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搜索结果

Search Results for " il-6/gp130 "
Targets Recommended: Estrogen Receptor/ERR Estrogen/progestogen Receptor

3

抑制剂 & 化合物

26

重组蛋白

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Cat. No. Product Name Target Signaling Pathways
T6404 Bazedoxifene hydrochloride

Bazedoxifene HCl,盐酸巴多昔芬,TSE-424

 Estrogen Receptor/ERR; Estrogen/progestogen Receptor Endocrinology/Hormones
Bazedoxifene hydrochloride (TSE-424) 是一种 IL-6/GP130蛋白相互作用抑制剂，可用于胰腺癌的研究。它也是一种有口服活性的，能透过血脑屏障的，非甾体、选择性的雌激素受体调节剂 (SERM)，对 ERα 和 ERβ 作用的 IC50值分别为 26 nM 和 99 nM，可用于研究骨质疏松症。
T2544 Bazedoxifene acetate

醋酸巴多昔芬,WAY-TES 424,TSE 424,WAY-140424

 Estrogen Receptor/ERR; Estrogen/progestogen Receptor Endocrinology/Hormones
Bazedoxifene acetate (WAY-TES 424) 是一种非甾体的、有口服活性的、选择性的雌激素受体调节剂，能够作用于 ERα (IC50:26 nM) 和 ERβ (IC50:99 nM) ，可用于研究骨质疏松症。它也是一种IL-6/GP130蛋白相互作用抑制剂，可用于研究胰腺癌。
T15769 LMT-28

IL Receptor Immunology/Inflammation
LMT-28 是一种 IL-6 抑制剂，选择性抑制 IL-6 诱导的 gp130、STAT3 和 JAK2 磷酸化。

化合物

Bazedoxifene hydrochloride
Cat.No: T6404
Synonym: Bazedoxifene HCl,盐酸巴多昔芬,TSE-424
Target: Estrogen Receptor/ERR, Estrogen/progestogen Receptor
Bazedoxifene acetate
Cat.No: T2544
Synonym: 醋酸巴多昔芬,WAY-TES 424,TSE 424,WAY-140424
Target: Estrogen Receptor/ERR, Estrogen/progestogen Receptor
LMT-28
Cat.No: T15769
Synonym:
Target: IL Receptor
Species：
Human (22)
Mouse (3)
Rhesus (1)
Expression System：
HEK293 Cells (22)
E. coli (4)
Tag：
C-hFc (6)
C-His (4)
Tag Free (4)
C-His-Avi (3)
N-6xHis (2)
N-His (2)
N-hFc (2)
C-6xHis (1)
C-mFc (1)
His, hFc (1)
Cat. No. Product Name Species Expression System
TMPY-01076 gp130/IL6ST Protein, Human, Recombinant (His & hFc)

interleukin 6 signal transducer,IL-6

Human HEK293 Cells
gp130/IL6ST Protein, Human, Recombinant (His & hFc) is expressed in HEK293 mammalian cells with His and hFc tag. The predicted molecular weight is 96 kDa and the accession number is P40189-1.
TMPK-00412 gp130/IL6ST Protein, Human, Recombinant (His)

gp130,CD130,IL-6

Human HEK293 Cells
gp130 is a common signal transducing component of the functional receptor complexes for the interleukin (IL)-6 family of cytokines, ie, IL-6, IL-11, leukemia inhibitory factor (LIF), oncostatin M, ciliary neurotrophic factor, and cardiotrophin-1. These cytokines exhibit pleiotropic biological activities in, for instance, immune, hematopoietic, and neural systems, and function in a redundant manner owing to the shared usage of gp130. gp130/IL6ST Protein, Human, Recombinant (His) is expressed in H...
TMPK-00646 gp130/IL6ST Protein, Rhesus macaque, Recombinant (His)

IL-6 R β,gp130,IL

Rhesus HEK293 Cells
gp130 is a common signal transducing component of the functional receptor complexes for the interleukin (IL)-6 family of cytokines, ie, IL-6, IL-11, leukemia inhibitory factor (LIF), oncostatin M, ciliary neurotrophic factor, and cardiotrophin-1. These cytokines exhibit pleiotropic biological activities in, for instance, immune, hematopoietic, and neural systems, and function in a redundant manner owing to the shared usage of gp130. gp130/IL6ST Protein, Rhesus macaque, Recombinant (His) is expre...
TMPY-00387 gp130/IL6ST Protein, Human, Recombinant (hFc)

GP130,CD130,interleukin 6

Human HEK293 Cells
gp130/IL6ST Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 94.4 kDa and the accession number is AAA59155.1.
TMPY-06745 gp130/IL6ST Protein, Human, Recombinant (mFc)

interleukin 6 signal transducer,CD130,CDW<...

