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Search Results for " histone deacetylase 6 "

Targets Recommended: Apoptosis HDAC

15

抑制剂 & 化合物

14

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T2489	Ricolinostat ACY-1215,Rocilinostat	Apoptosis; HDAC	Apoptosis; Chromatin/Epigenetic; DNA Damage/DNA Repair
	Ricolinostat (Rocilinostat) 是一种选择性HDAC6抑制剂，IC50为 5 nM。它还抑制HDAC1，HDAC2和HDAC3，IC50分别为 58，48 和 51 nM。
T69753	HDAC6 degrader 9c	HDAC	Chromatin/Epigenetic; DNA Damage/DNA Repair
	HDAC6 degrader 9c 是一种小分子组蛋白脱乙酰酶 6 （HDAC6）降解剂，可用于研究癌症或其他疾病。
T37427	(2R/S)-6-PNG 6-Prenylnaringenin,(±)-6-Prenylnaringenin	Calcium Channel; HDAC	Chromatin/Epigenetic; DNA Damage/DNA Repair; Membrane transporter/Ion channel; Metabolism
	(2R/S)-6-PNG (6-Prenylnaringenin) 是新型天然组蛋白脱乙酰酶抑制剂，具有抗癌抗肿瘤活性，可阻断T型钙通道可减轻小鼠的神经性和内脏疼痛。
T73515	MC2590	Apoptosis; HDAC	Apoptosis; Chromatin/Epigenetic; DNA Damage/DNA Repair
	MC2590 是一种具有有效性和选择性的组蛋白脱乙酰酶 (HDAC) 抑制剂，抑制 HDAC1-3、-6、-8 和 -10 的活性，诱导细胞周期停滞，促进细胞凋亡。
T16962	SW-100	HDAC	Chromatin/Epigenetic; DNA Damage/DNA Repair
	SW-100 是一种选择性组蛋白去乙酰化酶 6 抑制剂，IC50为2.3 nM。它有提高的穿过血脑屏障的能力，相对于其他 HDAC 同工酶，还显示出对 HDAC6 的至少高 1000 倍的选择性。
T1583	Vorinostat MK0683,伏立诺他,suberoylanilide hydroxamic acid,SAHA	Apoptosis; Mitophagy; Virus Protease; HDAC; Autophagy	Apoptosis; Autophagy; Chromatin/Epigenetic; DNA Damage/DNA Repair; Microbiology/Virology
	Vorinostat (SAHA) 是一种泛的组蛋白脱乙酰酶 (HDAC) 抑制剂 (IC50=10 nM)，对 HDAC1/2/3/6/7/11 均有抑制活性。 Vorinostat 具有抗肿瘤活性，可以诱导细胞分化，阻滞细胞周期，诱导细胞凋亡。
T82226	HDAC6-IN-21	HDAC	Chromatin/Epigenetic; DNA Damage/DNA Repair
	HDAC6-IN-21（化合物13）为一种靶向组蛋白去乙酰化酶6（histone deacetylase 6（HDAC6））的不可逆抑制剂。
T82225	HDAC6-IN-24	HDAC	Chromatin/Epigenetic; DNA Damage/DNA Repair
	HDAC6-IN-24（化合物N1）是一种HDAC6抑制剂。
T61337	PTG-0861	Others	Others
	PTG-0861 is a highly specific inhibitor of histone deacetylase 6 (HDAC6), demonstrating an impressive IC50 value of 5.92 nm. This compound effectively triggers apoptosis and holds potential for research pertaining to acute myeloid leukemia, multiple myeloma, and other hematological cancers [1].
T29007	Trichostatin A S-isomer (-)-Trichostatin A	Others	Others
	Trichostatin A S-isomer is the s-isomer of Trichostatin A. Trichostatin A is a histone deacetylase inhibitors (HDIs or HDACIs) that have a broad spectrum of epigenetic activities. Trichostatin A inhibits HDACs 1, 3, 4, 6 and 10 with IC50 values around 20
T36625	LSD1/HDAC6-IN-1 LSD1/HDAC6-IN-1	Others	Others
	LSD1/HDAC6-IN-1 is an orally active compound that functions as a dual inhibitor, targeting lysine specific demethylase 1 (LSD1) and histone deacetylase 6 (HDAC6). This compound demonstrates promising anti-tumor activity and is particularly valuable for research focused on multiple myeloma (MM) [1].
T73043	HDAC6-IN-15	Others	Others
	HDAC6-IN-15 是一种选择性组蛋白脱乙酰酶 6(HDAC6)抑制剂。HDAC6-IN-15 对 HDAC6具有有效的抑制活性，IC50值为 38.2 nM。HDAC6-IN-15 可用于癌症和神经退行性疾病的研究。
T78768	HDAC6-IN-16	HDAC	Chromatin/Epigenetic; DNA Damage/DNA Repair
	HDAC6-IN-16（compound 5c）是基于Quinazolin-4(3H)-One的一种HDAC6抑制剂，具备抑制肿瘤细胞集落形成的抗癌活性。该化合物能够引发G2期细胞周期阻滞并诱导细胞凋亡(apoptosis)。
T37068	NR-160	Others	Others
	NR-160 is an inhibitor of histone deacetylase 6 (HDAC6; IC50= 0.03 μM).1It is selective for HDAC6 over HDAC1, -2, -3, -4, and -8 (IC50s = 5.18, 2.26, 8.48, 55.4, and 14.7 μM, respectively). NR-160 is cytotoxic against a panel of seven cancer cell lines (IC50s = 22.5-51.8 μM). It enhances cytotoxicity induced by bortezomib in HL-60 cells, as well as cytotoxicity induced by epirubicin or daunorubicin in CCRF-HSB-2 T cell acute lymphoblastic leukemia cells.
T36629	Givinostat	Others	Others
	Givinostat (ITF-2357) is a HDAC inhibitor with an IC50 of 198 and 157 nM for HDAC1 and HDAC3, respectively. Givinostat (ITF2357) suppresses total LPS-induced IL-1β production robustly compared with the reduction by ITF3056. At 25, 50, and 100 nM, Givinostat reduced IL-1β secretion more than 70%. Givinostat (ITF-2357) suppresses the production of IL-6 in PBMCs stimulated with TLR agonists as well as the combination of IL-12 plus IL-18. IL-6 secretion decreases to 50% at 50 nM Givinostat, but at 1...

