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Search Results for " hedgehog "

Targets Recommended: Hedgehog/Smoothened Hedgehog/Smoothened

67

抑制剂 & 化合物

6

天然产物

3

化合物库

11

重组蛋白

4

同位素标记化合物

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Cat. No.	Product Name
L4300	Wnt/Hedgehog/Notch 通路化合物库		237 compounds
	237 个Wnt & Hedgehog & Notch 靶点相关的生物活性小分子化合物的特有集合，用于相关通路的研究及药物的筛选，可用于高通量、高内涵筛选。
L2195	抗前列腺癌化合物库		2070 compounds
	2070 种与前列腺癌相关的化合物，可以用于高通量和高内涵筛选
L7900	成骨分子库		317 compounds
	317 种成骨相关的生物活性小分子化合物的特有集合，用于高通量、高内涵筛选；

化合物库

Wnt/Hedgehog/Notch 通路化合物库

Cat.No: L4300

Compounds: 237

抗前列腺癌化合物库

Cat.No: L2195

Compounds: 2070

成骨分子库

Cat.No: L7900

Compounds: 317

Cat. No.	Product Name	Target	Signaling Pathways
T3156	Ciliobrevin A Hedgehog Pathway Inhibitor 4,HPI-4	Hedgehog/Smoothened	GPCR/G Protein; Stem Cells
	Ciliobrevin A (HPI-4) 是Hedgehog(Hh) 信号通路抑制剂，平均抑制浓度 (IC50) 值小于 10 μM。
T35537	Hedgehog Antagonist VIII	Others	Others
	Hedgehog (Hh) proteins, important regulators of development, bind the cell-surface protein Patched, allowing activation of Smoothened. In vertebrates, this ultimately leads to the activation of the zinc-finger transcription factors of the Gli family. Overactivation of this pathway contributes to certain cancers, including glioblastoma, for which the Gli proteins are named. Hh antagonist VIII is a cell-permeable quinazolinyl-urea compound that has been shown to inhibit Gli transcription activity ...
T79055	Hedgehog IN-2	Others	Others
	HedgehogIN-2 (Compound 20)为一Hedgehog信号通路抑制剂，其在C3H10T1/2细胞中表现出低于0.003 μM的IC50值。
T75148	Hedgehog IN-3	Others	Others
	HedgehogIN-3 (化合物 3) 是一种hedgehog 通路抑制剂 (IC50= 0.01 µM)。HedgehogIN-3 可用于癌症的研究。
T15183	Dynarrestin	Hedgehog/Smoothened	GPCR/G Protein; Stem Cells
	Dynarrestin 是一种细胞质动力蛋白 1 和 2的氨基噻唑抑制剂。它能够快速的、可逆的抑制动力蛋白 1 驱动的微管在体外滑动和细胞内动力蛋白 1 和 2 依赖性过程，且不影响 ATP 水解和干扰纤毛发生。它可抑制神经元前体和肿瘤细胞的刺猬因子依赖性增殖。
T6891	MK-4101	Apoptosis; Hedgehog/Smoothened; Smo	Apoptosis; GPCR/G Protein; Stem Cells
	MK-4101 是一种 SMO 拮抗剂，对 293 细胞的 IC50为 1.1 µM。它也是一种 hedgehog 信号通路的有效抑制剂，对小鼠细胞和KYSE180 食管癌细胞的IC50分别为 1.5 µM 和 1 µM。它能抗肿瘤，抑制肿瘤细胞增殖并诱导细胞凋亡。
T9531	MRT-14	Smo	Stem Cells
	MRT-14 是有效的 Smo 拮抗剂。Smo 是参与 Hedgehog 形态发生素信号转导的主要成分。MRT-14 在研究与异常 Hh 信号传导相关的多种癌症方面有价值。
T3588	JK184	Hedgehog/Smoothened	GPCR/G Protein; Stem Cells
	JK184 是 Hedgehog 抑制剂，在哺乳动物细胞中的IC50值为 30 nM。
T2450	SANT-1 SANT 1	Hedgehog/Smoothened; Smo	GPCR/G Protein; Stem Cells
	SANT-1 是Smo 拮抗剂，能够抑制Hedgehog 通路，在 Shh-LIGHT2 和 SmoA1-LIGHT2 实验中，得到的IC50值分别为 20 nM 和 30 nM。
