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Search Results for " il-10 "

Targets Recommended: TNF

76

抑制剂 & 化合物

7

天然产物

59

重组蛋白

1

同位素标记化合物

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Cat. No.	Product Name	Target	Signaling Pathways
T8692	(Rac)-Benpyrine	TNF	Apoptosis
	(Rac)-Benpyrine 是一种有效且具有口服活性的 TNF-α 抑制剂，是Benpyrine 的外消旋体。它可研究TNF-α介导的炎症和自身免疫性疾病。
T27695	JTE-607 JTE-607 dihydrochloride,JTE-607 HCl,甲氧番荔枝碱	Cysteine Protease	Proteases/Proteasome
	JTE-607 HCl 是高选择性的炎性细胞因子合成抑制剂，可保护小鼠免受内毒素休克。它作用于 LPS 刺激的人 PBMC，抑制TNF-α(IC50:11 nM)、IL-1β(IC50:5.9 nM)、IL-6(IC50:8.8 nM)、IL-8(IC50:7.3 nM)和IL-10(IC50:9.1 nM)。
T14778	BRD6989	IL Receptor; CDK; Interleukin	Cell Cycle/Checkpoint; Immunology/Inflammation
	BRD6989 是天然产物皮质抑素 A 的类似物，可抑制CDK8并上调IL-10，抑制重组 CDK8 或 CDK19 复合物的激酶活性。它选择性结合 CDK8 复合物，IC50约为 200 nM。
T8316	1V209 TLR7 agonist T7	TLR	Immunology/Inflammation
	1V209 (TLR7 agonist T7) 是一种 Toll 样受体 7 (TLR7) 激动剂，可与各种多糖缀合，以改善其水溶性，增强功效并保持低毒性，具有抗肿瘤作用。
T80557	Anti-Mouse IL-10 Antibody
	Anti-MouseIL-10Antibody为IgG1 isotype抗体，专一性针对小鼠IL-10，具有抑制功能，由大鼠作为宿主生产。
T61392	NLRP3-IN-10 ZVN26391	NOD	Immunology/Inflammation; NF-κB
	NLRP3-IN-10 (ZVN26391) 是强效的 NLRP3 抑制剂，抑制 IL-1β 释放的 IC50 为 251.1 nM。NLRP3-IN-10 通过减弱 ASC 斑点形成来抑制 NLRP3炎症小体激活。
T17107	TMC353121	IL Receptor; TNF; RSV	Apoptosis; Immunology/Inflammation; Microbiology/Virology
	TMC353121 是呼吸道合胞病毒 (RSV) 融合抑制剂，具有抗 RSV 活性，抑制炎性细胞因子 TNF-α、IL-6 和 IL-1β 以及趋化因子、KC、IP-10、MCP 和 MIP1-α 的产生。
T19480	NO-prednisolone NCX-1015	IL Receptor	Immunology/Inflammation
	NO-prednisolone (NCX-1015) 是一种有效刺激体内IL-10产生的化合物，是一种释放一氧化氮(NO)的Prednisolone 衍生物。
T6657	SB273005	Integrin	Cytoskeletal Signaling
	SB273005 是一种具有口服活性和高效性非肽整合素αvβ3 拮抗剂，抑制 αvβ3 和 αvβ5，可减少怀孕小鼠中 Th2 细胞和细胞因子 IL-10 的产生。
T4403	AX-024 hydrochloride AX-024 HCl	IL Receptor; TNF; COX; IFNAR; Interleukin	Apoptosis; Immunology/Inflammation; Neuroscience
	AX-024 hydrochloride (AX-024 HCl) 是一种细胞因子释放抑制剂，可强烈抑制 IL-6、TNFα、IFN-γ、IL-10 和 IL-17A 的产生。它是口服可利用的 TCR-Nck 相互作用抑制剂，可选择性地抑制 TCR 触发的 T 细胞活化。它通过靶向 SH3结构域调节细胞信号传导，具有低毒、高效和高选择性的特点。
T70277	Cynandione A	Others	Others
	Cynandione A 是从 Cynanchum wilfordii 中提取的苯乙酮，具有抗炎活性，可通过巨噬细胞 α7 nAChR 激活和随后的 IL-10 表达来显着减少促炎细胞因子的过表达。
T76778	Risankizumab Risankizumab rzaa,SKYRIZI,ABBV 066,BI-655066	IL Receptor	Immunology/Inflammation
	Risankizumab (BI 655066) 是一种人源化靶向 IL-23 p19 亚基的 IgG 单克隆抗体(Kd <10 pM)。 Risankizumab 能抑制人 IL-23 在小鼠脾细胞中诱导的 IL-17 产生，IC50 值为 2 pM。Risankizumab 可用于预防和治疗如寻常型银屑病、银屑病关节炎、广泛性脓疱型银屑病和红皮病型银屑病类的免疫性和炎症性疾病。
T6761	Ossirene AS101	IL Receptor; Caspase; Interleukin	Apoptosis; Immunology/Inflammation; Proteases/Proteasome
	Ossirene (AS101) 是一种免疫调节抑制剂，是一种新型 IL-1beta 转化酶抑制剂，可用于自身免疫性疾病和某些恶性肿瘤。它通过抑制IL-10消除 STAT3 的磷酸化，有效抑制Caspase-1。
T1813	VGX-1027 VGX1027,VGX 1027,GIT 27	IL Receptor; TNF; Interleukin	Apoptosis; Immunology/Inflammation
	VGX-1027 (GIT 27) 是一种口服有效的异恶唑化合物，靶向巨噬细胞，减少促炎性介质 TNF-α、IL-1β和 IL-10 的产生，具有免疫调节特性。它通过限制细胞因子介导的免疫炎症而具有抗糖尿病作用。
T15017	CU-T12-9	TLR	Immunology/Inflammation
	CU-T12-9 是特异性 TLR1/2激动剂，可激活先天免疫系统和适应性免疫系统。它选择性激活 TLR1/2 异二聚体，可通过促进 TLR1 和 TLR2 二聚而激活 NF-κB 信号，引起下游 TNF-α、IL-10 和 iNOS 增加。
T0097	MRT67307 MRT67307 HCl	IκB/IKK; Autophagy	Autophagy; NF-κB
	MRT67307 是一种IKKε和TBK-1的双抑制剂，IC50分别为 160 和 19 nM。它抑制细胞自噬，也可抑制ULK1和ULK2，IC50分别为 45 和 38 nM。
T16832	S18-000003	ROR	Metabolism
	S18-000003 是口服有活性的维甲酸相关孤儿受体 (RORγt) 选择性抑制剂，在竞争性结合试验中，对 hRORγt 的 IC50值小于 30 nM。它对 RORγt 的选择性比其他 ROR 家族成员 (IC50>10 μM)更高。它可用于银屑病的研究，胸腺畸变风险较低。
T3533	Apilimod mesylate 阿吡莫德甲磺酸盐,STA 5326 mesylate	IL Receptor; PI3K; Interleukin	Immunology/Inflammation; PI3K/Akt/mTOR signaling
	Apilimod mesylate (STA 5326 mesylate) 是一种 IL-12/IL-23 的有效抑制剂，抑制人和猴的 PBMC 细胞中的 IL-12的IC50值为 1 nM 和 2 nM。Apilimod 是高效的、选择性的PIKfyve 抑制剂。
T12982	SP4206	IL Receptor	Immunology/Inflammation
	SP4206 is an interaction inhibitor of IL-2/IL-2Rα (IL-2 and IL-2Rα with Kd of 70 nM and 10 nM,respectively)
T72549	IL-17A modulator-3	Others	Others
	IL-17Amodulator-3 是IL-17A 的调节剂。IL-17Amodulator-3 抑制 IL-17A/A，IC50值＜10 μM。IL-17Amodulator-3 可以用于炎症、癌症和自身免疫疾病的研究。
T63943	COX-2-IN-10	Others	Others
	COX-2-IN-10 是 COX-2 的有效抑制剂。COX-2-IN-10 对 IL-6、TNF-α 和 IL-1β 的产生表现出抑制作用。COX-2-IN-10 能够浓度依赖性地抑制 PGE2 的产生，其 IC50 值为 2.54 μM。COX-2-IN-10 在 mRNA 和蛋白水平上抑制 iNOS 和 COX-2 的表达。
T79025	TNF-α-IN-10	Others	Others
	TNF-α-IN-10 (compound 8a) 作为IL-6与TNF-α的抑制剂，表现出抗炎活性。
T63088	NOD2 antagonist 1	Others	Others
	NOD2 antagonist 1 (compound 32) 是一种有效的、选择性的 NOD2 拮抗剂 (IC50: 5.23 μM)。NOD2 antagonist 1 在 THP-1 细胞，对 Muramyl dipeptide (MDP) 诱导的 IL-8 分泌表现出抑制作用。NOD2 antagonist 1 在 PBMCs 细胞，可以抑制 MDP 诱导的 IL-6、IL-10 和 TNF-α 的水平升高。
T11357	Gamma-glutamylcysteine TFA γ-glutamylcysteine (TFA),Gamma-glutamylcysteine (TFA)	IL Receptor	Immunology/Inflammation
	Gamma-glutamylcysteine (TFA) also upregulates the level of the anti-inflammatory cytokine IL-10 and reduces the levels of the pro-inflammatory cytokines (TNF-α, IL-6, and IL-1β) and attenuates the changes in metalloproteinase activity in oligomeric Aβ40-treated astrocytes. Gamma-glutamylcysteine (TFA) ((γ-glutamylcysteine (TFA)), an intermediate in glutathione (GSH) synthesis, is a dipeptide served as an essential cofactor for the antioxidant enzyme glutathione peroxidase (GPx).
