Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T69975 |
Istaroxime oxalate
|
Others | Others |
Istaroxime, also known as PST-2744, is a positive inotropic agent that mediates its action through inhibition of sodium/potassium adenosine triphosphatase (Na+/K+ ATPase). Na+/K+ ATPase inhibition increases intracellular sodium levels, which reverses the driving force of the sodium/calcium exchanger, inhibiting calcium extrusion and possibly facilitating calcium entry. Additionally, Istaroxime increases intracellular calcium by improving the efficacy by which intracellular calcium triggers sarco... | |||
T15600 |
Istaroxime
PST2744 |
Others | Others |
Istaroxime is an effective inhibitor of Na+, K+-ATPase (IC50: 0.11 μM). | |||
T15599 |
Istaroxime hydrochloride
PST2744 hydrochloride |
Others | Others |
Istaroxime hydrochloride is an inhibitor of Na+/K+-ATPase (IC50: 0.11 μM). It also is a sarcoplasmic/endoplasmic reticulum calcium ATPase 2 (SERCA 2) activator. |