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Search Results for " ido1 "

Targets Recommended: IDO

56

抑制剂 & 化合物

3

天然产物

3

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T20513	IDO1-IN-1 IDO1 inhibitor 1,2 HzBTZ,2-肼基苯并噻唑,IDO1IN1,2-HzBTZ,IDO1-inhibitor-1	IDO	Metabolism
	IDO1-IN-1 (2 HzBTZ) 是一种吲哚胺 2,3-双加氧酶 1 (IDO1) 抑制剂。
T11901	IDO1-IN-5	IDO; Indoleamine 2,3-Dioxygenase (IDO)	Metabolism
	IDO1-IN-5 是可透过血脑屏障的、选择性的IDO1抑制剂，能够与缺乏血红素的 apo-IDO1 结合，但无法与成熟血红素的 IDO1 结合。
T39839	IDO1-IN-11 IDO1-IN-11	Others	Others
	IDO1-IN-11 is an IDO1 inhibitor with an IC 50 value of 0.6 nM.
T37329	PROTAC IDO1 Degrader-1 PROTAC IDO1 Degrader-1	PROTACs	PROTAC
	PROTAC IDO1 Degrader-1 is the first potent IDO1 (indoleamine 2,3-dioxygenase 1) degrader that hijacks IDO1 to CRBN E3 ligase to introduce IDO1 into UPS and eventually achieve ubiquitination and degradation (DC50=2.84 μM). PROTAC IDO1 Degrader-1 moderately improves the tumor-killing activity of H ER2 CAR-T cells[1]. PROTAC IDO1 Degrader-1 (compound 2c) (10 μM; 24 hours) notably decreases IDO1 level induced by IFN-γ[1].PROTAC IDO1 Degrader-1 and IFN-γ (5 ng/mL) are incubated with HeLa cells for 24...
T39946	IDO1-IN-12 IDO1-IN-12	Others	Others
	IDO1-IN-12 is a potent and orally available IDO1 inhibitor.
T39888	IDO1-IN-7 IDO1-IN-7	Others	Others
	IDO1-IN-7, a potent and selective indoleamine-2,3-dioxygenase-1 (IDO1) inhibitor, exhibits high potency with an IC 50 of 6.1 nM in the cellular assay (SKOV3). Apart from its inhibitory properties, IDO1-IN-7 also demonstrates immunomodulatory effects, contributing to its potential applications in cancer research.
T11624	IDO1-IN-2	IDO	Metabolism
	IDO1-IN-2 is a potent and selective IDO1 inhibitor with IC50s of 81 nM, 59 nM (mouse), and 28 nM (rat), respectively. It has anti-cancer activity.
T11625	IDO1 and HDAC1 Inhibitor	Others	Others
	IDO1 and HDAC1 Inhibitor is a dual IDO1 and HDAC1 inhibitor (IC50s: 69.0 nM and 66.5 nM).
T12668	(Rac)-IDO1-IN-5	Others	Others
	(Rac)-IDO1-IN-5 is a racemate of IDO1-IN-5, a potent, selective, and brain-penetrating inhibitor of Indoleamine 2,3-Dioxygenase 1 (IDO1) activity. It specifically binds to apo-IDO1, which lacks heme, instead of mature heme-bound IDO1.
T12801	(S)-IDO1-IN-5	Others	Others
	(S)-IDO1-IN-5 is an active S-isomer of IDO1-IN-5. (S)-IDO1-IN-5 binds to IDOL(IC50 value less than 1.5 µΜ).
T61789	IDO1-IN-14	Others	Others
	IDO1-IN-14 (compound 4a) is a highly effective inhibitor of the IDO1 enzyme, exhibiting an IC50 value of 396.9 nM. Additionally, IDO1-IN-14 demonstrates excellent suppression of cellular IDO1 activity, as observed in HeLa cells with an EC50 value of 3393 nM [1].
T60499	IDO1/TDO-IN-2	Others	Others
	IDO1/TDO-IN-2 (Compound 1) 是有效的IDO1/TDO 双重抑制剂，IC50s 分别为 0.1 和 0.07 μM，具有癌症研究的潜力。
T61385	IDO1/TDO-IN-1	Others	Others
