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Cat. No. | Product Name | ||
---|---|---|---|
L8700 | 铁死亡化合物库 | 779 compounds | |
779 种与铁死亡通路相关的化合物,可用于高通量和高内涵筛选; |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T9073 |
SRS16-86
|
Ferroptosis | Apoptosis |
SRS16-86 是一种铁死亡抑制剂,可研究肾缺血再灌注损伤和脊髓损伤。它在体内比 Ferrostatin-1 对代谢和血浆更稳定。 | |||
T22537 |
9-Phenanthrol
|
TRP/TRPV Channel | Membrane transporter/Ion channel |
9-Phenanthrol 是瞬时受体电位 melastatin 4 (TRPM) 通道的抑制剂,这是一种 Ca2+ 激活的非选择性阳离子通道。 | |||
T3102 |
NS-1619
|
Apoptosis; Potassium Channel | Apoptosis; Membrane transporter/Ion channel |
NS 1619 是 Ca2+激活的 K+(BK) 通道的激活剂,是一种高效的松弛剂,在血管和其他组织的几个平滑肌中的 EC50约为 10 – 30 μM。它抑制A2780卵巢癌细胞增殖并诱导细胞凋亡。 | |||
T9714 |
Atpenin A5
|
Potassium Channel | Membrane transporter/Ion channel |
Atpenin A5 是高度特异性的complex II 抑制剂,IC50为 ~10 nM。Dolastatin 10也是有效的mKATP 通道激动剂,具有心脏保活的作用。 | |||
T9232 |
Mitochondrial fusion promoter M1
|
Mitochondrial Metabolism | Metabolism |
Mitochondrial fusion promoter M1 是一种线粒体动态调节剂,能够保持线粒体功能并促进细胞呼吸,减轻心肌缺血/再灌注大鼠的心脏损伤和大脑损伤。 | |||
T24109 |
GSK329
GSK 329,GSK-329 |
Others | Others |
GSK329 是一种有效的选择性 TNNI3 相互作用激酶 (TNNI3K) 抑制剂。 GSK329 在缺血/再灌注心脏损伤模型中表现出积极的心脏保护作用。 | |||
T4612 |
NS309
|
EGFR; Potassium Channel; HER | Angiogenesis; JAK/STAT signaling; Membrane transporter/Ion channel; Tyrosine Kinase/Adaptors |
NS309 是选择性钙依赖性钾离子通道 SK/IK 的激活剂,在 BK 通道上没有激活作用。 | |||
T2058 |
Palosuran
ACT-058362 |
GPR | Endocrinology/Hormones; GPCR/G Protein |
Palosuran (ACT-058362) 是人类 UT 受体的新型强效特异性拮抗剂,对表达人重组受体的 CHO 细胞膜的IC50值为 3.6 nM。它可改善糖尿病大鼠的胰腺和肾脏功能。 | |||
T9765 |
TJ-M2010-5
|
MyD88 | Immunology/Inflammation |
TJ-M2010-5 是一种 MyD88 抑制剂,可与 TIR 结构域结合以干扰其同源二聚化并抑制 MyD88 信号传导。 TJ-M2010-5 可用于心肌缺血/再灌注损伤研究。 | |||
T1677 |
Montelukast
孟鲁司特,Singular |
Leukotriene Receptor; Lipoxygenase; LTR | GPCR/G Protein; Immunology/Inflammation; Metabolism |
Montelukast (Singular) 是可口服的半胱氨酸白三烯受体1 选择性拮抗剂,可用于研究预防哮喘和肝损伤。它还可减少心脏损伤,在肠缺血-再灌注损伤中也具有抗氧化作用。 | |||
T14186 |
17-ODYA
17-十八炔酸,Alkynyl Stearic Acid |
Others; PROTAC Linker | Others; PROTAC |
Alkynyl Stearic Acid 是 CYP450 ω-羟化酶抑制剂。它能够抑制与花生四烯酸孵育的大鼠肾皮质微粒体形成 20-HETE 、dihydroxyeicosatrienoic acids、epoxyeicosatrienoic acids。它可以改善异丙肾上腺素诱导的培养心肌细胞凋亡和坏死。 | |||
T1677L |
Montelukast sodium
MK0476,孟鲁司特钠 |
Leukotriene Receptor; LTR | GPCR/G Protein; Immunology/Inflammation |
Montelukast sodium (MK0476) 是可口服的半胱氨酸白三烯受体1 选择性拮抗剂,可用于研究预防哮喘和肝损伤。它还可减少心脏损伤,在肠缺血-再灌注损伤中也具有抗氧化作用。 | |||
T21334 |
Bucillamine
DE-019,Thiobutarit,Tiobutarit,布西拉明,SA96,DE 019,DE019 |
VEGFR; Antioxidant | Angiogenesis; oxidation-reduction; Tyrosine Kinase/Adaptors |
Bucillamine (DE019) 可防止高危器官移植中的缺血/再灌注损伤,抑制 VEGF 的产生。 Bucillamine 是一种具有抗风湿和抗血管生成特性的口服活性巯基供体和抗氧化剂。 Bucillamine 可用于脉络膜新生血管和类风湿性关节炎的研究。 | |||