 Human HEK293 Cells
gp130/IL6ST Protein, Human, Recombinant (mFc) is expressed in HEK293 mammalian cells with mFc tag. The predicted molecular weight is 94.11 kDa and the accession number is AAA59155.1.
TMPY-06039 gp130/IL6ST Protein, Human, Recombinant (aa 1-618, DDDDK)

GP130,CD130,interleukin 6

Human HEK293 Cells
gp130/IL6ST Protein, Human, Recombinant (aa 1-618, DDDDK) is expressed in HEK293 mammalian cells. The predicted molecular weight is 68.4 kDa and the accession number is P40189-1.
TMPJ-01467 Oncostatin M/OSM Protein, Human, Recombinant (E. coli, His)

Oncostatin-M,OSM

 Human E. coli
Oncostatin M (OSM) is a glycoprotein belonging to the interleukin-6 family of cytokines that includes leukemia-inhibitory factor, granulocyte colony-stimulating factor, and interleukin 6. OSM encodes a growth regulator, which Inhibits the proliferation of a number of tumor cell lines. It stimulates proliferation of AIDS-KS cells. OSM regulates cytokine production, including IL-6, G-CSF and GM-CSF from endothelial cells. OSM is considered as a pleiotropic cytokine that initiates its biological ac...
TMPK-00289 IL-6R alpha/CD126 Protein, Human, Recombinant (His & Avi)

IL-6R subunit alpha,IL-6...

 Human HEK293 Cells
The multifunctional factor interleukin 6 (IL-6) exerts its activities through binding to a high-affinity receptor complex consisting of two membrane glycoproteins: an 80 kDa component receptor that binds IL-6 with low affinity (IL-6R alpha) and a signal-transducing component of 130 kDa (gp130) that does not bind IL-6 by itself, but is required for high-affinity binding of IL-6 by the complex. Both components of the receptor complex, IL-6R alpha and gp130 have been cloned, sequenced, and expresse...
TMPK-01114 IL-31RA Protein, Human, Recombinant (aa 20-519, His)

GLM-RMGC125346,CRL3,GLM-R,PRO21384,Gp1...

 Human HEK293 Cells
Interleukin-31 receptor A (IL-31RA) is a newly identified type I cytokine receptor, that is related to gp130, the common receptor of the interleukin (IL) -6 family cytokines. IL-31RA forms a functional receptor complex for IL-31 together with the beta subunit of oncostatin M receptor (OSMRbeta). OSMRbeta is expressed in a subset of small-sized nociceptive neurons of adult dorsal root ganglia (DRGs).IL-31 and OSM may thus have redundant functions in the development of OSMRbeta-expressing neurons....
TMPK-01113 IL-31RA Protein, Human, Recombinant (aa 20-519, hFc)

PRO21384,GLM-RMGC125346,GLM-R,IL-31R-alpha...

 Human HEK293 Cells
Interleukin-31 receptor A (IL-31RA) is a newly identified type I cytokine receptor, that is related to gp130, the common receptor of the interleukin (IL) -6 family cytokines. IL-31RA forms a functional receptor complex for IL-31 together with the beta subunit of oncostatin M receptor (OSMRbeta). OSMRbeta is expressed in a subset of small-sized nociceptive neurons of adult dorsal root ganglia (DRGs).IL-31 and OSM may thus have redundant functions in the development of OSMRbeta-expressing neurons....
TMPK-01096 IL-31RA Protein, Mouse, Recombinant (His)

GPL,CRL3Glmr,IL-31RA,GLM-R,ZcytoR17,CRL3,P...