T40043	RORγt Inverse agonist 10	Others	Others
	RORγt Inverse agonist 10 is a highly potent and orally bioavailable compound that acts as an antagonist for the retinoic acid receptor-related orphan nuclear receptor gamma t (RORγt). With an IC50 of 51 nM, it effectively inhibits the activity of RORγt, a prominent transcription factor involved in the regulation of genes associated with the pathogenesis of psoriasis, including IL-17A, IL-22, and IL-23R.
T62310	CDK8-IN-5	Others	Others
	CDK8-IN-5 是一种有效的 CDK8抑制剂，IC50为 72 nM。CDK8-IN-5 显示抗炎活性和 43% 的 IL-10增强率。CDK8-IN-5 具有研究炎症性肠病的潜力。
T35453	β-Defensin-4 (human) (trifluoroacetate salt)
	β-Defensin-4 is a peptide with antimicrobial properties that protects the skin and mucosal membranes of the respiratory, genitourinary, and gastrointestinal tracts. It induces migration of monocytes in vitro when used at a concentration of 10 nM but does not affect migration of neutrophils and eosinophils. β-Defensin-4 (30 μg/ml) stimulates gene expression and production of IL-6, IL-10, CXCL10, CCL2, MIP-3α, and RANTES by keratinocytes. It also stimulates calcium mobilization, migration, and pro...
T38159	STING Agonist 12b	Others	Others
	STING agonist 12b is an agonist of stimulator of interferon genes (STING).1It binds to STING (Kd= 26.4 μM) and induces interferon reporter gene expression in cells expressing human or mouse STING (EC50s = 7.45 and 10.23 μM, respectively). STING agonist 12b (40 μM) induces expression of TNF-a, IL-6, IP-10, and IL-1b in THP-1 cells. 1.Hou, S., Lan, X.-j., Li, W., et al.Design, synthesis and biological evaluation of acridone analogues as novel STING receptor agonistsBioorg. Chem.95103556(2020)
T62959	LRH-1 modulator-1	Others	Others
	LRH-1 modulator-1 是一种有效的 LRH-1 (肝受体同源物 -1) 调节剂/激动剂。LRH-1 modulator-1 能够诱导抗炎细胞因子 IL-10，对炎症细胞因子 IL-1b 和 TNFa 表现出抑制作用。LRH-1 modulator-1 在肠道类器官中具有抗炎活性。
T83866	LCC-12 formate	Others	Others
	LCC-12是一种铜(II)螯合剂，为二甲双胍的衍生物。作为单体，它能结合铜(II)并在20 µM的浓度下减少氢过氧化物依赖的NADH向NAD+的氧化。在10 µM的浓度下，LCC-12降低一次性人类细胞因子激活的单核衍生的巨噬细胞(MDMs)中IL-1β、IL-2、IL-6、IL-8和TNF-α的细胞因子水平，以及JAK2、STAT2和IL-1受体相关激酶4(IRAK4)的水平。此外，同样浓度的LCC-12减少了细胞因子激活的MDMs中CD80+和CD86+的数量。每日0.3 mg/kg的剂量可提高LPS或盲肠结扎穿孔模型小鼠的存活率。
T80470	Citrullinated LL-37 2cit
	Citrullinated LL-37 2cit是瓜氨酸化的LL-37肽，在10 μg/mL浓度下可减弱LL-37对HRV活性的抑制，并降低LL-37的抗菌效果。此外，Citrullinated LL-37 2cit能显著降低RV1B诱导的IL-8、CCL5和IL-6 mRNA水平，并对HRV诱导的CCL5分泌能力有中度抑制作用。
TP1891	MMK 1
	Potent and selective human formyl peptide receptor FPR2 agonist (EC50 values are 1, 2 and > 10 000 nM at mFRP2, hFPR2 and hFPR1 respectively). Induces migration of human monocytes and neutrophils via a chemotactic mechanism and enhances production of proi
T74908	ODN 2336	Others	Others
	ODN 2336 是 A 类 CpG ODN（寡脱氧核苷酸），是一种有效的 TLR9激动剂。ODN 2336 诱导 IFN-α 的产生。ODN 2336 上调 IP-10 mRNA 和 IL-18mRNA 的表达。ODN 2336 可用作疫苗的佐剂。
T78762	SIKs-IN-1	Others	Others
	SIKs-IN-1（compound 8h）为一种嘧啶-5-羧酰胺衍生物，并充当盐诱导激酶（SIKs）的抑制剂。该化合物通过抑制SIK活性，上调IL-10抗炎细胞因子，下调IL-12促炎细胞因子，调控M1/M2巨噬细胞的极化，并在DSS诱导的结肠炎模型中展现出明显的抗炎效果。
T61071	AX-024	Others	Others
	AX-024 is a novel chemical compound that acts as an orally available inhibitor of the TCR-Nck interaction. Its primary mechanism of action is the selective inhibition of T cell activation triggered by TCR stimulation. With an IC50 value of approximately 1 nM, AX-024 effectively modulates cell signaling by specifically targeting SH3 domains. Additionally, AX-024 demonstrates desirable characteristics such as low acute toxicity, high potency, and excellent selectivity. Notably, it exhibits strong ...
T83773	Prostaglandin E2 Inhibitor 3 PGE2 Inhibitor 3	Others	Others
	Prostaglandin E2抑制剂3是一种microsomal prostaglandin E合酶-1 (mPGES-1; IC50 = 0.2 µM)的抑制剂，相较于COX-1、COX-2、5-lipoxygenase (5-LO)和soluble epoxide hydrolase (sEH)，在10 µM的无细胞试验中表现出对mPGES-1的选择性。在10 µM和1 µM的浓度下，该抑制剂能抑制A549细胞中IL-1β诱导的PGE2生成以及在J774A.1巨噬细胞中，LPS诱导的IL-6和PGE2生成。同时，它还能抑制由钙离子载体A23187单独或结合花生四烯酸和A23187诱导的5-LO产物形成，包括白三烯B4 (LTB4) 和5-H(p)ETE（IC50s分别为4.9和5.2 µM）。在体内，10 mg/kg剂量的Prostaglandin E2抑制剂3能防止在zymosan诱导的小鼠腹膜炎模型中白细胞渗入腹腔液中。
T75093	STING agonist-25	Others	Others
	STINGagonist-25 (CF505) 是一种非核苷酸小分子 STING 激动剂。STINGagonist-23 激活 STING，增加 STING、TBK1和 IRF3的磷酸化。STINGagonist-23 可促进肿瘤细胞中IFN-β、IL-6、CXCL-10、TNF-α、ISG-15和CCL-5的水平。STINGagonist-23 表现出抗SARS-CoV 系列的活性。
T75092	STING agonist-24	Others	Others
	STINGagonist-24 (CF504) 是一种非核苷酸小分子STING 激动剂。STINGagonist-23 激活STING，增加STING、TBK1和IRF3的磷酸化。STINGagonist-23 可促进肿瘤细胞中IFN-β、IL-6、CXCL-10、TNF-α、ISG-15和CCL-5的水平。STINGagonist-23 表现出抗SARS-CoV 系列的活性。
T36517	Resveratrol-3-O-sulfate sodium	Others	Others
	Resveratrol-3-O-sulfate is a metabolite of resveratrol . In U-937 cells stimulated with LPS, resveratrol-3-O-sulfate (1 μM) decreases the expression of IL-1α, IL-1β, and IL-6 by 61.2, 76.6, and 42.2%, respectively, and decreases the release of TNF-α and IL-6 to similar levels as resveratrol. It has antioxidant activity in a Trolox assay, dose-dependently decreases growth of Caco-2 colorectal adenocarcinoma cells when used at concentrations ranging from 10 to 100 μM, and induces apoptosis at conc...