T6986 |
Sivelestat
ONO5046,EI546,西维来司他,LY544349 |
Others; SARS-CoV; Serine Protease | Microbiology/Virology; Others; Proteases/Proteasome |
Sivelestat (ONO5046) 是一种选择性的中性粒细胞弹性蛋白酶抑制剂,其 IC50值为 44 nM,Ki 值为 200 nM。它有潜力研究 COVID-19 的急性肺损伤、急性呼吸窘迫综合征或弥散性血管内凝血。 | |||
T3230 |
NLRP3-IN-2
5-Chloro-N-(p-sulfamoylphenethyl)-o-anisamide,4-[2-(5-氯-2-甲氧基苯甲酰氨基)乙基]苯磺酰胺,NLRP3 Inflammasome Inhibitor I |
NOD-like Receptor (NLR); NOD | Immunology/Inflammation; NF-κB |
NLRP3-IN-2 (5-Chloro-N-(p-sulfamoylphenethyl)-o-anisamide) 是一种能够合成格列本脲的中间物,对心肌细胞中NLRP3炎症小体的形成具有抑制作用,在小鼠心肌缺血/再灌注后限制梗死面积,且对代谢无影响。 | |||
T15379 |
GGsTop
Nahlsgen |
Others | Others |
GGsTop is a non-toxic and irreversible inhibitor of γ glutamyl transpeptidase (GGT) (Ki: 170 μM for Human GGT). GGsTop protects hepatic ischemia-reperfusion injury in the rat model. GGsTop shows Kons of 150±10 and 51±3 /(M·s) against E.coli GGT and human GGT, respectively. | |||
T31795 |
FK-330
LS-192510,FR-260330,FK330,FK 330 |
NOS | Immunology/Inflammation |
FK-330(FR-260330) 是一种新型口服活性诱导型一氧化氮合酶抑制剂,具有潜在的抗癌和抗肿瘤活性,可预防大鼠肝移植缺血和再灌注损伤。 | |||
T3649 |
BGP-15
BGP15,BGP-15 2HCl |
PARP | Chromatin/Epigenetic; DNA Damage/DNA Repair |
BGP-15 (BGP-15 2HCl) 是一种PARP 抑制剂,IC50和Ki 值分别为 120 和 57 μM,在缺血再灌注损伤后具有保护作用。 | |||
T13603 |
CDDO-3P-Im
|
Necroptosis | Apoptosis |
CDDO-3P-Im 是一种具有口服活性的坏死性凋亡抑制剂,具有化学预防作用。 CDDO-3P-Im 可用于有关缺血/再灌注的研究。 | |||
T9180 |
LUF6096
CF-602 |
Adenosine Receptor | GPCR/G Protein; Neuroscience |
LUF6096 (CF-602) 是一种有效的腺苷 A3 受体 (adenosine A3 receptor) 变构增强剂。LUF6096 对任何腺苷受体显示出低正构亲和力。LUF6096 在心肌缺血/再灌注损伤中显示出保护作用。 | |||
T61933 |
MK-0159
|
CD38 | Immunology/Inflammation |
MK-0159 是一种可口服且具有高效性的 CD38 抑制剂,具有心肌损伤保护作,可用于研究心脏缺血和再灌注损伤。 | |||
T28978 |
Tirilazad mesylate
U-74006 mesylate,U74006 mesylate,U 74006 mesylate,U 74006F mesylate,U-74006F mesylate,U74006F mesylate |
Antiviral | Immunology/Inflammation |
Tirilazad mesylate (U 74006F) 是一种非糖皮质激素,是一种脂质过氧化抑制剂,具有抗病毒活性和神经保护活性。Tirilazad mesylate 能使细胞膜内病灶局限化,可减轻创伤、中风、缺血再灌注损伤引起的脊髓损伤,抑制狗体内毒素的作用,降低了内毒素诱导的肠系膜和肾脏 DO2 比容升高。Tirilazad mesylate 可用于研究神经系统疾病。 | |||
T32105 |
Cipepofol
HSK3486,HSK-3486,CS-0064163,HSK 3486 |
Apoptosis; GABA Receptor | Apoptosis; Membrane transporter/Ion channel; Neuroscience |
Cipepofol (HSK3486) 是一种 GABAA 受体激动剂,具有镇静作用,在多种心血管疾病中起保护作用。Cipepofol 可激活 Sirtuin1 (Sirt1)/Nrf2 通路,可诱导心肌细胞凋亡,可用于研究心肌梗塞、心肌缺血再灌注损伤和章鱼壶综合征。 | |||
T5483 |
DMX-5804
DMX-5084 |
MAPK | MAPK |
DMX-5804 是一种口服有活性的MAP4K4选择性抑制剂,其对人 MAP4K4 的IC50=3 nM,pIC50=8.55。对 MINK1/MAP4K6 (pIC50=8.18) 和 TNIK/MAP4K7 (pIC50=7.96) 的作用相对较弱。它可以提高心肌细胞存活率,降低小鼠的缺血再灌注损伤。 | |||
T34268 |
Raxofelast
IRFI016,IRFI-016,IRFI 016 |
