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Search Results for " hedgehog signaling pathway "

Targets Recommended: Hedgehog/Smoothened

21

抑制剂 & 化合物

2

天然产物

1

化合物库

1

重组蛋白

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Cat. No.	Product Name
L4300	Wnt/Hedgehog/Notch 通路化合物库		237 compounds
	237 个Wnt & Hedgehog & Notch 靶点相关的生物活性小分子化合物的特有集合，用于相关通路的研究及药物的筛选，可用于高通量、高内涵筛选。

化合物库

Wnt/Hedgehog/Notch 通路化合物库

Cat.No: L4300

Compounds: 237

Cat. No.	Product Name	Target	Signaling Pathways
T15019	CUR61414	Hedgehog/Smoothened	GPCR/G Protein; Stem Cells
	CUR61414 是 Hedgehog 信号通路的细胞渗透性抑制剂 (IC50 = 100-200 nM)，并选择性地结合 smoothened (Ki = 44 nM)。
T3156	Ciliobrevin A Hedgehog Pathway Inhibitor 4,HPI-4	Hedgehog/Smoothened	GPCR/G Protein; Stem Cells
	Ciliobrevin A (HPI-4) 是Hedgehog(Hh) 信号通路抑制剂，平均抑制浓度 (IC50) 值小于 10 μM。
T22089	HPI 1	Hedgehog/Smoothened	GPCR/G Protein; Stem Cells
	HPI 1 是一种刺猬 (Hh) 信号抑制剂。在 Shh-LIGHT2 细胞中抑制 Sonic Hedgehog (Shh)-、SAG- 和 Gli 诱导的 Hh 通路激活（Shh-、SAG-、Gli2- 和 Gli1 诱导的激活的 IC50 值为 1.5、1.5、4 和 6 μM） .
T64351	GI-560192 RL-0070933	Smo	Stem Cells
	GI-560192 (RL-0070933) 是一种有效的纤毛调节剂。GI-560192 通过 hedgehog 信号通路调节 smoothed (Smo) 向初级纤毛的易位和/或积累。
T1779	SAG Smoothened Agonist (SAG) HCl,Smoothened Agonist	Hedgehog/Smoothened; Smo	GPCR/G Protein; Stem Cells
	SAG (Smoothened Agonist) 是一种 Smo 受体激动剂 (EC50=3 nM)，具有细胞渗透性和选择性。SAG 可以直接结合 Smo 螺旋束调节 Smo 活性，可以活化 Hedgehog 信号通路。
T15019L	CUR61414 hydrochloride CUR61414 hydrochloride (334998-36-6 Free base)	Hedgehog/Smoothened	GPCR/G Protein; Stem Cells
	CUR61414 hydrochloride 是属于氨基脯氨酸类化合物的小分子。CUR61414 hydrochloride 是一种细胞渗透性的 Hedgehog 信号通路抑制剂(IC50= 100-200 nM)，可选择性结合 Smoothened (Smo, Ki= 44 nM)。CUR61414 hydrochloride 可以诱导癌细胞凋亡 (apoptosis) 而不影响非癌症细胞。
T40465	SAG dihydrochloride	Hedgehog/Smoothened	GPCR/G Protein; Stem Cells
	SAG dihydrochloride 是一种强效的 Smoothened（Smo）受体激动剂（EC 50 =3 nM；K d =59 nM）。SAG dihydrochloride 可激活刺猬信号通路并抵消环丙胺对 Smo 的抑制。
T5465	PF-5274857 PF-5274857 freebase	Smo	Stem Cells
	PF-5274857 (PF-5274857 free base) freebase 是有效的、具有口服活性的、选择性的、可透过血脑屏障的 Smo 拮抗剂，其 IC50=5.8 nM，Ki=4.6 nM。它有用于包括激活的 Hh 途径驱动的脑肿瘤和脑转移在内的多种肿瘤的研究潜力。
T16843	Saridegib IPI-926,Patidegib	Others	Others
	Saridegib is an effective and specific inhibitor of Smoothened and a key signaling transmembrane protein in the Hedgehog pathway.
T71455	Glasdegib hydrochloride	Others	Others
	Glasdegib hydrochloride is a small-molecule inhibitor of the Hedgehog (Hh) signaling pathway with potential antineoplastic activity.
T79055	Hedgehog IN-2	Others	Others
	HedgehogIN-2 (Compound 20)为一Hedgehog信号通路抑制剂，其在C3H10T1/2细胞中表现出低于0.003 μM的IC50值。
T3363L	Jervine HCl Jervine hydrochloride	Others	Others
	Jervine is a naturally occurring steroidal alkaloid derived from the Veratrum plant species. Over the Hedgehog signaling pathway, Jervine effectively inhibits tumor growth using three human tumor xenograft models. Jervine has the potential to advance to t
T71338	Patidegib HCl	Others	Others