T35452	β-Defensin-3 (human) (trifluoroacetate salt)
	β-Defensin-3 is a peptide with antimicrobial properties that protects the skin and mucosal membranes of the respiratory, genitourinary, and gastrointestinal tracts. It inhibits the growth of the periodontopathogenic and cariogenic bacteria F. nucleatum, S. mutans, S. sobrinus, S. salivarius, and L. casei (MICs = 12.5-100 mg/l). It also inhibits the growth of S. aureus, S. pyogenes, P. aeruginosa, E. coli, and C. albicans. β-Defensin-3 stimulates gene expression and production of IL-6, IL-10, CXC...
T83698	Cathelicidin-2 (128-153) (chicken) TFA Fowlicidin-2 (128-153),CATH-2 (128-153),Myeloid Antimicrobial Peptide 27 (128-153)
	Cathelicidin-2 (CATH-2) (128-153) 是一种合成抗菌肽，对应于鸡CATH-2的128至153个氨基酸。该化合物对E. coli、S. aureus、S. enteritidis和B. globigii展示出浓度依赖性的活性。CATH-2 (128-153) (40 µM) 可诱导孤立的鸡红细胞溶解，但对孤立的人外周血单个核细胞(PBMCs)无细胞毒性。它能促进化学因子(C-C-基序)配体2 (CCL2)的产生，并抑制LPS诱导的TNF-α、IL-6、IL-8和IL-10在孤立的人PBMCs中的产生。
T84969	M04	Others	Others
	M04 acts as a stimulator of interferon genes (STING) agonist, effectively inducing IFN reporter gene expression in HEK293T cells equipped with wild-type human STING. Its activity is specific, not affecting HEK293T cells with the R71H-G230A-R293Q (HAQ) human STING variant or mouse RAW 264.7 cells, showcasing allelic- and species-dependent effects at a concentration of 75 µM. This compound also stimulates the production of TNF-α, IL-10, IL-1β, and IL-12p70 in human peripheral blood mononuclear cel...
T75096	STING agonist-28	Others	Others
	STINGagonist-28 (CF510) 是一种非核苷酸小分子STING 激动剂。STINGagonist-23 激活STING，增加STING、TBK1和IRF3的磷酸化。STINGagonist-23 可促进肿瘤细胞中IFN-β、IL-6、CXCL-10、TNF-α、ISG-15和CCL-5的水平。STINGagonist-23 表现出抗SARS-CoV 系列的活性。
T75094	STING agonist-26	Others	Others
	STINGagonist-26 (CF508) 是一种非核苷酸小分子STING 激动剂。STINGagonist-23 激活STING，增加STING、TBK1和IRF3的磷酸化。STINGagonist-23 可促进肿瘤细胞中IFN-β、IL-6、CXCL-10、TNF-α、ISG-15和CCL-5的水平。STINGagonist-23 表现出抗SARS-CoV 系列的活性。
T75837	Spantide I TFA
	Spantide I TFA 是substance P 的类似物，是选择性的神经激肽-1 受体 (NK1receptor) 的拮抗剂，其对NK1和NK2受体的Ki 值分别为 230 nM 和8150 nM。Spantide I 可减少感染角膜的1型细胞因子和增强2型细胞因子IL-10，从而显著减少角膜穿孔。
T75091	STING agonist-23	Others	Others
	STINGagonist-23 (CF502) 是一种非核苷酸小分子 STING 激动剂。STINGagonist-23 激活 STING，增加 STING、TBK1和 IRF3的磷酸化。STINGagonist-23 可促进肿瘤细胞中 IFN-β、IL-6、CXCL-10、TNF-α、ISG-15和 CCL-5的水平。STINGagonist-23 表现出抗 SARS-CoV 系列的活性。
T35468	(±)19(20)-EDP Ethanolamide	Others	Others
	(±)19(20)-EDP ethanolamide is an ω-3 endocannabinoid epoxide and cannabinoid (CB) receptor agonist (EC50s = 108 and 280 nM for CB1 and CB2, respectively). It is produced through direct epoxygenation of docosahexaenoyl ethanolamide by cytochrome P450 (CYP) epoxygenases. (±)19(20)-EDP ethanolamide (25 μM) reduces the viability of 143B metastatic osteosarcoma cells. It decreases the production of IL-6 and increases the production of IL-10 when used at concentrations ranging from 2.5 to 10 μM in BV-...
T36862	Ganglioside GT1b Mixture (sodium salt) Ganglioside GT1b Mixture (sodium salt),Ganglioside G1 Mixture	Others	Others
	Ganglioside GT1b is a trisialoganglioside that is characterized by having two sialic residues linked to the inner galactose unit. It binds to the neurotoxins botulinum toxin serotype A (BTxA), BTxA heavy chain, and tetanus toxin with IC50 values of 11, 0.74, and 7.2 μM, respectively.[1] Ganglioside GT1b-containing liposomes bind to the major coat protein VP1 from Merkel cell polyomavirus (MCPyV), which has been identified in Merkel cell carcinomas, identifying ganglioside GT1b as a putative MCP...
T23028	MRT67307 HCl (1190378-57-4 free base) MRT67307 HCl	Others	Others
	MRT67307 is an inhibitor for TBK1, IKKε , MARK1-4 and NUAK1 with IC50 value of 19, 160, 27-52 and 230nM , respectively [1]. It is an inhibitor for ULK1and ULK2 with IC50 value of 45 and 38nM, respectively [2]. Also, it is a salt inducible kinase (SIK) inhibitor with IC50 value of 250, 67 and 430nM for SIK1, SIK2 and SIK3, respectively.<br />SIKs prevent the formation of regulatory macrophages and their inhibition induces increasing in some markers of regulatory macrophages, such as IL-10 and oth...
T37564	C4 Ceramide (d18:1/4:0) C4 Ceramide (d18:1/4:0),Cer(d18:1/4:0)	Others	Others
	C4 Ceramide is a bioactive sphingolipid and cell-permeable analog of naturally occurring ceramides. [1] [2] [3] It inhibits IL-4 production by 16% in EL4 T cells stimulated with phorbol 12-myristate 13-acetate when used at a concentration of 10 μM. [1] C4 Ceramide is cytotoxic to SK-BR-3 and MCF-7/Adr breast cancer cells (IC50s = 15.9 and 19.9 μM, respectively). [2] C4 Ceramide also increases maturation and stability of cystic fibrosis transmembrane conductance regulator (CFTR) proteins bearing...

