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Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T2968L |
Hyodeoxycholic acid sodium salt
Sodium hyodeoxycholate,HDCA sodium |
Others | Others |
Hyodeoxycholic acid sodium salt is a natural secondary bile acid. It improves high-density lipoprotein function, reduces farnesoid X receptor antagonist bile acids, and induces strong cytotoxicity, apoptosis, and IL-8 synthesis. | |||
T37178 |
Norhyodeoxycholic Acid
|
Others | Others |
Norhyodeoxycholic acid (NHDCA) is a synthetic bile acid and a derivative of hyodeoxycholic acid .1,2 NHDCA is an intermediate in the synthesis of 3β-sulfooxy-7β-hydroxy-24-nor-5-cholen-23-oic acid, which has been used as an internal standard for the quantification of δ5-bile acid conjugates that have been identified in patients with Niemann-Pick disease type C1.3 |1. Schteingart, C.D., and Hofmann, A.F. Synthesis of 24-nor-5β-cholan-23-oic acid derivatives: A convenient and efficient one-carbon ... |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T2968 |
Hyodeoxycholic acid
NSC 60672,猪去氧胆酸,α-Hyodeoxycholic Acid,HDCA |
FXR; Endogenous Metabolite; GPCR19 | GPCR/G Protein; Metabolism |
Hyodeoxycholic acid (NSC 60672) 是由肠道菌群在小肠中形成的次级胆汁酸,是TGR5(GPCR19)的激动剂, CHO 细胞中的EC50=31.6 µM。它已用于研究高胆固醇血症的治疗。 | |||
T8153 |
glycohyodeoxycholic acid
|
Others; Endogenous Metabolite | Metabolism; Others |
Glycohyodeoxycholic acid 是一种人体次级胆汁酸猪去氧胆酸的主要代谢物,能够预防胆结石的形成。 | |||
T37770 |
Taurohyodeoxycholic acid
|
Others | Others |
Taurohyodeoxycholic acid (THDCA) is a taurine-conjugated form of the secondary bile acid hyodeoxycholic acid .1THDCA decreases the size and weight of human gallstonesin vitro. It increases bile flow, biliary cholesterol secretion, and biliary lipid secretion in rats.2Co-administration of THDCA with taurochenodeoxycholic acid prevents TCDCA-induced hepatotoxicity, increasing bile flow as well as biliary acid and phospholipid secretion in rats.3THDCA also reduces myeloperoxidase activity, expressi... |