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Search Results for " ipf "

Targets Recommended: Others

31

抑制剂 & 化合物

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天然产物

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重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T36605	(±)5-iPF2α-VI (±)5-iPF2α-VI	Others	Others
	Isoprostanes are prostaglandin (PG)-like products of free-radical induced lipid peroxidation. Although the isoprostanes derived from arachidonic acid are the best characterized, many other polyunsaturated fatty acids can form isoprostanes. (±)5-iPF2α-VI is one of dozens of possible stereo- and regioisomeric isoprostanes which can be formed from arachidonic acid. To date, the most extensively studied of these is 8-isoprostane (8-epi-PGF2α, iPF2α-III). However, 8-isoprostane is a minor isoprostane...
T9592	OATD-01	Others	Others
	OATD-01 是一种壳三糖苷酶及酸性哺乳动物几丁质酶的高活性抑制剂，对CHIT1具有低纳摩尔活性 (hCHIT1,IC50=23 nM)。它在多个物种中显示出良好的药代动力学特征，在体内具有显著的抗纤维化活性，可用于研究肺纤维化。
T9688	CC-90001	JNK	MAPK
	CC-90001 是口服有效的 c-Jun N 末端激酶选择性抑制剂。在基于细胞的模型中，CC-90001显示出对JNK1的选择性是JNK2的 12.9 倍。CC-90001在特发性肺纤维化方面有研究价值。
T4016	BMS-986020 AM152,BMS986020	LPA Receptor; LPL Receptor	GPCR/G Protein
	BMS-986020 (AM152) 是一种高亲和力溶血磷脂酸受体 1 拮抗剂，有用于特发性肺纤维化的研究潜力。它抑制胆汁酸和磷脂转运蛋白，抑制 BSEP、MRP4 和 MDR3，IC50值分别为 4.8、6.2 和 7.5 μM。
T84398	8,12-iso-iPF2α-VI 12-iso-5,6E,14Z-PGF2α,12-iso-5,6E,14Z-Prostaglandin F2α,8,12-iso-Isoprostane-F2α-VI	Others	Others
	8,12-iso-iPF2α-VI, an isoprostane, arises from non-enzymatic, free radical-induced peroxidation of membrane lipids. It is the predominant isoprostane formed during lipid peroxidation and serves as a biomarker for oxidative stress. Detectable in hepatic tissue post CCl4-induced oxidative damage, 8,12-iso-iPF2α-VI levels are also elevated in the urine, blood, and cerebrospinal fluid of Alzheimer’s disease patients.
TMAZ-0269P	Anti-LIPF Monoclonal Antibody-PE

T19378	Ipfencarbazone	Akt	Cytoskeletal Signaling; PI3K/Akt/mTOR signaling
	Ipfencarbazone herbicide agent, is a substance being developed for the control of weeds such as watergrass in rice.
TMAZ-0269A4	Anti-LIPF Monoclonal Antibody-AF488

TMAZ-0269A6	Anti-LIPF Monoclonal Antibody-AF647

T68426	Dipfluzine	Others	Others
	Dipfluzine is a diphenylpiperazine calcium channel blocker with poor solubility.
T84732	Ipflufenoquin	Others	Others
	Ipflufenoquin，一种杀虫剂，可有效控制苹果黑星病的原发感染，建议施用时间为半寸绿至坐果期。
TMAZ-0269B	Anti-LIPF Monoclonal Antibody-Biotin