T14965	Ciliobrevin D	ATPase; Hedgehog/Smoothened	GPCR/G Protein; Membrane transporter/Ion channel; Stem Cells
	Ciliobrevin D 是细胞渗透性，可逆和特异性的 AAA + ATPase 运动细胞质动力蛋白抑制剂。它在体外抑制依赖于动力蛋白的微管滑动和 ATPase 活性。它抑制Hedgehog 信号和初级纤毛形成。
T22814	GSA-10	Hedgehog/Smoothened	GPCR/G Protein; Stem Cells
	GSA-10是新型的喹啉甲酰胺衍生物，有效激动平滑受体剂，EC50为 1.2 μM。它作用于Smo，促进多能间充质干细胞分化为成骨细胞。它介导 Hedgehog 信号传导，这可能对癌症疾病的再生医学具有研究意义。
T2590	Vismodegib Erivedge,GDC-0449,RG 3616,维莫德吉	Hedgehog/Smoothened; ABC; Autophagy	Autophagy; GPCR/G Protein; Membrane transporter/Ion channel; Stem Cells
	Vismodegib (GDC-0449) 是一种刺猬抑制剂，IC50值为 3 nM。它还可抑制 P-gp 和ABCG2的活性，IC50值分别为 3.0 μM 和 1.4 μM。
T26296	Triparanol 曲帕拉醇,MER-29,NSC 65345,NSC-65345,NSC65345	Apoptosis; Hedgehog/Smoothened	Apoptosis; GPCR/G Protein; Stem Cells
	Triparanol (NSC-65345) 干扰 Hedgehog 信号分子的翻译后修饰以及其受体 PTCH1 的甾醇传感域，导致 Hedgehog 信号的下调。 Triparanol 抑制人类肿瘤生长，是一种具有高眼毒性的抗血脂剂。
T20723	LGE-899 Sonidegib metabolite M48,LGE 899	Drug Metabolite	Metabolism
	LGE-899 (Sonidegib metabolite M48) 是 Sonidegib 的主要代谢物，是一种刺猬通路抑制剂。 LGE-899 (60 h) 的 Tmax 比 Sonidegib 长得多。
T22089	HPI 1	Hedgehog/Smoothened	GPCR/G Protein; Stem Cells
	HPI 1 是一种刺猬 (Hh) 信号抑制剂。在 Shh-LIGHT2 细胞中抑制 Sonic Hedgehog (Shh)-、SAG- 和 Gli 诱导的 Hh 通路激活（Shh-、SAG-、Gli2- 和 Gli1 诱导的激活的 IC50 值为 1.5、1.5、4 和 6 μM） .
T15019	CUR61414	Hedgehog/Smoothened	GPCR/G Protein; Stem Cells
	CUR61414 是 Hedgehog 信号通路的细胞渗透性抑制剂 (IC50 = 100-200 nM)，并选择性地结合 smoothened (Ki = 44 nM)。
T2666	Taladegib LY2940680	Hedgehog/Smoothened; Smo	GPCR/G Protein; Stem Cells
	Taladegib (LY2940680) 是smoothened 受体拮抗剂。
T1926	Sonidegib Erismodegib,NVP-LDE225,LDE225	Hedgehog/Smoothened; Smo	GPCR/G Protein; Stem Cells
	Sonidegib (Erismodegib) 是一种Smo 的选择性拮抗剂，能够抑制鼠 Smo (IC50:1.3 nM)和人 Smo (IC50:2.5 nM)。
T24754	Hh-Ag1.5 SAG-1.5,SAG1.5,SAG 1.5	Hedgehog/Smoothened	GPCR/G Protein; Stem Cells
	Hh-Ag1.5 (SAG-1.5) 是一种高效的 Hedgehog (Hh) 激动剂(EC50： 1 nM)和Smoothened (Smo)受体激动剂，对Smo的 EC50 为 1 nM、 Ki值在 0.5 和 2.3 nM 之间。Hh-Ag1.5 介导的重编程打破了非损伤肝脏干细胞的静止状态，从而挽救了肝衰竭。Hh-Ag1.5 诱导 hiPSCs 分化为皮肤前体细胞、脊髓运动神经元和脊髓感觉神经元。
T3460	HhAntag	Hedgehog/Smoothened; Smo	GPCR/G Protein; Stem Cells
	HhAntag 是高效的、特异性的、具有口服活性的 Hh 通路的SMO 拮抗剂。
T64351	GI-560192 RL-0070933	Smo	Stem Cells
	GI-560192 (RL-0070933) 是一种有效的纤毛调节剂。GI-560192 通过 hedgehog 信号通路调节 smoothed (Smo) 向初级纤毛的易位和/或积累。
T1779	SAG Smoothened Agonist (SAG) HCl,Smoothened Agonist	Hedgehog/Smoothened; Smo	GPCR/G Protein; Stem Cells
	SAG (Smoothened Agonist) 是一种 Smo 受体激动剂 (EC50=3 nM)，具有细胞渗透性和选择性。SAG 可以直接结合 Smo 螺旋束调节 Smo 活性，可以活化 Hedgehog 信号通路。
T9532	MRT-81	Others; Hedgehog/Smoothened	GPCR/G Protein; Others; Stem Cells
