Adaptors
	JAK-IN-21 是一种具有选择性和高效性的 JAK 抑制剂，对 JAK1、JAK2、J2V617F 和 TYK2 具有抑制作用，IC50 值分别为 1.73、2.04、109 和 62.9 nM。
T3080	Pyridone 6 Janus-Associated Kinase Inhibitor I,JAK Inhibitor,CMP 6,吡啶酮6,JAK Inhibitor I	Tyrosine Kinases; JAK	Angiogenesis; Chromatin/Epigenetic; JAK/STAT signaling; Stem Cells; Tyrosine Kinase/Adaptors
	Pyridone 6 (JAK Inhibitor) 是一种泛JAK 抑制剂，有效抑制 JAK 激酶家族，对JAK2、TYK2、JAK3和JAK1的IC50分别为 1、1、5 和 15 nM。
T78607	JAK-STAT-IN-1	JAK; STAT	Angiogenesis; Chromatin/Epigenetic; JAK/STAT signaling; Stem Cells
	JAK-STAT-IN-1 是一种特异性 JAK-STAT 抑制剂，适用于研究自身免疫性疾病。
T5492	JAK3-IN-6	JAK	Angiogenesis; Chromatin/Epigenetic; JAK/STAT signaling; Stem Cells
	JAK3-IN-6 是JAK3的选择性不可逆抑制剂，IC50值为 0.15 nM。
T11710L	JAK-IN-5 hydrochloride JAK-IN-5 hydrochloride(2096999-92-5 Free base)	JAK	Angiogenesis; Chromatin/Epigenetic; JAK/STAT signaling; Stem Cells
	JAK-IN-5 hydrochloride 是一种JAK 的抑制剂。
T39400	JAK-IN-15	Others	Others
	JAK-IN-15 is a JAK inhibitor. WO2016119700A1 (Compound 15).
T9764	JAK-IN-14	Others	Others
	JAK-IN-14 是一种有效和选择性的JAK1抑制剂，IC50值小于5μM。JAK-IN-14 对 JAK1 的选择性是 JAK2 和 JAK3 的 8倍以上。
T40443	JAK2-IN-6 JAK2-IN-6	JAK	Angiogenesis; Chromatin/Epigenetic; JAK/STAT signaling; Stem Cells
	JAK2-IN-6是一种有效的、有选择性的 JAK2抑制剂(ic50为22.86 μg/mL),是一种多取代氨基噻唑衍生物。JAK2-IN-6抑制 JAK2酶的活性，通过干扰与 JAK2相关的信号通路，从而对 JAK2失调的特定疾病产生治疗作用，对 JAK1和JAK3不显示出活性。JAK2是一种参与调节细胞生长和分裂的信号通路的蛋白质。JAK2的异常激活与多种疾病有关，包括某些类型的癌症和炎症性疾病。JAK2-IN-6对癌细胞具有抗增殖活性。
T35900	JAK2-IN-7 JAK2-IN-7	JAK	Angiogenesis; Chromatin/Epigenetic; JAK/STAT signaling; Stem Cells
	JAK2-IN-7 是一种选择性 JAK2抑制剂，对 JAK2，SET-2 和 Ba/F3V617F 细胞的IC50为 3、11.7 和 41 nM。 JAK2-IN-7 的选择性是 JAK1, JAK3，FLT3 的 14 倍以上。JAK2-IN-7 刺激细胞周期停滞在 G0/G1 期，并诱导肿瘤细胞凋亡 (apoptosis)，具有抗肿瘤活性。
T11703	JAK-IN-1	Others	Others
	JAK-IN-1 shows improved selectivity for JAK3 over JAK1. JAK-IN-1 is a JAK1/2/3 inhibitor with IC50s of 0.26, 0.8 and 3.2 nM, respectively.
T35899	JAK1-IN-8 JAK1-IN-8	JAK	Angiogenesis; Chromatin/Epigenetic; JAK/STAT signaling; Stem Cells
	JAK1-IN-8，Janus 激酶 1 (JAK1)的特异性抑制剂（IC50<500 nM）。
T11705	JAK-IN-4	Others	Others
	JAK-IN-4 is a prodrug of a JAK inhibitor, effective in murine collagen induced arthritis model.
T11704	JAK-IN-3	CCR	Immunology/Inflammation; Microbiology/Virology
	JAK-IN-3 is a potent JAK inhibitor, with IC50 values of 3 nM, 5 nM, 34 nM and 70 nM for JAK3, JAK1, TYK2 and JAK2, respectively.
T38436	JAK-2/3-IN-1	Others	Others
	JAK-2/3-IN-1 is a highly effective inhibitor targeting both JAK-2 and JAK-3 isoforms. It exhibits remarkable potency, with Ki values below 250 nM for both isoforms.
T2460	JAK 3 inhibitor IV ZM 39923 hydrochloride,Jak3 inhibitor IV	EGFR; Others; JAK	Angiogenesis; Chromatin/Epigenetic; JAK/STAT signaling; Others; Stem Cells; Tyrosine Kinase/Adaptors
	JAK 3 inhibitor IV (ZM 39923 hydrochloride) 是一种 JAK1/3 抑制剂，pIC50 为 4.4/7.1，对 JAK2 几乎没有活性，对 EGFR 有适度的作用；还发现对转谷氨酰胺酶敏感。
T3042	JAK2 Inhibitor V JAK2 Inhibitor V Z3,Z3,NSC42834	JAK	Angiogenesis; Chromatin/Epigenetic; JAK/STAT signaling; Stem Cells
	JAK2 Inhibitor V (JAK2 Inhibitor V Z3) 是一种新型的 Jak2 特异性抑制剂，以剂量依赖性方式抑制 Jak2-V617F 和 Jak2-WT 自磷酸化。
T79110	JAK-IN-27	JAK	Angiogenesis; Chromatin/Epigenetic; JAK/STAT signaling; Stem Cells
	JAK-IN-27（化合物1）是JAK家族激酶的口服有效抑制剂，对TYK2、JAK1和JAK3的IC50分别为3.0 nM、7.7 nM和629.6 nM。此外，JAK-IN-27能够抑制Jurkat细胞内由IFN-α2B诱导的STAT3磷酸化，其IC50为23.7 nM。
T8742	G5-7 JAK2 inhibitor G5-7	Apoptosis; JAK	Angiogenesis; Apoptosis; Chromatin/Epigenetic; JAK/STAT signaling; Stem Cells
	JAK2 inhibitor G5-7 (JAK2 inhibitor G5-7) 是具有口服活性的JAK2变构抑制剂，可通过结合到 JAK2，选择性的抑制JAK2介导的 EGFR 和 STAT3 的磷酸化和激活。它诱导细胞周阻滞和诱导凋亡、具有抗血管生成活性。它有用于胶质瘤研究的潜能。
T79116	JAK-IN-28	JAK	Angiogenesis; Chromatin/Epigenetic; JAK/STAT signaling; Stem Cells
	JAK-IN-28（Compound 111）为一JAK抑制剂，适用于癌症及炎症性疾病研究领域。
T63658	JAK-IN-18	Others	Others
	JAK-IN-18 是 JAK 的有效抑制剂，能够用于研究多种疾病，尤其是眼部、皮肤和呼吸系统疾病。
T63026	JAK-IN-19	Others	Others
	JAK-IN-19 是一种 JAK 的有效抑制剂，对 PBMC IFNγ 和 HLF Eotaxin 的 pIC50 值分别为 7.2 和 7.7。JAK-IN-19 能够减轻被醛氧化酶 (Aldehyde Oxidase, AO) 代谢，进而保持在肺内的良好保留特性，对 VEGFR2 选择性较低（对 VEGFR2 和 Aurora B 的 pIC50 值分别为 7.0 和 5.8）。
T78189	JAK-IN-26	JAK	Angiogenesis; Chromatin/Epigenetic; JAK/STAT signaling; Stem Cells
	JAK-IN-26（化合物2）为口服活性JAK抑制剂，展现优良药代动力学特性。该化合物有效抑制Jurkat细胞中IFN-α2B诱导的STAT3磷酸化（IC50=17.2 nM）。
T63581	JAK-IN-20	Others	Others
	JAK-IN-20 是有效的、口服具有活力的、广泛的 JAK 抑制剂，能够作用于 JAK1 (IC50: 7 nM)，JAK2 (IC50: 5 nM)，JAK3 (IC50: 14 nM)。JAK-IN-20 在体内具有优异的药代动力学和抗炎活性。