化合物

(Rac)-Benpyrine

Cat.No: T8692

Target: TNF

Cat.No: T27695

Synonym: JTE-607 dihydrochloride,JTE-607 HCl,甲氧番荔枝碱

Target: Cysteine Protease

Cat.No: T14778

Target: IL Receptor, CDK, Interleukin

Cat.No: T8316

Synonym: TLR7 agonist T7

Target: TLR

Anti-Mouse IL-10 Antibody

Cat.No: T80557

Cat.No: T61392

Synonym: ZVN26391

Target: NOD

Cat.No: T17107

Target: IL Receptor, TNF, RSV

NO-prednisolone

Cat.No: T19480

Synonym: NCX-1015

Target: IL Receptor

Cat.No: T6657

Target: Integrin

AX-024 hydrochloride

Cat.No: T4403

Synonym: AX-024 HCl

Target: IL Receptor, TNF, COX, IFNAR, Interleukin

Cat.No: T70277

Target: Others

Cat.No: T76778

Synonym: Risankizumab rzaa,SKYRIZI,ABBV 066,BI-655066

Target: IL Receptor

Cat.No: T6761

Synonym: AS101

Target: IL Receptor, Caspase, Interleukin

Cat.No: T1813

Synonym: VGX1027,VGX 1027,GIT 27

Target: IL Receptor, TNF, Interleukin

Cat.No: T15017

Target: TLR

Cat.No: T0097

Synonym: MRT67307 HCl

Target: IκB/IKK, Autophagy

Cat.No: T16832

Target: ROR

Apilimod mesylate

Cat.No: T3533

Synonym: 阿吡莫德甲磺酸盐,STA 5326 mesylate

Target: IL Receptor, PI3K, Interleukin

Cat.No: T12982

Target: IL Receptor

IL-17A modulator-3

Cat.No: T72549

Target: Others

Cat.No: T63943

Target: Others

Cat.No: T79025

Target: Others

NOD2 antagonist 1

Cat.No: T63088

Target: Others

Gamma-glutamylcysteine TFA

Cat.No: T11357

Synonym: γ-glutamylcysteine (TFA),Gamma-glutamylcysteine (TFA)

Target: IL Receptor

RORγt Inverse agonist 10

Cat.No: T40043

Target: Others

Cat.No: T62310

Target: Others

β-Defensin-4 (human) (trifluoroacetate salt)

Cat.No: T35453

STING Agonist 12b

Cat.No: T38159

Target: Others

LRH-1 modulator-1

Cat.No: T62959

Target: Others

Cat.No: T83866

Target: Others

Citrullinated LL-37 2cit

Cat.No: T80470

Cat.No: TP1891

Cat.No: T74908

Target: Others

Cat.No: T78762

Target: Others

Cat.No: T61071

Target: Others

Prostaglandin E2 Inhibitor 3

Cat.No: T83773

Synonym: PGE2 Inhibitor 3

Target: Others

STING agonist-25

Cat.No: T75093

Target: Others

STING agonist-24

Cat.No: T75092

Target: Others

Resveratrol-3-O-sulfate sodium

Cat.No: T36517

Target: Others

β-Defensin-3 (human) (trifluoroacetate salt)

Cat.No: T35452

Cathelicidin-2 (128-153) (chicken) TFA

Cat.No: T83698

Synonym: Fowlicidin-2 (128-153),CATH-2 (128-153),Myeloid Antimicrobial Peptide 27 (128-153)

Cat.No: T84969

Target: Others

STING agonist-28

Cat.No: T75096

Target: Others

STING agonist-26

Cat.No: T75094

Target: Others

Cat.No: T75837

STING agonist-23

Cat.No: T75091

Target: Others

(±)19(20)-EDP Ethanolamide

Cat.No: T35468

Target: Others

Ganglioside GT1b Mixture (sodium salt)

Cat.No: T36862

Synonym: Ganglioside GT1b Mixture (sodium salt),Ganglioside G1 Mixture

Target: Others

MRT67307 HCl (1190378-57-4 free base)

Cat.No: T23028

Synonym: MRT67307 HCl

Target: Others

C4 Ceramide (d18:1/4:0)

Cat.No: T37564

Synonym: C4 Ceramide (d18:1/4:0),Cer(d18:1/4:0)

Target: Others

Cat. No.	Product Name	Target	Signaling Pathways
T3829	Ginsenoside F3 人参皂苷F3	Others; IFNAR; Interleukin	Immunology/Inflammation; Others
	Ginsenoside F3 是一种皂苷，提取自Panax ginseng 叶片。它能够调节1 型 (IL-2, IFN-γ) 及 2 型细胞因子(IL-4 and IL-10) 的产生和表达，有免疫增强的作用。
T8033	Sodium Thiocyanate	Others; Reactive Oxygen Species; Interleukin	Immunology/Inflammation; Metabolism; NF-κB; Others
	Sodium thiocyanate 能够减少促炎细胞因子 IL-6水平，并增强抗炎细胞因子 IL-10水平，并显著减少 ROS 形成。
T5S2059	Glaucine	Calcium Channel; Dopamine Receptor; Influenza Virus; Adrenergic Receptor; PDE	GPCR/G Protein; Membrane transporter/Ion channel; Metabolism; Microbiology/Virology; Neuroscience
	Glaucine 是从海罂粟中分离的一种生物碱，具有镇咳、抗炎和支气管扩张作用。它是具有口服活性的磷酸二酯酶 4 选择性抑制剂。它还是非选择性的 α-肾上腺素受体拮抗剂，具有抗氧化和抗病毒活性。
TN4679	Nudiposide	IL Receptor; TNF	Apoptosis; Immunology/Inflammation
	Nudiposide has significant neuroprotective activities against glutamate-injured neurotoxicity in HT22 cells. It also exhibits protective effect against sepsis in a mouse model and can decrease the plasma levels of TNF-α, IL-10 and ALT activity.
TN2243	Sugiol 10-Deoxoxanthoperol	IL Receptor; TNF; ROS	Apoptosis; Immunology/Inflammation
	Sugiol (10-Deoxoxanthoperol) 是一种枞烷二萜，可从台湾板栗树 (Calocedrus formosana) 的树皮中分离出来。Sugiol 具有抗炎活性，可有效减少脂多糖 (LPS) 刺激巨噬细胞后的活性氧 (ROS) 产生。
TN5912	Macluraxanthone 3-Hydroxyblancoxanthone	Antioxidant; TNF	Apoptosis; oxidation-reduction
	Macluraxanthone (3-Hydroxyblancoxanthone) 具有许多生物活性，包括抗胆碱酯酶、抗氧化、抗癌、抗疟疾、抗炎和免疫调节作用。Macluraxanthone 通过增加表达CD86的巨噬细胞的百分比，同时减少其CD14、CD11b 和CD80的表达，来促进M1类促炎症巨噬细胞的极化。Macluraxanthone 在促炎症刺激物脂多糖的存在下明显减少了TNF-α和IL-10细胞因子的产生。
T35741	Gliovirin	Others	Others
	Gliovirin is a fungal metabolite that has been found inT. harzianumand has fungicidal, antimicrobial and anti-inflammatory activities.1It is active against the plant pathogenic fungusP. ultimum(MIC = 60 ng/ml) and the parasiteT. brucei brucei(IC50= 90 ng/ml), but has no effect on the plant pathogenic fungiR. solani,P. omnivorum,T. basicola,R. arrhizus, andV. dahliaeor the bacteriaB. thuringiensis,P. fluorescens, andX. malvacearumwhen used at concentrations up to 1,000 ng/ml.2,3Gliovirin decrease...