	MRT-81 是一种人和啮齿动物 smoothened 受体的有效拮抗剂，能够抑制 hedgehog 的活性，在 Shh-light2 细胞中的IC50值为 41 nM。它可用于研究癌症。
T77603	WAY-313170	PDE	Metabolism
	WAY-313170 对刺猬信号传导和磷酸二酯酶有抑制作用。
T35548	Dynapyrazole A	Dynamin	Cytoskeletal Signaling
	Dynapyrazole A 是微管动力蛋白的特异性抑制剂，对动力蛋白 1 和动力蛋白 2 依赖性微管滑动的 IC50 分别为 2.3 和 2.6 μM。 Dynapyrazole A 抑制 Hedgehog 信号传导，IC50 为 1.9 μM。
T63429	SMO-IN-2	Hedgehog/Smoothened	GPCR/G Protein; Stem Cells
	SMO-IN-2 是一种有效的 smoothened (SMO) 抑制剂，对 hedgehog (Hh) 信号传导有抑制作用。SMO-IN-2 对人髓母细胞瘤细胞系显示出抗增殖活性和抗癌活性。SMO-IN-2 可用于研究癌症。
T35559	SAG 21k	Hedgehog/Smoothened	GPCR/G Protein; Stem Cells
	SAG 21k 是一种可透过血脑屏障且具有口服生物活性和有效性的 Hedgehog 信号激活剂，可用于研究软骨再生。
T15019L	CUR61414 hydrochloride CUR61414 hydrochloride (334998-36-6 Free base)	Hedgehog/Smoothened	GPCR/G Protein; Stem Cells
	CUR61414 hydrochloride 是属于氨基脯氨酸类化合物的小分子。CUR61414 hydrochloride 是一种细胞渗透性的 Hedgehog 信号通路抑制剂(IC50= 100-200 nM)，可选择性结合 Smoothened (Smo, Ki= 44 nM)。CUR61414 hydrochloride 可以诱导癌细胞凋亡 (apoptosis) 而不影响非癌症细胞。
T21325	TAK-441 TAK441	Hedgehog/Smoothened	GPCR/G Protein; Stem Cells
	TAK-441 是一种具有口服活性的 Hedgehog 信号抑制剂 (IC50 = 4.4 nM)，具有有效的抗肿瘤活性。 TAK-441 抑制转录因子 Gli1 mRNA 表达和肿瘤生长。
T26723	AZD8542 AZD-8542,AZD 8542	Hedgehog/Smoothened; Smo	GPCR/G Protein; Stem Cells
	AZD8542 是 Smoothened (SMO) 的拮抗剂，也是一种 Hedgehog (Hh) 通路拮抗剂，具有抗癌抗增殖活性，可抑制生物体内肿瘤的生长，可用于研究前列腺癌和结肠癌。
T3070	GANT 61 NSC 136476,GANT61	Hedgehog/Smoothened; Autophagy	Autophagy; GPCR/G Protein; Stem Cells
	GANT 61 (GANT61) 是一种Gli1和Gli2抑制剂，靶向Hedgehog/GLi 通路。
T24159	IHR-1 IHR 1	Smo	Stem Cells
	IHR-1 是一种Smo 拮抗剂，不能透过细胞膜。
T40465	SAG dihydrochloride	Hedgehog/Smoothened	GPCR/G Protein; Stem Cells
	SAG dihydrochloride 是一种强效的 Smoothened（Smo）受体激动剂（EC 50 =3 nM；K d =59 nM）。SAG dihydrochloride 可激活刺猬信号通路并抵消环丙胺对 Smo 的抑制。
T12109	MRT-83	Smo	Stem Cells
	MRT-83 是一种 Smo 拮抗剂，其IC50值在纳摩尔级别。它能够抑制 Hedgehog 信号通路。
T23027	MRT-10	Hedgehog/Smoothened	GPCR/G Protein; Stem Cells
	MRT 10 是一种七跨膜平滑受体 (Smo) 拮抗剂，通过多种 Hedgehog (Hh) 测定，其IC50=0.65 μM。它与Smo 受体结合的位点是 Bodipycyclopamine。它可用于研究癌症。
T12797	RU-SKI 43 RUSKI 43	Hedgehog/Smoothened; Acyltransferase	GPCR/G Protein; Metabolism; Stem Cells
	RU-SKI 43 是一种有效的选择性刺猬酰基转移酶 (Hhat) 抑制剂，IC50 为 850 nM。RU-SKI 43 具有抗癌活性，是治疗肺腺癌的潜在化合物。RU-SKI 43 通过独立于平滑化的非规范信号传导降低 Gli-1 激活，并抑制 Akt 和 mTOR 通路活性。
T5465	PF-5274857 PF-5274857 freebase	Smo	Stem Cells
	PF-5274857 (PF-5274857 free base) freebase 是有效的、具有口服活性的、选择性的、可透过血脑屏障的 Smo 拮抗剂，其 IC50=5.8 nM，Ki=4.6 nM。它有用于包括激活的 Hh 途径驱动的脑肿瘤和脑转移在内的多种肿瘤的研究潜力。
T71299	M-25	Others	Others
	M-25 is a Smoothened antagonist and inhibitor of the Hedgehog pathway.
T12797L	RU-SKI 43 hydrochloride	Others	Others