	IDO1/TDO-IN-1 (30) is a highly effective inhibitor that targets both IDO1 and TDO enzymes with uncompetitive (Ki = 0.23 μM) and competitive (Ki = 0.73 μM) mechanisms, respectively. This compound, IDO1/TDO-IN-1 (30), exhibits a significant capacity to induce cell apoptosis via the potential mitochondria-mediated Bcl-2/Bax pathway [1].
T74507	IDO1-IN-20	Others	Others
	IDO1-IN-20是一种催化色氨酸氧化代谢的酶，能在肿瘤微环境中对肿瘤进行免疫抑制。
T60318	IDO1/TDO-IN-4	Others	Others
	IDO1/TDO-IN-4 显示出对 IDO1 (IC50 = 3.53 μM) 和 TDO (IC50 = 1.15 μM) 的有效抑制作用，并且具有可接受的安全性和药代动力学特性。IDO1/TDO-IN-4 可与 IDO1 形成氢键，与 TDO 产生 π-π 堆积相互作用。 IDO1/TDO-IN-4 可用于抑郁症以及炎症引起的抑郁症的研究。
T78795	IDO1/TDO-IN-6	Indoleamine 2,3-Dioxygenase (IDO)	Metabolism
	IDO1/TDO-IN-6（compound 11）为IDO1/TDO双重抑制剂，其IC50值分别为2.25 μM和2.89 μM。在抑制IDO1和TDO方面，其Ki值分别为1.9 μM和3.1 μM。IDO1/TDO-IN-6适用于癌症与免疫学领域的研究。
T61140	IDO1/TDO-IN-3	Others	Others
	IDO1/TDO-IN-3 is a powerful inhibitor targeting IDO1 and TDO enzymes. It displays noteworthy effectiveness against IDO1 (IC50: 0.005 μM) and TDO (IC50: 0.004 μM). Additionally, IDO1/TDO-IN-3 demonstrates considerable in vivo anti-tumor properties while exhibiting no apparent toxicity [1].
T63222	IDO1/2-IN-1	Others	Others
	IDO1/2-IN-1 是一个有效的、口服具有活力的 IDO1/IDO2 双重抑制剂，对 IDO1 和 IDO2 的IC50分别为 28 nM 和 144 nM，表现出抗肿瘤作用。
T62638	IDO1-IN-18	Others	Others
	IDO1-IN-18 (Compound 14) 是一种 IDO1 的有效抑制剂。IDO1-IN-18 具有潜力进行癌症疾病的研究。
T78975	IDO1-IN-22	Indoleamine 2,3-Dioxygenase (IDO)	Metabolism
	IDO1-IN-22（Compound 3）是一种效能显著的IDO1抑制剂，具备低纳摩尔级生化活性（hIDO1 IC50：67.4 nM）以及显著的细胞内抑制效果（HeLa细胞中hIDO1 IC50：17.6 nM）。在小鼠LLC异种移植模型中表现出卓越的抗肿瘤效果，并表现出有利的药代动力学（PK）特性。
T63651	IDO1/2-IN-1 hydrochloride	Others	Others
	IDO1/2-IN-1 hydrochloride 是一个有效的 IDO1 (IC50: 28 nM) 和 IDO2 (IC50: 144 nM) 双重抑制剂，口服具有活力。IDO1/2-IN-1 hydrochloride 表现出抗肿瘤作用。
T63780	IDO1-IN-16	Others	Others
	IDO1-IN-16 (I-1) 是一种 IDO1 抑制剂，能够靶向holo-IDO1 (IC50: 127 nM)。
T63034	IDO1-IN-13	Others	Others
	IDO1-IN-13 (compound 27a) 是一种 IDO1 的有效抑制剂 (IC50: 61.6 nM)。IDO1-IN-13 能够抑制细胞 IDO1，对 HeLa 的 EC50 值为 30 nM。在 SK-OV-3 异种移植肿瘤组织中，IDO1-IN-13 减少了 51% 的 kyn/trp 比率。
T73111	IDO1-IN-17	Others	Others
	IDO1-IN-17 (I-4) 是IDO1的抑制剂，其在 hela 细胞中的IC50值为 0.44 μM。
T63082	IDO1-IN-19	Others	Others
	IDO1-IN-19 (Compound 17) 是一种 IDO1 的有效抑制剂，具有潜力进行癌症疾病的研究。
T78687	IDO1-IN-21	Indoleamine 2,3-Dioxygenase (IDO)	Metabolism
	IDO1-IN-21（化合物10m）为IDO1抑制剂，其IC50值为0.64 μM。该化合物在小鼠体内可有效抑制肿瘤生长。
T61944	IDO1-IN-15	Others	Others
	IDO1-IN-15 是有效的IDO1抑制剂，IC50为127 nM。IDO1-IN-15与Epacadostat 在体外对抗 IDO1 酶的效力相当。
T82082	IDO1-IN-23	Indoleamine 2,3-Dioxygenase (IDO)	Metabolism
	IDO1-IN-23（化合物41）是一种有效的人类IDO1抑制剂，具备13 μM的IC50值。
T11616	IDO-IN-13 GS-4361	IDO; Indoleamine 2,3-Dioxygenase (IDO)	Metabolism
	IDO-IN-13 (GS-4361) 是 indoleamine 2,3-dioxygenase 1 抑制剂，EC50=17 nM。
T3548	Epacadostat INCB 024360,艾卡哚司他,IDO Inhibitor 1	IDO; Indoleamine 2,3-Dioxygenase (IDO)	Metabolism
	Epacadostat (INCB 024360) 是选择性的IDO1抑制剂，IC50=71.8 nM。
T4532	Linrodostat BMS-986205	IDO; Indoleamine 2,3-Dioxygenase (IDO)	Metabolism
	Linrodostat (BMS-986205) 是选择性的、不可逆的吲哚胺 2,3-双加氧酶 1(IDO1) 抑制剂，能够有效抑制 IDO1-HEK293 细胞，其IC50=1.1 nM。它在晚期癌症中具有良好的药理特性。