Others | Others |
Raxofelast (IRFI-016) 具有治疗糖尿病并发症和动脉粥样硬化的潜力 | |||
T81034L |
TAT-NSF700 Fusion Peptide acetate
|
||
TAT-NSF700 Fusion Peptide acetate 是一种可渗透细胞膜的 N-乙基-马来酰亚胺敏感因子 (NSF) 抑制剂,是一种融合多肽,具有潜在的抗炎活性。TAT-NSF700 Fusion Peptide acetate 与细胞内细胞器相互作用,可用于研究心肌缺血和再灌注损伤。 | |||
T20563 |
PD-166793
PD-166793-0000,PD 166793,PD166793 |
MMP | Proteases/Proteasome |
PD-166793是一种具有口服活性、有效性和选择性的 MMP 抑制剂,对 MMP-2,MMP-3 和 MMP-13 具有抑制作用。PD-166793 在大鼠心力衰竭模型中改善心肌缺血和再灌注损伤。 | |||
T23356 |
Linsidomine hydrochloride
SIN-1 chloride |
Others | Others |
Linsidomine hydrochloride (SIN-1 chloride) 是莫西多明的代谢产物,具有舒张血管、抑制血小板聚集和抗心绞痛的活性。在心肌缺血-再灌注模型中,Linsidomine hydrochloride 减少心肌坏死和再灌注诱导的内皮功能障碍,与海绵体的作用机制涉及一氧化氮的释放有关。 | |||
T68879 |
FK-330 dihydrate
FR-260330 dihydrate |
NO Synthase | Immunology/Inflammation |
FK-330 dihydrate(FR-260330 dihydrate) 是一种新型口服活性诱导型一氧化氮合酶抑制剂,具有潜在的抗癌和抗肿瘤活性,可预防大鼠肝移植缺血和再灌注损伤。 | |||
T11879 |
LS-102
LS102 |
Ligand for E3 Ligase | PROTAC |
LS-102 是一种选择性的 E3 连接酶 synoviolin (Syvn1) 抑制剂,是 黄芪甲苷IV衍生物,通过抑制线粒体裂变来缓解心肌缺血再灌注损伤。LS-102 抑制 Syvn1 自泛素化,可改善阿霉咪唑诱导的心率减慢,有研究心血管疾病。 | |||
T37379 |
Protectin D1
Neuroprotectin D1,NPD1 |
Akt; PI3K | Cytoskeletal Signaling; PI3K/Akt/mTOR signaling |
Protectin D1 (Neuroprotectin D1) 是神经细胞产生的神经保护素 ,是一种潜在的心脏保护剂。Protectin D1 通过调节 PI3K/AKT 信号通路缓解心肌缺血/再灌注损伤,抑制咪喹莫特诱导的银屑病样皮肤炎症。 | |||
T38287 |
C3a Receptor Agonist
C3a receptor agonist 1,C3a受体激动剂,Complement 3a Receptor Agonist |
Complement System | Immunology/Inflammation |
C3a Receptor Agonist (C3a receptor agonist 1) 结合免疫系统补体途径中的G 蛋白偶联C3a 受体(C3aRs)。在肠缺血再灌注损伤模型中,C3aR 的激活可防止中性粒细胞动员。C3aRs 在成年小鼠的神经祖细胞和未成熟神经元上表达。C3a 在体外刺激神经祖细胞的分化。 | |||
T36569 |
KR-32568
|
Sodium Channel | Membrane transporter/Ion channel |
KR-32568是一种钠/氢交换器1(NHE-1)抑制剂(IC50:230 nM)。KR-32568具有强大的心脏保护作用。当使用浓度为10μM 时,它能在离体的缺血大鼠心脏模型中恢复心脏收缩功能。KR-32568(0.3mg/kg)在缺血和再灌注损伤的大鼠模型中减少了心肌梗死的大小。 | |||
T50098 |
TIQ-A
|
PARP | Chromatin/Epigenetic; DNA Damage/DNA Repair |
TIQ-A 是一种 PARP1 抑制剂,通过碱基切除修复途径参与 DNA 单链断裂修复。 PARP1 由 DNA 损伤触发,其过度激活已被认为是许多病理状况的致病因素,包括缺血和再灌注损伤、哮喘相关炎症和动脉粥样硬化形成。 | |||
T9948 |
NecroX-7
LC-280126,LC28-0126,LC28 0126 |
NADPH-oxidase | Immunology/Inflammation |
NecroX-7 (LC-280126) 是一种有效的自由基清除剂和 HMGB1(高迁移率族蛋白 1) 抑制剂。NecroX-7 可以作为对乙酰氨基酚毒性的解毒剂。NecroX-7 通过抑制缺血/再灌注损伤中 HMGB1 的释放发挥保护作用。NecroX-7 抑制 HMGB1 诱导的 TNF 和 IL-6的释放,以及TLR-4和晚期糖基化终产物受体的表达,用于移植物抗宿主病 (GVHD) 研究。 | |||
T21967 |
MEG hemisulfate
Mercaptoethylguanidine hemisulfate |
NOS | Immunology/Inflammation |
MEG hemisulfate (Mercaptoethylguanidine hemisulfate) 是一种有效和选择性的诱导型 NO 合酶 (iNOS) 的抑制剂,在组织匀浆中抑制 iNOS,ecNOS 和 bNOS 的 EC50 值分别为 11.5,110 和 60 μM。MEG hemisulfate 也有效的过氧亚硝酸盐清除剂,可抑制过氧亚硝酸盐诱导的氧化过程。MEG hemisulfate 在许多炎症实验模型中具有保护作用,包括缺血/再灌注损伤,牙周炎,失血性休克,炎性肠病以及内毒素和败血性休克。 | |||