	RU-SKI 43 hydrochloride is a potent and selective inhibitor of Hedgehog acyltransferase (Hhat)(IC50 of 850 nM), has anti-cancer activity.
T26899	BRD50837 BRD-50837,BRD 50837	Others	Others
	BRD50837 is a potent and selective inhibitor of Sonic Hedgehog (Shh).
T26901	BRD-9526 BRD 9526	Others	Others
	BRD-9526 is a potent and selective inhibitor of Sonic Hedgehog (Shh).
T34451	RUSKI-201 RU-SKI-201	Others	Others
	RUSKI-201 is the first selective Hedgehog acyltransferase (Hhat) chemical probe in cells.
T23307	SANT 2 SANT-2	Others	Others
	SANT-2 is an inhibitor of Sonic hedgehog signaling and also antagonizes smoothened receptor activity (KD = 12 nM).
T3363L	Jervine HCl Jervine hydrochloride	Others	Others
	Jervine is a naturally occurring steroidal alkaloid derived from the Veratrum plant species. Over the Hedgehog signaling pathway, Jervine effectively inhibits tumor growth using three human tumor xenograft models. Jervine has the potential to advance to t
T16843	Saridegib IPI-926,Patidegib	Others	Others
	Saridegib is an effective and specific inhibitor of Smoothened and a key signaling transmembrane protein in the Hedgehog pathway.
T71455	Glasdegib hydrochloride	Others	Others
	Glasdegib hydrochloride is a small-molecule inhibitor of the Hedgehog (Hh) signaling pathway with potential antineoplastic activity.
T79907	HPP-9	Others	Others
	HPP-9为一种蛋白降解靶向嵌合体(PROTACs)，基于Hedgehog通路抑制剂(HPI-1)开发，pIC50值为6.71，能够降解BET溴结构域，并表现出抗肿瘤活性[1]。
T71520	LEQ-506	Others	Others
	LEQ506, also known as NPV-LEQ506, is an orally bioavailable small-molecule Smoothened (Smo) antagonist with potential antineoplastic activity. Smoothened antagonist LEQ506 selectively binds to the Hedgehog (Hh)-ligand cell surface receptor Smo, which may result in the suppression of the Hh signaling pathway, thereby inhibiting tumor cell growth.
T71338	Patidegib HCl	Others	Others
	Patidegip, laos known as Saridegib and IPI-926, is an orally bioavailable, cyclopamine-derived (for structure comparison see Fig 1) inhibitor of the Hedgehog (Hh) pathway with potential antineoplastic activity. Specifically, Hedgehog pathway inhibitor IPI-926 binds to and inhibits the cell membrane-spanning G-protein coupled receptor SMO, which may result in the suppression of Hh pathway signaling and a decrease in tumor cell proliferation and survival. SMO is activated upon binding of Hh ligan...
T63387	SMO-IN-3	Others	Others
	SMO-IN-3 是 smoothened (SMO) 对有效抑制剂，能够作用于 hedgehog (Hh) 信号通路 (IC50: 34.09 nM)。SMO-IN-3 能够抑制人髓母细胞瘤细胞系 Daoy 的增殖，表现出抗癌作用。