TMAZ-0269A	Anti-LIPF Monoclonal Antibody-APC

TMAZ-0269A5	Anti-LIPF Monoclonal Antibody-AF555

T75004	TGFβ1-IN-2	Others	Others
	TGFβ1-IN-2，一种二芳基酰基腙衍生物，有效抑制成纤维细胞活化与增殖，常用于特发性肺纤维化(IPF)研究。
T76804	Pamrevlumab FG-3019	Apoptosis	Apoptosis
	Pamrevlumab (FG-3019) 是一种对缔组织生长因子（CTGF）有亲和力的人源抗体，参与抗结缔组织生长因子疗法，可用于治疗特发性肺纤维化 (IPF) 。
T75005	TGFβ1-IN-3	Others	Others
	TGFβ1-IN-3 是一种二芳基酰基腙衍生物，对成纤维细胞的活化和增殖有抑制作用。TGFβ1-IN-3 是治疗特发性肺纤维化 (IPF) 的候选化合物。
T39933	Bexotegrast PLN-74809	Integrin	Cytoskeletal Signaling
	Bexotegrast (PLN-74809)是一种具有口服活性和强效性的 αvβ6和αvβ1 整合素抑制剂，具有抗纤维化作用，抑制 αvβ6 和 αvβ1 诱导的 TGF-β 激活，可用于研究特发性肺纤维化（IPF）和非特异性间质性肺炎（NSIP）。
T76856	Andecaliximab GS-5745	MMP; Virus Protease	Microbiology/Virology; Proteases/Proteasome
	Andecaliximab 是一种靶向基质金属蛋白酶 9 (MMP9) 的重组 IgG4 单克隆抗体。Andecaliximab 在特发性肺纤维化小鼠模型中显示出抗纤维化作用。Andecaliximab 可用于研究胃腺癌和特发性肺纤维化 (IPF) 以及登革热病毒。
T73035	STAT3-IN-15	Others	Others
	STAT3-IN-15是一款有效、具口服活性的STAT3抑制剂，用于对抗特发性肺纤维化（IPF）。该化合物阻止STAT3磷酸化，同时抑制TGF-β1引起的上皮细胞迁移及变形，并防止上皮间质转化（EMT）。
T11935	Macitentan (n-butyl analogue)	Others	Others
	Macitentan n-butyl analogue, a derivative of Macitentan, functions as an orally active dual antagonist targeting both endothelin ETA and ETB receptors. This compound shows promise for treating idiopathic pulmonary fibrosis (IPF) and pulmonary arterial hypertension (PAH), leveraging its non-peptide structure for potential therapeutic applications.
T72380	PI3K/mTOR Inhibitor-13	Others	Others
	PI3K/mTOR Inhibitor-13 是一种具有口服活性的磷酸肌醇 3-激酶 (PI3K) 和mTOR 激酶双重抑制剂。PI3K/mTOR Inhibitor-13 在性疾病、实体瘤和特发性肺纤维化 (IPF) 中有潜在应用。
T74402	FAP-PI3KI1	Others	Others
	FAP-PI3KI1 是一种成纤维细胞活化蛋白 (FAP) 靶向 PI3K 抑制剂，可选择性靶向表达 FAP 的人特发性肺纤维化 (IPF)细胞并有效抑制胶原蛋白合成，减少胶原蛋白沉积。
T64008	Thi-DPPY	Others	Others
	Thi-DPPY 是一种有效的、口服具有活力的 JAK3 抑制剂，能够作用于 BTK (IC50: 62.4 nM)、JAK (IC50: 1.38 nM)。Thi-DPPY 能够抗 HBE 细胞的增殖。Thi-DPPY 在体内具有抗炎作用。Thi-DPPY 对特发性肺纤维化（IPF）表现出研究潜力。
T63439	BMS-986020 sodium	Others	Others
	BMS-986020 sodium 是高亲和力的溶血磷脂酸受体 1 (LPA1) 拮抗剂，能够抑制胆汁酸和磷脂转运蛋白，并抑制 BSEP (IC50: 4.8 μM)，MRP4 (IC50: 6.2 μM) 和 MDR3 (IC50: 7.5 μM)。BMS-986020 sodium 表现出特发性肺纤维化 (IPF) 的研究潜力。
T77031	Ifabotuzumab
	Ifabotuzumab (KB004) 是靶向 EphA3的 IgG1κ 抗体 (KD=610 pM)。Ifabotuzumab 能够导致肿瘤细胞凋亡，并激活抗体依赖性细胞介导的细胞毒作用 (ADCC)，破坏肿瘤脉管系统。Ifabotuzumab 能够减少人特发性肺纤维化 (IPF) CCR10+细胞，改善肺纤维化。
T63486	DPPY	Others	Others
	DPPY 是 PTK 的有效抑制剂，能够作用于 EGFR (IC50<10 nM)、BTK (IC50<10 nM)、JAK3 (IC50<10 nM)。DPPY 能够抑制 B 细胞淋巴瘤细胞的增殖，对特发性肺纤维化（IPF）具有研究潜力。
T74632	TP0556351	MMP	Proteases/Proteasome
	TP0556351是一种高效且选择性地抑制基质金属蛋白酶2 (MMP2) 的化合物，其IC50值为0.2 nM。在Bleomycin诱导的肺纤维化小鼠模型中，该化合物能显著减少肺部胶原蛋白的含量，适用于特发性肺纤维化(IPF)的研究。
T69517	Bexotegrast HCl	Others	Others
	Bexotegrast, also known as PLN-74809, is a small-molecule, dual selective inhibitor of αVβ1 / αVβ6 for idiopathic pulmonary fibrosis (IPF) and primary sclerosing cholangitis (PSC). These integrins cause upstream activation of TGF-β1 in actively fibrotic tissue. Inhibition of these integrins will block TGF-β1 activation, thereby preventing the growth of fibrotic tissue within the lung and bile ducts.
T63776	PDE1-IN-4	Others	Others
	PDE1-IN-4 是有效的、选择性的 PDE1 (磷酸二酯酶 -1) 抑制剂，能够作用于 PDE1C (IC50: 10 nM)、PDE1A (IC50: 145 nM) 和 PDE1B (IC50: 354 nM)。PDE1-IN-4 能够调控 cAMP (3′,5′- 环磷酸腺苷) 和 cGMP (3′,5′- 环磷酸鸟苷)，表现出抗纤维化效果。PDE1-IN-4 能够抑制 TGF-β1 诱导的人肺成纤维细胞分化。PDE1-IN-4 能够用于研究特发性肺纤维化 (IPF)。
T63584	ATX inhibitor 12	Others	Others
	ATX inhibitor 12 是口服具有活力的 ATX 抑制剂 (IC50: 1.72 nM)。在 C57Bl/6J 小鼠中，口服剂量为 60 mg/kg 的 ATX inhibitor 12 时，能够有效抑制肺结构损伤，降低纤维化病变。ATX inhibitor 12 能够用于研究特发性肺纤维化 (IPF) 。