T79882	JAK-IN-31	JAK	Angiogenesis; Chromatin/Epigenetic; JAK/STAT signaling; Stem Cells
	JAK-IN-31（实施例 75）作为JAK抑制剂，对JAK1、JAK2、JAK3及Tyk2的IC50值分别为≤0.01µM、≤0.01µM、0.01-0.1µM、≤0.01µM，适用于癌症研究领域。
T78175	JAK-IN-25	JAK	Angiogenesis; Chromatin/Epigenetic; JAK/STAT signaling; Stem Cells
	JAK-IN-25（化合物19）是一种高效的JAK抑制剂，对TYK2、JAK1、JAK2和JAK3的IC50值分别为6 nM、21 nM、8 nM、1051 nM。该化合物还能抑制人全血中IL-12（HEB IL-12），IC50为28 nM，显示其在癌症研究中的潜在应用价值。
T73250	JAK-IN-17	Others	Others
	JAK-IN-17 是一种有效的JAK 抑制剂。JAK-IN-17 可用于多种疾病的研究，尤其是眼部、皮肤和呼吸系统疾病[1]。
T79222	JAK-IN-29	JAK	Angiogenesis; Chromatin/Epigenetic; JAK/STAT signaling; Stem Cells
	JAK-IN-29（compound 3）为一种高效JAK抑制剂，在体外实验中展现出显著的抑制活性。
T82017	JAK-IN-34	JAK	Angiogenesis; Chromatin/Epigenetic; JAK/STAT signaling; Stem Cells
	JAK-IN-34 对JAKs具有有效抑制作用，其IC50值分别针对JAK1、JAK2、JAK3、TYK2为0.40、0.83、2.10、1.95 nM 。此外，JAK-IN-34 能够降低关节肿胀，并展现出良好的安全性。
TP1269	Tyrosine Protein Kinase JAK 2 (Phospho-Tyr8, 9) Tyrosine Protein Kinase JAK2 Phospho-Tyr8, 9
	Tyrosine Protein Kinase JAK 2 (Phospho-Tyr8, 9) is a peptide derived from mouse JAK2, specifically composed of amino acids 475 to 491.
T82018	JAK-IN-33	JAK	Angiogenesis; Chromatin/Epigenetic; JAK/STAT signaling; Stem Cells
	JAK-IN-33（化合物3（R））为一种JAK抑制剂。
T62556	JAK-IN-23	Others	Others
	JAK-IN-23 是一种口服具有活力的、双重的 JAK/STAT 和 NF-κB 抑制剂。JAK-IN-23 能够抑制 J AK1 (IC50: 8.9 nM)、J AK2 (IC50: 15 nM)、J AK3 (IC50: 46.2 nM)。JAK-IN-23 能够较强抑制干扰素刺激基因 (ISG) (IC50: 3.3 nM) 和 NF-κB 通路 (IC50: 150.7 nM)。JAK-IN-23 表现出很强的抗炎效果，可以降低各种促炎因子的释放。JAK-IN-23 能够用于研究炎症性肠病 (IBD)。
T73330	JAK-IN-24	Others	Others
	JAK-IN-24 是一种 JAK 抑制剂，在 4 μM 或 1 mM ATP 存在时，IC50分别为 0.534 和 24 nM。JAK-IN-24 还抑制 PBMCIL-15诱导的 STAT5磷酸化，IC50为 86.171 nM。
T79235	JAK-IN-30	JAK	Angiogenesis; Chromatin/Epigenetic; JAK/STAT signaling; Stem Cells
	JAK-IN-30（化合物31）是一种具有水溶性的JAK抑制剂，对JAK2、JAK1、JAK3及TYK2的IC50值分别为2、15、18及2 nM。该化合物作为研究干眼症（DED）的潜在药物而备受关注。
T38624	Fosifidancitinib	JAK	Angiogenesis; Chromatin/Epigenetic; JAK/STAT signaling; Stem Cells
	Fosifidancitinib 是有效的JAK 激酶 1/3 选择性抑制剂。它在过敏、哮喘和自身免疫性疾病中有研究价值。
T63086	SYK/JAK-IN-1	Others	Others
	SYK/JAK-IN-1 是一种 SYK/JAK 双重抑制剂，对 SYK 和 JAK2 的 IC50 值均小于 5 nM。
T79807	JAK kinase-IN-1	JAK	Angiogenesis; Chromatin/Epigenetic; JAK/STAT signaling; Stem Cells
	JAKkinase-IN-1 (Example 1)为一种JAK抑制剂，其对TYK2、JAK1、JAK2和JAK3的抑制IC50值分别为4.2 nM、32 nM、27 nM及3473 nM。
T79768	HDAC/JAK/BRD4-IN-1	Epigenetic Reader Domain	Chromatin/Epigenetic
	HDAC/JAK/BRD4-IN-1（compound 25ap）是一种针对HDAC/JAK/BRD4的三重抑制剂，该化合物能有效抑制MDA-MB-231细胞增殖，并诱导apoptosis，同时在体内表现出显著的抗癌活性。
T78708	JAK/HDAC-IN-2	JAK	Angiogenesis; Chromatin/Epigenetic; JAK/STAT signaling; Stem Cells
	JAK/HDAC-IN-2 是一款高效的 JAK/HDAC 双靶点抑制剂，能在纳摩尔浓度范围内有效抑制 HDAC3/6 与 JAK1/2。此化合物不仅促进细胞凋亡，还能抑制组蛋白去乙酰化和 STAT3 磷酸化，对血液肿瘤和实体肿瘤细胞展现出了显著的抗增殖效果。
T9811	JAK3-IN-11	Others	Others
	JAK3- in -11 (Compound 12) 是表现出强效的、无细胞毒性、不可逆、口服活性的JAK3抑制活性，IC50值为1.7 nM，具有出色的选择性(高于其他 JAK3 亚型的588倍)，共价结合到 JAK3 的 ATP-binding pocket。 JAK3-IN-11 强烈抑制 JAK3 依赖的信号转导和T 细胞增殖，是研究自身免疫性疾病的有效工具。
T67754	JAK3-IN-14	FLT	Angiogenesis; Tyrosine Kinase/Adaptors
	JAK3-IN-14 是一种有效的、选择性的口服活性FLT3抑制剂，对FLT3-WT、FLT3-D835Y 和FLT3-D83H 的IC50分别为～40、8和4nM。
T60895	JAK-2/3-IN-3	Others	Others
	JAK-2/3-IN-3 (化合物 ST4j) 可用于研究淋巴源性疾病和白血病。JAK-2/3-IN-3 以时间和剂量依赖性的方式抑制JAK2的自磷酸化并诱导细胞凋亡。JAK-2/3-IN-3 是 JAK2/3 的有效抑制剂，对JAK2和JAK3的IC50值分别为 13.00 和 14.86 nM。
T61323	JAK-2/3-IN-2	Others	Others
	JAK-2/3-IN-2 (Compound 3h) is a potent dual inhibitor of JAK2 and JAK3. It exhibits inhibitory activity with IC50 values of 23.85 nM and 18.9 nM against JAK2 and JAK3, respectively [1].
T10009	JAK3-IN-7	JAK	Angiogenesis; Chromatin/Epigenetic; JAK/STAT signaling; Stem Cells
	JAK3-IN-7 是一种有效的选择性 JAK3 抑制剂（IC50<0.01 μM），可用于治疗器官移植中的排斥反应、器官移植后的移植物抗宿主反应、自身免疫性疾病、过敏性疾病和慢性骨髓增生性疾病。
T3069	AZD-1480	JAK	Angiogenesis; Chromatin/Epigenetic; JAK/STAT signaling; Stem Cells
	AZD1480 是 ATP 竞争型JAK1和JAK2抑制剂，IC50分别为 1.3 和 0.4 nM。
T9813	JAK3/BTK-IN-2	JAK; BTK	Angiogenesis; Chromatin/Epigenetic; JAK/STAT signaling; Stem Cells; Tyrosine Kinase/Adaptors
	JAK3/BTK-IN-2 是一种有效的 JAK3/BTK 抑制剂。JAK3/BTK-IN-2对BTK 和 JAK3具有抑制作用（ BTK 和 JAK3是自身免疫性疾病的两个重要靶点）JAK3/BTK-IN-2同时抑制 BTK/JAK3 信号通路表现出协同效应。JAK3/BTK-IN-2 具有治疗 JAK3 和BTK 活性异常引起相关疾病的潜力。
T6122	CEP-33779 CEP33779	JAK	Angiogenesis; Chromatin/Epigenetic; JAK/STAT signaling; Stem Cells
	CEP-33779是一种新型，选择性，有口服活性的JAK2抑制剂，IC50值为1.8±0.6 nM。