天然产物

Cat.No: T3829

Synonym: 人参皂苷F3

Target: Others, IFNAR, Interleukin

Sodium Thiocyanate

Cat.No: T8033

Target: Others, Reactive Oxygen Species, Interleukin

Cat.No: T5S2059

Target: Calcium Channel, Dopamine Receptor, Influenza Virus, Adrenergic Receptor, PDE

Cat.No: TN4679

Target: IL Receptor, TNF

Cat.No: TN2243

Synonym: 10-Deoxoxanthoperol

Target: IL Receptor, TNF, ROS

Macluraxanthone

Cat.No: TN5912

Synonym: 3-Hydroxyblancoxanthone

Target: Antioxidant, TNF

Cat.No: T35741

Target: Others

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-05064	IL-10 Protein, Mouse, Recombinant 白介素,白细胞介素,CSIF,interleukin 10,Il-10	Mouse	E. coli
	IL-10 Protein, Mouse, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 18.9 kDa and the accession number is A0A7R8GUQ3.
TMPY-03547	IL-10 Protein, Human, Recombinant Interleukin-10,TGIF,CSIF,IL10A,	Human	E. coli
	IL-10 Protein, Human, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 18.6 kDa and the accession number is P22301.
TMPY-01845	IL-10 Protein, Human, Recombinant (His) GVHDS,TGIF,CSIF,interleukin 10,IL-10	Human	HEK293 Cells
	IL-10 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 20.9 kDa and the accession number is P22301.
TMPY-05338	IL-10R alpha/IL-10RA Protein, Human, Recombinant (His) CDW210A,interleukin 10 receptor, alpha,	Human	HEK293 Cells
	IL-10R alpha/IL-10RA Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 25.8 kDa and the accession number is Q13651.
TMPY-02959	IL-20 Protein, Human, Recombinant ZCYTO10,interleukin-20,IL10D,白细胞介...	Human	E. coli
	IL-20 Protein, Human, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 17.7 kDa and the accession number is Q9NYY1.
TMPK-00057	IL-10 Protein, Human, Recombinant (His & Avi), Biotinylated IL-10,GVHDS,Interleukin-10,白介素,白细...	Human	HEK293 Cells
	Interleukin 10 (IL10) is a key anti-inflammatory cytokine that can inhibit proinflammatory responses of both innate and adaptive immune cells. An association between IL10 and intestinal mucosal homeostasis became clear with the discovery that IL10 and IL10 receptor (IL10R)-deficient mice develop spontaneous intestinal inflammation. Similarly, patients with deleterious mutations in IL10, IL10RA, or IL10RB present with severe enterocolitis within the first months of life. IL-10 Protein, Human, Rec...
TMPK-00056	IL-10 Protein, Human, Recombinant (His & Avi) MGC126450,白细胞介素,GVHDS,B-TCGF,IL10A,白介素,TGI...	Human	HEK293 Cells
	Interleukin 10 (IL10) is a key anti-inflammatory cytokine that can inhibit proinflammatory responses of both innate and adaptive immune cells. An association between IL10 and intestinal mucosal homeostasis became clear with the discovery that IL10 and IL10 receptor (IL10R)-deficient mice develop spontaneous intestinal inflammation. Similarly, patients with deleterious mutations in IL10, IL10RA, or IL10RB present with severe enterocolitis within the first months of life. IL-10 Protein, Human, Rec...
TMPY-05584	CD25/IL2R alpha Protein, Human, Recombinant (His & Avi), Biotinylated CD25,p55,interleukin 2 receptor, alpha,TCGFR,IL-2RA...	Human	HEK293 Cells
	CD25/IL2R alpha Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with His and Avi tag. The predicted molecular weight is 25 kDa and the accession number is P01589.
TMPY-01103	CD25/IL2R alpha Protein, Human, Recombinant (His) interleukin 2 receptor, α,IL-2RA,IDDM10,	Human	HEK293 Cells
	CD25/IL2R alpha Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 23.3 kDa and the accession number is P01589.
TMPJ-01424	IL-10R alpha/IL-10RA Protein, Macaca mulatta, Recombinant (His) IL-10RA,Interleukin-10 receptor s...	Macaca Mulatta	HEK293 Cells
	Interleukin-10 Receptor alpha (IL-10 R alpha), also known as IL-10 R1, is transmembrane glycoprotein member of the class II cytokine receptor family. Interleukin-10 (IL10) is a key anti-inflammatory cytokine that is produced predominantly by leukocytes including T cells, B cells, monocytes, macrophages, and dendritic cells (DCs), as well as by some epithelial cells. The receptor for IL10 is a heterotetramer complex comprising two IL10Ra (also referred to as IL10R1) molecules and two IL10Rb (also...
TMPK-00537	IL-10R alpha/IL-10RA Protein, Cynomolgus, Recombinant (His) HIL-10R,IL-10R subunit 1...	Cynomolgus	HEK293 Cells
	IL-10R alpha/IL-10RA Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells with C-His tag. The predicted molecular weight is 25.34 kDa and the accession number is A0A2K5WJ66.
TMPK-00334	IL-10R alpha/IL-10RA Protein, Human, Recombinant (His & Avi) CDw210a,IL-10 R alpha,IBD28,I...	Human	HEK293 Cells
	IL-10R alpha/IL-10RA Protein, Human, Recombinant (His & Avi) is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 27 kDa and the accession number is Q13651.
TMPK-00335	IL-10R alpha/IL-10RA Protein, Human, Recombinant (His & Avi), Biotinylated IBD28,IL-10 R α,IL-10RA,...	Human	HEK293 Cells
	IL-10R alpha/IL-10RA Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 27 kDa and the accession number is Q13651.
TMPK-00650	HLA-A*02:01 & B2M & MART-1 (ELAGIGILTV) Monomer Protein, Cynomolgus, Recombinant (His) IL10A,GVHDS,IL-10,MGC126...	Cynomolgus	HEK293 Cells
	Interleukin 10 (IL10) is a key anti-inflammatory cytokine that can inhibit proinflammatory responses of both innate and adaptive immune cells. An association between IL10 and intestinal mucosal homeostasis became clear with the discovery that IL10 and IL10 receptor (IL10R)-deficient mice develop spontaneous intestinal inflammation. Similarly, patients with deleterious mutations in IL10, IL10RA, or IL10RB present with severe enterocolitis within the first months of life. HLA-A*02:01 & B2M & MART-...
TMPJ-00062	IL-22 Protein, Human, Recombinant (hIgG4 hFc) IL-10-related T-cell-derived-inducible fac...	Human	HEK293 Cells
	IL-22 Protein, Human, Recombinant (hIgG4 hFc) is expressed in HEK293 mammalian cells with C-hIgG4 Fc tag. The predicted molecular weight is 50-75 KDa and the accession number is Q9GZX6.
TMPJ-01340	IL-22 Protein, Mouse, Recombinant (mFc) IL-10-related T-cell-derived-inducible fac...	Mouse	HEK293 Cells
	IL-22 Protein, Mouse, Recombinant (mFc) is expressed in HEK293 mammalian cells with C-mFc tag. The predicted molecular weight is 50-65 KDa and the accession number is Q9JJY9.
TMPJ-00061	IL-22 Protein, Human, Recombinant (hIgG2 hFc) 白细胞介素,Cytokine Zcyto18,Interleukin-22,IL-TIF,IL...	Human	HEK293 Cells
	IL-22 Protein, Human, Recombinant (hIgG2 hFc) is expressed in HEK293 mammalian cells with C-hIgG2 Fc tag. The predicted molecular weight is 50-62 KDa and the accession number is Q9GZX6.
TMPJ-01339	IL-22 Protein, Mouse, Recombinant (E. coli) IL-TIF Alpha,Il22a,IL-22,Il	Mouse	E. coli
	IL-22 Protein, Mouse, Recombinant (E. coli) is expressed in E. coli expression system. The predicted molecular weight is 15 KDa and the accession number is Q9JJY9.
TMPY-04175	IL-1F10 Protein, Human, Recombinant (His) FIL1-theta,IL1-θ,IL1-theta,interl...	Human	P. pastoris (Yeast)
	IL-1F10 Protein, Human, Recombinant (His) is expressed in yeast with His tag. The predicted molecular weight is 18.4 kDa and the accession number is AAK68048.1.
TMPY-00525	IL-10 Protein, Feline, Recombinant interleukin 10	Feline	E. coli
	IL-10 Protein, Feline, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 18.9 kDa and the accession number is P55029.2.