化合物

Cat.No: T3156

Synonym: Hedgehog Pathway Inhibitor 4,HPI-4

Target: Hedgehog/Smoothened

Hedgehog Antagonist VIII

Cat.No: T35537

Target: Others

Hedgehog IN-2

Cat.No: T79055

Target: Others

Hedgehog IN-3

Cat.No: T75148

Target: Others

Cat.No: T15183

Target: Hedgehog/Smoothened

Cat.No: T6891

Target: Apoptosis, Hedgehog/Smoothened, Smo

Cat.No: T9531

Target: Smo

Cat.No: T3588

Target: Hedgehog/Smoothened

Cat.No: T2450

Synonym: SANT 1

Target: Hedgehog/Smoothened, Smo

Cat.No: T14965

Target: ATPase, Hedgehog/Smoothened

Cat.No: T22814

Target: Hedgehog/Smoothened

Cat.No: T2590

Synonym: Erivedge,GDC-0449,RG 3616,维莫德吉

Target: Hedgehog/Smoothened, ABC, Autophagy

Cat.No: T26296

Synonym: 曲帕拉醇,MER-29,NSC 65345,NSC-65345,NSC65345

Target: Apoptosis, Hedgehog/Smoothened

Cat.No: T20723

Synonym: Sonidegib metabolite M48,LGE 899

Target: Drug Metabolite

Cat.No: T22089

Target: Hedgehog/Smoothened

Cat.No: T15019

Target: Hedgehog/Smoothened

Cat.No: T2666

Synonym: LY2940680

Target: Hedgehog/Smoothened, Smo

Cat.No: T1926

Synonym: Erismodegib,NVP-LDE225,LDE225

Target: Hedgehog/Smoothened, Smo

Cat.No: T24754

Synonym: SAG-1.5,SAG1.5,SAG 1.5

Target: Hedgehog/Smoothened

Cat.No: T3460

Target: Hedgehog/Smoothened, Smo

Cat.No: T64351

Synonym: RL-0070933

Target: Smo

Cat.No: T1779

Synonym: Smoothened Agonist (SAG) HCl,Smoothened Agonist

Target: Hedgehog/Smoothened, Smo

Cat.No: T9532

Target: Others, Hedgehog/Smoothened

Cat.No: T77603

Target: PDE

Cat.No: T35548

Target: Dynamin

Cat.No: T63429

Target: Hedgehog/Smoothened

Cat.No: T35559

Target: Hedgehog/Smoothened

CUR61414 hydrochloride

Cat.No: T15019L

Synonym: CUR61414 hydrochloride (334998-36-6 Free base)

