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Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T24055 |
FAUC 213
FAUC213,FAUC-213 |
Dopamine Receptor | GPCR/G Protein; Neuroscience |
FAUC 213 是一种具有口服活性的‘、高度选择性的、可透过血脑屏障的多巴胺 D4受体完全拮抗剂,对 hD4.4的 Ki=2.2 nM。它对 D2和 D3受体的活性较低,对于 hD2、hD3的 Ki 分别为 3.4 μM、5.3 μM。它表现出非典型的抗精神病活性。 | |||
T1684 |
Nitisinone
尼替西农,NTBC,SC0735,Nitisone |
Others; Reactive Oxygen Species | Immunology/Inflammation; Metabolism; NF-κB; Others |
Nitisinone (SC0735) 是一种 4-羟基苯丙酮酸双加氧酶抑制剂。 | |||
T37197 |
5-HT1A modulator 2 hydrochloride
|
5-HT Receptor | GPCR/G Protein; Neuroscience |
5-HT1A modulator 2 hydrochloride 是 8-OH-DPAT 的一种衍生物,是5-HT1A 的调节剂,Ki 为 53 nM。 | |||
T10168 |
5-HT1A modulator 1
5-HT1Amodulator1 |
Phospholipase; Dopamine Receptor; 5-HT Receptor; Adrenergic Receptor | GPCR/G Protein; Metabolism; Neuroscience |
5-HT1A modulator 1 对 5-HT1A、α1-肾上腺素能受体和 D2 受体具有非常高的亲和力(IC50s = 2 nM、10 nM 和 40 nM)。 | |||
T62843 |
5-HT1A antagonist 1
|
Others | Others |
5-HT1A antagonist 1 (compound 6f) 是一种有效的、选择性的 5-HT1Areceptor 受体拮抗剂 (Ki: 35 nM)。5-HT1A antagonist 1 能够用于研究中枢神经系统疾病。 | |||
T27558 |
HT1042
HT 1042,HT-1042 |
Others | Others |
HT1042 is an inhibitor of the β5i component of the 20S proteasome complex, it is used to aid in the treatment of inflammatory diseases, autoimmune and hematologic malignancies. | |||
T12207 |
NEO 376
SPI-376 |
Dopamine Receptor; 5-HT Receptor; GABA Receptor | GPCR/G Protein; Membrane transporter/Ion channel; Neuroscience |
NEO 376 (SPI-376) 是选择性5-HT1 受体、GABA 受体和多巴胺受体调节剂,可用于精神病的研究。 | |||
T8666 |
Naratriptan
|
5-HT Receptor | GPCR/G Protein; Neuroscience |
Naratriptan 是一种5-HT1受体选择性激动剂,可作用于偏头疼。 | |||
T0203 |
Sumatriptan succinate
舒马普坦琥珀酸盐,GR 43175,琥珀酸舒马曲坦 |
5-HT Receptor | GPCR/G Protein; Neuroscience |
Sumatriptan succinate (GR 43175) 是一种5-HT1受体激动剂,可作用于偏头疼的急性治疗。 | |||
T10872L |
CP 96021
|
5-HT Receptor | GPCR/G Protein; Neuroscience |
CP 96021是一组5-HT1受体和5-HT2受体拮抗剂,具有抗炎特性,是治疗胃肠道和呼吸道哮喘的非自身抗溃疡化合物。 | |||
T21385 |
Cinitapride
西尼必利,Paxapride,Cidine,cinitapride tartrate,Blaston,Cintapro,Cinmove |
5-HT Receptor | GPCR/G Protein; Neuroscience |
Cinitapride (Blaston) 是一种促胃药。它减缓肌肉的活动,以减轻诸如胃酸反流、胃排空延迟和溃疡性消化不良等病症的症状。 Cinitapride 作为 5-HT2 受体的拮抗剂和 5-HT1 和 5-HT4 受体的激动剂。 | |||
T22534 |
8-Hydroxy-DPAT hydrobromide
7-(二丙基氨基)-5,6,7,8-四氢-1-萘酚氢溴酸盐,8-OH-DPAT hydrobromide |
5-HT Receptor | GPCR/G Protein; Neuroscience |
8-Hydroxy-DPAT hydrobromide (8-OH-DPAT hydrobromide) 是一种选择性5-HT1A 激动剂,pIC50为 8.19。它对 5-HT1结合位点的亚型有近 1000 倍的选择性。 | |||
T23382 |
Spiroxatrine
R 5188 |
Dopamine Receptor; 5-HT Receptor; Adrenergic Receptor | GPCR/G Protein; Neuroscience |
Spiroxatrine (R 5188) 是一种选择性和有效性的 5-HT1α 和 α2-adrenergic 双重拮抗剂,具有镇静活性,对5-HT1α、5-HT1 β、5-HT2和多巴胺受体具有抑制作用。Spiroxatrine 可用于研究心血管系统相关疾病。 | |||