化合物

Cat.No: T2489

Synonym: ACY-1215,Rocilinostat

Target: Apoptosis, HDAC

HDAC6 degrader 9c

Cat.No: T69753

Target: HDAC

Cat.No: T37427

Synonym: 6-Prenylnaringenin,(±)-6-Prenylnaringenin

Target: Calcium Channel, HDAC

Cat.No: T73515

Target: Apoptosis, HDAC

Cat.No: T16962

Target: HDAC

Cat.No: T1583

Synonym: MK0683,伏立诺他,suberoylanilide hydroxamic acid,SAHA

Target: Apoptosis, Mitophagy, Virus Protease, HDAC, Autophagy

Cat.No: T82226

Target: HDAC

Cat.No: T82225

Target: HDAC

Cat.No: T61337

Target: Others

Trichostatin A S-isomer

Cat.No: T29007

Synonym: (-)-Trichostatin A

Target: Others

LSD1/HDAC6-IN-1

Cat.No: T36625

Synonym: LSD1/HDAC6-IN-1

Target: Others

Cat.No: T73043

Target: Others

Cat.No: T78768

Target: HDAC

Cat.No: T37068

Target: Others

Cat.No: T36629

Target: Others

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-01333	HDAC8 Protein, Human, Recombinant (GST) histone deacetylase 8,CDA07,MRXS6...	Human	Baculovirus Insect Cells
	HDAC8 Protein, Human, Recombinant (GST) is expressed in Baculovirus insect cells with GST tag. The predicted molecular weight is 68 kDa and the accession number is Q9BY41-1.
TMPH-01474	HDAC6 Protein, Human, Recombinant (His) Protein deacetylase HDAC6,Histone...	Human	E. coli
	HDAC6 Protein, Human, Recombinant (His) is expressed in E. coli.
TMPJ-00567	NCR1 Protein, Human, Recombinant (hFc) hNKp46,Natural cytotoxicity triggering receptor 1,N...	Human	HEK293 Cells
	Natural cytotoxicity triggering receptor 1(NCR1) is a single-pass type I membrane protein .It contains 2 Ig-like (immunoglobulin-like) domains and belongs to the natural cytotoxicity receptor (NCR) family. The protein is a natural killer (NK) lymphocyte-activating receptor. It is involved in major aspects of NK immune function and shows a high degree of lineage specificity in blood and bone marrow.
TMPY-03128	LAIR1 Protein, Mouse, Recombinant (hFc) leukocyte-associated immunoglobulin-like receptor 1,BB1152	Mouse	HEK293 Cells
	LAIR1 Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 39.6 kDa and the accession number is Q8BG84-6.
TMPJ-00827	Tau-D Protein, Human, Recombinant (His) PHF-Tau,MAPTL,MAPT,Paired Helical Filament-Tau,Microtubule-A...	Human	E. coli
	Microtubule-Associated Protein TAU is abundantly expressed in neurons of the central nervous system and less commonly expressed elsewhere, but is also expressed at very low levels in CNS astrocytes and oligodendrocytes. Tau interacts with tubulin to stabilize microtubules and promotes tubulin assembly into microtubules. The C-terminus of TAU binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau acts as a linker protein. When tau is defective,...
TMPY-05798	VEGF145 Protein, Human, Recombinant 血管内皮生长因子,vascular endothelial growth factor A,VPF,MVCD1,VEGF...	Human	HEK293 Cells
	VEGF145 Protein, Human, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 16.92 kDa and the accession number is P15692-6.
TMPY-04277	CD45 Protein, Mouse, Recombinant (hFc) Cd45,protein tyrosine phosphatase, receptor type, C,Ly-5,L-C...	Mouse	HEK293 Cells
	CD45 Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 71.7 kDa and the accession number is P06800-6.
TMPY-02600	NRG1 beta 1 Protein, Human, Recombinant (EGF Domain, hFc) neuregulin 1,HRGA,NRG1 β1,HGL,MST131,MSTP131,HRG,ARIA,NDF,GG...	Human	HEK293 Cells