Target: Hedgehog/Smoothened

Cat.No: T21325

Synonym: TAK441

Target: Hedgehog/Smoothened

Cat.No: T26723

Synonym: AZD-8542,AZD 8542

Target: Hedgehog/Smoothened, Smo

Cat.No: T3070

Synonym: NSC 136476,GANT61

Target: Hedgehog/Smoothened, Autophagy

Cat.No: T24159

Synonym: IHR 1

Target: Smo

SAG dihydrochloride

Cat.No: T40465

Target: Hedgehog/Smoothened

Cat.No: T12109

Target: Smo

Cat.No: T23027

Target: Hedgehog/Smoothened

Cat.No: T12797

Synonym: RUSKI 43

Target: Hedgehog/Smoothened, Acyltransferase

Cat.No: T5465

Synonym: PF-5274857 freebase

Target: Smo

Cat.No: T71299

Target: Others

RU-SKI 43 hydrochloride

Cat.No: T12797L

Target: Others

Cat.No: T26899

Synonym: BRD-50837,BRD 50837

Target: Others

Cat.No: T26901

Synonym: BRD 9526

Target: Others

Cat.No: T34451

Synonym: RU-SKI-201

Target: Others

Cat.No: T23307

Synonym: SANT-2

Target: Others

Cat.No: T3363L

Synonym: Jervine hydrochloride

Target: Others

Cat.No: T16843

Synonym: IPI-926,Patidegib

Target: Others

Glasdegib hydrochloride

Cat.No: T71455

Target: Others

Cat.No: T79907

Target: Others

Cat.No: T71520

Target: Others

Cat.No: T71338

Target: Others

Cat.No: T63387

Target: Others

Cat. No.	Product Name	Target	Signaling Pathways
T2825	Cyclopamine 环巴胺,11-Deoxojervine	Hedgehog/Smoothened; Endogenous Metabolite; Smo	GPCR/G Protein; Metabolism; Stem Cells
	Cyclopamine (11-Deoxojervine) 是Hedgehog 通路的拮抗剂，细胞实验中IC50=46 nM。它还是选择性Smo 抑制剂。
T3912	Saikosaponin B1 柴胡皂苷B1,柴胡皂苷 B1	Others	Others
	Saikosaponin B1 是柴胡的生物活性成分，具有抗癌作用。它能够靶向SMO 抑制 Hedgehog 通路，显著抑制髓母细胞瘤模型中的肿瘤生长。
T3363	Jervine 蒜黎芦碱,Iervin,11-Ketocyclopamine,Jerwiny	Hedgehog/Smoothened; Smo	GPCR/G Protein; Stem Cells
	Jervine (Jerwiny) 是一种有效的刺猬 (Hh) 抑制剂(IC50:500-700 nM)。它是一种天然致畸性甾体生物碱，来自于 Veratrumalbum 的根茎，具有抗炎和抗氧化作用。
T1011	Itraconazole 伊曲康唑,R51211	P450; Hedgehog/Smoothened; Antibiotic; Autophagy; Antifungal	Autophagy; GPCR/G Protein; Metabolism; Microbiology/Virology; Stem Cells
	Itraconazole (R51211) 属于三唑类天然产物，是一种抗真菌剂，具有口服活性。Itraconazole 是一种 Hedgehog 信号通路拮抗剂，一种 oxysterol-binding protein (OSBP) 抑制剂，也是一种细胞色素 P-450 依赖性酶的抑制剂。
T1155	Mebendazole 甲苯达唑,甲苯咪唑,Telmin,Mebenvet,Vermox,Pantelmin	Apoptosis; Microtubule Associated; Parasite	Apoptosis; Cytoskeletal Signaling; Microbiology/Virology
	Mebendazole (Mebenvet) 是一种 hedgehog 抑制剂，用作驱虫药。
T4592	TOMATIDINE HYDROCHLORIDE Tomatidine,Tomatidine HCl,盐酸番茄碱	Others; NF-κB; JNK; Autophagy	Autophagy; MAPK; NF-κB; Others
	Tomatidine hydrochloride (Tomatidine HCl) 是一种甾体生物碱，可防止肌肉萎缩并促进肌肉生长。它通过阻断 NF-κB 和JNK 信号发挥抗炎作用，可激活哺乳动物细胞或秀丽隐杆线虫中的自噬。

