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Search Results for " ifng "

Targets Recommended: Others

2

抑制剂 & 化合物

26

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T71890	F5446	Others	Others
	F5446 is a SUV39H1 inhibitor. F5446 has an EC50 of 0.496 μmol/L for SUV39H1 enzymatic activity. H3K9me3 was enriched in the promoters of GZMB, PRF1, FASLG, and IFNG in quiescent T cells. F5446 inhibited H3K9me3, thereby upregulating expression of these effectors in tumor-infiltrating CTLs and suppressing colon carcinoma growth in a CD8+ CTL-dependent manner in vivo. Our data indicate that SUV39H1 represses CTL effector gene expression and, in doing so, confers colon cancer immune escape.
T72626	A2AR-antagonist-1	Adenosine Receptor	GPCR/G Protein; Neuroscience
	A2AR-antagonist-1 (compound 38) 为一种口服活性的腺苷 A2A 受体 (A2AR) 拮抗剂，IC50 值为 29 nM。此化合物展示出抗肿瘤作用，并在小鼠肝微粒体中表现出良好的代谢稳定性，半衰期为 86.1 分钟。同时，A2AR-antagonist-1 能够作为 T 细胞激活剂，通过抑制免疫抑制分子 LAG-3 和 TIM-3，以及增强 GZMB、IFNG 和 IL-2 等效应分子的表达。