T2647	IDO5L INCB024360 analogue,INCB14943	IDO; Indoleamine 2,3-Dioxygenase (IDO)	Metabolism
	IDO5L (INCB024360 analogue) 是一种有效的吲哚胺-2,3-双加氧酶 (IDO) 抑制剂，IC50=67 nM。
T9164	BMS-986242 BMS986242	IDO; Indoleamine 2,3-Dioxygenase (IDO)	Metabolism
	BMS-986242 是具有口服具有活力、强效的、选择性的 indoleamine-2,3-dioxygenase 1 抑制剂，可用于研究癌症。
T1806	IDO-IN-7 NLG919,Navoximod,NLG-919 analogue,GDC-0919	Indoleamine 2,3-Dioxygenase (IDO)	Metabolism
	IDO-IN-7 (NLG-919 analogue) 是 IDO1 抑制剂，IC50=38 nM。
T4307	PF-06840003 EOS200271,PF 06840003	IDO; Indoleamine 2,3-Dioxygenase (IDO)	Metabolism
	PF-06840003 (EOS200271) 是口服具有活力的、选择性的IDO-1抑制剂，抑制 hIDO-1， dIDO-1和 mIDO-1 的IC50分别为 0.41 μM， 0.59 μM，和 1.5 μM。
T73437	DP00477	Others	Others
	DP00477，一种高效IDO1(indoleamine 2,3-dioxygenase 1)抑制剂，IC50为7.0 µM，展现在癌症研究中的潜力。
T71954	MMG-0358	Others	Others
	MMG-0358 is a novel potent IDO1 inhibitor, showing low cytotoxicity and higher selectivity for IDO1 over TDO enzyme.
T39779	BMT-297376	Others	Others
	BMT-297376, the optimized Linrodostat, is a potent IDO1 inhibitor.
T40093	IDO-IN-15	Others	Others
	IDO-IN-15 is an IDO1 inhibitor ( IC 50 < 0.51 nM).
T70361	BITMC	Others	Others
	BITMC is a novel potent IDO1 inhibitor.
T60698	Roxyl-9	Others	Others
	Roxyl-9 是一种 IDO1 (吲哚胺2,3-双加氧酶1) 抑制剂。
T71838	VIS351	Others	Others
	VIS351 is the first potent activator of the ITIM-mediated function of the IDO1 enzyme.
T4532L	Linrodostat mesylate ONO-7701,BMS-986205,ONO 7701,BMS986205,BMS 986205	Others	Others
	Linrodostat (BMS-986205, ONO-7701, and F001287) is a selective and orally active IDO1 inhibitor with potential immunomodulating and antineoplastic activities. By inhibiting IDO1 and reducing kynurenine in tumor cells, BMS-986205 restores and promotes the
T28175	Nitrobenzofuroxan NSC 228079,NSC-228079,B-2789,B 2789,B2789	Others	Others
	Nitrobenzofuroxan, is a HIV-1 and IDO1 inhibitor.
T74992	NU223612	Others	Others
	NU223612 是一种有效的PROTAC(PROTACs)，可降解吲哚胺 2,3-双加氧酶 1 (IDO1) (Indoleamine 2,3-Dioxygenase (IDO))，Kd 为 640 nM。NU223612 通过CRBN 介导的蛋白酶体降解有效降解IDO1蛋白。NU223612 以 290 nM 的亲和力与 CRBN 结合。NU223612 可以穿过血脑屏障 (BBB)。
T78235	4-Phenyl-1H-1,2,3-triazole	Indoleamine 2,3-Dioxygenase (IDO)	Metabolism
	4-Phenyl-1H-1,2,3-triazole，一种IDO1抑制剂（IC50：60 μM），可应用于癌症研究。
T79189	1-Isopropyltryptophan 1-IsoPT	Indoleamine 2,3-Dioxygenase (IDO)	Metabolism
	1-Isopropyltryptophan (1-IsoPT)为IDO1抑制剂，能够抑制IFN-γ刺激下IDO-1与IDO-2 mRNA的表达水平。
T71289	9-O-Demethyltrigonostemone	Others	Others
	9-O-Demethyltrigonostemone is a natural IDO1 inhibitor, cytotoxic and antiplasmodial agent from the Roots of Strophioblachia fimbricalyx.
T62326	NUCC-0223619	Others	Others
	NUCC-0223619 是一种 IDO1 抑制剂，能够诱导 IDO 蛋白降解，可参与 PROTAC 的合成。
T40148	Pom-8PEG	Others	Others
	Pom-8PEG is an E3 ubiquitin ligase ligand-linker conjugate consisting of a cereblon (CRBN) ligand and an 8-unit PEG linker. This compound can be utilized for the synthesis of PROTAC, including the IDO1 PROTAC degrader.

