Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T67749 |
Fuzapladib
IS-741 |
Phospholipase | Metabolism |
Fuzapladib (IS-741) (IS-741)是一种磷脂酶A2抑制剂,可以抑制细胞粘附分子Mac-1的表达。fuzpladib 阻断炎症细胞表面表达的粘附分子(integrin)的激活,阻止炎症细胞粘附血管内皮细胞和浸润组织,控制胰腺炎的恶化。 | |||
T69386 |
IS-741 sodium monohydrate
|
Others | Others |
IS-741 sodium monohydrate is a phospholipase A2 inhibitor. | |||
T70742 |
IS-741 calcium
|
Others | Others |
IS-741 calcium is a phospholipase A2 inhibitor. | |||
T70743 |
IS-741 potassium
|
Others | Others |
IS-741 potassium is a phospholipase A2 inhibitor. | |||
T70741 |
AZ-TAK1
|
Others | Others |
AZ-Tak1 is a potent and a relatively selective inhibitor of TAK1 kinase activity, with an IC50 of 0.009 mM. AZ-Tak1 treatment decreased the level of p38 and ERK in mantle cell lymphoma cells, and induced apoptosis in a dose and time dependent manner, with an IC50 of 0.1–0.5 mM. Using the annexin-V and PI staining and FACS analysis, After 48 hours of incubation, AZ-Tak1 (0.1 mM) induced apoptosis in 28%, 34% and 86% of Mino, SP53, and Jeko cells, respectively, which was increased to 32%, 42%, and... | |||
T70740 |
Nnc 09-0026
|
Others | Others |
Nnc 09-0026 is a neuronal calcium channel blocker | |||
T70211 |
CAM741
|
||
CAM741 is a novel selective inhibitor of vascular cell adhesion molecule 1 (VCAM1) synthesis in endothelial cells, blocking the process of cotranslational translocation, which is dependent on the signal peptide of VCAM1. | |||
T75994 |
SPR741 TFA
|
||
SPR741 TFA (NAB741 TFA),一种源自多粘菌素B的阳离子肽增效剂,通过提升革兰氏阴性细菌外膜通透性用于对抗重度革兰氏阴性细菌感染。它能够抑制多重耐药性革兰氏阴性细菌,并在与抗生素联用时扩大抗生素的活性谱。 | |||
T35547 |
YW1128
|
Others | Others |
YW1128 is an inhibitor of Wnt/β-catenin signaling with an IC50 value of 4.1 nM in a reporter assay.1 It decreases protein levels of β-catenin in the presence of the GSK3β inhibitor lithium chloride and increases protein levels of Axin1 in HEK293 cells. YW1128 decreases lipid accumulation and the expression of gluconeogenic and lipogenic genes in Huh7 cells. It decreases the hepatic expression of Wnt target genes, improves glucose tolerance, and prevents body weight increases and hepatic lipid ac... | |||
T35406 |
α-MSH TFA
|
||
α-Melanocyte-stimulating hormone (α-MSH) is a 13-amino acid peptide hormone produced by post-translational processing of proopiomelanocortin (POMC) in the pituitary gland, as well as in keratinocytes, astrocytes, monocytes, and gastrointestinal cells.1It is an agonist of melanocortin receptor 3 (MC3R) and MC4R that induces cAMP production in Hepa cells expressing the human receptors (EC50s = 0.16 and 56 nM, respectively).2α-MSH (100 pM) reducesS. aureuscolony formation andC. albicansgerm tube fo... |