天然产物

Cat.No: T2825

Synonym: 环巴胺,11-Deoxojervine

Target: Hedgehog/Smoothened, Endogenous Metabolite, Smo

Saikosaponin B1

Cat.No: T3912

Synonym: 柴胡皂苷B1,柴胡皂苷 B1

Target: Others

Cat.No: T3363

Synonym: 蒜黎芦碱,Iervin,11-Ketocyclopamine,Jerwiny

Target: Hedgehog/Smoothened, Smo

Cat.No: T1011

Synonym: 伊曲康唑,R51211

Target: P450, Hedgehog/Smoothened, Antibiotic, Autophagy, Antifungal

Cat.No: T1155

Synonym: 甲苯达唑,甲苯咪唑,Telmin,Mebenvet,Vermox,Pantelmin

Target: Apoptosis, Microtubule Associated, Parasite

TOMATIDINE HYDROCHLORIDE

Cat.No: T4592

Synonym: Tomatidine,Tomatidine HCl,盐酸番茄碱

Target: Others, NF-κB, JNK, Autophagy

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-03345	SHH Protein, Mouse, Recombinant (His) Hhg1,Hxl3,9530036O11Rik,Dsh,Hx,sonic hedgehog,M1000...	Mouse	HEK293 Cells
	SHH Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 21 kDa and the accession number is Q62226.
TMPJ-01171	SHH Protein, Mouse, Recombinant (C25II) HHG-1,SHH,Sonic Hedgehog Protein	Mouse	E. coli
	SHH Protein, Mouse, Recombinant (C25II) is expressed in E. coli expression system. The predicted molecular weight is 18-20 KDa and the accession number is Q62226.
TMPJ-01127	SHH Protein, Human, Recombinant Sonic Hedgehog Protein,SHH,HHG-1	Human	E. coli
	SHH Protein, Human, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 19 KDa and the accession number is Q15465.
TMPJ-01128	SHH Protein, Human, Recombinant (C24II) HHG-1,Sonic Hedgehog Protein,SHH	Human	E. coli
	SHH Protein, Human, Recombinant (C24II) is expressed in E. coli expression system. The predicted molecular weight is 20 KDa and the accession number is Q15465.
TMPJ-01170	SHH Protein, Mouse, Recombinant HHG-1,Sonic Hedgehog Protein,SHH	Mouse	E. coli
	SHH Protein, Mouse, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 20 KDa and the accession number is Q62226.
TMPH-01528	IHH Protein, Human, Recombinant (His) HHG-2,IHH,Indian hedgehog protein	Human	E. coli
	Intercellular signal essential for a variety of patterning events during development. Binds to the patched (PTC) receptor, which functions in association with smoothened (SMO), to activate the transcription of target genes. Implicated in endochondral ossification: may regulate the balance between growth and ossification of the developing bones. Induces the expression of parathyroid hormone-related protein (PTHRP).
TMPH-01215	DHH Protein, Human, Recombinant (GST & His & Myc) Desert hedgehog protein,HHG-3,DHH	Human	E. coli
	Intercellular signal essential for a variety of patterning events during development. May function as a spermatocyte survival factor in the testes. Essential for testes development.
TMPY-02832	SHH Protein, Human, Recombinant (aa 198-462, His) SMMCI,HLP3,HHG1,TPTPS,HPE3,MCOPCB5,TPT,Sonic hedgehog	Human	HEK293 Cells
	SHH Protein, Human, Recombinant (aa 198-462, His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 29 kDa and the accession number is Q15465.
TMPY-02905	SHH Protein, Human, Recombinant (aa 1-197, His) HHG1,MCOPCB5,SMMCI,Sonic hedgehog,TPTPS,HPE3,HLP3,T...	Human	HEK293 Cells
	SHH Protein, Human, Recombinant (aa 1-197, His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 21 kDa and the accession number is Q15465.
TMPH-02540	GRK2 Protein, Mouse, Recombinant (His & SUMO) Beta-adrenergic receptor kinase 1,Grk2,G-protein-coupled rec...	Mouse	E. coli
	Specifically phosphorylates the agonist-occupied form of the beta-adrenergic and closely related receptors, probably inducing a desensitization of them. Key regulator of LPAR1 signaling. Competes with RALA for binding to LPAR1 thus affecting the signaling properties of the receptor. Desensitizes LPAR1 and LPAR2 in a phosphorylation-independent manner. Positively regulates ciliary smoothened (SMO)-dependent Hedgehog (Hh) signaling pathway by facilitating the trafficking of SMO into the cilium and...
TMPY-02384	MTSS1 Protein, Human, Recombinant (aa1-250, His & MBP) metastasis suppressor 1,MIMB,MIM,MIMA	Human	E. coli
	MTSS1 (Metastasis suppressor 1), also known as Missing in metastasis (MIM), is a tissue-specific regulator of plasma membrane dynamics. MTSS1 is well described for its function as a metastasis suppressor gene and is expressed in a variety of tissues. MTSS1 might be involved in shaping neuronal membranes in vivo. MTSS1 deforms phosphoinositide-rich membranes through its I-BAR domain and interacts with actin monomers through its WH2 domain. MTSS1/MIM was first identified as a metastasis suppressor...