化合物

Cat.No: T20513

Synonym: IDO1 inhibitor 1,2 HzBTZ,2-肼基苯并噻唑,IDO1IN1,2-HzBTZ,IDO1-inhibitor-1

Target: IDO

Cat.No: T11901

Target: IDO, Indoleamine 2,3-Dioxygenase (IDO)

Cat.No: T39839

Synonym: IDO1-IN-11

Target: Others

PROTAC IDO1 Degrader-1

Cat.No: T37329

Synonym: PROTAC IDO1 Degrader-1

Target: PROTACs

Cat.No: T39946

Synonym: IDO1-IN-12

Target: Others

Cat.No: T39888

Synonym: IDO1-IN-7

Target: Others

Cat.No: T11624

Target: IDO

IDO1 and HDAC1 Inhibitor

Cat.No: T11625

Target: Others

(Rac)-IDO1-IN-5

Cat.No: T12668

Target: Others

(S)-IDO1-IN-5

Cat.No: T12801

Target: Others

Cat.No: T61789

Target: Others

IDO1/TDO-IN-2

Cat.No: T60499

Target: Others

IDO1/TDO-IN-1

Cat.No: T61385

Target: Others

Cat.No: T74507

Target: Others

IDO1/TDO-IN-4

Cat.No: T60318

Target: Others

IDO1/TDO-IN-6

Cat.No: T78795

Target: Indoleamine 2,3-Dioxygenase (IDO)

IDO1/TDO-IN-3

Cat.No: T61140

Target: Others

Cat.No: T63222

Target: Others

Cat.No: T62638

Target: Others

Cat.No: T78975

Target: Indoleamine 2,3-Dioxygenase (IDO)

IDO1/2-IN-1 hydrochloride

Cat.No: T63651

Target: Others

Cat.No: T63780

Target: Others

Cat.No: T63034

Target: Others

Cat.No: T73111

Target: Others

Cat.No: T63082

Target: Others

Cat.No: T78687

Target: Indoleamine 2,3-Dioxygenase (IDO)

Cat.No: T61944

Target: Others

Cat.No: T82082

Target: Indoleamine 2,3-Dioxygenase (IDO)

Cat.No: T11616

Synonym: GS-4361

Target: IDO, Indoleamine 2,3-Dioxygenase (IDO)

Cat.No: T3548

Synonym: INCB 024360,艾卡哚司他,IDO Inhibitor 1

Target: IDO, Indoleamine 2,3-Dioxygenase (IDO)

Cat.No: T4532

Synonym: BMS-986205

Target: IDO, Indoleamine 2,3-Dioxygenase (IDO)

Cat.No: T2647

Synonym: INCB024360 analogue,INCB14943

Target: IDO, Indoleamine 2,3-Dioxygenase (IDO)

Cat.No: T9164

Synonym: BMS986242

Target: IDO, Indoleamine 2,3-Dioxygenase (IDO)

Cat.No: T1806

Synonym: NLG919,Navoximod,NLG-919 analogue,GDC-0919

Target: Indoleamine 2,3-Dioxygenase (IDO)

Cat.No: T4307

Synonym: EOS200271,PF 06840003

Target: IDO, Indoleamine 2,3-Dioxygenase (IDO)