TMPY-01220	IL-22BP Protein, Human, Recombinant (His) ZCYTOR16,CRF2X,IL-22R-α-2,interleukin 22 receptor, ...	Human	HEK293 Cells
	IL-22BP Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 26.1 kDa and the accession number is Q969J5-2.
TMPY-01108	IL-10R beta/IL-10RB Protein, Human, Recombinant (His & hFc) interleukin 10 receptor, β,CDW210B,D21S58,...	Human	HEK293 Cells
	IL-10R beta/IL-10RB Protein, Human, Recombinant (His & hFc) is expressed in HEK293 mammalian cells with His and hFc tag. The predicted molecular weight is 51.7 kDa and the accession number is Q08334.
TMPY-01236	IL-10R beta/IL-10RB Protein, Human, Recombinant (His) CRF2-4,D21S66,CDW210B,interleukin 10 recep...	Human	HEK293 Cells
	IL-10R beta/IL-10RB Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 25 kDa and the accession number is Q08334.
TMPY-04900	IL-22BP Protein, Human, Recombinant (hFc) IL-22BP,CRF2X,ZCYTOR16,IL-22R-α-2,interleu...	Human	HEK293 Cells
	IL-22BP Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 55 kDa and the accession number is Q969J5-1.
TMPY-02324	IL-10R beta/IL-10RB Protein, Mouse, Recombinant (hFc) IL-10R2,Crfb4,Il10r2,CRF...	Mouse	HEK293 Cells
	IL-10R beta/IL-10RB Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 50.5 kDa and the accession number is Q8VHM7.
TMPJ-00119	IL-22RA2 Protein, Human, Recombinant (hFc) Cytokine Receptor Family 2 Member 10,CRF2-...	Human	HEK293 Cells
	Interleukin-22 Receptor Subunit α-2 (IL22RA2) belongs to the type II cytokine receptor family. IL22RA2 is a secreted protein and contains three fibronectin type-III domains. IL22RA2 is widely expressed in many tissues. IL22RA2 functions as an IL22 antagonist and may be important in the regulation of inflammatory response. Three alternatively spliced transcript variants encoding distinct isoforms have been described.
TMPY-01324	IL-22BP Protein, Human, Recombinant (His & hFc) interleukin 22 receptor, alpha 2,CRF2-S1,IL-22BP,in...	Human	HEK293 Cells
	IL-22BP Protein, Human, Recombinant (His & hFc) is expressed in HEK293 mammalian cells with His and hFc tag. The predicted molecular weight is 52.8 kDa and the accession number is Q969J5-2.
TMPK-00165	IL-2 R alpha/CD25 Protein, Human, Recombinant (His & Avi), Biotinylated IL2RA,CD25,IL-2 R alpha,TCGFR,IL-...	Human	HEK293 Cells
	Human IL-2 receptor alpha (IL-2 R alpha), also known as Tac antigen and as CD25, was initially identified as a 55 kDa membrane glycoprotein that is capable of binding IL‑2.eceptor for interleukin-2. The receptor is involved in the regulation of immune tolerance by controlling regulatory T cells (TREGs) activity. TREGs suppress the activation and expansion of autoreactive T-cells. IL-2 R alpha/CD25 Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with C...
TMPY-02325	IL-10R beta/IL-10RB Protein, Mouse, Recombinant (His) AI528744,interleukin 10 receptor, beta,D21S58h,CRF2...	Mouse	HEK293 Cells
	IL-10R beta/IL-10RB Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 25 kDa and the accession number is Q8VHM7.
TMPY-04219	IL-10 Protein, Rat, Recombinant 白介素,interleukin 10,白细胞介素	Rat	E. coli
	IL-10 Protein, Rat, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 18.6 kDa and the accession number is A0A7R8C3K4.
TMPJ-00030	IL-1F10 Protein, Human, Recombinant Interleukin-1 Family Member 10,白介素,Interle...	Human	E. coli
	Human Interleukin 1 Family Member 10 (IL-1F10) is thought to participate in a network of Interleukin 1 cytokine family members to regulate adapted and innate immune responses. IL-1F10 was expressed in fetal skin, spleen and tonsil, mostly in the basal epithelia of skin and in proliferating B-cells of the tonsil. IL-1F10 binds soluble IL-1 receptor type 1 and may be implicated in regulating adapted and innate immune responses. Two alternatively spliced transcript variants encoding the same protei...
TMPK-00164	IL-2 R alpha/CD25 Protein, Human, Recombinant (His & Avi) IL-2 R alpha,IL-2 R α,IL2RA,I...	Human	HEK293 Cells
	Human IL-2 receptor alpha (IL-2 R alpha), also known as Tac antigen and as CD25, was initially identified as a 55 kDa membrane glycoprotein that is capable of binding IL‑2.eceptor for interleukin-2. The receptor is involved in the regulation of immune tolerance by controlling regulatory T cells (TREGs) activity. TREGs suppress the activation and expansion of autoreactive T-cells. IL-2 R alpha/CD25 Protein, Human, Recombinant (His & Avi) is expressed in HEK293 mammalian cells with C-His-Avi tag. ...
TMPY-00858	CD25/IL2R alpha Protein, Human, Recombinant (hFc) CD25,interleukin 2 receptor, alpha,IL2R,IDDM10<...	Human	HEK293 Cells
	CD25/IL2R alpha Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 48.5 kDa and the accession number is P01589.
TMPY-00466	IL-10 Protein, Sus scrofa (Pig), Recombinant interleukin 10,白细胞介素,白介素	Sus scrofa (Pig)	E. coli
	IL-10 Protein, Sus scrofa (Pig), Recombinant is expressed in E. coli expression system. The predicted molecular weight is 18.2 kDa and the accession number is Q29055.
TMPJ-00018	CCL16 Protein, Human, Recombinant NCC-4,Lymphocyte and Monocyte Chemoattractant,LMC,NCC4,HCC-4...	Human	E. coli
	CCL16 is a member of CC chemokine family. CCL16 cDNA encodes a 120 amino acid peptide along with a 23 amino acids signal peptide that is cleaved to generate 97 amino acid protein. CCL16 is distantly related to other CC chemokines, showing less than 30% sequence identity. CCL16 elicits its effects on cells by interacting with cell surface chemokine receptors such as CCR1, CCR2, CCR5 and CCR8. Recombinant CCL16 has been shown to chemoattract human monocytes and THP1 cells but not resting lymphocyt...
TMPY-06981	IL-1 alpha/IL-1A Protein, Human, Recombinant (E. coli) interleukin 1 α,IL1,白介素,IL-1F1,IL...	Human	E. coli
	IL-1 alpha is a member of the interleukin 1 cytokine family. Cytokines are proteinaceous signaling compounds that are major mediators of the immune response. They control many different cellular functions including proliferation, differentiation, and cell survival/apoptosis but are also involved in several pathophysiological processes including viral infections and autoimmune diseases. Cytokines are synthesized under various stimuli by a variety of cells of both the innate (monocytes, macrophage...
TMPH-01195	Human cytomegalovirus (HCMV) (strain Merlin) Viral interleukin-10 homolog UL111A,Viral interleukin-10 homolog	HCMV	E. coli
	Functional viral IL-10 homolog. Can bind to the human IL-10 receptor and compete with human IL-10 for binding sites. Requires both subunits of the human IL-10 receptor complex to induce signal transduction events and biological activities. IL-10 signaling pathway has several immunosuppressive activities that are exploited by the virus. Inhibits TLR-induced type I interferon production in host plasmacytoid dendritic cells. Human cytomegalovirus (HCMV) (strain Merlin) Viral interleukin-10 homolog ...
TMPH-02273	JAK1 Protein, Human, Recombinant (His) JAK1,Janus kinase 1,Tyrosine-protein kinase JAK1	Human	P. pastoris (Yeast)
	Tyrosine kinase of the non-receptor type, involved in the IFN-alpha/beta/gamma signal pathway. Kinase partner for the interleukin (IL)-2 receptor as well as interleukin (IL)-10 receptor. Directly phosphorylates STAT but also activates STAT signaling through the transactivation of other JAK kinases associated with signaling receptors.