	NRG1 beta 1 Protein, Human, Recombinant (EGF Domain, hFc) is expressed in HEK293 mammalian cells with Fc tag. The predicted molecular weight is 36.7 kDa and the accession number is Q02297-6.
TMPY-02705	NRG1 beta 1 Protein, Human, Recombinant (hFc) MSTP131,HRG1,NRG1-IT2,ARIA,HGL,SMDF,GGF,HRG,NDF,MST131,neure...	Human	HEK293 Cells
	NRG1 beta 1 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with Fc tag. The predicted molecular weight is 55.2 kDa and the accession number is Q02297-6.
TMPY-03010	NRG1 beta 1 Protein, Human, Recombinant NDF,GGF,MSTP131,Neuregulin 1,MST131,ARIA,NRG1-IT2,SMDF,NRG1 ...	Human	HEK293 Cells
	NRG1 beta 1 Protein, Human, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 26.8 kDa and the accession number is Q02297-6.
TMPK-00614	NKp46/NCR1 Protein, Human, Recombinant (His) NKp46,MAR-1,Ly94,NCR1,NKP46FLJ99094,CD335	Human	HEK293 Cells
	NKp46, along with NKp30 and NKp44, are activating receptors that have been collectively termed the natural cytotoxicity receptors (NCR).These receptors lack significant sequence homology to one another. They are expressed almost exclusively by NK cells and play a major role in triggering some of the key lytic activities of NK cells. NKp46/NCR1 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with N-His tag. The predicted molecular weight is 27.5 kDa and the accession numb...
TMPK-00615	NKp46/NCR1 Protein (Primary Amine Labeling), Human, Recombinant (His), Biotinylated CD335,NCR1,NKp46,NKP46FLJ99094,Ly94,MAR-1	Human	HEK293 Cells
	NKp46, along with NKp30 and NKp44, are activating receptors that have been collectively termed the natural cytotoxicity receptors (NCR).These receptors lack significant sequence homology to one another. They are expressed almost exclusively by NK cells and play a major role in triggering some of the key lytic activities of NK cells. NKp46/NCR1 Protein (Primary Amine Labeling), Human, Recombinant (His), Biotinylated is expressed in HEK293 mammalian cells with N-His tag. The predicted molecular we...
TMPK-01364	SIRP alpha V6 Protein, Human, Recombinant (His & Avi), Biotinylated SIRP α,MFR,SHPS1,SIRPA,BIT,SHPS-1,MYD-1,SIRP alpha,P84,CD172...	Human	HEK293 Cells
	Signal regulatory protein α (SIRPα) is a regulatory membrane glycoprotein from SIRP family expressed mainly by myeloid cells and also by stem cells or neurons.SIRPα acts as inhibitory receptor and interacts with a broadly expressed transmembrane protein CD47 also called the "don´t eat me" signal.Cancer cells highly expressed CD47 that activate SIRP α and inhibit macrophage-mediated destruction. SIRP alpha V6 Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian c...
TMPK-01358	SIRP alpha V6 Protein, Human, Recombinant (His & Avi) P84,SIRPA,SIRP alpha,SHPS-1,MFR,BIT,MYD1,SIRP α V6,...	Human	HEK293 Cells
	Signal regulatory protein α (SIRPα) is a regulatory membrane glycoprotein from SIRP family expressed mainly by myeloid cells and also by stem cells or neurons.SIRPα acts as inhibitory receptor and interacts with a broadly expressed transmembrane protein CD47 also called the "don´t eat me" signal.Cancer cells highly expressed CD47 that activate SIRP α and inhibit macrophage-mediated destruction. SIRP alpha V6 Protein, Human, Recombinant (His & Avi) is expressed in HEK293 mammalian cells with C-Hi...