化合物

Cat.No: T27650

Synonym: JAK-3i,JAK 3i

Target: JAK

Cat.No: T13571

Target: JAK

Cat.No: T11710

Target: JAK

Cat.No: T12549

Synonym: R-348

Target: JAK

Cat.No: T61494

Target: Tyrosine Kinases, JAK

Cat.No: T3080

Synonym: Janus-Associated Kinase Inhibitor I,JAK Inhibitor,CMP 6,吡啶酮6,JAK Inhibitor I

Target: Tyrosine Kinases, JAK

JAK-STAT-IN-1

Cat.No: T78607

Target: JAK, STAT

Cat.No: T5492

Target: JAK

JAK-IN-5 hydrochloride

Cat.No: T11710L

Synonym: JAK-IN-5 hydrochloride(2096999-92-5 Free base)

Target: JAK

Cat.No: T39400

Target: Others

Cat.No: T9764

Target: Others

Cat.No: T40443

Synonym: JAK2-IN-6

Target: JAK

Cat.No: T35900

Synonym: JAK2-IN-7

Target: JAK

Cat.No: T11703

Target: Others

Cat.No: T35899

Synonym: JAK1-IN-8

Target: JAK

Cat.No: T11705

Target: Others

Cat.No: T11704

Target: CCR

Cat.No: T38436

Target: Others

JAK 3 inhibitor IV

Cat.No: T2460

Synonym: ZM 39923 hydrochloride,Jak3 inhibitor IV

Target: EGFR, Others, JAK

JAK2 Inhibitor V

Cat.No: T3042

Synonym: JAK2 Inhibitor V Z3,Z3,NSC42834

Target: JAK

Cat.No: T79110

Target: JAK

Cat.No: T8742

Synonym: JAK2 inhibitor G5-7

Target: Apoptosis, JAK

Cat.No: T79116

Target: JAK

Cat.No: T63658

Target: Others

Cat.No: T63026

Target: Others

Cat.No: T78189

Target: JAK

Cat.No: T63581

Target: Others

Cat.No: T79882

Target: JAK

Cat.No: T78175

Target: JAK

Cat.No: T73250

Target: Others

Cat.No: T79222

Target: JAK

Cat.No: T82017

Target: JAK

Tyrosine Protein Kinase JAK 2 (Phospho-Tyr8, 9)