化合物

Cat.No: T71890

Target: Others

A2AR-antagonist-1

Cat.No: T72626

Target: Adenosine Receptor

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPH-03495	IFN gamma Protein, Sheep, Recombinant (His) IFNG,Interferon gamma	Sheep	P. pastoris (Yeast)
	IFN gamma Protein, Sheep, Recombinant (His) is expressed in yeast with N-6xHis tag. The predicted molecular weight is 18.9 kDa and the accession number is P17773.
TMPH-02451	IFN gamma Protein, Marmota monax, Recombinant (His) IFNG,Interferon gamma	Marmota monax	P. pastoris (Yeast)
	Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. IFN gamma Protein, Marmota monax, Recombinant (His) is expressed in yeast with N-6xHis tag. The predicted molecular weight is 18.6 kDa and the accession numb...
TMPH-00775	IFN gamma Protein, Goat, Recombinant (His & Myc) Interferon gamma,IFNG	Goat	E. coli
	Type II interferon produced by immune cells such as T-cells and NK cells that plays crucial roles in antimicrobial, antiviral, and antitumor responses by activating effector immune cells and enhancing antigen presentation. Primarily signals through the JAK-STAT pathway after interaction with its receptor IFNGR1 to affect gene regulation. Upon IFNG binding, IFNGR1 intracellular domain opens out to allow association of downstream signaling components JAK2, JAK1 and STAT1, leading to STAT1 activati...
TMPH-00373	IFN gamma Protein, Chicken, Recombinant (GST) Interferon gamma,IFNG	Chicken	E. coli
	Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. IFN gamma Protein, Chicken, Recombinant (GST) is expressed in E. coli expression system with N-GST tag. The predicted molecular weight is 43.7 kDa and the ac...
TMPH-03494	IFN gamma Protein, Sheep, Recombinant (E. coli, His) IFNG,Interferon gamma	Sheep	E. coli
	IFN gamma Protein, Sheep, Recombinant (E. coli, His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 20.9 kDa and the accession number is P17773.
TMPK-00047	IFN gamma Protein, Human, Recombinant (His & Avi) IFN gamma,interferon,Interferon-γ,γ,IFI,干扰素,Interferon-gamma...	Human	HEK293 Cells
	Interferon-gamma (IFN gamma) is a cytokine that plays physiologically important roles in promoting innate and adaptive immune responses. The absence of IFN gamma production or cellular responsiveness in humans and experimental animals significantly predisposes the host to microbial infection, a result that validates the physiologic importance of this cytokine in preventing infectious disease. IFN gamma Protein, Human, Recombinant (His & Avi) is expressed in HEK293 mammalian cells with C-His-Avi ...
TMPK-00048	IFN gamma Protein, Human, Recombinant (His & Avi), Biotinylated IFNγ,IFN γ/IFNG,gamma,γ,IFG,IFN γ,IFN gamma,Interfe...	Human	HEK293 Cells
	Interferon-gamma (IFN gamma) is a cytokine that plays physiologically important roles in promoting innate and adaptive immune responses. The absence of IFN gamma production or cellular responsiveness in humans and experimental animals significantly predisposes the host to microbial infection, a result that validates the physiologic importance of this cytokine in preventing infectious disease. IFN gamma Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells w...
TMPY-01151	IFNGR1 Protein, Human, Recombinant (His) IMD27B,IFNGR,interferon gamma receptor 1,CD119,IMD2...	Human	HEK293 Cells
	IFNGR1 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 27.3 kDa and the accession number is A0A0S2Z3Y2.
TMPY-02355	IFNGR1 Protein, Mouse, Recombinant (His) interferon gamma receptor 1,Nktar,interferon γ receptor 1,IF...	Mouse	HEK293 Cells
	IFNGR1 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 27.4 kDa and the accession number is P15261.
TMPY-05831	IFNGR1 Protein, Human, Recombinant (hFc) IFNGR,interferon gamma receptor 1,IMD27B,CD119,inte...	Human	HEK293 Cells
	IFNGR1 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 52.51 kDa and the accession number is A0A0S2Z3Y2.
TMPY-03379	IFNGR1 Protein, Cynomolgus, Recombinant (hFc) interferon gamma receptor 1,interferon γ receptor 1	Cynomolgus	HEK293 Cells
	IFNGR1 Protein, Cynomolgus, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 52.8 kDa and the accession number is G7P327.
TMPY-03668	IFNGR1 Protein, Cynomolgus, Recombinant (His) interferon γ receptor 1,interferon gamma receptor 1	Cynomolgus	HEK293 Cells
	IFNGR1 Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 42.3 kDa and the accession number is G7P327.
TMPY-02122	IFNGR2 Protein, Mouse, Recombinant (His) interferon γ receptor 2 (interferon γ transducer 1),interfer...	Mouse	HEK293 Cells
	Interferon-gamma receptor beta chain (IFNgammaR2), also known as IFNGR2, belongs to the type II cytokine receptor family, whose deficiency is a cause of autosomal recessive mendelian susceptibility to mycobacterial disease (MSMD), also known as familial disseminated atypical mycobacterial infection. This accessory factor is an integral part of the IFN-gamma signal transduction pathway and is likely to interact with GAF, JAK1, and/or JAK2. IFNGR2 is a component of the IFNgamma receptor complex al...
TMPY-02354	IFNGR1 Protein, Mouse, Recombinant (hFc) IFN-gammaR,Ifgr,interferon γ receptor 1,IFN-γR,CD119,Nktar,<...	Mouse	HEK293 Cells
	IFNGR1 Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 53 kDa and the accession number is P15261.
TMPY-03346	IFNGR1 Protein, Rat, Recombinant (hFc) interferon gamma receptor 1,interferon γ receptor 1	Rat	HEK293 Cells
	IFNGR1 Protein, Rat, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 52.4 kDa and the accession number is Q6P6T3.
TMPH-03742	EEF1A1 Protein, Cricetulus griseus, Recombinant (His) EEF1A,Elongation factor 1-alpha 1,eEF1A-1,EF-1-alpha-1,EF-Tu...	Chinese hamster	E. coli
	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. Plays a role in the positive regulation of IFNG transcription in T-helper 1 cells as part of an IFNG promoter-binding complex with TXK and PARP1.