TMPK-00052	IL-20 Protein, Human, Recombinant (His) 白细胞介素,MGC96907,Zcyto10,IL-20,白介素,IL	Human	HEK293 Cells
	Interleukin (IL)-20 is a member of the IL-10 family of cytokines, which has been reported to participate in autoimmune inflammatory diseases. However, the potential role of IL-20 in hepatocellular carcinoma (HCC) progression has not yet been investigated. In addition, IL-20 expression was significantly associated with tumor size, metastasis, TNM stage and poor prognosis in patients with HCC. IL-20 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with N-His tag. The predic...
TMPK-01071	IL-22RA1 Protein, Mouse, Recombinant (hFc) IL-22R α1,IL22R,zcytoR11,IL-TIF-R...	Mouse	HEK293 Cells
	Interleukin (IL)-22 is a member of the IL-10 family of cytokines and represents an important effector molecule of activated Th22, Th1, and Th17 cells, as well as Tc-cell subsets, gammadelta T cells, natural killer (NK), and NKT cells. IL-22 mediates its effects via a heterodimeric transmembrane receptor complex consisting of IL-22R1 and IL-10R2 and subsequent Janus kinase-signal transducers and activators of transcription (JAK-STAT) signaling pathways including Jak1, Tyk2, and STAT3. IL-22RA1 Pr...
TMPH-01560	IL-26 Protein, Human, Recombinant (His & Trx) Interleukin-26,Protein AK155,IL26	Human	E. coli
	May play a role in local mechanisms of mucosal immunity and seems to have a proinflammatory function. May play a role in inflammatory bowel disease. Activates STAT1 and STAT3, MAPK1/3 (ERK1/2), JUN and AKT. Induces expression of SOCS3, TNF-alpha and IL-8, secretion of IL-8 and IL-10 and surface expression of ICAM1. Decreases proliferation of intestinal epithelial cells. Is inhibited by heparin. IL-26 Protein, Human, Recombinant (His & Trx) is expressed in E. coli expression system with N-6xHis-T...
TMPK-01105	IL-22RA1 Protein, Human, Recombinant (hFc) IL-22R-alpha-1,CRF2-9,IL-TIF-R1,IL	Human	HEK293 Cells
	Interleukin (IL)-22 is a member of the IL-10 family of cytokines and represents an important effector molecule of activated Th22, Th1, and Th17 cells, as well as Tc-cell subsets, gammadelta T cells, natural killer (NK), and NKT cells. IL-22 mediates its effects via a heterodimeric transmembrane receptor complex consisting of IL-22R1 and IL-10R2 and subsequent Janus kinase-signal transducers and activators of transcription (JAK-STAT) signaling pathways including Jak1, Tyk2, and STAT3. IL-22RA1 Pr...
TMPH-01559	IL-26 Protein, Human, Recombinant (His) Protein AK155,Interleukin-26,IL26	Human	P. pastoris (Yeast)
	May play a role in local mechanisms of mucosal immunity and seems to have a proinflammatory function. May play a role in inflammatory bowel disease. Activates STAT1 and STAT3, MAPK1/3 (ERK1/2), JUN and AKT. Induces expression of SOCS3, TNF-alpha and IL-8, secretion of IL-8 and IL-10 and surface expression of ICAM1. Decreases proliferation of intestinal epithelial cells. Is inhibited by heparin. IL-26 Protein, Human, Recombinant (His) is expressed in yeast with N-6xHis tag. The predicted molecula...
TMPH-02272	JAK1 Protein, Human, Recombinant (E. coli, His) Tyrosine-protein kinase JAK1,JAK1,Janus kinase 1	Human	E. coli
	Tyrosine kinase of the non-receptor type, involved in the IFN-alpha/beta/gamma signal pathway. Kinase partner for the interleukin (IL)-2 receptor as well as interleukin (IL)-10 receptor. Directly phosphorylates STAT but also activates STAT signaling through the transactivation of other JAK kinases associated with signaling receptors.
TMPK-00051	IL-20 Protein, Human, Recombinant (hFc) 白细胞介素,MGC96907,白介素,IL10D,Cytokine Zcyto	Human	HEK293 Cells
	Interleukin (IL)-20 is a member of the IL-10 family of cytokines, which has been reported to participate in autoimmune inflammatory diseases. However, the potential role of IL-20 in hepatocellular carcinoma (HCC) progression has not yet been investigated. In addition, IL-20 expression was significantly associated with tumor size, metastasis, TNM stage and poor prognosis in patients with HCC. IL-20 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with N-hFc tag. The predic...
TMPK-01198	IL-20 Protein, Mouse, Recombinant (His) Cytokine Zcyto10,IL-20,白细胞介素,IL	Mouse	HEK293 Cells
	Interleukin (IL)-20 is a member of the IL-10 family of cytokines, which has been reported to participate in autoimmune inflammatory diseases. However, the potential role of IL-20 in hepatocellular carcinoma (HCC) progression has not yet been investigated. In addition, IL-20 expression was significantly associated with tumor size, metastasis, TNM stage and poor prognosis in patients with HCC. IL-20 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with N-His tag. The predic...
TMPK-01197	IL-20 Protein, Mouse, Recombinant (hFc) 白细胞介素,IL-20,IL10D,Zcyto10	Mouse	HEK293 Cells
	Interleukin (IL)-20 is a member of the IL-10 family of cytokines, which has been reported to participate in autoimmune inflammatory diseases. However, the potential role of IL-20 in hepatocellular carcinoma (HCC) progression has not yet been investigated. In addition, IL-20 expression was significantly associated with tumor size, metastasis, TNM stage and poor prognosis in patients with HCC. IL-20 Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with N-hFc tag. The predic...
TMPH-01464	HNRNPM Protein, Human, Recombinant (His & SUMO) Heterogeneous nuclear ribonucleoprotein M,HNRNPM	Human	E. coli
	Pre-mRNA binding protein in vivo, binds avidly to poly(G) and poly(U) RNA homopolymers in vitro. Involved in splicing. Acts as a receptor for carcinoembryonic antigen in Kupffer cells, may initiate a series of signaling events leading to tyrosine phosphorylation of proteins and induction of IL-1 alpha, IL-6, IL-10 and tumor necrosis factor alpha cytokines. HNRNPM Protein, Human, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weig...
TMPH-02961	JAK1 Protein, Mouse, Recombinant (His) Janus kinase 1,Jak1,Tyrosine-protein kinase JAK1	Mouse	E. coli
	Tyrosine kinase of the non-receptor type, involved in the IFN-alpha/beta/gamma signal pathway. Kinase partner for the interleukin (IL)-2 receptor as well as interleukin (IL)-10 receptor. Directly phosphorylates STAT but also activates STAT signaling through the transactivation of other JAK kinases associated with signaling receptors. JAK1 Protein, Mouse, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 39.1 kDa and the accession numb...
TMPY-00493	IL-19 Protein, Human, Recombinant (His) interleukin 19,Interleukin-19,IL-10C,NG.1,...	Human	Baculovirus Insect Cells
	The molecular features at the IL19 locus may modestly alter the establishment of HIV-1 infection. Interleukin (IL) 19, IL-20, and IL-24 belong to the IL-10 cytokine family and have been identified to play a role in the regulation of epidermal functions and inflammation. The expression of IL19 in biopsies of patients with active ulcerative colitis was increased compared with patients with quiescent ulcerative colitis and that colitis was attenuated in IL-19-deficient mice. The disruption of the e...
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重组蛋白