重组蛋白

SHH Protein, Mouse, Recombinant (His)

Cat.No: TMPY-03345

Species: Mouse

Expression System: HEK293 Cells

SHH Protein, Mouse, Recombinant (C25II)

Cat.No: TMPJ-01171

Species: Mouse

Expression System: E. coli

SHH Protein, Human, Recombinant

Cat.No: TMPJ-01127

Species: Human

Expression System: E. coli

SHH Protein, Human, Recombinant (C24II)

Cat.No: TMPJ-01128

Species: Human

Expression System: E. coli

SHH Protein, Mouse, Recombinant

Cat.No: TMPJ-01170

Species: Mouse

Expression System: E. coli

IHH Protein, Human, Recombinant (His)

Cat.No: TMPH-01528

Species: Human

Expression System: E. coli

DHH Protein, Human, Recombinant (GST & His & Myc)

Cat.No: TMPH-01215

Species: Human

Expression System: E. coli

SHH Protein, Human, Recombinant (aa 198-462, His)

Cat.No: TMPY-02832

Species: Human

Expression System: HEK293 Cells

SHH Protein, Human, Recombinant (aa 1-197, His)

Cat.No: TMPY-02905

Species: Human

Expression System: HEK293 Cells

GRK2 Protein, Mouse, Recombinant (His & SUMO)

Cat.No: TMPH-02540

Species: Mouse

Expression System: E. coli

MTSS1 Protein, Human, Recombinant (aa1-250, His & MBP)

Cat.No: TMPY-02384

Species: Human

Expression System: E. coli

Cat. No.	Product Name	Target	Signaling Pathways
TMIJ-0471	Mebendazole-d3
	Mebendazole-d3 是 Mebendazole 的氘代化合物。Mebendazole 的 CAS 号为 31431-39-7。Mebendazole是一种hedgehog抑制剂，用作驱虫药。
TMIJ-0277	Vismodegib-d7
	Vismodegib-d7 是 Vismodegib 的氘代化合物。Vismodegib 的 CAS 号为 879085-55-9。Vismodegib 是一种刺猬抑制剂，IC50值为 3 nM。它还可抑制P-gp和ABCG2的活性，IC50值分别为 3.0 μM 和 1.4 μM。
TMIJ-0276	Vismodegib-d4
	Vismodegib-d4 是 Vismodegib 的氘代化合物。Vismodegib 的 CAS 号为 879085-55-9。Vismodegib 是一种刺猬抑制剂，IC50值为 3 nM。它还可抑制P-gp和ABCG2的活性，IC50值分别为 3.0 μM 和 1.4 μM。
TMIJ-0214	Itraconazole-d5
	Itraconazole-d5 是 Itraconazole 的氘代化合物。Itraconazole 的 CAS 号为 84625-61-6。Itraconazole是三唑类抗真菌药，也是口服活性的Hedgehog信号通路拮抗剂，IC50约为 800 nM。它也是 oxysterol-binding protein抑制剂。它抑制羊毛甾醇 14α-脱甲基酶，从而抑制羊毛甾醇向麦角固醇的氧化转化。它有抗癌和抗血管作用。

同位素标记化合物

Cat.No: TMIJ-0471

Cat.No: TMIJ-0277

Cat.No: TMIJ-0276

Itraconazole-d5

Cat.No: TMIJ-0214

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