 Mouse HEK293 Cells
Interleukin-31 receptor A (IL-31RA) is a newly identified type I cytokine receptor, that is related to gp130, the common receptor of the interleukin (IL) -6 family cytokines. IL-31RA forms a functional receptor complex for IL-31 together with the beta subunit of oncostatin M receptor (OSMRbeta). OSMRbeta is expressed in a subset of small-sized nociceptive neurons of adult dorsal root ganglia (DRGs).IL-31 and OSM may thus have redundant functions in the development of OSMRbeta-expressing neurons....
TMPJ-00086 CT-1 Protein, Human, Recombinant (His)

CTF1,CT-1,Cardiotrophin-1

 Human E. coli
Cardiotrophin-1, also known as CT-1 and CTF1, is a member of the IL-6 superfamily. It is a sreted cytokine that is expressed in heart, skeletal muscle, prostate and ovary, and to lower levels in lung, kidney, pancreas, thymus, testis and small intestine. The protein exerts its cellular effects by interacting with the glycoprotein 130 (gp130)/leukemia inhibitory factor receptor beta (LIFR) heterodimer. In addition, CT-1 activates phosphatidylinositol 3-kinase (PI-3 kinase) in cardiac myocytes and...
TMPJ-00047 IL-31 Protein, Human, Recombinant

IL-31,Interleukin-31,白介素,白细胞介素,IL31

 Human E. coli
Human Interleukin 31 (IL-31) is a cytokine containing a four-helix bundle structure. It shares several structural and functional characteristics with IL-6, Oncostatin M, LIF, and Cardiotrophin-1. Human IL-31 cDNA encodes a 164 amino acid precursor that contains a 23 amino acid signal peptide and a 141 amino acid mature protein. Human and mouse IL-31 share 24% sequence identity in the mature region. IL-31 is mainly associated with activated T cells and is preferentially expressed by type 2 helper...
TMPY-02843 GPX7 Protein, Human, Recombinant (hFc)

GSHPx-7,UNQ469/PRO828,NPGPx,CL683...

 Human HEK293 Cells
GPX7 gene contains 3 distinct gt-ag introns. Transcription produces 4 different mRNAs, 3 alternatively spliced variants, and 1 unspliced form. There are 5 validated alternative polyadenylation sites. The mRNAs appear to differ by overlapping exons with different boundaries. GPX7 is an enzyme. It has molecular functions (glutathione peroxidase activity, oxidoreductase activity) and to localize in various compartments (extracellular space, extracellular region). GPX7 gene has been proposed to part...
TMPJ-00567 NCR1 Protein, Human, Recombinant (hFc)

hNKp46,Natural cytotoxicity triggering receptor 1,N...

 Human HEK293 Cells
Natural cytotoxicity triggering receptor 1(NCR1) is a single-pass type I membrane protein .It contains 2 Ig-like (immunoglobulin-like) domains and belongs to the natural cytotoxicity receptor (NCR) family. The protein is a natural killer (NK) lymphocyte-activating receptor. It is involved in major aspects of NK immune function and shows a high degree of lineage specificity in blood and bone marrow.
TMPY-03128 LAIR1 Protein, Mouse, Recombinant (hFc)

leukocyte-associated immunoglobulin-like receptor 1,BB1152

Mouse HEK293 Cells
LAIR1 Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 39.6 kDa and the accession number is Q8BG84-6.
TMPJ-00827 Tau-D Protein, Human, Recombinant (His)

PHF-Tau,MAPTL,MAPT,Paired Helical Filament-Tau,Micr...

 Human E. coli
Microtubule-Associated Protein TAU is abundantly expressed in neurons of the central nervous system and less commonly expressed elsewhere, but is also expressed at very low levels in CNS astrocytes and oligodendrocytes. Tau interacts with tubulin to stabilize microtubules and promotes tubulin assembly into microtubules. The C-terminus of TAU binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau acts as a linker protein. When tau is defective,...
TMPY-05798 VEGF145 Protein, Human, Recombinant

血管内皮生长因子,vascular endothelial growth factor A,VPF,MVCD1,VEGF...