IL-10 Protein, Mouse, Recombinant

Cat.No: TMPY-05064

Species: Mouse

Expression System: E. coli

IL-10 Protein, Human, Recombinant

Cat.No: TMPY-03547

Species: Human

Expression System: E. coli

IL-10 Protein, Human, Recombinant (His)

Cat.No: TMPY-01845

Species: Human

Expression System: HEK293 Cells

IL-10R alpha/IL-10RA Protein, Human, Recombinant (His)

Cat.No: TMPY-05338

Species: Human

Expression System: HEK293 Cells

IL-20 Protein, Human, Recombinant

Cat.No: TMPY-02959

Species: Human

Expression System: E. coli

IL-10 Protein, Human, Recombinant (His & Avi), Biotinylated

Cat.No: TMPK-00057

Species: Human

Expression System: HEK293 Cells

IL-10 Protein, Human, Recombinant (His & Avi)

Cat.No: TMPK-00056

Species: Human

Expression System: HEK293 Cells

CD25/IL2R alpha Protein, Human, Recombinant (His & Avi), Biotinylated

Cat.No: TMPY-05584

Species: Human

Expression System: HEK293 Cells

CD25/IL2R alpha Protein, Human, Recombinant (His)

Cat.No: TMPY-01103

Species: Human

Expression System: HEK293 Cells

IL-10R alpha/IL-10RA Protein, Macaca mulatta, Recombinant (His)

Cat.No: TMPJ-01424

Species: Macaca Mulatta

Expression System: HEK293 Cells

IL-10R alpha/IL-10RA Protein, Cynomolgus, Recombinant (His)

Cat.No: TMPK-00537

Species: Cynomolgus

Expression System: HEK293 Cells

IL-10R alpha/IL-10RA Protein, Human, Recombinant (His & Avi)

Cat.No: TMPK-00334

Species: Human

Expression System: HEK293 Cells

IL-10R alpha/IL-10RA Protein, Human, Recombinant (His & Avi), Biotinylated

Cat.No: TMPK-00335

Species: Human

Expression System: HEK293 Cells

HLA-A*02:01 & B2M & MART-1 (ELAGIGILTV) Monomer Protein, Cynomolgus, Recombinant (His)

Cat.No: TMPK-00650

Species: Cynomolgus

Expression System: HEK293 Cells

IL-22 Protein, Human, Recombinant (hIgG4 hFc)

Cat.No: TMPJ-00062

Species: Human

Expression System: HEK293 Cells

IL-22 Protein, Mouse, Recombinant (mFc)

Cat.No: TMPJ-01340

Species: Mouse

Expression System: HEK293 Cells

IL-22 Protein, Human, Recombinant (hIgG2 hFc)

Cat.No: TMPJ-00061

Species: Human

Expression System: HEK293 Cells

IL-22 Protein, Mouse, Recombinant (E. coli)

Cat.No: TMPJ-01339

Species: Mouse

Expression System: E. coli

IL-1F10 Protein, Human, Recombinant (His)

Cat.No: TMPY-04175

Species: Human

Expression System: P. pastoris (Yeast)

IL-10 Protein, Feline, Recombinant

Cat.No: TMPY-00525

Species: Feline

Expression System: E. coli

IL-22BP Protein, Human, Recombinant (His)

Cat.No: TMPY-01220

Species: Human

Expression System: HEK293 Cells

IL-10R beta/IL-10RB Protein, Human, Recombinant (His & hFc)

Cat.No: TMPY-01108

Species: Human

Expression System: HEK293 Cells

IL-10R beta/IL-10RB Protein, Human, Recombinant (His)

Cat.No: TMPY-01236

Species: Human

Expression System: HEK293 Cells

IL-22BP Protein, Human, Recombinant (hFc)

Cat.No: TMPY-04900

Species: Human

Expression System: HEK293 Cells

IL-10R beta/IL-10RB Protein, Mouse, Recombinant (hFc)

Cat.No: TMPY-02324

Species: Mouse

Expression System: HEK293 Cells

IL-22RA2 Protein, Human, Recombinant (hFc)

Cat.No: TMPJ-00119

Species: Human

Expression System: HEK293 Cells

IL-22BP Protein, Human, Recombinant (His & hFc)

Cat.No: TMPY-01324

Species: Human

Expression System: HEK293 Cells

IL-2 R alpha/CD25 Protein, Human, Recombinant (His & Avi), Biotinylated

Cat.No: TMPK-00165

Species: Human

Expression System: HEK293 Cells

IL-10R beta/IL-10RB Protein, Mouse, Recombinant (His)

Cat.No: TMPY-02325

Species: Mouse

Expression System: HEK293 Cells

IL-10 Protein, Rat, Recombinant

Cat.No: TMPY-04219

Species: Rat

Expression System: E. coli

IL-1F10 Protein, Human, Recombinant

Cat.No: TMPJ-00030

Species: Human

Expression System: E. coli

IL-2 R alpha/CD25 Protein, Human, Recombinant (His & Avi)

Cat.No: TMPK-00164

Species: Human

Expression System: HEK293 Cells

CD25/IL2R alpha Protein, Human, Recombinant (hFc)

Cat.No: TMPY-00858

Species: Human

Expression System: HEK293 Cells

IL-10 Protein, Sus scrofa (Pig), Recombinant

Cat.No: TMPY-00466

Species: Sus scrofa (Pig)

Expression System: E. coli

CCL16 Protein, Human, Recombinant

Cat.No: TMPJ-00018

Species: Human

Expression System: E. coli

IL-1 alpha/IL-1A Protein, Human, Recombinant (E. coli)

Cat.No: TMPY-06981

Species: Human

Expression System: E. coli

Human cytomegalovirus (HCMV) (strain Merlin) Viral interleukin-10 homolog

Cat.No: TMPH-01195

Species: HCMV

Expression System: E. coli

JAK1 Protein, Human, Recombinant (His)

Cat.No: TMPH-02273

Species: Human

Expression System: P. pastoris (Yeast)

IL-20 Protein, Human, Recombinant (His)

Cat.No: TMPK-00052

Species: Human

Expression System: HEK293 Cells

IL-22RA1 Protein, Mouse, Recombinant (hFc)

Cat.No: TMPK-01071

Species: Mouse

Expression System: HEK293 Cells

IL-26 Protein, Human, Recombinant (His & Trx)

Cat.No: TMPH-01560

Species: Human

Expression System: E. coli

IL-22RA1 Protein, Human, Recombinant (hFc)

Cat.No: TMPK-01105

Species: Human

Expression System: HEK293 Cells

IL-26 Protein, Human, Recombinant (His)

Cat.No: TMPH-01559

Species: Human

Expression System: P. pastoris (Yeast)

JAK1 Protein, Human, Recombinant (E. coli, His)

Cat.No: TMPH-02272

Species: Human

Expression System: E. coli

IL-20 Protein, Human, Recombinant (hFc)

Cat.No: TMPK-00051

Species: Human

Expression System: HEK293 Cells

IL-20 Protein, Mouse, Recombinant (His)

Cat.No: TMPK-01198

Species: Mouse

Expression System: HEK293 Cells

IL-20 Protein, Mouse, Recombinant (hFc)

Cat.No: TMPK-01197

Species: Mouse

Expression System: HEK293 Cells

HNRNPM Protein, Human, Recombinant (His & SUMO)

Cat.No: TMPH-01464

Species: Human

Expression System: E. coli

JAK1 Protein, Mouse, Recombinant (His)

Cat.No: TMPH-02961

Species: Mouse

Expression System: E. coli

IL-19 Protein, Human, Recombinant (His)

Cat.No: TMPY-00493

Species: Human

Expression System: Baculovirus Insect Cells

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Cat. No.	Product Name	Target	Signaling Pathways
T36408	Rhein-13C4 Rhein-13C4
	Rhein-13C4 is intended for use as an internal standard for the quantification of rhein by GC- or LC-MS. Rhein is an anti-inflammatory anthraquinone found in rhubarb and is the bioactive derivative of its prodrug diacerein . At 10 μM, rhein inhibits IL-1β signaling, suppressing signaling through NF-κB, and reduces the expression of the matrix metalloproteases MMP-1 and MMP-13.1 It inhibits IKKβ (IC50 = 11.8 μM), decreasing iNOS and IL-6 expression in LPS-stimulated macrophages but paradoxically i...

同位素标记化合物

Cat.No: T36408

Synonym: Rhein-13C4

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