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Targets Recommended: BTK

抑制剂 & 化合物

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T3626	Acalabrutinib ACP-196,阿可替尼	BTK	Angiogenesis; Tyrosine Kinase/Adaptors
	Acalabrutinib (ACP-196) 是一种不可逆的、高效的、具有口服活性、选择性的第二代BTK 抑制剂。它与 BTK 的 ATP 结合口袋中的 Cys481 共价结合。它在慢性淋巴细胞性白血病 (CLL) 小鼠模型中显示出强大的靶向作用和功效。
T6771	AZD3264	IκB/IKK	NF-κB
	AZD3264 是 IkB 激酶 IKK2抑制剂。
T24629	PHA-408 PHA 408	Others	Others
	PHA-408 is a novel potent, highly selective and ATP-competitive inhibitor of IKB kinase-2.
T15243	Ertiprotafib PTP 112	Phosphatase; PPAR	DNA Damage/DNA Repair; Metabolism
	Ertiprotafib is a PTP1B, IkB kinase β (IKK-β), and a dual PPARα and PPARβ agonist inhibitor ( IC50s: 1.6 μM for PTP1B, 400 nM for IKK-β, an EC50 of ~1 μM for PPARα/PPARβ).
T62044	Anticancer agent 71	Others	Others
	Anticancer agent 71 (Compound 4b) 是有效的抗癌剂。Anticancer agent 71 将细胞周期阻滞在 G2/M 期。Anticancer agent 71通过上调 Bax、Ikb-α 和切割 PARP 并下调 Bcl-2 表达水平诱导细胞凋亡。

化合物

Acalabrutinib

Cat.No: T3626

Synonym: ACP-196,阿可替尼

Target: Phosphatase, PPAR

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-05800	IKB beta/NFKBIB Protein, Human, Recombinant (GST) NFKB inhibitor β,NFKB inhibitor beta,TRIP9,IKBB,	Human	E. coli
	NFKBIB (NFKB Inhibitor Beta) is a Protein Coding gene. The protein encoded by this gene belongs to the NF-kappa-B inhibitor family, which inhibits NF-kappa-B by complexing with and trapping it in the cytoplasm. Phosphorylation of serine residues on these proteins by kinases marks them for destruction via the ubiquitination pathway, thereby allowing activation of the NF-kappa-B, which translocates to the nucleus to function as a transcription factor. NF-kappaB regulation involves the inhibitor pr...
TMPY-01710	IkB alpha/NFKBIA Protein, Human, Recombinant (His) IkB α,IKBA,nuclear factor of kappa light p...	Human	E. coli
	Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha (IkB alpha, NFKBIA, or IKBA), is a member of the NF-kappa-B inhibitor family that function to inhibit the NF-kB transcription factor. NFKBIA inhibits NF-kB by masking the nuclear localization signals (NLS) of NF-kB proteins and keeping them sequestered in an inactive state in the cytoplasm. Also, NFKBIA blocks the ability of NF-κB transcription factors to bind to DNA, which is required for NF-kB's proper function...
TMPH-01531	IKBKB Protein, Human, Recombinant (His) Serine/threonine protein kinase IKBKB,Nuclear facto...	Human	Baculovirus Insect Cells
	Serine kinase that plays an essential role in the NF-kappa-B signaling pathway which is activated by multiple stimuli such as inflammatory cytokines, bacterial or viral products, DNA damages or other cellular stresses. Acts as part of the canonical IKK complex in the conventional pathway of NF-kappa-B activation. Phosphorylates inhibitors of NF-kappa-B on 2 critical serine residues. These modifications allow polyubiquitination of the inhibitors and subsequent degradation by the proteasome. In tu...
TMPH-01532	IKBKB Protein, Human, Recombinant (E. coli, His) Nuclear factor NF-kappa-B inhibitor kinase beta,Serine/threo...	Human	E. coli
	Serine kinase that plays an essential role in the NF-kappa-B signaling pathway which is activated by multiple stimuli such as inflammatory cytokines, bacterial or viral products, DNA damages or other cellular stresses. Acts as part of the canonical IKK complex in the conventional pathway of NF-kappa-B activation. Phosphorylates inhibitors of NF-kappa-B on 2 critical serine residues. These modifications allow polyubiquitination of the inhibitors and subsequent degradation by the proteasome. In tu...