TMPH-01283	EEF1A1 Protein, Human, Recombinant (His) EF-1-alpha-1,EEF1A,EEF1A1,Elongation factor 1-alpha 1,EF1A,e...	Human	E. coli
	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. Plays a role in the positive regulation of IFNG transcription in T-helper 1 cells as part of an IFNG promoter-binding complex with TXK and PARP1.; (Microbial infection) Required for the translation of viral proteins and viral replication during human coronavirus SARS-CoV-2 infection.
TMPY-06983	IFN gamma Protein, Human, Recombinant (E. coli) Interferon Gamma,IFN γ,IFN gamma,IFG,IFI,干扰素,Interferon γ	Human	E. coli
	IFN gamma, also known as IFNG, is a secreted protein that belongs to the type II interferon family. IFN gamma is produced predominantly by natural killer and natural killer T cells as part of the innate immune response, and by CD4 and CD8 cytotoxic T lymphocyte effector T cells once antigen-specific immunity develops. IFN gamma has antiviral, immunoregulatory, and anti-tumor properties. IFNG, in addition to having antiviral activity, has important immunoregulatory functions, it is a potent activ...
TMPH-01284	EEF1A1 Protein, Human, Recombinant EF-Tu,LENG7,EEF1A,eEF1A-1,EF1A,EF-1-alpha-1,EEF1A1,Elongatio...	Human	E. coli
	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. Plays a role in the positive regulation of IFNG transcription in T-helper 1 cells as part of an IFNG promoter-binding complex with TXK and PARP1.; (Microbial infection) Required for the translation of viral proteins and viral replication during human coronavirus SARS-CoV-2 infection.
TMPH-01020	BTN3A1 Protein, Human, Recombinant (Yeast, His) Butyrophilin subfamily 3 member A1,BTN3A1,CD277,BTF5	Human	P. pastoris (Yeast)
	Plays a role in T-cell activation and in the adaptive immune response. Regulates the proliferation of activated T-cells. Regulates the release of cytokines and IFNG by activated T-cells. Mediates the response of T-cells toward infected and transformed cells that are characterized by high levels of phosphorylated metabolites, such as isopentenyl pyrophosphate. BTN3A1 Protein, Human, Recombinant (Yeast, His) is expressed in yeast with N-6xHis tag. The predicted molecular weight is 26.2 kDa and the...
TMPH-01021	BTN3A1 Protein, Human, Recombinant (E. coli, His) CD277,Butyrophilin subfamily 3 member A1,BTN3A1,BTF5	Human	E. coli
	Plays a role in T-cell activation and in the adaptive immune response. Regulates the proliferation of activated T-cells. Regulates the release of cytokines and IFNG by activated T-cells. Mediates the response of T-cells toward infected and transformed cells that are characterized by high levels of phosphorylated metabolites, such as isopentenyl pyrophosphate. BTN3A1 Protein, Human, Recombinant (E. coli, His) is expressed in E. coli expression system with N-10xHis tag. The predicted molecular wei...
TMPK-00090	NKp30/NCR3 Protein, Human, Recombinant (His & Avi) NKp30,1C7,MALS,CD337,LY117,NCR3	Human	HEK293 Cells
	NKp30, along with NKp44 and NKp46, constitute a group of receptors termed "Natural Cytotoxicity Receptors". These receptors play a major role in triggering NK-mediated killing of most tumor cells lines.NKp30 stimulates NK cells cytotoxicity toward neighboring cells producing these ligands. It controls, for instance, NK cells cytotoxicity against tumor cells. Engagement of NCR3 by BAG6 also promotes myeloid dendritic cells (DC) maturation, both through killing DCs that did not acquire a mature ph...
TMPH-01322	FANCC Protein, Human, Recombinant (His & SUMO) FANCC,Fanconi anemia group C protein	Human	E. coli
	DNA repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. May be implicated in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability. Upon IFNG induction, may facilitate STAT1 activation by recruiting STAT1 to IFNGR1. FANCC Protein, Human, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 79.4 kDa and the accession number is Q00597.
TMPJ-00219	BTN3A2 Protein, Human, Recombinant (His & Avi), Biotinylated BTF3,BTN3A2,Butyrophilin subfamily 3 member A2,BTF4,BT3.2	Human	HEK293 Cells
	Butyrophilin subfamily 3 member A2, also known as BT3.2, BTF3, BTF4 and BTN3A2, is a single-pass type I membrane protein. It is a member of the butyrophilin (BTN) family and the immunoglobulin (IG) superfamily. Mature human BTN3A2 is a 305 amino acid (aa) glycoprotein. It contains a 219 aa extracellular region with one V-type Ig-like domain, and a 65 aa cytoplasmic tail. The cytoplasmic region undergoes phosphorylation on two serines. There are three potential splice forms. BTN3A2 is postulated ...
TMPH-02632	TRIM21 Protein, Mouse, Recombinant (E. coli, His) Trim21,52 kDa ribonucleoprotein autoantigen Ro/SS-A,Triparti...	Mouse	E. coli
	E3 ubiquitin-protein ligase whose activity is dependent on E2 enzymes, UBE2D1, UBE2D2, UBE2E1 and UBE2E2. Forms a ubiquitin ligase complex in cooperation with the E2 UBE2D2 that is used not only for the ubiquitination of USP4 and IKBKB but also for its self-ubiquitination. Component of cullin-RING-based SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes such as SCF(SKP2)-like complexes. A TRIM21-containing SCF(SKP2)-like complex is shown to mediate ubiquitination of CDKN1B ('Thr...
TMPH-02633	TRIM21 Protein, Mouse, Recombinant (His) Tripartite motif-containing protein 21,E3 ubiquitin-protein ...	Mouse	Baculovirus Insect Cells
	E3 ubiquitin-protein ligase whose activity is dependent on E2 enzymes, UBE2D1, UBE2D2, UBE2E1 and UBE2E2. Forms a ubiquitin ligase complex in cooperation with the E2 UBE2D2 that is used not only for the ubiquitination of USP4 and IKBKB but also for its self-ubiquitination. Component of cullin-RING-based SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes such as SCF(SKP2)-like complexes. A TRIM21-containing SCF(SKP2)-like complex is shown to mediate ubiquitination of CDKN1B ('Thr...

