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Targets Recommended: Apoptosis Histone Demethylase

抑制剂 & 化合物

天然产物

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T70008	Bomedemstat ditosylate MK-3543 ditosylate,IMG-7289 ditosylate	Apoptosis; Histone Demethylase	Apoptosis; Chromatin/Epigenetic
	Bomedemstat ditosylate (IMG-7289 ditosylate) 是一种具有口服活性的 lysine-specific demethylase 1 (LSD1) 抑制剂，具有抗肿瘤活性，增强 SCLC 同基因模型中对 PD-1 抑制的反应，抑制癌细胞增殖，诱导细胞凋亡。Bomedemstat ditosylate 可用于研究骨髓增生性肿瘤和骨髓纤维化。
T70007	CT-179	Others	Others
	CT-179 is a highly potent and selective small molecule inhibitor of Olig2 with excellent drug-like properties.
T12717	Basimglurant CTEP Derivative,RG7090	GluR	Neuroscience
	Basimglurant (CTEP Derivative) 是一种高效，选择性，可口服的 mGlu5负变构调节剂，Kd 值为1.1 nM。
T76811	Imgatuzumab
	Imgatuzumab (RG 7160) 是一种针对EGFR 的人源化单克隆抗体。Imgatuzumab 是一种免疫调节剂。Imgatuzumab 可用于癌症研究。
T63935	Bomedemstat hydrochloride	Others	Others
	Bomedemstat (IMG-7289) hydrochloride 是一种口服具有活力的、不可逆的 lysine-specific demethylase 1(LSD1) 抑制剂。Bomedemstat hydrochloride 能够增加 H3K4 和 H3K9 的甲基化，并改变基因表达。Bomedemstat hydrochloride 能够抑制癌细胞增殖并诱导细胞凋亡，表现出抗癌效果。
T9634	Bomedemstat	Others	Others
	Bomedemstat (IMG-7289) 是一种有效的，具有口服活性的且不可逆的赖氨酸特异性脱甲基酶 1 (LSD1) 抑制剂，具有表观遗传活性。Bomedemstat 具有抗癌活性，可用于急性髓性白血病 (AML) 和骨髓纤维化 (MF) 的研究。

化合物

Bomedemstat ditosylate

Cat.No: T70008

Synonym: MK-3543 ditosylate,IMG-7289 ditosylate

Target: Apoptosis, Histone Demethylase

Synonym: CTEP Derivative,RG7090

Bomedemstat hydrochloride

Cat. No.	Product Name	Target	Signaling Pathways
TN4337	Isotschimgin	Others	Others
	Isotschimgin 是一种天然产物，可用于生命科学领域的相关研究。其产品编号为 TN4337，CAS号为 62356-47-2。

天然产物

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPK-00513	LRIG1 Protein, Cynomolgus, Recombinant (His) Img,LIG1,LIG-1,LRIG1,D6Bwg0781e	Cynomolgus	HEK293 Cells
	LRIG1 Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells with C-His tag. The predicted molecular weight is 84.16 kDa and the accession number is A0A2K5V8J9.
TMPK-01143	LRIG1 Protein, Human, Recombinant (His) LIG1,Img,LRIG1,LIG-1,D6Bwg0781e	Human	HEK293 Cells
	LRIG1 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with C-His tag. The predicted molecular weight is 83 kDa and the accession number is Q96JA1-1.
TMPY-02264	LRIG1 Protein, Mouse, Recombinant (His) LIG-1,D6Bwg0781e,leucine-rich repeats and immunoglobulin-lik...	Mouse	HEK293 Cells
	Leucine-rich repeats and immunoglobulin-like domains 1 (LRIG1) is a tumor suppressor and a negative regulator of several receptor tyrosine kinases. Leucine-rich repeats and immunoglobulin-like domains containing protein 1 (LRIG1) is an endogenous feedback regulator of receptor tyrosine kinases (RTKs) and was recently shown to inhibit the growth of different types of malignancies. Leucine-rich repeats and immunoglobulin-like domains 1(LRIG1)is a kind of transmembrane glycoprotein, which is induce...