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Search Results for " ifnb1 "

Targets Recommended: STING

3

抑制剂 & 化合物

2

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T9028	STING-IN-2 C-170	STING	Immunology/Inflammation
	STING-IN-2 (C-170) 是一种 STING 共价抑制剂，可抑制小鼠 STING (mmSTING) 和人类 STING (hsSTING)，可用于自身炎症性疾病的研究。
T80570	Dazukibart	IFNAR	Immunology/Inflammation
	Dazukibart为针对小鼠源性干扰素β1(IFNB1)设计的人源化IgG1κ单克隆抗体。
T83775	STING Agonist 12L Stimulator of Interferon Genes Agonist 12L
	STING激动剂12L是一种刺激干扰素基因(STING)的激动剂。它与野生型STING结合(IC50 = 1.15 µM)，以及STING的R232、AQ和Q变体(IC50分别为1.06、0.61和1.12 µM)，并在THP-1和RAW 264.7细胞中诱导报告基因表达(EC50分别为0.38和12.94 µM)。STING激动剂12L (5 µM)在THP-1细胞中诱导IFNB1、CXCL10和IL6 mRNA的表达。在体内，STING激动剂12L (10 mg/kg)提高了血浆IFN-β水平，并且在B16/F10小鼠黑色素瘤模型中减少了肿瘤体积和肺转移灶的数量。

化合物

Cat.No: T9028

Synonym: C-170

Target: STING

Cat.No: T80570

Target: IFNAR

STING Agonist 12L

Cat.No: T83775

Synonym: Stimulator of Interferon Genes Agonist 12L

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPH-01270	TRAIP Protein, Human, Recombinant (His) E3 ubiquitin-protein ligase TRAIP,TRAF-interacting protein,T...	Human	E. coli
	E3 ubiquitin ligase required to protect genome stability in response to replication stress. Acts as a key regulator of interstrand cross-link repair, which takes place when both strands of duplex DNA are covalently tethered together, thereby blocking replication and transcription. Controls the choice between the two pathways of replication-coupled interstrand-cross-link repair by mediating ubiquitination of MCM7 subunit of the CMG helicase complex. Short ubiquitin chains on MCM7 promote recruitm...
TMPH-02841	Prohibitin Protein, Mouse, Recombinant (His) Phb1,B-cell receptor-associated protein 32,Prohibit...	Mouse	E. coli
	Protein with pleiotropic attributes mediated in a cell-compartment- and tissue-specific manner, which include the plasma membrane-associated cell signaling functions, mitochondrial chaperone, and transcriptional co-regulator of transcription factors in the nucleus. Plays a role in adipose tissue and glucose Homeostasis in a sex-specific manner. Contributes to pulmonary vascular remodeling by accelerating proliferation of pulmonary arterial smooth muscle cells.; In the mitochondria, together with...

重组蛋白

TRAIP Protein, Human, Recombinant (His)

Cat.No: TMPH-01270

Species: Human

Expression System: E. coli

Prohibitin Protein, Mouse, Recombinant (His)

Cat.No: TMPH-02841

Species: Mouse

Expression System: E. coli

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