Cat.No: TP1269

Synonym: Tyrosine Protein Kinase JAK2 Phospho-Tyr8, 9

Cat.No: T82018

Target: JAK

Cat.No: T62556

Target: Others

Cat.No: T73330

Target: Others

Cat.No: T79235

Target: JAK

Fosifidancitinib

Cat.No: T38624

Target: JAK

Cat.No: T63086

Target: Others

JAK kinase-IN-1

Cat.No: T79807

Target: JAK

HDAC/JAK/BRD4-IN-1

Cat.No: T79768

Target: Epigenetic Reader Domain

JAK/HDAC-IN-2

Cat.No: T78708

Target: JAK

Cat.No: T9811

Target: Others

Cat.No: T67754

Target: FLT

Cat.No: T60895

Target: Others

Cat.No: T61323

Target: Others

Cat.No: T10009

Target: JAK

Cat.No: T3069

Target: JAK

JAK3/BTK-IN-2

Cat.No: T9813

Target: JAK, BTK

Cat.No: T6122

Synonym: CEP33779

Target: JAK

Cat. No.	Product Name	Target	Signaling Pathways
T4672	Brevilin A	Apoptosis; Anti-infection; JAK; STAT; Autophagy	Angiogenesis; Apoptosis; Autophagy; Chromatin/Epigenetic; JAK/STAT signaling; Microbiology/Virology; Stem Cells
	Brevilin A 是从Centipeda minima 中分离的倍半萜内酯，具有抗癌活性。它通过线粒体途径和 PI3K/AKT/mTOR 失活诱导结肠腺癌细胞 CT26 的凋亡和自噬。它是一种选择性JAK-STAT 信号通路抑制剂，通过减弱 JAK 信号和阻塞 STAT3 信号起作用。
TJS1779	Protosappanin A 原苏木素A,PTA	NADPH-oxidase; IL Receptor; IκB/IKK; TNF; NF-κB; TLR; ROS; COX; HIV Protease; JAK; NO Synthase; STAT	Angiogenesis; Apoptosis; Chromatin/Epigenetic; Immunology/Inflammation; JAK/STAT signaling; Microbiology/Virology; Neuroscience; NF-κB; Proteases/Proteasome; Stem Cells
	Protosappanin A (PTA) 是从苏木中分离得到的免疫抑制成分和主要联苯化合物，通过下调 JAK2和 STAT3的磷酸化，抑制 JAK2/STAT3依赖的炎症通路。
T6S1966	Curculigoside Curculigoside A,仙茅苷	Antioxidant; NF-κB; JAK; STAT	Angiogenesis; Chromatin/Epigenetic; JAK/STAT signaling; NF-κB; oxidation-reduction; Stem Cells
	Curculigoside (Curculigoside A) 是仙茅中的主要皂苷，具有显著的抗氧化、抗骨质疏松、抗抑郁和神经保护作用。它通过调节JAK/STAT/NF-κB 信号传导途径，具有抗关节炎作用。
T5S0167	Atractylenolide I 白术内酯 I,白术内酯I；苍术内酯I	IL Receptor; TNF; TLR; JAK; STAT	Angiogenesis; Apoptosis; Chromatin/Epigenetic; Immunology/Inflammation; JAK/STAT signaling; Stem Cells
	Atractylenolide I 是从白术根中得到的一种倍半萜烯，具有神经保护、抗过敏、抗炎和抗癌等多种生物活性。它是一种TLR4拮抗剂，在 A375 细胞中，能够降低JAK2和STAT3的磷酸化水平。
TQ0196	Cucurbitacin I NSC-521777,JSI-124,Elatericin B,葫芦素 I	JAK; STAT	Angiogenesis; Chromatin/Epigenetic; JAK/STAT signaling; Stem Cells
	Cucurbitacin I (JSI-124) 是从曲莲中提取的一种天然产物，是 JAK2/STAT3选择性抑制剂，有抗肿瘤活性。
T4S1499	Ginsenoside Rk1 人参皂苷RK1,人参皂苷	Apoptosis; Others; NF-κB; PI3K; JAK	Angiogenesis; Apoptosis; Chromatin/Epigenetic; JAK/STAT signaling; NF-κB; Others; PI3K/Akt/mTOR signaling; Stem Cells
	Ginsenoside Rk1 是人参的高温加工提取物，抑制Jak2/Stat3信号通路和NF-κB 的激活。它具有抗肿瘤、抗血小板聚集活性、抗炎、抗胰岛素抵抗、肾保护和抗菌作用，可使认知功能增强，脂质积聚减少和预防骨质疏松症，还诱导细胞凋亡。
T16324	Nimbolide	Apoptosis; NF-κB; CDK	Apoptosis; Cell Cycle/Checkpoint; NF-κB
	Nimbolide 是源自印楝叶和花的一种三萜。它抑制CDK4/CDK6激酶活性。它抑制 NF-κB，Wnt，PI3K-Akt，MAPK 和 JAK-STAT 信号通路。它通过抑制NF-κB 而诱导肿瘤细胞凋亡。
TN1013	Cucurbitacin D	Apoptosis	Apoptosis
	Cucurbitacin D 是一种从 Ecballium elaterium （L.）分离出来的三萜类化合物，具有抗癌抗肿瘤活性，抑制转移性 PrC 中的葡萄糖摄取和乳酸产生，诱导独立于 ERK1/2 激活的炎症小体激活。 Cucurbitacin D 是巨噬细胞中的一种新的炎症小体激活剂，通过调节 JAK/STAT3、PI3K/Akt/mTOR 和 MAPK 信号通路抑制 HepG2 细胞增殖并诱导细胞凋亡，可用于研究宫颈癌、白血病和前列腺癌。
TN1567	Delphinidin chloride	Estrogen Receptor/ERR; VEGFR	Angiogenesis; Endocrinology/Hormones; Tyrosine Kinase/Adaptors
	Delphinidin chloride 是一种花青素，是一种可从浆果和红酒中分离得到的天然植物色素，是某些花青素的前体。Delphinidin chloride 诱导血管内皮释放一氧化氮，引起血管松弛。在1 ~ 40 μM 剂量下，对上皮生长因子受体的信号传导和雌激素受体α的表达有抑制作用，与细胞凋亡和自噬有关。Delphinidin chloride 能调节 JAK/STAT3 和 MAPKinase 信号传导。Delphinidin 还能抑制 p300/CBP 的组蛋白乙酰转移酶活性(IC50 在约为30 μM)
T3673	Mollugin 大叶茜草素,Rubimaillin	HER; JAK	Angiogenesis; Chromatin/Epigenetic; JAK/STAT signaling; Stem Cells; Tyrosine Kinase/Adaptors
	Mollugin (Rubimaillin) 是Rubia cordifolia L.中主要的生物活性成分。它能通过 p38-Smad 信号通路增强 BMP-2 的成骨作用。它通过抑制 TNF-α 诱导的 NF-κB 激活起抗癌疗效。
T5S1897	Linderalactone	Apoptosis; Others; JAK	Angiogenesis; Apoptosis; Chromatin/Epigenetic; JAK/STAT signaling; Others; Stem Cells
	Linderalactone 是从乌药中分离出来的一种倍半萜烯内酯，通过调节凋亡相关蛋白的表达和抑制 JAK/STAT 信号通路来抑制癌细胞生长。它以 IC50值为 15 µM 来抑制肺癌 A-549 细胞的增殖。
T6S1141	Ganoderic acid A 灵芝酸 A,灵芝酸A	Apoptosis; NF-κB; Endogenous Metabolite; Autophagy	Apoptosis; Autophagy; Metabolism; NF-κB
	Ganoderic acid A 能够抑制 JAK-STAT3信号通路，也能抑制细胞增殖，存活率和 ROS。它对人骨肉瘤 HOS 和MG-63细胞具有增殖抑制、凋亡和侵袭抑制作用。
T19934	Dehydrocrenatidine TOP 3,TOP-3,O-Methylpicrasidine I,TOP3,Kumujian G	Apoptosis; JAK	Angiogenesis; Apoptosis; Chromatin/Epigenetic; JAK/STAT signaling; Stem Cells
	Dehydrocrenatidine (Kumujian G) 是 JAK 的抑制剂，可诱导细胞凋亡。
TN4774	Physalin A	ERK; BCL; p38 MAPK; NF-κB; Androgen Receptor; ROS; JAK; JNK; STAT; p53; Autophagy	Angiogenesis; Apoptosis; Autophagy; Chromatin/Epigenetic; Endocrinology/Hormones; Immunology/Inflammation; JAK/STAT signaling; MAPK; NF-κB; Stem Cells
	Physalin A exerts anti-tumor activity in non-small cell lung cancer cell lines by suppressing JAK/STAT3 signaling, it inhibits androgen-independent prostate cancer cell growth through activation of cell apoptosis and downregulation of androgen receptor ex
TN3364	Agrimonolide	Apoptosis; Dehydrogenase; p38 MAPK; ROS; JAK	Angiogenesis; Apoptosis; Chromatin/Epigenetic; Immunology/Inflammation; JAK/STAT signaling; MAPK; Metabolism; Stem Cells
	Agrimonolide 是一种来自异香豆素的化合物，主要存在于草药Agrimonia pilosa Ledeb 中，具有显著的生物活性。Agrimonolide 通过抑制脂多糖（LPS）诱导的JAK-STATs 和p38 MAPKs 信号通路的激活而发挥抗炎作用。Agrimonolide 及其衍生物去甲阿戈莫内德已显示出能够有效提高肝细胞中胰岛素介导的糖原水平，可能在调节胰岛素抵抗的HepG2细胞中发挥关键作用。Agrimonolide 通过靶向卵巢癌细胞中的SCD1，对癌症的进展和诱导细胞死亡和凋亡表现出抑制作用。特别是，Agrimonolide 对A2780和SKOV-3细胞的增殖、迁移和侵袭表现出剂量依赖性的抑制，同时促进细胞凋亡。该化合物还被发现能诱导铁介导的细胞死亡，同时增加活性氧（ROS）和总铁的水平。Agrimonolide 很容易穿过血脑屏障，表明其在神经系统疾病的治疗应用方面具有潜力。