 Human HEK293 Cells
VEGF145 Protein, Human, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 16.92 kDa and the accession number is P15692-6.
TMPY-04277 CD45 Protein, Mouse, Recombinant (hFc)

Cd45,protein tyrosine phosphatase, receptor type, C,Ly-5,L-C...

 Mouse HEK293 Cells
CD45 Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 71.7 kDa and the accession number is P06800-6.
TMPY-02600 NRG1 beta 1 Protein, Human, Recombinant (EGF Domain, hFc)

neuregulin 1,HRGA,NRG1 β1,HGL,MST131,MSTP131,HRG,ARIA,NDF,GG...

 Human HEK293 Cells
NRG1 beta 1 Protein, Human, Recombinant (EGF Domain, hFc) is expressed in HEK293 mammalian cells with Fc tag. The predicted molecular weight is 36.7 kDa and the accession number is Q02297-6.
TMPY-02705 NRG1 beta 1 Protein, Human, Recombinant (hFc)

MSTP131,HRG1,NRG1-IT2,ARIA,HGL,SMDF,GGF,HRG,NDF,MST131,neure...

 Human HEK293 Cells
NRG1 beta 1 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with Fc tag. The predicted molecular weight is 55.2 kDa and the accession number is Q02297-6.
TMPY-03010 NRG1 beta 1 Protein, Human, Recombinant

NDF,GGF,MSTP131,Neuregulin 1,MST131,ARIA,NRG1-IT2,SMDF,NRG1 ...

 Human HEK293 Cells
NRG1 beta 1 Protein, Human, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 26.8 kDa and the accession number is Q02297-6.
TMPK-00614 NKp46/NCR1 Protein, Human, Recombinant (His)

NKp46,MAR-1,Ly94,NCR1,NKP46FLJ99094,CD335

 Human HEK293 Cells
NKp46, along with NKp30 and NKp44, are activating receptors that have been collectively termed the natural cytotoxicity receptors (NCR).These receptors lack significant sequence homology to one another. They are expressed almost exclusively by NK cells and play a major role in triggering some of the key lytic activities of NK cells. NKp46/NCR1 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with N-His tag. The predicted molecular weight is 27.5 kDa and the accession numb...
TMPK-00615 NKp46/NCR1 Protein (Primary Amine Labeling), Human, Recombinant (His), Biotinylated

CD335,NCR1,NKp46,NKP46FLJ99094,Ly94,MAR-1

 Human HEK293 Cells
NKp46, along with NKp30 and NKp44, are activating receptors that have been collectively termed the natural cytotoxicity receptors (NCR).These receptors lack significant sequence homology to one another. They are expressed almost exclusively by NK cells and play a major role in triggering some of the key lytic activities of NK cells. NKp46/NCR1 Protein (Primary Amine Labeling), Human, Recombinant (His), Biotinylated is expressed in HEK293 mammalian cells with N-His tag. The predicted molecular we...
TMPK-01364 SIRP alpha V6 Protein, Human, Recombinant (His & Avi), Biotinylated

SIRP α,MFR,SHPS1,SIRPA,BIT,SHPS-1,MYD-1,SIRP alpha,P84,CD172...

 Human HEK293 Cells
Signal regulatory protein α (SIRPα) is a regulatory membrane glycoprotein from SIRP family expressed mainly by myeloid cells and also by stem cells or neurons.SIRPα acts as inhibitory receptor and interacts with a broadly expressed transmembrane protein CD47 also called the "don´t eat me" signal.Cancer cells highly expressed CD47 that activate SIRP α and inhibit macrophage-mediated destruction. SIRP alpha V6 Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian c...
TMPK-01358 SIRP alpha V6 Protein, Human, Recombinant (His & Avi)

P84,SIRPA,SIRP alpha,SHPS-1,MFR,BIT,MYD1,SIRP α V6,...

 Human HEK293 Cells
Signal regulatory protein α (SIRPα) is a regulatory membrane glycoprotein from SIRP family expressed mainly by myeloid cells and also by stem cells or neurons.SIRPα acts as inhibitory receptor and interacts with a broadly expressed transmembrane protein CD47 also called the "don´t eat me" signal.Cancer cells highly expressed CD47 that activate SIRP α and inhibit macrophage-mediated destruction. SIRP alpha V6 Protein, Human, Recombinant (His & Avi) is expressed in HEK293 mammalian cells with C-Hi...