化合物

(±)5-iPF2α-VI

Cat.No: T36605

Synonym: (±)5-iPF2α-VI

Target: Others

Cat.No: T9592

Target: Others

Cat.No: T9688

Target: JNK

Cat.No: T4016

Synonym: AM152,BMS986020

Target: LPA Receptor, LPL Receptor

8,12-iso-iPF2α-VI

Cat.No: T84398

Synonym: 12-iso-5,6E,14Z-PGF2α,12-iso-5,6E,14Z-Prostaglandin F2α,8,12-iso-Isoprostane-F2α-VI

Target: Others

Anti-LIPF Monoclonal Antibody-PE

Cat.No: TMAZ-0269P

Ipfencarbazone

Cat.No: T19378

Target: Akt

Anti-LIPF Monoclonal Antibody-AF488

Cat.No: TMAZ-0269A4

Anti-LIPF Monoclonal Antibody-AF647

Cat.No: TMAZ-0269A6

Cat.No: T68426

Target: Others

Ipflufenoquin

Cat.No: T84732

Target: Others

Anti-LIPF Monoclonal Antibody-Biotin

Cat.No: TMAZ-0269B

Anti-LIPF Monoclonal Antibody-APC

Cat.No: TMAZ-0269A

Anti-LIPF Monoclonal Antibody-AF555

Cat.No: TMAZ-0269A5

Cat.No: T75004

Target: Others

Cat.No: T76804

Synonym: FG-3019

Target: Apoptosis

Cat.No: T75005

Target: Others

Cat.No: T39933

Synonym: PLN-74809

Target: Integrin

Cat.No: T76856

Synonym: GS-5745

Target: MMP, Virus Protease

Cat.No: T73035

Target: Others

Macitentan (n-butyl analogue)

Cat.No: T11935

Target: Others

PI3K/mTOR Inhibitor-13

Cat.No: T72380

Target: Others

Cat.No: T74402

Target: Others

Cat.No: T64008

Target: Others

BMS-986020 sodium

Cat.No: T63439

Target: Others

Cat.No: T77031

Cat.No: T63486

Target: Others

Cat.No: T74632

Target: MMP

Bexotegrast HCl

Cat.No: T69517

Target: Others

Cat.No: T63776

Target: Others

ATX inhibitor 12

Cat.No: T63584

Target: Others

Cat. No.	Product Name	Target	Signaling Pathways
T3795	Corilagin	Apoptosis; TLR; Reverse Transcriptase; Antibacterial; Autophagy	Apoptosis; Autophagy; Immunology/Inflammation; Microbiology/Virology
	Corilagin 是一种鞣酸，有抑制 RNA 肿瘤病毒逆转录酶的活性。它抑制金黄色葡萄球菌的生长，MIC 为 25 μg/mL。它有抗肿瘤活性，可用于肝癌和卵巢癌。

天然产物

Cat.No: T3795

Target: Apoptosis, TLR, Reverse Transcriptase, Antibacterial, Autophagy

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-04079	LIPF Protein, Human, Recombinant (His) GL,HLAL,lipase, gastric,HGL	Human	Baculovirus Insect Cells
	LIPF Protein, Human, Recombinant (His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 44.6 kDa and the accession number is AAI12273.1.
TMPY-00371	STC1 Protein, Human, Recombinant (His) stanniocalcin 1,STC	Human	HEK293 Cells
	Stanniocalcin-1 (STC1) is a paracrine factor associated with inflammation and carcinogenesis. STC1 is a secreted glycoprotein hormone and involved in various types of human malignancies. Stanniocalcin-1 (STC1), which has myriad functions, including the maintenance of calcium homeostasis, the promotion of early wound healing, uncoupling respiration (aerobic glycolysis), reepithelialization in damaged tissues, the inhibition of vascular leakage, and the regulation of macrophage functions to keep e...

重组蛋白

LIPF Protein, Human, Recombinant (His)

Cat.No: TMPY-04079

Species: Human

Expression System: Baculovirus Insect Cells

STC1 Protein, Human, Recombinant (His)

Cat.No: TMPY-00371

Species: Human

Expression System: HEK293 Cells

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