天然产物

Cat.No: T4672

Target: Apoptosis, Anti-infection, JAK, STAT, Autophagy

Protosappanin A

Cat.No: TJS1779

Synonym: 原苏木素A,PTA

Target: NADPH-oxidase, IL Receptor, IκB/IKK, TNF, NF-κB, TLR, ROS, COX, HIV Protease, JAK, NO Synthase, STAT

Cat.No: T6S1966

Synonym: Curculigoside A,仙茅苷

Target: Antioxidant, NF-κB, JAK, STAT

Atractylenolide I

Cat.No: T5S0167

Synonym: 白术内酯 I,白术内酯I；苍术内酯I

Target: IL Receptor, TNF, TLR, JAK, STAT

Cat.No: TQ0196

Synonym: NSC-521777,JSI-124,Elatericin B,葫芦素 I

Target: JAK, STAT

Ginsenoside Rk1

Cat.No: T4S1499

Synonym: 人参皂苷RK1,人参皂苷

Target: Apoptosis, Others, NF-κB, PI3K, JAK

Cat.No: T16324

Target: Apoptosis, NF-κB, CDK

Cat.No: TN1013

Target: Apoptosis

Delphinidin chloride

Cat.No: TN1567

Target: Estrogen Receptor/ERR, VEGFR

Cat.No: T3673

Synonym: 大叶茜草素,Rubimaillin

Target: HER, JAK

Cat.No: T5S1897

Target: Apoptosis, Others, JAK

Ganoderic acid A

Cat.No: T6S1141

Synonym: 灵芝酸 A,灵芝酸A

Target: Apoptosis, NF-κB, Endogenous Metabolite, Autophagy

Dehydrocrenatidine

Cat.No: T19934

Synonym: TOP 3,TOP-3,O-Methylpicrasidine I,TOP3,Kumujian G

Target: Apoptosis, JAK

Cat.No: TN4774

Target: ERK, BCL, p38 MAPK, NF-κB, Androgen Receptor, ROS, JAK, JNK, STAT, p53, Autophagy