	Patidegip, laos known as Saridegib and IPI-926, is an orally bioavailable, cyclopamine-derived (for structure comparison see Fig 1) inhibitor of the Hedgehog (Hh) pathway with potential antineoplastic activity. Specifically, Hedgehog pathway inhibitor IPI-926 binds to and inhibits the cell membrane-spanning G-protein coupled receptor SMO, which may result in the suppression of Hh pathway signaling and a decrease in tumor cell proliferation and survival. SMO is activated upon binding of Hh ligan...
T28388	PF-5274857 mseylate (1373615-35-0 free base) PF5274857 HCl,PF 5274857,PF-5274857,PF-5274857 mesylate,PF-5274857 mseylate	Others	Others
	PF-5274857 is a potent, orally active and selective inhibitor of hedgehog (Hh) signaling pathway (IC50 = 5.8 nM, Ki = 4.6 nM) . PF-5274857 effectively penetrates the blood-brain barrier and inhibits Smo activity in the brain of primary medulloblastoma mic
T71520	LEQ-506	Others	Others
	LEQ506, also known as NPV-LEQ506, is an orally bioavailable small-molecule Smoothened (Smo) antagonist with potential antineoplastic activity. Smoothened antagonist LEQ506 selectively binds to the Hedgehog (Hh)-ligand cell surface receptor Smo, which may result in the suppression of the Hh signaling pathway, thereby inhibiting tumor cell growth.
T38767	MRT-83 hydrochloride	Others	Others
	MRT-83 (hydrochloride) is a potent antagonist of the Smoothened (Smo) receptor, effectively inhibiting the Hedgehog (Hh) signaling pathway and BODIPY-cyclopamine binding to human Smo. With its potential applications in the study of cancer disease, MRT-83 (hydrochloride) demonstrates promising prospects for research purposes.
T40755	Glabrescione B	Others	Others
	Glabrescione B is a novel compound that specifically binds to Gli1, an important modulator of the Hedgehog (Hh) signaling pathway. By disrupting the Gli1-DNA interaction, Glabrescione B effectively impairs the activity of Gli1. Moreover, Glabrescione B demonstrates potent inhibitory effects on the growth of tumor cells that rely on Hedgehog signaling, as well as on the self-renewal capacity and clonogenicity of tumor-derived stem cells.
T63387	SMO-IN-3	Others	Others
	SMO-IN-3 是 smoothened (SMO) 对有效抑制剂，能够作用于 hedgehog (Hh) 信号通路 (IC50: 34.09 nM)。SMO-IN-3 能够抑制人髓母细胞瘤细胞系 Daoy 的增殖，表现出抗癌作用。
T35538	HPI-1 (hydrate) HPI-1 hydrate	Others	Others
	HPI-1 (hydrate) is a Hedgehog (Hh) pathway inhibitor that suppresses signaling through Sonic Hh (IC50= 1.5 μM) without significantly affecting Wnt signaling (IC50≥ 30 μM).1HPI-1 suppresses Hh activation induced by loss of Suppressor of Fused or by Gli overexpression, suggesting action at posttranslational modification of Gli protein or at the interaction of Gli with a co-factor.1HPI-1 (hydrate) also inhibits signaling through the oncogenic Smoothened (Smo) mutant SmoM2 in neuron precursors, prev...
T35539	IHR-Cy3 IHR-Cy3	Others	Others
	Potent fluorescent Smo antagonist (IC50 = 100 nM). Non-fluorescent analog also available. Fan et al (2014) The Hedgehog pathway effector smoothened exhibits signaling competency in the absence of ciliary accumulation. Chem.Biol. 21 1680 PMID:25484239
T22077	Eggmanone	Others	Others
	Eggmanone (EGM1) 是一种有效的、选择性的磷酸二酯酶 4(PDE4)拮抗剂，对 PDE4D3 的 IC50为 72 nM。Eggmanone 对 PDE4D3 的选择性大约是其他 PDE 的 40-50 倍。Eggmanone 通过选择性拮抗 PDE4 发挥 Hh 抑制作用，导致蛋白激酶 A 激活和随后的 Hh 阻断。

