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Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T80600 |
Peginterferon lambda-1a
BMS-914143 |
IFNAR | Immunology/Inflammation |
Peginterferon lambda-1a (BMS-914143)为靶向IFNLR1受体的单克隆抗体,构成于IFNL1与pegol的偶联物。 |
Cat. No. | Product Name | Species | Expression System |
---|---|---|---|
TMPH-01551 |
IFNLR1 Protein, Human, Recombinant (His & SUMO)
Cytokine receptor class-II member 12,Likely interle... |
Human | E. coli |
The IFNLR1/IL10RB dimer is a receptor for the cytokine ligands IFNL2 and IFNL3 and mediates their antiviral activity. The ligand/receptor complex stimulate the activation of the JAK/STAT signaling pathway leading to the expression of IFN-stimulated genes (ISG), which contribute to the antiviral state. Determines the cell type specificity of the lambda interferon action. Shows a more restricted pattern of expression in the epithelial tissues thereby limiting responses to lambda interferons primar... |