T68878 |
L-2286
|
Others | Others |
L-2286 is a novel PARP inhibitor. L-2286 exerted significant protective effect against ischemia-reperfusion-induced myocardial injury in both experimental models. More importantly, L-2286 facilitated the ischemia-reperfusion-induced activation of Akt, extracellular signal-regulated kinase, and p38-MAPK in both isolated hearts and in vivo cardiac injury. | |||
T37697 |
D-GsMTx4
D-GsMTx4 |
||
TRPC1/6 and Piezo2 inhibitor. Exhibits same effect as L-enantiomer, GsMTx4 (Cat. No. 4912) on TRPC channels. Inhibits mechanosensitive currents by ~70%. Protects against myocardial infarction in mouse ischemia/reperfusion model. Resistant to proteolytic digestion. | |||
T33451 |
ML 7
ML7,ML-7 |
Others | Others |
ML 7 is an inhibitor of myosin light chain kinase that protects cardiac function from ischemia/reperfusion (I/R) injury. | |||
T38693 |
TRC160334
TRC160334 |
Others | Others |
TRC160334 is a hydroxylase inhibitor of hypoxia-inducible factor (HIF). It is employed in research about ischemia/reperfusion injury. | |||
T30512 |
BMS-284640
UNII-XP87V064PV,CHEMBL51879,XP87V064PV |
Others | Others |
BMS-284640 is a Na(+)/H(+) exchange agent (NHE) inhibitor that has provided substantial protection in various animal models of myocardial ischemia (MI) and reperfusion in preclinical studies. | |||
T36509 |
U-74389G
U-74389G,Methylated Tirilazad |
Others | Others |
U-74389G is an antioxidant which prevents iron-dependent lipid peroxidation. It protects against ischemia-reperfusion injury in animal heart, liver, and kidney models.[1],[2],[3],[4] | |||
T11327 |
FR 167653
FR 167653 sulfate |
p38 MAPK | MAPK |
FR 167653 (FR 167653 sulfate) is effective in treating inflammation, relieving trauma and ischemia-reperfusion injury in vivo. FR 167653 , an orally active and selective p38 MAPK inhibitor, is a potent suppressor of TNF-α and IL-1β production via specific inhibition of p38 MAPK activity. | |||
T78019 |
Nangibotide TFA
LR12 TFA |
||
Nangibotide TFA为TREM-1受体抑制剂,调控先天免疫反应。该化合物能降低啮齿动物心肌缺血再灌注模型的系统性及局部炎症。 | |||
T39795 |
Tricarbonyldichlororuthenium(II) dimer
CORM-2 |
Others | Others |
Tricarbonyldichlororuthenium(II) dimer, a pharmacological CO donor, prevents ischemia/reperfusion (I/R)-induced oxidative damage to the gastric mucosa by enhancing gastric blood flow (GBF) and reducing DNA oxidation and systemic inflammatory response. | |||
T39890 |
8-Bromo-AMP
8-Bromoadenosine 5'-monophosphate,8-Bromo-AMP,8-Bromoadenylicacid |
Others | Others |