重组蛋白

gp130/IL6ST Protein, Human, Recombinant (His & hFc)
Cat.No: TMPY-01076
Species: Human
Expression System: HEK293 Cells
gp130/IL6ST Protein, Human, Recombinant (His)
Cat.No: TMPK-00412
Species: Human
Expression System: HEK293 Cells
gp130/IL6ST Protein, Rhesus macaque, Recombinant (His)
Cat.No: TMPK-00646
Species: Rhesus
Expression System: HEK293 Cells
gp130/IL6ST Protein, Human, Recombinant (hFc)
Cat.No: TMPY-00387
Species: Human
Expression System: HEK293 Cells
gp130/IL6ST Protein, Human, Recombinant (mFc)
Cat.No: TMPY-06745
Species: Human
Expression System: HEK293 Cells
gp130/IL6ST Protein, Human, Recombinant (aa 1-618, DDDDK)
Cat.No: TMPY-06039
Species: Human
Expression System: HEK293 Cells
Oncostatin M/OSM Protein, Human, Recombinant (E. coli, His)
Cat.No: TMPJ-01467
Species: Human
Expression System: E. coli
IL-6R alpha/CD126 Protein, Human, Recombinant (His & Avi)
Cat.No: TMPK-00289
Species: Human
Expression System: HEK293 Cells
IL-31RA Protein, Human, Recombinant (aa 20-519, His)
Cat.No: TMPK-01114
Species: Human
Expression System: HEK293 Cells
IL-31RA Protein, Human, Recombinant (aa 20-519, hFc)
Cat.No: TMPK-01113
Species: Human
Expression System: HEK293 Cells
IL-31RA Protein, Mouse, Recombinant (His)
Cat.No: TMPK-01096
Species: Mouse
Expression System: HEK293 Cells
CT-1 Protein, Human, Recombinant (His)
Cat.No: TMPJ-00086
Species: Human
Expression System: E. coli
IL-31 Protein, Human, Recombinant
Cat.No: TMPJ-00047
Species: Human
Expression System: E. coli
GPX7 Protein, Human, Recombinant (hFc)
Cat.No: TMPY-02843
Species: Human
Expression System: HEK293 Cells
NCR1 Protein, Human, Recombinant (hFc)
Cat.No: TMPJ-00567
Species: Human
Expression System: HEK293 Cells
LAIR1 Protein, Mouse, Recombinant (hFc)
Cat.No: TMPY-03128
Species: Mouse
Expression System: HEK293 Cells
Tau-D Protein, Human, Recombinant (His)
Cat.No: TMPJ-00827
Species: Human
Expression System: E. coli
VEGF145 Protein, Human, Recombinant
Cat.No: TMPY-05798
Species: Human
Expression System: HEK293 Cells
CD45 Protein, Mouse, Recombinant (hFc)
Cat.No: TMPY-04277
Species: Mouse
Expression System: HEK293 Cells
NRG1 beta 1 Protein, Human, Recombinant (EGF Domain, hFc)
Cat.No: TMPY-02600
Species: Human
Expression System: HEK293 Cells
NRG1 beta 1 Protein, Human, Recombinant (hFc)
Cat.No: TMPY-02705
Species: Human
Expression System: HEK293 Cells
NRG1 beta 1 Protein, Human, Recombinant
Cat.No: TMPY-03010
Species: Human
Expression System: HEK293 Cells
NKp46/NCR1 Protein, Human, Recombinant (His)
Cat.No: TMPK-00614
Species: Human
Expression System: HEK293 Cells
NKp46/NCR1 Protein (Primary Amine Labeling), Human, Recombinant (His), Biotinylated
Cat.No: TMPK-00615
Species: Human
Expression System: HEK293 Cells
SIRP alpha V6 Protein, Human, Recombinant (His & Avi), Biotinylated
Cat.No: TMPK-01364
Species: Human
Expression System: HEK293 Cells
SIRP alpha V6 Protein, Human, Recombinant (His & Avi)
Cat.No: TMPK-01358
Species: Human
Expression System: HEK293 Cells
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