T4978 |
Sarpogrelate hydrochloride
盐酸沙格雷酯,MCI-9042 |
5-HT Receptor | GPCR/G Protein; Neuroscience |
Sarpogrelate hydrochloride (MCI-9042) 是一种选择性5-HT2R 拮抗剂,可用于研究与血栓形成有关的血管疾病,对 5-HT2A、5-HT2B 和 5-HT2C 受体的pKi 值分别为 8.52、6.57 和 7.43。 | |||
T1512 |
Rizatriptan benzoate
苯甲酸利扎曲坦,MK-462 Benzoate |
5-HT Receptor | GPCR/G Protein; Neuroscience |
Rizatriptan benzoate (MK-462 Benzoate) 是 5-HT1激动剂,通过选择性结合并激活血清素 (5-HT) 1B 受体和 5-HT 1D 受体,从而缓解偏头痛。 | |||
T0162 |
Quetiapine
ICI204636,Quetiapin,喹硫平 |
Dopamine Receptor; 5-HT Receptor; Adrenergic Receptor; AChR; Histamine Receptor | GPCR/G Protein; Immunology/Inflammation; Neuroscience |
Quetiapine (ICI204636) 是5-HT 受体激动剂和多巴胺受体拮抗剂,对人5-HT1A 的 pEC50值为 4.77,对人 D2的 pIC50值为 6.33。它用于治疗精神分裂症,以及治疗与 I 型双相情感障碍相关的急性躁狂发作。它对人 D2、HT1、5-HT2A、5-HT2C 受体具有中高等亲和力,pKi 值为 7.25、5.74、7.54和5.55。 | |||
T6602 |
Naratriptan hydrochloride
Naratriptan HCl,Amerge,Naramig,盐酸那拉曲坦,GR-85548A hydrochloride |
5-HT Receptor | GPCR/G Protein; Neuroscience |
Naratriptan hydrochloride (GR-85548A hydrochloride) 是一种5-HT1受体激动剂,有抗偏头疼特性。它还可以通过刺激三叉神经系统感觉神经末梢上的 5-HT1D/1B 受体来发挥其作用,从而减少促炎神经肽的释放。 | |||
T23405 |
Sumatriptan
|
Others | Others |
Sumatriptan succinate is a selective 5-HT1 receptor agonist with specificity towards 5-HT1D, 5-HT1B, and 5-HT1A. | |||
T4375 |
Methiothepin maleate
Metitepine,甲替平 |
5-HT Receptor | GPCR/G Protein; Neuroscience |
Methiothepin maleate (Metitepine) 是一种 5-HT1、5-HT6、5-HT7 血清素受体拮抗剂,可阻断血清素自身受体。 | |||
T68176 |
Isamoltane
|
Others | Others |
Isamoltane is a serotonin 5-HT1 Receptor Antagonist | |||
T27021 |
Cinitapride Tartrate
|
Others | Others |
Cinitapride Tartrate is an agonist of the 5-HT1 and 5-HT4 receptors and is also an antagonist of the 5-HT2 receptors. | |||
T22294 |
Cinitapride Hydrogen Tartrate
|
5-HT Receptor | GPCR/G Protein; Neuroscience |
Cinitapride Hydrogen Tartrate is a gastroprokinetic agent that acts as an antagonist of the 5-HT2 receptors and as an agonist of the 5-HT1 and 5-HT4 receptors | |||
T60989 |
Sumatriptan hydrochloride
|
Others | Others |
Sumatriptan (GR 43175) hydrochloride 可用于研究偏头痛,它是一种口服有效的5-HT1受体激动剂。Sumatriptan hydrochloride 对5-HT1D、5-HT1B 和5-HT1A 受体的 Ki 值分别为 17 nM、27 nM 和 100 nM。 | |||
T70257 |
Avitriptan HCl
|
Others | Others |
Avitriptan, also known as BMS-180048, is a selective 5-HT1-like receptor agonist. Avitriptan is an effective compound for the treatment of migraine headaches with a prolonged duration of response. Avitriptan Is a Ligand and Agonist of Human Aryl Hydrocarbon Receptor That Induces CYP1A1 in Hepatic and Intestinal Cells. | |||
T22959 |
m-Chlorophenylbiguanide hydrochloride
1-(3-Chlorophenyl)biguanidehydrochloride,1-(3-氯苯基)双胍 |