重组蛋白

IFN gamma Protein, Sheep, Recombinant (His)

Cat.No: TMPH-03495

Species: Sheep

Expression System: P. pastoris (Yeast)

IFN gamma Protein, Marmota monax, Recombinant (His)

Cat.No: TMPH-02451

Species: Marmota monax

Expression System: P. pastoris (Yeast)

IFN gamma Protein, Goat, Recombinant (His & Myc)

Cat.No: TMPH-00775

Species: Goat

Expression System: E. coli

IFN gamma Protein, Chicken, Recombinant (GST)

Cat.No: TMPH-00373

Species: Chicken

Expression System: E. coli

IFN gamma Protein, Sheep, Recombinant (E. coli, His)

Cat.No: TMPH-03494

Species: Sheep

Expression System: E. coli

IFN gamma Protein, Human, Recombinant (His & Avi)

Cat.No: TMPK-00047

Species: Human

Expression System: HEK293 Cells

IFN gamma Protein, Human, Recombinant (His & Avi), Biotinylated

Cat.No: TMPK-00048

Species: Human

Expression System: HEK293 Cells

IFNGR1 Protein, Human, Recombinant (His)

Cat.No: TMPY-01151

Species: Human

Expression System: HEK293 Cells

IFNGR1 Protein, Mouse, Recombinant (His)

Cat.No: TMPY-02355

Species: Mouse

Expression System: HEK293 Cells

IFNGR1 Protein, Human, Recombinant (hFc)

Cat.No: TMPY-05831

Species: Human

Expression System: HEK293 Cells

IFNGR1 Protein, Cynomolgus, Recombinant (hFc)

Cat.No: TMPY-03379

Species: Cynomolgus

Expression System: HEK293 Cells

IFNGR1 Protein, Cynomolgus, Recombinant (His)

Cat.No: TMPY-03668

Species: Cynomolgus

Expression System: HEK293 Cells

IFNGR2 Protein, Mouse, Recombinant (His)

Cat.No: TMPY-02122

Species: Mouse

Expression System: HEK293 Cells

IFNGR1 Protein, Mouse, Recombinant (hFc)

Cat.No: TMPY-02354

Species: Mouse

Expression System: HEK293 Cells

IFNGR1 Protein, Rat, Recombinant (hFc)

Cat.No: TMPY-03346

Species: Rat

Expression System: HEK293 Cells

EEF1A1 Protein, Cricetulus griseus, Recombinant (His)

Cat.No: TMPH-03742

Species: Chinese hamster

Expression System: E. coli

EEF1A1 Protein, Human, Recombinant (His)

Cat.No: TMPH-01283

Species: Human

Expression System: E. coli

IFN gamma Protein, Human, Recombinant (E. coli)

Cat.No: TMPY-06983

Species: Human

Expression System: E. coli

EEF1A1 Protein, Human, Recombinant

Cat.No: TMPH-01284

Species: Human

Expression System: E. coli

BTN3A1 Protein, Human, Recombinant (Yeast, His)

Cat.No: TMPH-01020

Species: Human

Expression System: P. pastoris (Yeast)

BTN3A1 Protein, Human, Recombinant (E. coli, His)

Cat.No: TMPH-01021

Species: Human

Expression System: E. coli

NKp30/NCR3 Protein, Human, Recombinant (His & Avi)

Cat.No: TMPK-00090

Species: Human

Expression System: HEK293 Cells

FANCC Protein, Human, Recombinant (His & SUMO)

Cat.No: TMPH-01322

Species: Human

Expression System: E. coli

BTN3A2 Protein, Human, Recombinant (His & Avi), Biotinylated

Cat.No: TMPJ-00219

Species: Human

Expression System: HEK293 Cells

TRIM21 Protein, Mouse, Recombinant (E. coli, His)

Cat.No: TMPH-02632

Species: Mouse

Expression System: E. coli

TRIM21 Protein, Mouse, Recombinant (His)

Cat.No: TMPH-02633

Species: Mouse

Expression System: Baculovirus Insect Cells

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