Cat.No: TN3364

Target: Apoptosis, Dehydrogenase, p38 MAPK, ROS, JAK

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPH-02919	SOCS1 Protein, Mouse, Recombinant (His & Myc) STAT-induced STAT inhibitor 1,Suppressor of cytokine signali...	Mouse	E. coli
	SOCS1 Protein, Mouse, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 28.7 kDa and the accession number is O35716.
TMPH-02155	SOCS1 Protein, Human, Recombinant (E. coli, His) Tec-interacting protein 3,JAK-binding protein,Suppr...	Human	E. coli
	SOCS1 Protein, Human, Recombinant (E. coli, His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 27.6 kDa and the accession number is O15524.
TMPH-02156	SOCS1 Protein, Human, Recombinant (His) SOCS1,STAT-induced STAT inhibitor 1,JAK-binding pro...	Human	P. pastoris (Yeast)
	SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS1 is involved in negative regulation of cytokines that signal through the JAK/STAT pathway. Through binding to JAKs and IFNGR1, inhibits their kinase activity. In vitro, also suppresses Tec protein-tyrosine activity. Appears to be a major regulator of signaling by interleukin 6 (IL6) and leukemia inhibitory factor (LIF). Regulates interferon-gamma mediated sensory neuron surviv...
TMPH-02273	JAK1 Protein, Human, Recombinant (His) JAK1,Janus kinase 1,Tyrosine-protein kinase JAK...	Human	P. pastoris (Yeast)
	Tyrosine kinase of the non-receptor type, involved in the IFN-alpha/beta/gamma signal pathway. Kinase partner for the interleukin (IL)-2 receptor as well as interleukin (IL)-10 receptor. Directly phosphorylates STAT but also activates STAT signaling through the transactivation of other JAK kinases associated with signaling receptors.
TMPH-02274	JAK2 Protein, Human, Recombinant (His) JAK2,Janus kinase 2,Tyrosine-protein kinase JAK...	Human	E. coli
	Non-receptor tyrosine kinase involved in various processes such as cell growth, development, differentiation or histone modifications. Mediates essential signaling events in both innate and adaptive immunity. In the cytoplasm, plays a pivotal role in signal transduction via its association with type I receptors such as growth hormone (GHR), prolactin (PRLR), leptin (LEPR), erythropoietin (EPOR), thrombopoietin (THPO); or type II receptors including IFN-alpha, IFN-beta, IFN-gamma and multiple int...
TMPH-02961	JAK1 Protein, Mouse, Recombinant (His) Janus kinase 1,Jak1,Tyrosine-protein kinase JAK...	Mouse	E. coli
	Tyrosine kinase of the non-receptor type, involved in the IFN-alpha/beta/gamma signal pathway. Kinase partner for the interleukin (IL)-2 receptor as well as interleukin (IL)-10 receptor. Directly phosphorylates STAT but also activates STAT signaling through the transactivation of other JAK kinases associated with signaling receptors. JAK1 Protein, Mouse, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 39.1 kDa and the accession numb...
TMPH-02272	JAK1 Protein, Human, Recombinant (E. coli, His) Tyrosine-protein kinase JAK1,JAK1,Janus ki...	Human	E. coli
	Tyrosine kinase of the non-receptor type, involved in the IFN-alpha/beta/gamma signal pathway. Kinase partner for the interleukin (IL)-2 receptor as well as interleukin (IL)-10 receptor. Directly phosphorylates STAT but also activates STAT signaling through the transactivation of other JAK kinases associated with signaling receptors.
TMPK-00474	IL-22RA1 Protein, Cynomolgus, Recombinant (His) CRF2-9,IL22R1,IL-22R-α-1,IL-22RA1,zcytoR11,IL22R,IL-22R-alph...	Cynomolgus	HEK293 Cells
	IL-22 receptor, also known as IL-22 R alpha 1 and CRF2-9, is an approximately 65 kDa transmembrane glycoprotein in the type II cytokine receptor family (CRF).Component of the receptor for IL20, IL22 and IL24. Component of IL22 receptor formed by IL22RA1 and IL10RB enabling IL22 signaling via JAK/STAT pathways. IL22 also induces activation of MAPK1/MAPK3 and Akt kinases pathways. Component of one of the receptor for IL20 and IL24 formed by IL22RA1 and IL20RB also signaling through STATs activatio...
TMPJ-00059	IL-7 Protein, Human, Recombinant (His) Interleukin-7,IL7,白细胞介素,IL-7,白介素	Human	HEK293 Cells
	Human Interleukin 7 (IL-7) is a potent lymphoid cell growth factor stimulating the proliferation of lymphoid progenitors. IL7 can associate with the hepatocyte growth factor (HGF) to form a hybrid cytokine that functions as a pre-pro-B cell growth-stimulating factor. Human IL7 cDNA encodes a 177 amino acid precursor protein containing a 25 amino acid signal peptide and a 152 amino acid mature protein. Human and mouse IL7 share 65% sequence identity in the mature region and both exhibit cross-spe...
TMPH-00779	IL-23 P19/IL23A Protein, Guinea Pig, Recombinant (His & Myc) Interleukin-23 subunit p19,Interleukin-23 subunit alpha,IL23...	Guinea pig	E. coli
	Associates with IL12B to form the IL-23 interleukin, a heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak-Stat signaling cascade, stimulates memory rather than naive T-cells and promotes production of proinflammatory cytokines. IL-23 induces autoimmune inflammation and thus may be responsible fo...
TMPK-01071	IL-22RA1 Protein, Mouse, Recombinant (hFc) IL-22R α1,IL22R,zcytoR11,IL-TIF-R1,CRF2-9,IL-22R-alpha-1,IL-...	Mouse	HEK293 Cells
	Interleukin (IL)-22 is a member of the IL-10 family of cytokines and represents an important effector molecule of activated Th22, Th1, and Th17 cells, as well as Tc-cell subsets, gammadelta T cells, natural killer (NK), and NKT cells. IL-22 mediates its effects via a heterodimeric transmembrane receptor complex consisting of IL-22R1 and IL-10R2 and subsequent Janus kinase-signal transducers and activators of transcription (JAK-STAT) signaling pathways including Jak1, Tyk2, and STAT3. IL-22RA1 Pr...
TMPJ-00076	IL-28B Protein, Human, Recombinant IL-28C,IFN-λ-4,IFNL4,Interferon λ-4,IL28B,IL-28B,Interleukin...	Human	HEK293 Cells
	Interleukin-28B, also known as Cytokine Zcyto22, Interferon lambda-3, Interferon lambda-4, IFNL3, IFNL4, ZCYTO22 and IL28B, is a secreted cytokine which belongs to the IL-28/IL-29 family. IL-28 has also been shown to play a role in the adaptive immune response. IL28B has immunomodulatory activity and up-regulates MHC class I antigen expression. IL28B displays potent antiviral activity and antitumor activity. In addition, IL28B is a ligand for the heterodimeric class II cytokine receptor composed...
TMPK-01105	IL-22RA1 Protein, Human, Recombinant (hFc) IL-22R-alpha-1,CRF2-9,IL-TIF-R1,IL-22R-α-1,IL22R1,zcytoR11,I...	Human	HEK293 Cells
