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Search Results for " irak1 "

Targets Recommended: IRAK

10

抑制剂 & 化合物

1

天然产物

5

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T9203	JH-X-119-01	IRAK	Immunology/Inflammation; NF-κB
	JH-X-119-01 是白介素 1 受体相关激酶 1 的选择性抑制剂。它能够改善 LPS 诱导的小鼠败血症。它可以抑制 IRAK1(IC50:9 nM)，在浓度达到 10 μM 时，也不会对 IRAK4 产生抑制作用。
T14367	AZ1495	IRAK; CDK; Haspin Kinase	Cell Cycle/Checkpoint; Immunology/Inflammation; NF-κB
	AZ1495 是一种口服有活性的白介素-1受体相关激酶 4(IRAK4)抑制剂，能够作用于 IRAK4 (IC50:5 nM)和 IRAK1 (IC50:23 nM)。可用于研究突变型 MYD88L265P 弥漫性 B 细胞淋巴瘤 (DLBCL) 。
T2457	IRAK-1-4 Inhibitor I IRAK-1/4 Inhibitor I,IRAK-1/4 Inhibitor	IRAK	Immunology/Inflammation; NF-κB
	IRAK-1-4 Inhibitor I 是一种IRAK1/4双重抑制剂，其IC50分别为 0.2 μM 和 0.3 μM。
T62209	HS-276	MAPK	MAPK
	HS-276 是一种高度选择性的、口服具有活力的 TAK1 抑制剂 (Ki: 2.5 nM)。HS-276 能够显著抑制 TAK1 (IC50: 8.25 nM)、CLK2 (IC50: 29 nM)、GCK (IC50: 22 nM)、ULK2 (IC50: 63 nM)、MAP4K5 (IC50: 125 nM)、IRAK1 (IC50: 264 nM)、NUAK (IC50: 270 nM)、CSNK1G2 (IC50: 810 nM)、CAMKKβ-1 (IC50: 1280 nM) 和 MLK1 (IC50: 5585 nM)。HS-276 能够用于研究类风湿关节炎 (RA)。
T9631	IRAK-4 protein kinase inhibitor 2	IRAK	Immunology/Inflammation; NF-κB
	IRAK-4 protein kinase inhibitor 2 是有效的白介素 1 受体相关激酶 4 抑制剂，IC50为 4 μM。它在与炎症和免疫相关的疾病领域有研究价值。
T78054	JNJ-1013	Apoptosis	Apoptosis
	JNJ-1013是一种选择性IRAK1降解剂，其对IRAK1、IRAK4、VHLFP的IC50值分别为72、443、1071nM。该化合物能诱导细胞凋亡(Apoptosis)并增加cleavagedPARP表达，同时降低IRAK1、p-IKBα、pSTAT3(Tyr705)的水平。
T71548	JH-I-25	Others	Others
	JH-I-25 is an IRAK1 kinase inhibitor.
T40225	JH-X-119-01 hydrochloride	Others	Others
	JH-X-119-01 hydrochloride is a potent and selective inhibitor of interleukin-1 receptor-associated kinases 1 (IRAK1). It effectively alleviates lipopolysaccharide (LPS)-induced sepsis in mice.
T22376	NCGC1481	Others	Others
	NCGC1481 is a potent inhibitor of FLT3 and IRAK1/4 with improved stability, solubility, and permeability properties.
T75113	GLPG2534 GLPG-2534	IRAK	Immunology/Inflammation; NF-κB
	GLPG2534 是一种具有口服活性、选择性和有效性的 IRAK4 抑制剂，具有抗炎活性。GLPG2534 对人和小鼠 IRAK4 具有抑制作用，可用于研究银屑病和特应性皮炎。

化合物

Cat.No: T9203

Target: IRAK

Cat.No: T14367

Target: IRAK, CDK, Haspin Kinase

IRAK-1-4 Inhibitor I

Cat.No: T2457

Synonym: IRAK-1/4 Inhibitor I,IRAK-1/4 Inhibitor

Target: IRAK

Cat.No: T62209

Target: MAPK

IRAK-4 protein kinase inhibitor 2

Cat.No: T9631

Target: IRAK

Cat.No: T78054

Target: Apoptosis

Cat.No: T71548

Target: Others

JH-X-119-01 hydrochloride

Cat.No: T40225

Target: Others

Cat.No: T22376

Target: Others

Cat.No: T75113

Synonym: GLPG-2534

Target: IRAK

Cat. No.	Product Name	Target	Signaling Pathways
TN1134	Euscaphic acid	Apoptosis; LDL; PI3K; DNA/RNA Synthesis; NO Synthase; Prostaglandin Receptor	Apoptosis; Cell Cycle/Checkpoint; DNA Damage/DNA Repair; GPCR/G Protein; Immunology/Inflammation; Metabolism; PI3K/Akt/mTOR signaling
	Euscaphic acid 是来源于枣的一种三萜，是DNA 聚合酶抑制剂，可诱导细胞凋亡。它抑制小牛 DNA 聚合酶 α 和大鼠 DNA 聚合酶 β 的IC50值分别为 61 和 108 μM。