化合物

Cat.No: T15019

Target: Hedgehog/Smoothened

Cat.No: T3156

Synonym: Hedgehog Pathway Inhibitor 4,HPI-4

Target: Hedgehog/Smoothened

Cat.No: T22089

Target: Hedgehog/Smoothened

Cat.No: T64351

Synonym: RL-0070933

Target: Smo

Cat.No: T1779

Synonym: Smoothened Agonist (SAG) HCl,Smoothened Agonist

Target: Hedgehog/Smoothened, Smo

CUR61414 hydrochloride

Cat.No: T15019L

Synonym: CUR61414 hydrochloride (334998-36-6 Free base)

Target: Hedgehog/Smoothened

SAG dihydrochloride

Cat.No: T40465

Target: Hedgehog/Smoothened

Cat.No: T5465

Synonym: PF-5274857 freebase

Target: Smo

Cat.No: T16843

Synonym: IPI-926,Patidegib

Target: Others

Glasdegib hydrochloride

Cat.No: T71455

Target: Others

Hedgehog IN-2

Cat.No: T79055

Target: Others

Cat.No: T3363L

Synonym: Jervine hydrochloride

Target: Others

Cat.No: T71338

Target: Others

PF-5274857 mseylate (1373615-35-0 free base)

Cat.No: T28388

Synonym: PF5274857 HCl,PF 5274857,PF-5274857,PF-5274857 mesylate,PF-5274857 mseylate

Target: Others

Cat.No: T71520

Target: Others

MRT-83 hydrochloride

Cat.No: T38767

Target: Others

Cat.No: T40755

Target: Others

Cat.No: T63387

Target: Others

HPI-1 (hydrate)

Cat.No: T35538

Synonym: HPI-1 hydrate

Target: Others

Cat.No: T35539

Synonym: IHR-Cy3

Target: Others

Cat.No: T22077

Target: Others

Cat. No.	Product Name	Target	Signaling Pathways
T3912	Saikosaponin B1 柴胡皂苷B1,柴胡皂苷 B1	Others	Others
	Saikosaponin B1 是柴胡的生物活性成分，具有抗癌作用。它能够靶向SMO 抑制 Hedgehog 通路，显著抑制髓母细胞瘤模型中的肿瘤生长。
T1011	Itraconazole 伊曲康唑,R51211	P450; Hedgehog/Smoothened; Antibiotic; Autophagy; Antifungal	Autophagy; GPCR/G Protein; Metabolism; Microbiology/Virology; Stem Cells
	Itraconazole (R51211) 属于三唑类天然产物，是一种抗真菌剂，具有口服活性。Itraconazole 是一种 Hedgehog 信号通路拮抗剂，一种 oxysterol-binding protein (OSBP) 抑制剂，也是一种细胞色素 P-450 依赖性酶的抑制剂。

天然产物

Saikosaponin B1

Cat.No: T3912

Synonym: 柴胡皂苷B1,柴胡皂苷 B1

Target: Others

Cat.No: T1011

Synonym: 伊曲康唑,R51211

Target: P450, Hedgehog/Smoothened, Antibiotic, Autophagy, Antifungal

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPH-02540	GRK2 Protein, Mouse, Recombinant (His & SUMO) Beta-adrenergic receptor kinase 1,Grk2,G-protein-coupled rec...	Mouse	E. coli
	Specifically phosphorylates the agonist-occupied form of the beta-adrenergic and closely related receptors, probably inducing a desensitization of them. Key regulator of LPAR1 signaling. Competes with RALA for binding to LPAR1 thus affecting the signaling properties of the receptor. Desensitizes LPAR1 and LPAR2 in a phosphorylation-independent manner. Positively regulates ciliary smoothened (SMO)-dependent Hedgehog (Hh) signaling pathway by facilitating the trafficking of SMO into the cilium and...

重组蛋白

GRK2 Protein, Mouse, Recombinant (His & SUMO)

Cat.No: TMPH-02540

Species: Mouse

Expression System: E. coli

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