	Interleukin (IL)-22 is a member of the IL-10 family of cytokines and represents an important effector molecule of activated Th22, Th1, and Th17 cells, as well as Tc-cell subsets, gammadelta T cells, natural killer (NK), and NKT cells. IL-22 mediates its effects via a heterodimeric transmembrane receptor complex consisting of IL-22R1 and IL-10R2 and subsequent Janus kinase-signal transducers and activators of transcription (JAK-STAT) signaling pathways including Jak1, Tyk2, and STAT3. IL-22RA1 Pr...
TMPU-00003	STAT2 Protein, Human, Recombinant (His)	Human	E. coli
	Signal transducer and activator of transcription that mediates signaling by type I IFNs (IFN-alpha and IFN-beta). Following type I IFN binding to cell surface receptors, Jak kinases (TYK2 and JAK1) are activated, leading to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize, associate with ISGF3G/IRF-9 to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of...
TMPJ-00326	CD122/IL2RB Protein, Human, Recombinant (aa 27-239, His & Avi), Biotinylated IL-2R subunit beta,High affinity IL-2 receptor subunit β,Int...	Human	HEK293 Cells
	Human IL-2RB, also known asinterleukin-2 receptor subunit beta,is the receptor for interleukin-2. IL2 receptor complex is involved in receptor mediated endocytosis and transduces the mitogenic signals of IL2. IL2 receptor complex has three forms with respect to ability to bind IL2. IL-2RB is belonged to a type I membrane protein,and has a 26 residue signal peptide, a 214 residue extracellular region, a 25 residue transmembrane region and a 286 residue cytoplasmic domain. IL-2RB is the subunit c...
TMPH-01551	IFNLR1 Protein, Human, Recombinant (His & SUMO) Cytokine receptor class-II member 12,Likely interleukin or c...	Human	E. coli
	The IFNLR1/IL10RB dimer is a receptor for the cytokine ligands IFNL2 and IFNL3 and mediates their antiviral activity. The ligand/receptor complex stimulate the activation of the JAK/STAT signaling pathway leading to the expression of IFN-stimulated genes (ISG), which contribute to the antiviral state. Determines the cell type specificity of the lambda interferon action. Shows a more restricted pattern of expression in the epithelial tissues thereby limiting responses to lambda interferons primar...
TMPY-02624	IL-9R Protein, Rat, Recombinant (His) interleukin 9 receptor	Rat	HEK293 Cells
	IL9R (Interleukin 9 Receptor) is a Protein Coding gene. The protein encoded by this gene is a cytokine receptor that specifically mediates the biological effects of interleukin 9 (IL9). IL9 is involved in mast cell maturation and the enhancement of IgE production by B cells. Furthermore, linkage data in the human and mice have suggested that IL9 may contribute to asthma. The ligand binding of this receptor leads to the activation of various JAK kinases and STAT proteins, which connect to differe...
TMPJ-00194	IL-20RB Protein, Human, Recombinant (hFc) DIRS1,IL-20R-β,Interleukin-20 receptor subunit β,IL-20 recep...	Human	HEK293 Cells
	Interleukin-20 receptor subunit beta（IL20RB） is a single-pass type I membrane protein and belongs to the type II cytokine receptor family. It contains 2 fibronectin type-III domains. There are two kinds of type II cytokine receptors : cytokine receptors that bind type I and type II interferons; cytokine receptors that bind members of the interleukin-10 family (interleukin-10, interleukin-20 and interleukin-22). Type II cytokine receptors are similar to type I cytokine receptors except they do no...
TMPJ-00495	ISG15 Protein, Human, Recombinant (His) ISG15,Ubiquitin Cross-Reactive Protein,G1P2,Interferon-Induc...	Human	E. coli
	Ubiquitin-Like Protein ISG15 (ISG15) is a ubiquitin-like protein that becomes conjugated to many cellular proteins upon activation by interferon-alpha and -beta. Several functions have been ascribed to the encoded protein, including chemotactic activity towards neutrophils, direction of ligated target proteins to intermediate filaments, cell-to-cell signaling, and antiviral activity during viral infections. While conjugates of this protein have been found to be noncovalently attached to intermed...
TMPY-02194	SOCS3 Protein, Human, Recombinant (His & Trx) SOCS-3,SSI-3,ATOD4,Cish3,SSI3,suppressor of cytokine signali...	Human	E. coli
	Suppressor of cytokine signaling 3, also known as SOCS-3, Cytokine-inducible SH2 protein 3, CIS-3, STAT-induced STAT inhibitor 3, SOCS3 and CIS3, is a protein which is widely expressed with high expression in heart, placenta, skeletal muscle, peripheral blood leukocytes, fetal and adult lung, and fetal liver and kidney. SOCS3 / CIS3 contains one SH2 domain and one SOCS box domain. SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. ...
TMPJ-01003	STAT5B Protein, Human, Recombinant (His) Signal Transducer and Activator of Transcription 5B,STAT5B	Human	E. coli
	Signal Transducer and Activator of Transcription 5b (STAT5B) is a member of the STAT family of transcription factors. They are responsible for an array of cellular activities including regulating growth, survival, differentiation, motility, and the immune response. STAT5B mediates the signal transduction triggered by various cell ligands, such as IL2, IL4, CSF1, and different growth hormones. It has been shown to be involved in diverse biological processes, such as TCR signaling, apoptosis, adul...
TMPY-04084	ANGPTL1 Protein, Canine, Recombinant (hFc) angiopoietin-like 1	Canine	HEK293 Cells
	Angiopoietin-like protein 1 (ANGPTL1) has been reported to suppress migration and invasion in lung and breast cancer, acting as a novel tumor suppressor candidate. Downregulation of tumor suppressor signaling plays an important role in the pathogenesis of hepatocellular carcinoma (HCC).The downregulation of the angiopoietin-like protein ANGPTL1 is associated with vascular invasion, tumor thrombus, metastasis, and poor prognosis in HCC. Ectopic expression of ANGPTL1 in HCC cells effectively decre...
TMPH-00775	IFN gamma Protein, Goat, Recombinant (His & Myc) Interferon gamma,IFNG	Goat	E. coli
	Type II interferon produced by immune cells such as T-cells and NK cells that plays crucial roles in antimicrobial, antiviral, and antitumor responses by activating effector immune cells and enhancing antigen presentation. Primarily signals through the JAK-STAT pathway after interaction with its receptor IFNGR1 to affect gene regulation. Upon IFNG binding, IFNGR1 intracellular domain opens out to allow association of downstream signaling components JAK2, JAK1 and STAT1, leading to STAT1 activati...