8-Bromo-AMP, also known as 8-Bromoadenosine 5'-monophosphate, is a membrane permeable cAMP analogue. It enhances cardiac recovery from ischemia and reperfusion by elevating ATP, ADP, and total adenine nucleotide concentrations. | |||
T80965 |
Torapsel
42-89-glycoprotein,WAY164339,pMT21:PL85 |
||
Torapsel(42-89-glycoprotein; WAY164339)为一种免疫球蛋白融合蛋白,适用于缺血再灌注损伤预防研究。 | |||
T85138 |
2-Stearoyl-rac-glycerol
18:0-MG,2-Monostearin,MG(0:0/18:0/0:0) |
Others | Others |
2-Stearoyl-rac-glycerol, a monoacylglycerol with stearic acid at the sn-2 position, exhibits elevated levels in mouse plasma after low-dose ionizing radiation exposure and in rat kidney following ischemia-reperfusion injury models. | |||
TP1373 |
Ac2-26
|
||
Ac2-26 TFA is an active n-terminal peptide in annexin A1 (AnxA1), which can alleviate acute lung injury caused by ischemia-reperfusion. | |||
T11327L | FR 167653 free base | Others | Others |
FR 167653 free base is an orally active p38 MAPK inhibitor and is effective in treating inflammation, relieving trauma, and ischemia-reperfusion injury in vivo. It also is a potent suppressor of TNF-α and IL-1β production via specific inhibition of p38 MA |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T3672 |
Nomilin
|
MAPK | MAPK |
Nomilin 是一种柠檬苦素类化合物,从柑桔类提取物中获得,是抗肥胖症和降糖药。 | |||
TN1895 |
Luteolinidin chloride
|
CD38 | Immunology/Inflammation |
Luteolinidin chloride 是天然的脱氧花青素,分离自苔藓和蕨类植物中。它是一种有效的 CD38 抑制剂,可以保留 eNOS 功能并预防体内内皮功能障碍,同时可以保护心脏免受 I/R 损伤。 | |||
TN6490 |
Regaloside C
|
Others | Others |
Regaloside C 是一种从百合属的中分离出来的甘油葡糖苷,具有抗炎作用。 | |||
T3890 |
Verbenalin
Verbenalol β-D-glucopyranoside,马鞭草苷,Verbenaloside,Verbenalol glucoside,Cornin |
Others | Others |
Verbenalin (Verbenaloside) 是马鞭草苷,具有抗炎、抗真菌、抗病毒等活性。它能减轻脑缺血再灌注损伤。它可用于前列腺炎的研究。 | |||
T2163 |
Dihydrocapsaicin
CCRIS1589,二氢辣椒素,6,7-Dihydrocapsaicin,8-Methyl-N-vanillylnonanamide |
Others; TRP/TRPV Channel | Membrane transporter/Ion channel; Others |
Dihydrocapsaicin (CCRIS1589) 是一种天然来源的辣椒素,是TRPV1的选择性激动剂,同时可以增加 p-Akt 水平。它可以增强低温诱导的神经保护。 | |||
TN1984 |
Neoisoliquiritin
|
Others | Others |
Neoisoliquiritin 是一种提取自甘草中的活性物质。 | |||
T5217 |
2-(2-Phenylacetamido)acetic acid
Phenaceturic acid,Phenyl-ac-Gly-OH,苯乙酰甘氨酸,Phenylacetyl glycine |
Others; Endogenous Metabolite | Metabolism; Others |
Phenyl-ac-Gly-OH 是内源性代谢产物的一种,可激活 β2AR,可用于研究缺血/再灌注引起的心脏损伤。 | |||
TN4661 |
Nodosin
|
IL Receptor; Autophagy | Autophagy; Immunology/Inflammation |
Nodosin 是一种二萜化合物,从Isodon trichocarpusKudo 和I. JaponicusHARA 中提取得到。 | |||
T1208 |
Citicoline sodium
Citicoline sodium salt,CDP-choline,胞磷胆碱钠 |
Apoptosis; Others; Endogenous Metabolite | Apoptosis; Metabolism; Others |
Citicoline sodium (CDP-choline) 是一种合成细胞膜组分磷脂酰胆碱的中间体,有神经保护作用。 | |||
T4S2084 |