重组蛋白

HDAC8 Protein, Human, Recombinant (GST)

Cat.No: TMPY-01333

Species: Human

Expression System: Baculovirus Insect Cells

HDAC6 Protein, Human, Recombinant (His)

Cat.No: TMPH-01474

Species: Human

Expression System: E. coli

NCR1 Protein, Human, Recombinant (hFc)

Cat.No: TMPJ-00567

Species: Human

Expression System: HEK293 Cells

LAIR1 Protein, Mouse, Recombinant (hFc)

Cat.No: TMPY-03128

Species: Mouse

Expression System: HEK293 Cells

Tau-D Protein, Human, Recombinant (His)

Cat.No: TMPJ-00827

Species: Human

Expression System: E. coli

VEGF145 Protein, Human, Recombinant

Cat.No: TMPY-05798

Species: Human

Expression System: HEK293 Cells

CD45 Protein, Mouse, Recombinant (hFc)

Cat.No: TMPY-04277

Species: Mouse

Expression System: HEK293 Cells

NRG1 beta 1 Protein, Human, Recombinant (EGF Domain, hFc)

Cat.No: TMPY-02600

Species: Human

Expression System: HEK293 Cells

NRG1 beta 1 Protein, Human, Recombinant (hFc)

Cat.No: TMPY-02705

Species: Human

Expression System: HEK293 Cells

NRG1 beta 1 Protein, Human, Recombinant

Cat.No: TMPY-03010

Species: Human

Expression System: HEK293 Cells

NKp46/NCR1 Protein, Human, Recombinant (His)

Cat.No: TMPK-00614

Species: Human

Expression System: HEK293 Cells

NKp46/NCR1 Protein (Primary Amine Labeling), Human, Recombinant (His), Biotinylated

Cat.No: TMPK-00615

Species: Human

Expression System: HEK293 Cells

SIRP alpha V6 Protein, Human, Recombinant (His & Avi), Biotinylated

Cat.No: TMPK-01364

Species: Human

Expression System: HEK293 Cells

SIRP alpha V6 Protein, Human, Recombinant (His & Avi)

Cat.No: TMPK-01358

Species: Human

Expression System: HEK293 Cells

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