重组蛋白

SOCS1 Protein, Mouse, Recombinant (His & Myc)

Cat.No: TMPH-02919

Species: Mouse

Expression System: E. coli

SOCS1 Protein, Human, Recombinant (E. coli, His)

Cat.No: TMPH-02155

Species: Human

Expression System: E. coli

SOCS1 Protein, Human, Recombinant (His)

Cat.No: TMPH-02156

Species: Human

Expression System: P. pastoris (Yeast)

JAK1 Protein, Human, Recombinant (His)

Cat.No: TMPH-02273

Species: Human

Expression System: P. pastoris (Yeast)

JAK2 Protein, Human, Recombinant (His)

Cat.No: TMPH-02274

Species: Human

Expression System: E. coli

JAK1 Protein, Mouse, Recombinant (His)

Cat.No: TMPH-02961

Species: Mouse

Expression System: E. coli

JAK1 Protein, Human, Recombinant (E. coli, His)

Cat.No: TMPH-02272

Species: Human

Expression System: E. coli

IL-22RA1 Protein, Cynomolgus, Recombinant (His)

Cat.No: TMPK-00474

Species: Cynomolgus

Expression System: HEK293 Cells

IL-7 Protein, Human, Recombinant (His)

Cat.No: TMPJ-00059

Species: Human

Expression System: HEK293 Cells

IL-23 P19/IL23A Protein, Guinea Pig, Recombinant (His & Myc)

Cat.No: TMPH-00779

Species: Guinea pig

Expression System: E. coli

IL-22RA1 Protein, Mouse, Recombinant (hFc)

Cat.No: TMPK-01071

Species: Mouse

Expression System: HEK293 Cells

IL-28B Protein, Human, Recombinant

Cat.No: TMPJ-00076

Species: Human

Expression System: HEK293 Cells

IL-22RA1 Protein, Human, Recombinant (hFc)

Cat.No: TMPK-01105

Species: Human

Expression System: HEK293 Cells

STAT2 Protein, Human, Recombinant (His)

Cat.No: TMPU-00003

Species: Human

Expression System: E. coli

CD122/IL2RB Protein, Human, Recombinant (aa 27-239, His & Avi), Biotinylated

Cat.No: TMPJ-00326

Species: Human

Expression System: HEK293 Cells

IFNLR1 Protein, Human, Recombinant (His & SUMO)

Cat.No: TMPH-01551

Species: Human

Expression System: E. coli

IL-9R Protein, Rat, Recombinant (His)

Cat.No: TMPY-02624

Species: Rat

Expression System: HEK293 Cells

IL-20RB Protein, Human, Recombinant (hFc)

Cat.No: TMPJ-00194

Species: Human

Expression System: HEK293 Cells

ISG15 Protein, Human, Recombinant (His)

Cat.No: TMPJ-00495

Species: Human

Expression System: E. coli

SOCS3 Protein, Human, Recombinant (His & Trx)

Cat.No: TMPY-02194

Species: Human

Expression System: E. coli

STAT5B Protein, Human, Recombinant (His)

Cat.No: TMPJ-01003

Species: Human

Expression System: E. coli

ANGPTL1 Protein, Canine, Recombinant (hFc)

Cat.No: TMPY-04084

Species: Canine

Expression System: HEK293 Cells

IFN gamma Protein, Goat, Recombinant (His & Myc)

Cat.No: TMPH-00775

Species: Goat

Expression System: E. coli

Cat. No.	Product Name	Target	Signaling Pathways
T14687	Deucravacitinib BMS-986165	Tyrosine Kinases; JAK; IFNAR; Interleukin	Angiogenesis; Chromatin/Epigenetic; Immunology/Inflammation; JAK/STAT signaling; Stem Cells; Tyrosine Kinase/Adaptors
	Deucravacitinib (BMS-986165) 是一种高选择性、口服生物可利用的变构 TYK2 抑制剂，用于治疗自身免疫性疾病。它通过稳定调节 JH2 结构域来阻断受体介导的 Tyk2 激活，可抑制IL-12/23和 I 型IFN 途径。它选择性结合 TYK2 假激酶 (JH2) 结构域，IC50为1.0 nM。
TMIJ-0267	Upadacitinib-15N-d2
	Upadacitinib-15N-d2 是 Upadacitinib 的 15N 和氘代化合物。Upadacitinib 的 CAS 号为 1310726-60-3。Upadacitinib 是高效选择性的，具有口服活性的JAK1抑制剂，IC50为43 nM，可用于多种自身免疫性疾病的研究。它对 JAK1 的选择性约为 JAK2 的 74 倍。

同位素标记化合物

Deucravacitinib

Cat.No: T14687

Synonym: BMS-986165

Target: Tyrosine Kinases, JAK, IFNAR, Interleukin

Upadacitinib-15N-d2

Cat.No: TMIJ-0267

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