天然产物

Cat.No: TN1134

Target: Apoptosis, LDL, PI3K, DNA/RNA Synthesis, NO Synthase, Prostaglandin Receptor

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-04483	IRAK4 Protein, Human, Recombinant (His) IPD1,NY-REN-64,REN64,interleukin-1 recepto...	Human	Baculovirus Insect Cells
	Interleukin-1 receptor-associated kinase 4, also known as Renal carcinoma antigen NY-REN-64, IRAK-4, and IRAK4, is a member of the protein kinase superfamily, TKL Ser/Thr protein kinase family, and Pelle subfamily. IRAK4 contains one death domain and one protein kinase domain. IRAK4 is required for the efficient recruitment of IRAK1 to the IL-1 receptor complex following IL-1 engagement, triggering intracellular signaling cascades leading to transcriptional up-regulation and mRNA stabilization. ...
TMPH-02738	IRAK3 Protein, Mouse, Recombinant (His & Myc) Irak3,Inactive IL-1 receptor-associated ki...	Mouse	Baculovirus Insect Cells
	Putative inactive protein kinase which regulates signaling downstream of immune receptors including IL1R and Toll-like receptors. Inhibits dissociation of IRAK1 and IRAK4 from the Toll-like receptor signaling complex by either inhibiting the phosphorylation of IRAK1 and IRAK4 or stabilizing the receptor complex. Upon IL33-induced lung inflammation, positively regulates expression of IL6, CSF3, CXCL2 and CCL5 mRNAs in dendritic cells. IRAK3 Protein, Mouse, Recombinant (His & Myc) is expressed in ...
TMPH-01265	PELI3 Protein, Human, Recombinant (His) PELI3,E3 ubiquitin-protein ligase pellino homolog 3	Human	E. coli
	E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. Involved in the TLR and IL-1 signaling pathways via interaction with the complex containing IRAK kinases and TRAF6. Mediates 'Lys-63'-linked polyubiquitination of IRAK1. Can activate AP1/JUN and ELK1. Not required for NF-kappa-B activation. PELI3 Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 54.8 kDa and the access...
TMPH-02212	TLR8 Protein, Human, Recombinant (His) TLR8,Toll-like receptor 8	Human	P. pastoris (Yeast)
	Endosomal receptor that plays a key role in innate and adaptive immunity. Controls host immune response against pathogens through recognition of RNA degradation products specific to microorganisms that are initially processed by RNASET2. Recognizes GU-rich single-stranded RNA (GU-rich RNA) derived from SARS-CoV-2, SARS-CoV-1 and HIV-1 viruses. Upon binding to agonists, undergoes dimerization that brings TIR domains from the two molecules into direct contact, leading to the recruitment of TIR-con...
TMPH-02211	TLR7 Protein, Human, Recombinant (His & Myc) TLR7,Toll-like receptor 7	Human	E. coli
	Endosomal receptor that plays a key role in innate and adaptive immunity. Controls host immune response against pathogens through recognition of uridine-containing single strand RNAs (ssRNAs) of viral origin or guanosine analogs. Upon binding to agonists, undergoes dimerization that brings TIR domains from the two molecules into direct contact, leading to the recruitment of TIR-containing downstream adapter MYD88 through homotypic interaction. In turn, the Myddosome signaling complex is formed i...

重组蛋白

IRAK4 Protein, Human, Recombinant (His)

Cat.No: TMPY-04483

Species: Human

Expression System: Baculovirus Insect Cells

IRAK3 Protein, Mouse, Recombinant (His & Myc)

Cat.No: TMPH-02738

Species: Mouse

Expression System: Baculovirus Insect Cells

PELI3 Protein, Human, Recombinant (His)

Cat.No: TMPH-01265

Species: Human

Expression System: E. coli

TLR8 Protein, Human, Recombinant (His)

Cat.No: TMPH-02212

Species: Human

Expression System: P. pastoris (Yeast)

TLR7 Protein, Human, Recombinant (His & Myc)

Cat.No: TMPH-02211

Species: Human

Expression System: E. coli

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