5-HT Receptor | GPCR/G Protein; Neuroscience |
m-Chlorophenylbiguanide hydrochloride 是一种 5-HT3 受体激动剂。它选择性结合 5-HT3(Ki: 0.002 µM) 超过 5-HT1A(Ki: 10 µM) 和 5-HT2(Ki: 10 µM) 受体,但也结合多巴胺转运蛋白上的高亲和力和低亲和力位点( DAT;IC50:在大鼠尾状壳核突触体膜中分别为 0.4 和 34.8 µM)。 | |||
T78184 |
MMV009085
|
Others | Others |
MMV009085是一种针对恶性疟原虫己糖转运体PfHT1的特异性抑制剂,具有潜在的抗疟效果。它同时抑制人葡萄糖转运蛋白,强效抑制葡萄糖吸收(IC50:2.6 μM)及恶性疟原虫3D7株的生长(EC50:1.23±0.04 μM)。 | |||
T8136 |
Perospirone hydrochloride
Perospirone HCl,盐酸哌罗匹隆,SM-9018 hydrochloride |
Dopamine Receptor; 5-HT Receptor | GPCR/G Protein; Neuroscience |
Perospirone hydrochloride (Perospirone HCl) 是非典型的抗精神病剂,可用于精神分裂症的研究。它是可口服的5-HT2A 受体和多巴胺 D2受体的拮抗剂,也是5-HT1A 受体的部分激动剂。 | |||
T12480 |
Pipamperone
Floropipamide,McN-JR 3345,酰胺哌啶酮,R 3345 |
Others; Dopamine Receptor; 5-HT Receptor | GPCR/G Protein; Neuroscience; Others |
Pipamperone (McN-JR 3345) 是5-HT2A 受体和D4受体的高亲和力拮抗剂,也是D2受体的低亲和力拮抗剂,pKi 分别为 8.2、8.0 和 6.7。 | |||
T38145 |
Eltoprazine
|
Others | Others |
Eltoprazine(DU28853) is a serenic or antiaggressive agent which as an agonist at the 5-HT1A and 5-HT1B receptors and as an antagonist at the 5-HT2C receptor.IC50 value:Target: 5-HT1A/1B agonist; 5-HT2C antagonistin vitro: The binding of [3H]eltoprazine to whole tissue sections was saturable and revealed an apparent dissociation constant (Kd) of 11 nM. Specific [3H]eltoprazine binding was completely displaced by 5-HT; conversely, unlabelled eltoprazine reduced [3H]5-HT binding to the levels of no... |
Cat. No. | Product Name | Species | Expression System |
---|---|---|---|
TMPH-03448 |
EHT1 Protein, S. cerevisiae, Recombinant (His)
EHT1,Ethanol hexanoyl transferase 1 |
Saccharomyces cerevisiae | E. coli |
Displays enzymatic activity both for medium-chain fatty acid (MCFA) ethyl ester synthesis and hydrolysis (esterase activity). MCFA are toxic for yeast and this enzyme could thus be involved in their detoxification by esterification. EHT1 Protein, S. cerevisiae, Recombinant (His) is expressed in E. coli expression system with N-10xHis tag. The predicted molecular weight is 57.3 kDa and the accession number is P38295. |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T12176 |
Naratriptan D3 Hydrochloride
GR-85548A D3 |
Others | Others |
Naratriptan D3 Hydrochloride is the deuterium labeled Naratriptan, is a selective agonist of 5-HT1 receptor subtype. | |||
TMID-0035 |
Naratriptan-d3
|
||
Naratriptan-d3 是 Naratriptan 的氘代化合物。Naratriptan 的 CAS 号为 121679-13-8。Naratriptan是一种5-HT1受体选择性激动剂,可作用于偏头疼。 | |||
TMIJ-0272 |
Sarpogrelate-d3 HCl
|
||
Sarpogrelate-d3 HCl 是 Sarpogrelate HCl 的氘代化合物。Sarpogrelate HCl 的 CAS 号为 135159-51-2。Sarpogrelate hydrochloride 是一种选择性5-HT2R拮抗剂,可用于研究与血栓形成有关的血管疾病,对 5-HT2A、5-HT2B 和 5-HT2C 受体的pKi值分别为 8.52、6.57 和 7.43。 |