3'-Methoxypuerarin
3'-甲氧基葛根素,3’- Methoxy Puerarin |
Antioxidant | oxidation-reduction |
3'-Methoxypuerarin 是一种提取自葛根中的异黄酮,具有神经元保护作用。 | |||
T2S0500 |
Ilexsaponin A
毛冬青皂苷A,毛冬青皂苷甲,Ilexsaponin A1 |
Others | Others |
Ilexsaponin A (Ilexsaponin A1)1 是分离自冬凌草的根中,利用抗凋亡途径减轻缺血再灌注引起的心肌损伤。它能够减少心肌梗塞的大小,减少 LDH,AST 和 CK-MB 的血清水平,促进细胞活力并抑制缺氧/复氧心肌细胞的凋亡。 | |||
T5S2178 |
Fargesin
辛夷脂素,(+/-)-Fargesin |
Adrenergic Receptor | GPCR/G Protein; Neuroscience |
Fargesin ((+/-)-Fargesin) 是一种活性新木脂素,从木兰植物中分离得到,具有抗高血压和抗炎活性。 | |||
T3900 |
Emodin-8-glucoside
大黄素-8-β-D-吡喃葡萄糖苷,Emodin glucoside B,Anthraglycoside B |
Others | Others |
Emodin-8-glucoside (Anthraglycoside B) 是从芦荟中分离出的蒽醌衍生物,与 DNA 的小沟结合。它具有保护缺血和再灌注引起的局灶性脑损伤的作用。它直接刺激成骨细胞的细胞增殖和分化。 | |||
T3388 |
Calycosin-7-O-β-D-glucoside
毛蕊异黄酮苷,calycosin-7-O-beta-D-glucopyranoside,Calycosin-7-O-beta-D-glucoside |
MMP; Reactive Oxygen Species | Immunology/Inflammation; Metabolism; NF-κB; Proteases/Proteasome |
Calycosin-7-O-β-D-glucoside (calycosin-7-O-beta-D-glucopyranoside) 是一种异黄酮,从黄芪中分离得到。它具有多种生物活性,包括心脏保护、神经保护、抗炎和抗氧化作用。 | |||
T4518 |
Licochalcone D
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ERK; NF-κB | MAPK; NF-κB |
Licochalcone D 是一种 NF-κB p65的有效抑制剂,是一种存在于 Glycyrrhiza inflate 中的黄酮类化合物,具有抗氧化、抗炎、抗癌等作用。 | |||
T3893 |
Forsythoside B
连翘酯苷 B,连翘脂苷B |
TNF; NF-κB | Apoptosis; NF-κB |
Forsythoside B 是传统中药植物独一味叶子中分离的一种苯乙醇苷。它可抑制 TNF-alpha,IL-6,IκB, 调节 NF-κB。它抑制炎症反应,具有抗氧化和神经保护作用。 | |||
T3779 |
Crocin II
Crocin 2,西红花苷II,Crocetin gentiobiosylglucosyl ester,藏红花,Tricrocin,Crocin B |
Caspase; COX; NO Synthase | Apoptosis; Immunology/Inflammation; Neuroscience; Proteases/Proteasome |
Crocin II (Crocetin gentiobiosylglucosyl ester) 是从栀子果实中分离出来的一种天然产物,具有抗氧化、抗癌和抗抑郁活性。它抑制 iNOS 和 COX-2的蛋白质和 m-RNA 的表达,还抑制NO 产生,IC50值为 31.1 μM。 | |||
TN1618 | Erigeroside | Others | Others |
Erigeroside has the protective effects on cerebral ischemia-reperfusion injury in rat, its ability of anti-oxidation and scavenging oxidation free radical may be one of its protective mechanisms. | |||
TN1431 |
Baohuoside VII
宝藿苷,宝藿苷VII |
Others | Others |
Baohuoside aglycone possesses cardioprotective effect in prevention of ischemia/ reperfusion injury and reduce the myocardial infraction, the mechnism is due to the reduction of the injury of free radicals. Baohuoside VII in vivo exhibits significant anti | |||
TN3914 |
Echinatine
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ATPase; IL Receptor; TNF | Apoptosis; Immunology/Inflammation; Membrane transporter/Ion channel |
Echinatin exerts a protective effect against ischemia/reperfusion (I/R)-induced myocardial injury on hearts, this effect may be attributed to the antioxidant and anti-inflammatory activities of this compound. Echinatin can inhibit DNP-ATPase activity whil | |||