Cat.No: T73437

Target: Others

Cat.No: T71954

Target: Others

Cat.No: T39779

Target: Others

Cat.No: T40093

Target: Others

Cat.No: T70361

Target: Others

Cat.No: T60698

Target: Others

Cat.No: T71838

Target: Others

Linrodostat mesylate

Cat.No: T4532L

Synonym: ONO-7701,BMS-986205,ONO 7701,BMS986205,BMS 986205

Target: Others

Nitrobenzofuroxan

Cat.No: T28175

Synonym: NSC 228079,NSC-228079,B-2789,B 2789,B2789

Target: Others

Cat.No: T74992

Target: Others

4-Phenyl-1H-1,2,3-triazole

Cat.No: T78235

Target: Indoleamine 2,3-Dioxygenase (IDO)

1-Isopropyltryptophan

Cat.No: T79189

Synonym: 1-IsoPT

Target: Indoleamine 2,3-Dioxygenase (IDO)

9-O-Demethyltrigonostemone

Cat.No: T71289

Target: Others

Cat.No: T62326

Target: Others

Cat.No: T40148

Target: Others

Cat. No.	Product Name	Target	Signaling Pathways
T3S1967	(S)-Indoximod N-ME-Tryptophan,Abrine,相思豆碱,L-Abrine	Others; Indoleamine 2,3-Dioxygenase (IDO)	Metabolism; Others
	(S)-Indoximod (L-Abrine) 是一种吲哚胺-2,3-双加氧酶 (IDO) 抑制剂，可用于研究癌症。
T6407	β-Lapachone 3,4-二氢-2,2-二甲基-2H-萘并[1,2-B]吡喃-5,6-二酮,Beta-Lapachone,NSC-26326,SL-11001,ARQ-501	IDO; Apoptosis; Topoisomerase; Autophagy	Apoptosis; Autophagy; DNA Damage/DNA Repair; Metabolism
	β-Lapachone (ARQ-501) 是一种萘醌类天然产物，是拓扑异构酶 I 抑制剂，通过抑制细胞周期进程来诱导细胞凋亡。
T8214	Kushenol E 苦参醇E,Flemiphilippinin D	IDO; Indoleamine 2,3-Dioxygenase (IDO)	Metabolism
	Kushenol E (Flemiphilippinin D) 是一种分离自Sophora flavescens 中的类黄酮，是一种IDO1的非竞争性抑制剂，其IC50=7.7 µM，Ki=为 9.5 µM，具有抗肿瘤特性。

天然产物

Cat.No: T3S1967

Synonym: N-ME-Tryptophan,Abrine,相思豆碱,L-Abrine

Target: Others, Indoleamine 2,3-Dioxygenase (IDO)

Cat.No: T6407

Synonym: 3,4-二氢-2,2-二甲基-2H-萘并[1,2-B]吡喃-5,6-二酮,Beta-Lapachone,NSC-26326,SL-11001,ARQ-501

Target: IDO, Apoptosis, Topoisomerase, Autophagy

Cat.No: T8214

Synonym: 苦参醇E,Flemiphilippinin D

Target: IDO, Indoleamine 2,3-Dioxygenase (IDO)

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-01821	IDO Protein, Human, Recombinant (His) IDO,indoleamine 2,3-dioxygenase 1,Indoleam...	Human	E. coli
	IDO Protein, Human, Recombinant (His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 46 kDa and the accession number is P14902-1.
TMPY-02928	IDO Protein, Human, Recombinant IDO-1,Indoleamine 2,3‑dioxygenase,indoleam...	Human	E. coli
	IDO Protein, Human, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 45.2 kDa and the accession number is A0A348GSI3.
TMPY-02803	IDO2 Protein, Human, Recombinant (His) indoleamine 2,3-dioxygenase 2,INDOL1	Human	E. coli
	IDO2 belongs to the indoleamine 2,3-dioxygenase family. Indoleamine 2,3-dioxgyenase (IDO), is a cytosolic haem protein which, together with the hepatic enzyme tryptophan 2,3-dioxygenase, catalyzes the conversion of tryptophan and other indole derivatives to kynurenines. In addition to classic IDO (IDO1), a new variant, IDO2, has recently been described. IDO2 is expressed in the liver, small intestine, spleen, placenta, thymus, lung, brain, kidney, and colon. IDO is widely distributed in human ti...

重组蛋白

IDO Protein, Human, Recombinant (His)

Cat.No: TMPY-01821

Species: Human

Expression System: E. coli

IDO Protein, Human, Recombinant

Cat.No: TMPY-02928

Species: Human

Expression System: E. coli

IDO2 Protein, Human, Recombinant (His)

Cat.No: TMPY-02803

Species: Human

Expression System: E. coli

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