T36448 |
(E)-Ajoene
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Others | Others |
(E)-Ajoene is a disulfide that has been found inA. sativumand has diverse biological activities.1,2,3,4It is active against Gram-positive and Gram-negative bacteria (MICs = 10-250 and 150->500 μg/ml, respectively) and fungi (MICs = 15-50 μg/ml).1(E)-Ajoene inhibits proliferation of a variety of cancer cells, including MDA-MB-231 breast, HeLa cervical, and WHCO1 esophageal cancer cells (IC50s = 18.6, 61, and 39.2 μM, respectively).2It also inhibits human glutathione reductase andT. cruzitrypanoth... |
Cat. No. | Product Name | Species | Expression System |
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TMPY-04424 |
MST3 Protein, Human, Recombinant (His)
HEL-S-95,STE20,MST3B,RP11-111L24.5,MST3,STK3,serine/threonin... |
Human | Baculovirus Insect Cells |
Aberrant STK24 expression was an independent prognostic indicator in lung adenocarcinoma patients. Its dysregulation was associated with its DNA copy number alteration and methylation. STK24/CCM3-regulated exocytosis plays an important role in the protection of kidneys from ischemia-reperfusion injury. | |||
TMPJ-00082 |
NGAL/Lipocalin-2 Protein, Mouse, Recombinant (hFc)
Lipocalin-2,SV-40-induced 24P3 protein,Siderocalin LCN2,LCN2... |
Mouse | HEK293 Cells |
Lipocalin-2, also known as Neutrophil Gelatinase-Associated Lipocalin (NGAL), is a secretory protein of the lipocalin superfamily. Lipocalin-2 contains a signal peptide that enables it to be secreted and form complexes with matrix metalloproteinase-9 (MMP-9) through disulfide bonds. Similar to other lipocalin family members, Lipocalin-2 is involved in diverse cellular processes, including the transport of small hydrophobic molecules, protection of MMP-9 from proteolytic degradation, and cell sig... |
Cat. No. | Product Name | Target | Signaling Pathways |
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T71402 |
Nicorandil-d4
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Nicorandil-d4 is intended for use as an internal standard for the quantification of nicorandil by GC- or LC-MS. Nicorandil is an activator of sulfonylurea receptor 2B (SUR2B) linked to ATP-sensitive potassium channel Kir6.2 (EC50 = ~10 µM) and a nitric oxide (NO) donor. It is selective for SUR2B/Kir6.2 over the SUR2A/Kir6.2 channel (EC50 = >500 µM). Nicorandil activates soluble guanylate cyclase in a cell-free assay and relaxes partially depolarized isolated bovine coronary artery strips (EC50 =... |